Abstract:
:Nitrative stress is thought to be involved in the inflammatory process in COPD airways, and the alveolar nitric oxide concentration (CAlv) has been reported to be increased. However, the CAlv levels are also regulated by gas diffusion at alveolar sites. The aim of the study was to assess the relationship between the CAlv and pulmonary function in COPD patients, while taking into account the lung diffusion capacity. Twenty stable COPD patients (GOLD stage1/2/3/4 = 6/8/6/0) and 16 healthy subjects took part in this cross-sectional study. Fractional exhaled nitric oxide (FE(NO)), CAlv, and pulmonary functions were measured. Pulmonary function, including single nitrogen washout curve (dN2) and diffusion capacity for carbon monoxide (DL(CO)), was also evaluated in patients with COPD. The mean FE(NO) levels (20.7 ppb versus 16.3 ppb, p < 0.05) and the mean CAlv levels (6.4 ppb versus 4.2 ppb, p < 0.01) in COPD patients were significantly increased compared to those in HS. The CAlv level in COPD was significantly correlated with dN2, %DL(CO)/alveolar volume (VA). Using the standard entry method of multivariate analysis to adjust for dN2 and %DL(CO)/VA, dN2 (β = 0.54, p = 0.005) and %DL(CO)/VA (β = -0.44, p = 0.018) still showed significant correlations with the CAlv levels. These results suggest that the CAlv could be a useful marker for the small airway dysfunction in COPD. Airway inflammation, including excess nitric oxide generation in the peripheral airways, might be related to the pathophysiology of COPD.
journal_name
J Breath Resjournal_title
Journal of breath researchauthors
Hirano T,Matsunaga K,Sugiura H,Minakata Y,Koarai A,Akamatsu K,Ichikawa T,Furukawa K,Ichinose Mdoi
10.1088/1752-7155/7/4/046002subject
Has Abstractpub_date
2013-12-01 00:00:00pages
046002issue
4eissn
1752-7155issn
1752-7163journal_volume
7pub_type
杂志文章abstract::Concentrations of exhaled volatile organic compounds (VOCs) may depend not only on biochemical or pathologic processes but also on physiological parameters. As breath sampling may be done in different body positions, effects of the sampling position on exhaled VOC concentrations were investigated by means of real-time...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/9/4/047105
更新日期:2015-11-19 00:00:00
abstract::In this study, the effects of aerobic exercise on the upper airways and their defense mechanisms were investigated in athletes. The athletes ran in two different environments: the downtown streets of the city of São Paulo (Street), more polluted, and an urban forest (Forest), less polluted. Thirty-eight young healthy ...
journal_title:Journal of breath research
pub_type: 杂志文章,随机对照试验
doi:10.1088/1752-7163/10/4/046018
更新日期:2016-12-21 00:00:00
abstract::Leptin plays a key role in obstructive sleep apnea syndrome (OSAS). Leptin production in human airways has been previously evaluated by measuring leptin concentration in the exhaled breath condensate and in the induced sputum. The aim was to study leptin expression in the cells of induced sputum and in exhaled breath ...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/4/3/036003
更新日期:2010-09-01 00:00:00
abstract::Due to its high sensitivity, compact size and low cost ion mobility spectrometry (IMS) has the potential to become a point-of-care breath analyzer. Therefore, we developed a prototype of a compact, closed gas loop IMS with gas chromatographic (GC) pre-separation and high resolving power of R = 90. In this study, we ...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/2/026004
更新日期:2016-04-08 00:00:00
abstract::This study aimed to analyze the impact of chewing gum on halitosis parameters. Three databases were searched with the following focused question: 'Can chewing gum additionally reduce halitosis parameters, such as organoleptic scores and volatile sulfur compounds (VSC), when compared to a control treatment'? Controlled...
journal_title:Journal of breath research
pub_type: 杂志文章,meta分析,评审
doi:10.1088/1752-7163/aa5cc2
更新日期:2017-02-17 00:00:00
abstract::Early detection of lung cancer (LC) is a priority since LC is characterized by symptoms mimicking other respiratory conditions, but it remains the leading cause of oncological disease death. Properly trained dogs can perceive the volatile organic compounds (VOCs) related to cancer thanks to their acute sense of smell....
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/ab716e
更新日期:2020-03-11 00:00:00
abstract::Exhaled nitric oxide (eNO) has been suggested to be a marker of small airway injury. We investigated the effects of different ventilation strategies on eNO. Sixty-nine patients who received elective open abdominal surgery under general anesthesia with more than 2 h of surgery duration were randomly divided into three ...
journal_title:Journal of breath research
pub_type: 杂志文章,随机对照试验
doi:10.1088/1752-7155/9/1/016006
更新日期:2015-02-26 00:00:00
abstract::The sensitivity of selected ion flow tube mass spectrometry, SIFT-MS, has been increased such that it is now possible to detect metabolites present at a part-per-billion, ppb, level in single breath exhalations. However, to utilize this improved sensitivity, the overlaps (coincidences) of those ions resulting from int...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/2/4/046003
更新日期:2008-12-01 00:00:00
abstract::The forehead was studied as a possible sampling site for capturing changes in volatile organic compound (VOC) profiles associated with psychological-stress. Skin-VOCs were sampled with a polydimethylsilicone (PDMS)-coupon and the resulting VOCs were recovered and analysed with two-stage thermal desorption gas chromato...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/4/046012
更新日期:2016-11-21 00:00:00
abstract::While there has been progress in making use of breath tests to guide clinical decision making, the full potential of exhaled breath analysis still remains to be exploited. Here we summarize some of the reasons why this is the case, what we have done so far to overcome some of the existing obstacles, and our vision of ...
journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7163/aa9ee3
更新日期:2018-02-07 00:00:00
abstract::The lung just like all other organs is affected by age. The lung matures by the age of 20 and age-related changes start around middle age, at 40-50 years. Exhaled nitric oxide (FENO) has been shown to be age, height and gender dependent. We hypothesize that the nitric oxide (NO) parameters alveolar NO (CANO), airway f...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aa7957
更新日期:2017-09-13 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD)/emphysema risk groups are well defined and screening allows for early identification of disease. The capability of exhaled volatile organic compounds (VOCs) to detect emphysema, as found by computed tomography (CT) in current and former heavy smokers participating in a lung...
journal_title:Journal of breath research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1088/1752-7155/5/4/046009
更新日期:2011-12-01 00:00:00
abstract::Oxidative stress is associated with numerous health conditions and disorders, and aldehydes are known biomarkers of oxidative stress that can be non-invasively measured in exhaled human breath. Few studies report breath aldehyde levels in human populations, and none claim participant numbers in the hundreds or more. F...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/ab8865
更新日期:2020-07-21 00:00:00
abstract::Robust methods for breath sampling and analysis are required for potential clinical applications. We have evaluated an improved sampling and experimental design, assessing instrumental and biological variability within and across breath measurements. Calibration curves for selected relevant volatile organic compounds...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/6/2/026002
更新日期:2012-06-01 00:00:00
abstract::The results of experiments are described in which a known quantity of sterile deuterated water is injected directly into the pulmonary circulation via the right internal jugular vein of several haemodialysis patients and the deuterium to hydrogen ratio, D/H, in the exhaled lung water was measured using the flowing aft...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/6/3/036005
更新日期:2012-09-01 00:00:00
abstract::Biogenic amines are interesting compounds which may be of use for medical diagnosis or therapeutic monitoring. The present paper deals with the problems that occur with concentration determination of dimethylamine (DMA) and trimethylamine (TMA). These occur in the breath of people suffering from renal disease. The mea...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/4/2/026002
更新日期:2010-06-01 00:00:00
abstract::Oral malodour is a common condition which affects a large proportion of the population, resulting in social, emotional and psychological stress. Certain oral bacteria form a coating called a biofilm on the tongue dorsum and degrade organic compounds releasing volatile sulfur compounds that are malodourous. Current che...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/4/046009
更新日期:2016-10-18 00:00:00
abstract::The objective of this study is to evaluate tonsil odor as a contributor to halitosis and to study the reduction of oral malodor by mouth rinsing, without tonsil treatment. In 48 halitosis patients, tonsil odor and oral malodor were assessed through the 0-5 scale. In tonsil odor assessment, a dental burnisher was inser...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/2/1/017016
更新日期:2008-03-01 00:00:00
abstract::The current diagnostic challenge with diagnosing hepatic encephalopathy (HE) is identifying those with minimal HE as opposed to the more clinically apparent covert/overt HE. Rifaximin, is an effective therapy but earlier identification and treatment of HE could prevent liver disease progression and hospitalization. Ou...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/1/016012
更新日期:2016-02-11 00:00:00
abstract:BACKGROUND:The analysis of volatile organic compounds (VOCs) in breath allows non-invasive investigations of diseases. Animal studies are conducted as a model to perform research of VOCs and their relation to diseases. In large animal models ruminants were often used as experimental targets. The effect of their physiol...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aabdaf
更新日期:2018-05-14 00:00:00
abstract::Staphylococcus aureus (S. aureus) is a common bacterium infecting children with cystic fibrosis (CF). Since current detection methods are difficult to perform in children, there is need for an alternative. This proof of concept study investigates whether breath profiles can discriminate between S. aureus infected and ...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/4/046014
更新日期:2016-11-30 00:00:00
abstract::Analysis of breath acetone could be useful in the Intensive Care Unit (ICU) setting to monitor evidence of starvation and metabolic stress. The aims of this study were to examine the relationship between acetone concentrations in breath and blood in critical illness, to explore any changes in breath acetone concentrat...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/7/3/037102
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a highly heterogeneous disease and airflow limitation and symptoms only partially capture such heterogeneity. Since COPD is known to affect the production of volatile organic compounds (VOCs), we aimed to verify to which extent exhaled VOCs can characterize new...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aac273
更新日期:2018-06-08 00:00:00
abstract::Breath gas analysis provides insight into human metabolism of healthy and ill individuals. As an innovative and non-invasive method, it opens up options to improve diagnostics, monitoring and treatment decisions. Mid-infrared laser absorption spectroscopy is utilized to detect CH(4), H(2)O, CO(2), NH(3) and CH(3)OH in...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/5/2/027101
更新日期:2011-06-01 00:00:00
abstract::Exhaled air contains sub-micron droplets of lung liquid, which potentially bear biomarkers of lung diseases. After dehydration they form dry residue particles (DRPs). As a first step in developing techniques to characterize individual DRPs, a new electrostatic collector was designed in which DRPs are charged within a ...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aa5359
更新日期:2017-01-09 00:00:00
abstract::Rodent and nonhuman primate studies indicate that developmental programming by reduced perinatal nutrition negatively impacts life course cardio-metabolic health. We have developed a baboon model in which we feed control mothers (CON) ad libitum while nutrient restricted mothers are fed 70% of ad libitum global feed i...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aaba84
更新日期:2018-05-14 00:00:00
abstract::Exhaled breath condensate (EBC) is increasingly being used as a non-invasive method for disease diagnosis and environmental exposure assessment. We previously detected the nucleic acids of bacterial pathogens in EBC. Influenza viruses can be transmitted through aerosols during coughing and exhaling. Existing detection...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/abd14c
更新日期:2021-01-12 00:00:00
abstract::The discovery of nitric oxide (NO) as a signalling and regulatory molecule and its subsequent detection in the exhaled breath has not only yielded new mechanistic insights but also diagnostic opportunities and therapeutic targets in several important medical conditions. In diseases involving chronic pulmonary inflamma...
journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7155/7/1/017118
更新日期:2013-03-01 00:00:00
abstract::Despite growing interest and considerable progress in breath research over the last decade, standardized practices for the sampling and analysis of breath gas volatiles remain elusive. The primary reasons for this are (a) the rich chemical diversity of exhaled breath that covers an extensive range of volatile organic ...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/8/3/037101
更新日期:2014-09-01 00:00:00
abstract::The haloamines, including the chloramines (H(2)NCl, HNCl(2)) and bromamine (H(2)NBr), are diffusible gases that are likely to be produced during inflammation and so may be present as markers of lung inflammation on breath. Although haloamines are quite reactive, it is possible to measure these compounds in humid sampl...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/5/3/037105
更新日期:2011-09-01 00:00:00