Abstract:
:Microbial cultures and/or microbial associated diseases often have a characteristic smell. Volatile organic compounds (VOCs) are produced by all microorganisms as part of their normal metabolism. The types and classes of VOC produced is wide, including fatty acids and their derivatives (e.g. hydrocarbons, aliphatic alcohols and ketones), aromatic compounds, nitrogen containing compounds, and volatile sulfur compounds. A diversity of ecological niches exist in the human body which can support a polymicrobial community, with the exact VOC profile of a given anatomical site being dependent on that produced by both the host component and the microbial species present. The detection of VOCs is of interest to various disciplines, hence numerous analytical approaches have been developed to accurately characterize and measure VOCs in the laboratory, often from patient derived samples. Using these technological advancements it is evident that VOCs are indicative of both health and disease states. Many of these techniques are still largely confined to the research laboratory, but it is envisaged that in future bedside 'VOC profiling' will enable rapid characterization of microbial associated disease, providing vital information to healthcare practitioners.
journal_name
J Breath Resjournal_title
Journal of breath researchauthors
Thorn RM,Greenman Jdoi
10.1088/1752-7155/6/2/024001subject
Has Abstractpub_date
2012-06-01 00:00:00pages
024001issue
2eissn
1752-7155issn
1752-7163journal_volume
6pub_type
杂志文章,评审abstract::Wheeze is a common symptom in preschool children. The role of bacteria, regulatory T (T(reg)) cells and their association with airway inflammation in preschool wheeze is largely unknown. We evaluated inflammatory markers in exhaled breath condensate (EBC), bacterial colonization and circulating T(reg) cells in prescho...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/6/4/046001
更新日期:2012-12-01 00:00:00
abstract::Radiation dose is important in radiotherapy. Too little, and the treatment is not effective, too much causes radiation toxicity. A biochemical measurement of the effect of radiotherapy would be useful in personalisation of this treatment. This study evaluated changes in exhaled breath volatile organic compounds (VOC) ...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aba816
更新日期:2020-10-24 00:00:00
abstract::Aircraft engine exhaust increases the number concentration of nanoparticles (NP) in the surrounding environment. Health concerns related to NP raise the question of the exposure and health monitoring of airport workers. No biological monitoring study on this profession has been reported to date. The aim was to evaluat...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/3/036006
更新日期:2016-07-13 00:00:00
abstract::Leptin plays a key role in obstructive sleep apnea syndrome (OSAS). Leptin production in human airways has been previously evaluated by measuring leptin concentration in the exhaled breath condensate and in the induced sputum. The aim was to study leptin expression in the cells of induced sputum and in exhaled breath ...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/4/3/036003
更新日期:2010-09-01 00:00:00
abstract::Sugar malabsorption in the bowel can lead to bloating, cramps, diarrhea and other symptoms of irritable bowel syndrome as well as affecting absorption of other nutrients. The hydrogen breath test is now a well established noninvasive test for assessing malabsorption of sugars in the small intestine. However, there are...
journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7155/7/2/024001
更新日期:2013-06-01 00:00:00
abstract::The results of experiments are described in which a known quantity of sterile deuterated water is injected directly into the pulmonary circulation via the right internal jugular vein of several haemodialysis patients and the deuterium to hydrogen ratio, D/H, in the exhaled lung water was measured using the flowing aft...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/6/3/036005
更新日期:2012-09-01 00:00:00
abstract::Breath analysis represents a new frontier in medical diagnosis and a powerful tool for cancer biomarker discovery due to the recent development of analytical platforms for the detection and identification of human exhaled volatile compounds. Statistical and bioinformatic tools may represent an effective complement to ...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/9/3/031001
更新日期:2015-09-21 00:00:00
abstract::The human genome is the counterpart to the human exposome with respect to the gene × environment interaction that describes health state and outcome. The genome has already been sequenced and is in the process of being assessed for specific functionality; to similarly decode the exposome will require the measurement a...
journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7155/5/4/046005
更新日期:2011-12-01 00:00:00
abstract::Methods for breath sampling and analysis require robust quality assessment to minimise the risk of false discoveries. Planning large-scale multi-site breath metabolite profiling studies also requires careful consideration of systematic and random variation as a result of sampling and analysis techniques. In this study...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aae557
更新日期:2018-10-30 00:00:00
abstract::The current diagnostic challenge with diagnosing hepatic encephalopathy (HE) is identifying those with minimal HE as opposed to the more clinically apparent covert/overt HE. Rifaximin, is an effective therapy but earlier identification and treatment of HE could prevent liver disease progression and hospitalization. Ou...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/1/016012
更新日期:2016-02-11 00:00:00
abstract::The measurement of the peak exhaled breath temperature (EBT) during multiple tidal breaths offers an easy, non-invasive tool for monitoring airway inflammation. Chronic obstructive pulmonary disease (COPD) is linked to airway inflammation, which is further aggravated by exacerbations of the disease. However, the peak ...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/8/4/046002
更新日期:2014-09-18 00:00:00
abstract::While there has been progress in making use of breath tests to guide clinical decision making, the full potential of exhaled breath analysis still remains to be exploited. Here we summarize some of the reasons why this is the case, what we have done so far to overcome some of the existing obstacles, and our vision of ...
journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7163/aa9ee3
更新日期:2018-02-07 00:00:00
abstract::This study aimed to analyze the impact of chewing gum on halitosis parameters. Three databases were searched with the following focused question: 'Can chewing gum additionally reduce halitosis parameters, such as organoleptic scores and volatile sulfur compounds (VSC), when compared to a control treatment'? Controlled...
journal_title:Journal of breath research
pub_type: 杂志文章,meta分析,评审
doi:10.1088/1752-7163/aa5cc2
更新日期:2017-02-17 00:00:00
abstract::Fractional exhaled nitric oxide (FENO) is a marker of airway inflammation. Measuring FENO at multiple flow rates enables calculation of NO parameters: bronchial NO output (J awNO), bronchial wall (C awNO) and alveolar (C ANO) NO concentrations, and bronchial diffusion factor of NO (D awNO). FENO is known to rapidly re...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/abc054
更新日期:2020-11-05 00:00:00
abstract::Oxidative stress is associated with numerous health conditions and disorders, and aldehydes are known biomarkers of oxidative stress that can be non-invasively measured in exhaled human breath. Few studies report breath aldehyde levels in human populations, and none claim participant numbers in the hundreds or more. F...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/ab8865
更新日期:2020-07-21 00:00:00
abstract::Reactive oxygen species are associated with tissue inflammation and injury. Our laboratory has demonstrated that ethane, a stable product of lipid peroxidation, in exhaled breath can be used to measure total body oxidative stress. Herein patients were studied who underwent outpatient surgery, laproscopic bilateral tub...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/3/1/016002
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Recent studies have highlighted the possible involvement of leptin in inflammation. The leptin receptor is also expressed by alveolar macrophages, T lymphocytes and bronchial epitelial cells, suggesting a possible role in the cascade of airway inflammation. OBJECTIVES:The aim of the study was to evaluate th...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aa61c5
更新日期:2017-09-27 00:00:00
abstract::Exhaled breath collection is used to identify and monitor inflammatory or oxidative components in breath. Exhaled breath sample collection is noninvasive and would greatly benefit human pollutant exposure research. We demonstrate the efficacy of exhaled breath collection and analysis in two human exposure studies to o...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/2/3/037019
更新日期:2008-09-01 00:00:00
abstract::Breath tests have been used to investigate many physiological functions. Recently, we have developed a breath test system by using a non-invasive technique in conscious rats. In this study, we investigated the effect of atropine sulfate on the gastric emptying and gastrocecal transit time using [1-(13)C]acetic acid an...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/3/4/047003
更新日期:2009-12-01 00:00:00
abstract::A point-of-care, non-invasive, low-cost and sensitive nano-biodiagnostic is needed in today's age for rapid and accurate self-diagnosis as well as for the management of asthma, which is advantageous for low resource areas where asthma is prevalent. The objective of this research work was to prepare the miniature, nano...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/ab1faf
更新日期:2019-06-25 00:00:00
abstract::Breath analysis techniques offer a potential revolution in health care diagnostics, especially if these techniques can be brought into standard use in the clinic and at home. The advent of microsensors combined with smart sensor system technology enables a new generation of sensor systems with significantly enhanced c...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/5/3/037111
更新日期:2011-09-01 00:00:00
abstract::Experimental studies using trained dogs to identify breath odour markers of human cancer, published in the recent decade, have been analyzed and compared with the authors' own results. Particular published studies differ as regards the experimental setup, kind of odour samples (breath, urine, tumor tissue, serum), sam...
journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7155/9/2/027001
更新日期:2015-05-06 00:00:00
abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a highly heterogeneous disease and airflow limitation and symptoms only partially capture such heterogeneity. Since COPD is known to affect the production of volatile organic compounds (VOCs), we aimed to verify to which extent exhaled VOCs can characterize new...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aac273
更新日期:2018-06-08 00:00:00
abstract::This study investigated whether oral malodour with plaque-related periodontal disease was associated with the prevalence of periodontopathic bacteria in saliva and tongue debris. The subjects were 30 patients who visited the Breath Odour Clinic. An oral examination was performed at baseline and two months after period...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/2/1/017006
更新日期:2008-03-01 00:00:00
abstract::The data obtained for the concentration distributions of the most abundant volatile metabolites in exhaled breath determined in two independent studies are reviewed, the first limited study involving five healthy volunteers providing daily breath samples over a month, and the subsequent study involving 30 healthy volu...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/1/1/014004
更新日期:2007-09-01 00:00:00
abstract::Bronchiectasis, bronchiolectasis, and bronchiolisation of alveolar regions are salient features of idiopathic pulmonary fibrosis (IPF). We asked whether IPF was associated with physiological changes consistent with increases in the volume of conducting airways, and whether airway volume was related to the severity of ...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/1/016005
更新日期:2016-02-01 00:00:00
abstract::Volatile organic compounds (VOCs) in exhaled human breath can serve as potential disease-specific and exposure biomarkers and therefore can reveal information about a subject's health and environment. Pyridine, a VOC marker for exposure to tobacco smoke, and isoprene, a liver disease biomarker, were studied using atmo...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/7/2/026005
更新日期:2013-06-01 00:00:00
abstract::Blood ammonia is routinely used in clinical settings to assess systemic ammonia in hepatic encephalopathy and urea cycle disorders. Despite its drawbacks, blood measurement is often used as a comparator in breath studies because it is a standard clinical test. We sought to evaluate sources of measurement error and pot...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/9/4/047109
更新日期:2015-12-14 00:00:00
abstract::Nitric oxide has an important role in the development of the structure and function of the airways and vessel walls. Fractional exhaled nitric oxide (FE(NO)) is inversely related to the markers and risk factors of atherosclerosis. We aimed to estimate the relative contribution of genes and shared and non-shared enviro...
journal_title:Journal of breath research
pub_type: 杂志文章,多中心研究
doi:10.1088/1752-7155/7/2/026008
更新日期:2013-06-01 00:00:00
abstract::Oral malodour is a common condition which affects a large proportion of the population, resulting in social, emotional and psychological stress. Certain oral bacteria form a coating called a biofilm on the tongue dorsum and degrade organic compounds releasing volatile sulfur compounds that are malodourous. Current che...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/4/046009
更新日期:2016-10-18 00:00:00