Breath biomarkers in environmental health science: exploring patterns in the human exposome.

abstract：:Biogenic amines are interesting compounds which may be of use for medical diagnosis or therapeutic monitoring. The present paper deals with the problems that occur with concentration determination of dimethylamine (DMA) and trimethylamine (TMA). These occur in the breath of people suffering from renal disease. The mea...

journal_title：Journal of breath research

authors： Wzorek B,Mochalski P,Sliwka I,Amann A

更新日期：2010-06-01 00:00:00

abstract：:Based on the adsorption of analytes in the sampling loop, a time-resolved dynamic dilution introduction method was developed for negative ion mobility spectrometry to continuously monitor end-tidal propofol without other sample pre-separation. The dynamic dilution characteristics of propofol and moisture in the Teflon...

journal_title：Journal of breath research

authors： Zhou Q,Li E,Wang Z,Gong Y,Wang C,Guo L,Li H

更新日期：2015-01-05 00:00:00

abstract：:Exhaled air contains sub-micron droplets of lung liquid, which potentially bear biomarkers of lung diseases. After dehydration they form dry residue particles (DRPs). As a first step in developing techniques to characterize individual DRPs, a new electrostatic collector was designed in which DRPs are charged within a ...

journal_title：Journal of breath research

authors： Morozov VN,Mikheev AY

更新日期：2017-01-09 00:00:00

abstract：:Fractional exhaled nitric oxide (FENO) is a marker of airway inflammation. Measuring FENO at multiple flow rates enables calculation of NO parameters: bronchial NO output (J awNO), bronchial wall (C awNO) and alveolar (C ANO) NO concentrations, and bronchial diffusion factor of NO (D awNO). FENO is known to rapidly re...

journal_title：Journal of breath research

authors： Karvonen T,Sepponen-Lavikko A,Holm K,Schultz R,Moilanen E,Lehtimäki L

更新日期：2020-11-05 00:00:00

abstract：:The haloamines, including the chloramines (H(2)NCl, HNCl(2)) and bromamine (H(2)NBr), are diffusible gases that are likely to be produced during inflammation and so may be present as markers of lung inflammation on breath. Although haloamines are quite reactive, it is possible to measure these compounds in humid sampl...

journal_title：Journal of breath research

authors： Storer MK,Dummer JD,Cook J,McEwan M,Epton MJ

更新日期：2011-09-01 00:00:00

abstract：:The design, realization and testing of a CO(2)-triggered breath sampler, capable of a separate collection of dead space and end-tidal air on multiple breaths, is presented. This sampling procedure has advantages in terms of the sample volume, insights regarding the origin of compounds, increased reproducibility and hi...

journal_title：Journal of breath research

authors： Di Francesco F,Loccioni C,Fioravanti M,Russo A,Pioggia G,Ferro M,Roehrer I,Tabucchi S,Onor M

更新日期：2008-09-01 00:00:00

abstract：:There is much clinical interest in the development of a low-cost and reliable test for diagnosing inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), two very distinct diseases that can present with similar symptoms. The assessment of stool samples for the diagnosis of gastro-intestinal diseases is in...

journal_title：Journal of breath research

authors： Shepherd SF,McGuire ND,de Lacy Costello BP,Ewen RJ,Jayasena DH,Vaughan K,Ahmed I,Probert CS,Ratcliffe NM

更新日期：2014-06-01 00:00:00

abstract：:Wheeze is a common symptom in preschool children. The role of bacteria, regulatory T (T(reg)) cells and their association with airway inflammation in preschool wheeze is largely unknown. We evaluated inflammatory markers in exhaled breath condensate (EBC), bacterial colonization and circulating T(reg) cells in prescho...

journal_title：Journal of breath research

authors： van de Kant KD,Klaassen EM,van Aerde KJ,Damoiseaux J,Bruggeman CA,Stelma FF,Stobberingh EE,Muris JW,Jöbsis Q,van Schayck OC,Dompeling E

更新日期：2012-12-01 00:00:00

abstract：:The objective of this study is to evaluate tonsil odor as a contributor to halitosis and to study the reduction of oral malodor by mouth rinsing, without tonsil treatment. In 48 halitosis patients, tonsil odor and oral malodor were assessed through the 0-5 scale. In tonsil odor assessment, a dental burnisher was inser...

journal_title：Journal of breath research

authors： Talebian A,Tazhibi M,Iranpoor R,Semyari H,Taherzadeh M

更新日期：2008-03-01 00:00:00

abstract：:Since the ancient discovery of the 'sweet odor' in human breath gas, pursuits of the breath analysis-based disease diagnostics have never stopped. Actually, the 'smell' of the breath, as one of three key disease diagnostic techniques, has been used in Eastern-Medicine for more than three thousand years. With advanceme...

journal_title：Journal of breath research

authors： Wang Z,Wang C

更新日期：2013-09-01 00:00:00

abstract：:Nitric oxide has an important role in the development of the structure and function of the airways and vessel walls. Fractional exhaled nitric oxide (FE(NO)) is inversely related to the markers and risk factors of atherosclerosis. We aimed to estimate the relative contribution of genes and shared and non-shared enviro...

journal_title：Journal of breath research

authors： Tarnoki DL,Tarnoki AD,Medda E,Littvay L,Lazar Z,Toccaceli V,Fagnani C,Stazi MA,Nisticó L,Brescianini S,Penna L,Lucatelli P,Boatta E,Zini C,Fanelli F,Baracchini C,Meneghetti G,Koller A,Osztovits J,Jermendy G,Preda

更新日期：2013-06-01 00:00:00

abstract：:Despite growing interest and considerable progress in breath research over the last decade, standardized practices for the sampling and analysis of breath gas volatiles remain elusive. The primary reasons for this are (a) the rich chemical diversity of exhaled breath that covers an extensive range of volatile organic ...

journal_title：Journal of breath research

authors： Herbig J,Beauchamp J

更新日期：2014-09-01 00:00:00

abstract：:Blood ammonia is routinely used in clinical settings to assess systemic ammonia in hepatic encephalopathy and urea cycle disorders. Despite its drawbacks, blood measurement is often used as a comparator in breath studies because it is a standard clinical test. We sought to evaluate sources of measurement error and pot...

journal_title：Journal of breath research

authors： Spacek LA,Mudalel M,Tittel F,Risby TH,Solga SF

更新日期：2015-12-14 00:00:00

abstract：:Staphylococcus aureus (S. aureus) is a common bacterium infecting children with cystic fibrosis (CF). Since current detection methods are difficult to perform in children, there is need for an alternative. This proof of concept study investigates whether breath profiles can discriminate between S. aureus infected and ...

journal_title：Journal of breath research

authors： Neerincx AH,Geurts BP,van Loon J,Tiemes V,Jansen JJ,Harren FJ,Kluijtmans LA,Merkus PJ,Cristescu SM,Buydens LM,Wevers RA

更新日期：2016-11-30 00:00:00

abstract：:This study investigated whether oral malodour with plaque-related periodontal disease was associated with the prevalence of periodontopathic bacteria in saliva and tongue debris. The subjects were 30 patients who visited the Breath Odour Clinic. An oral examination was performed at baseline and two months after period...

journal_title：Journal of breath research

authors： Kurata H,Awano S,Yoshida A,Ansai T,Takehara T

更新日期：2008-03-01 00:00:00

abstract：:Experimental studies using trained dogs to identify breath odour markers of human cancer, published in the recent decade, have been analyzed and compared with the authors' own results. Particular published studies differ as regards the experimental setup, kind of odour samples (breath, urine, tumor tissue, serum), sam...

journal_title：Journal of breath research

authors： Jezierski T,Walczak M,Ligor T,Rudnicka J,Buszewski B

更新日期：2015-05-06 00:00:00

abstract：:The forehead was studied as a possible sampling site for capturing changes in volatile organic compound (VOC) profiles associated with psychological-stress. Skin-VOCs were sampled with a polydimethylsilicone (PDMS)-coupon and the resulting VOCs were recovered and analysed with two-stage thermal desorption gas chromato...

journal_title：Journal of breath research

authors： Martin HJ,Turner MA,Bandelow S,Edwards L,Riazanskaia S,Thomas CL

更新日期：2016-11-21 00:00:00

abstract：:To investigate the premise that levels of endogenous volatile organic compounds (VOC) in breath reflect those in blood, the concentration of acetone and isoprene were measured in radial arterial blood, peripheral venous blood and breath samples from ten healthy volunteers. Coefficients of repeatability as a percentage...

journal_title：Journal of breath research

authors： O'Hara ME,Clutton-Brock TH,Green S,Mayhew CA

更新日期：2009-06-01 00:00:00

abstract：:Breath contains hundreds of volatile organic compounds (VOCs), the composition of which is altered in a wide variety of diseases. Bacteria are implicated in the formation of VOCs, but the biochemical mechanisms that lead to the formation of breath VOCs remain largely hypothetical. We hypothesized that bacterial DNA fr...

journal_title：Journal of breath research

authors： Bos LD,Meinardi S,Blake D,Whiteson K

更新日期：2016-12-17 00:00:00

abstract：:Robust methods for breath sampling and analysis are required for potential clinical applications. We have evaluated an improved sampling and experimental design, assessing instrumental and biological variability within and across breath measurements. Calibration curves for selected relevant volatile organic compounds...

journal_title：Journal of breath research

authors： Basanta M,Ibrahim B,Douce D,Morris M,Woodcock A,Fowler SJ

更新日期：2012-06-01 00:00:00

abstract：:Bronchiectasis, bronchiolectasis, and bronchiolisation of alveolar regions are salient features of idiopathic pulmonary fibrosis (IPF). We asked whether IPF was associated with physiological changes consistent with increases in the volume of conducting airways, and whether airway volume was related to the severity of ...

journal_title：Journal of breath research

authors： Plantier L,Debray MP,Estellat C,Flamant M,Roy C,Bancal C,Borie R,Israël-Biet D,Mal H,Crestani B,Delclaux C

更新日期：2016-02-01 00:00:00

abstract：:Proton transfer reaction time-of-flight mass spectrometry (PTR-ToF-MS) represents an attractive tool for the real-time analysis of VOC profiles in human breath. Quantification of breath VOCs by means of direct MS may be affected by the matrix, as human breath not only contains several hundred VOCs at the ppbV-pptV lev...

journal_title：Journal of breath research

authors： Trefz P,Schubert JK,Miekisch W

更新日期：2018-03-01 00:00:00

abstract：:Cancer cells prefer hyperglycolysis versus oxidative phosphorylation, even in the presence of oxygen. This phenomenon is used through the FDG-PET scans, and may affect the exhaled volatile signature. This study investigates the volatile signature in lung cancer (LC) before and after an oral glucose tolerance test (OGT...

journal_title：Journal of breath research

authors： Feinberg T,Alkoby-Meshulam L,Herbig J,Cancilla JC,Torrecilla JS,Gai Mor N,Bar J,Ilouze M,Haick H,Peled N

更新日期：2016-06-07 00:00:00

abstract：:Sugar malabsorption in the bowel can lead to bloating, cramps, diarrhea and other symptoms of irritable bowel syndrome as well as affecting absorption of other nutrients. The hydrogen breath test is now a well established noninvasive test for assessing malabsorption of sugars in the small intestine. However, there are...

journal_title：Journal of breath research

authors： de Lacy Costello BP,Ledochowski M,Ratcliffe NM

更新日期：2013-06-01 00:00:00

abstract：:Exhaled breath condensate (EBC) is increasingly being used as a non-invasive method for disease diagnosis and environmental exposure assessment. We previously detected the nucleic acids of bacterial pathogens in EBC. Influenza viruses can be transmitted through aerosols during coughing and exhaling. Existing detection...

journal_title：Journal of breath research

authors： Li X,Wang M,Chen J,Lin F,Wang W

更新日期：2021-01-12 00:00:00

abstract：:The sensitivity of selected ion flow tube mass spectrometry, SIFT-MS, has been increased such that it is now possible to detect metabolites present at a part-per-billion, ppb, level in single breath exhalations. However, to utilize this improved sensitivity, the overlaps (coincidences) of those ions resulting from int...

journal_title：Journal of breath research

authors： Spaněl P,Smith D

更新日期：2008-12-01 00:00:00

abstract：:The current diagnostic challenge with diagnosing hepatic encephalopathy (HE) is identifying those with minimal HE as opposed to the more clinically apparent covert/overt HE. Rifaximin, is an effective therapy but earlier identification and treatment of HE could prevent liver disease progression and hospitalization. Ou...

journal_title：Journal of breath research

authors： Arasaradnam RP,McFarlane M,Ling K,Wurie S,O'Connell N,Nwokolo CU,Bardhan KD,Skinner J,Savage RS,Covington JA

更新日期：2016-02-11 00:00:00

abstract：:Exhaled NO (FE(NO)) measurements have been utilized as a marker to diagnose asthma as well as a non-invasive tool for monitoring airway inflammation and the response to anti-inflammatory medications. One area where this non-invasive monitoring may be helpful is for asthmatic athletes as they train for competitive even...

journal_title：Journal of breath research

authors： Grob NM,Laskowski D,Dweik RA

更新日期：2008-09-01 00:00:00

abstract：:In the present longitudinal study, we followed volatile organic compounds (VOCs) excreted in exhaled breath of 20 healthy individuals over time, while adhering to a gluten-free diet for 4 weeks prior to adherence to a normal diet. We used gas chromatography coupled with mass spectrometry (TD-GC-tof-MS) in combination ...

journal_title：Journal of breath research

authors： Baranska A,Tigchelaar E,Smolinska A,Dallinga JW,Moonen EJ,Dekens JA,Wijmenga C,Zhernakova A,van Schooten FJ

更新日期：2013-09-01 00:00:00

abstract：:The discovery of nitric oxide (NO) as a signalling and regulatory molecule and its subsequent detection in the exhaled breath has not only yielded new mechanistic insights but also diagnostic opportunities and therapeutic targets in several important medical conditions. In diseases involving chronic pulmonary inflamma...

journal_title：Journal of breath research

authors： Boshier PR,Hanna GB,Marczin N

更新日期：2013-03-01 00:00:00