Abstract:
:Breath tests have been used to investigate many physiological functions. Recently, we have developed a breath test system by using a non-invasive technique in conscious rats. In this study, we investigated the effect of atropine sulfate on the gastric emptying and gastrocecal transit time using [1-(13)C]acetic acid and lactose-[(13)C]ureide, respectively. Gastric emptying was significantly delayed by atropine sulfate in a dose-dependent manner (0.03-0.3 mg kg(-1)), but the effects of 0.1 and 0.3 mg kg(-1) were almost equal. C(max) and T(max) values were also significantly and dose-dependently decreased and delayed, respectively. However, AUC(120 min) values were not significantly different for the three doses of atropine sulfate. This suggests that although atropine sulfate slows the emptying of the gastric content, it is excreted eventually to the same content as the control. The gastrocecal transit time was significantly delayed by atropine sulfate at a dose of 1 mg kg(-1), but not at a dose of 0.1 mg kg(-1). These findings demonstrate that the breath tests can evaluate the effect of atropine sulfate on the gastric emptying and gastrocecal transit time. The effective dose of atropine sulfate may be different for gastric emptying and gastrocecal transit time.
journal_name
J Breath Resjournal_title
Journal of breath researchauthors
Uchida M,Yoshida K,Shimizu Kdoi
10.1088/1752-7155/3/4/047003subject
Has Abstractpub_date
2009-12-01 00:00:00pages
047003issue
4eissn
1752-7155issn
1752-7163pii
S1752-7155(09)23101-6journal_volume
3pub_type
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journal_title:Journal of breath research
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doi:10.1088/1752-7163/ab433d
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doi:10.1088/1752-7155/3/2/027005
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journal_title:Journal of breath research
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doi:10.1088/1752-7155/2/3/037019
更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1088/1752-7155/9/3/031001
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/6/3/036005
更新日期:2012-09-01 00:00:00
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journal_title:Journal of breath research
pub_type: 历史文章,杂志文章,评审
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更新日期:2013-09-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/4/046014
更新日期:2016-11-30 00:00:00
abstract::Cancer cells prefer hyperglycolysis versus oxidative phosphorylation, even in the presence of oxygen. This phenomenon is used through the FDG-PET scans, and may affect the exhaled volatile signature. This study investigates the volatile signature in lung cancer (LC) before and after an oral glucose tolerance test (OGT...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/2/026012
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pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7155/6/2/024001
更新日期:2012-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1088/1752-7155/8/2/026003
更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1088/1752-7155/6/2/026002
更新日期:2012-06-01 00:00:00
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journal_title:Journal of breath research
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2011-12-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aac5a5
更新日期:2018-06-08 00:00:00
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pub_type: 杂志文章
doi:10.1088/1752-7163/aa9eea
更新日期:2018-03-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7155/6/2/027103
更新日期:2012-06-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/1/016012
更新日期:2016-02-11 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7155/5/4/046005
更新日期:2011-12-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7163/aa9ee3
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aa7957
更新日期:2017-09-13 00:00:00
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pub_type: 杂志文章
doi:10.1088/1752-7163/abba6c
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journal_title:Journal of breath research
pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章
doi:10.1088/1752-7155/4/1/017105
更新日期:2010-03-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aabdaf
更新日期:2018-05-14 00:00:00