Breath testing for intra-abdominal infection: appendicitis, a preliminary study.

abstract：:Exhaled breath is coming to the forefront of non-invasive biomarker discovery efforts. Concentration of exhaled breath volatile organic compounds (VOCs) on thermal desorption (TD) tubes with subsequent analysis by gas chromatography-mass spectrometry (GC-MS) has dominated this field. As discovery experimentation incre...

journal_title：Journal of breath research

authors： Harshman SW,Mani N,Geier BA,Kwak J,Shepard P,Fan M,Sudberry GL,Mayes RS,Ott DK,Martin JA,Grigsby CC

更新日期：2016-10-12 00:00:00

abstract：:Proton transfer reaction time-of-flight mass spectrometry (PTR-ToF-MS) represents an attractive tool for the real-time analysis of VOC profiles in human breath. Quantification of breath VOCs by means of direct MS may be affected by the matrix, as human breath not only contains several hundred VOCs at the ppbV-pptV lev...

journal_title：Journal of breath research

authors： Trefz P,Schubert JK,Miekisch W

更新日期：2018-03-01 00:00:00

abstract：:Concentrations of exhaled volatile organic compounds (VOCs) may depend not only on biochemical or pathologic processes but also on physiological parameters. As breath sampling may be done in different body positions, effects of the sampling position on exhaled VOC concentrations were investigated by means of real-time...

journal_title：Journal of breath research

authors： Sukul P,Trefz P,Kamysek S,Schubert JK,Miekisch W

更新日期：2015-11-19 00:00:00

abstract：:The haloamines, including the chloramines (H(2)NCl, HNCl(2)) and bromamine (H(2)NBr), are diffusible gases that are likely to be produced during inflammation and so may be present as markers of lung inflammation on breath. Although haloamines are quite reactive, it is possible to measure these compounds in humid sampl...

journal_title：Journal of breath research

authors： Storer MK,Dummer JD,Cook J,McEwan M,Epton MJ

更新日期：2011-09-01 00:00:00

abstract：:There have been a number of studies in which metal oxide sensors (MOS) have replaced conventional analytical detectors in gas chromatography systems. However, despite the use of these instruments in a range of applications including breath research the sensor responses (i.e. resistance changes w.r.t. concentration of ...

journal_title：Journal of breath research

authors： Gould O,Wieczorek T,de Lacy Costello B,Persad R,Ratcliffe N

更新日期：2017-12-06 00:00:00

abstract：:Profiling the body chemistry by means of volatile organic compounds (VOCs) in the breath opens exciting new avenues in medical diagnostics. Gas sensors could provide ideal platforms for realizing portable, hand-held breath testing devices in the near future. This review summarizes the latest developments and applicati...

journal_title：Journal of breath research

authors： Tisch U,Haick H

更新日期：2014-06-01 00:00:00

abstract：:This study aimed to analyze the impact of chewing gum on halitosis parameters. Three databases were searched with the following focused question: 'Can chewing gum additionally reduce halitosis parameters, such as organoleptic scores and volatile sulfur compounds (VSC), when compared to a control treatment'? Controlled...

journal_title：Journal of breath research

authors： Muniz FW,Friedrich SA,Silveira CF,Rösing CK

更新日期：2017-02-17 00:00:00

abstract：:Cancer cells prefer hyperglycolysis versus oxidative phosphorylation, even in the presence of oxygen. This phenomenon is used through the FDG-PET scans, and may affect the exhaled volatile signature. This study investigates the volatile signature in lung cancer (LC) before and after an oral glucose tolerance test (OGT...

journal_title：Journal of breath research

authors： Feinberg T,Alkoby-Meshulam L,Herbig J,Cancilla JC,Torrecilla JS,Gai Mor N,Bar J,Ilouze M,Haick H,Peled N

更新日期：2016-06-07 00:00:00

abstract：:Exhaled nitric oxide (eNO) has been suggested to be a marker of small airway injury. We investigated the effects of different ventilation strategies on eNO. Sixty-nine patients who received elective open abdominal surgery under general anesthesia with more than 2 h of surgery duration were randomly divided into three ...

journal_title：Journal of breath research

authors： Cui Y,Pi X,Wang C,Liu S,Gong Y,Wang Y,Zhang F,Shi J,Lin Z,Zhang X,Li E

更新日期：2015-02-26 00:00:00

abstract：:Nitric oxide has an important role in the development of the structure and function of the airways and vessel walls. Fractional exhaled nitric oxide (FE(NO)) is inversely related to the markers and risk factors of atherosclerosis. We aimed to estimate the relative contribution of genes and shared and non-shared enviro...

journal_title：Journal of breath research

authors： Tarnoki DL,Tarnoki AD,Medda E,Littvay L,Lazar Z,Toccaceli V,Fagnani C,Stazi MA,Nisticó L,Brescianini S,Penna L,Lucatelli P,Boatta E,Zini C,Fanelli F,Baracchini C,Meneghetti G,Koller A,Osztovits J,Jermendy G,Preda

更新日期：2013-06-01 00:00:00

abstract：:Exhaled breath collection is used to identify and monitor inflammatory or oxidative components in breath. Exhaled breath sample collection is noninvasive and would greatly benefit human pollutant exposure research. We demonstrate the efficacy of exhaled breath collection and analysis in two human exposure studies to o...

journal_title：Journal of breath research

authors： Sawyer K,Samet JM,Ghio AJ,Pleil JD,Madden MC

更新日期：2008-09-01 00:00:00

abstract：:Oxidative stress is associated with numerous health conditions and disorders, and aldehydes are known biomarkers of oxidative stress that can be non-invasively measured in exhaled human breath. Few studies report breath aldehyde levels in human populations, and none claim participant numbers in the hundreds or more. F...

journal_title：Journal of breath research

authors： McCartney MM,Thompson CJ,Klein LR,Ngo JH,Seibel JD,Fabia F,Simms LA,Borras E,Young BS,Lara J,Turnlund MW,Nguyen AP,Kenyon NJ,Davis CE

更新日期：2020-07-21 00:00:00

abstract：:Early detection of lung cancer (LC) is a priority since LC is characterized by symptoms mimicking other respiratory conditions, but it remains the leading cause of oncological disease death. Properly trained dogs can perceive the volatile organic compounds (VOCs) related to cancer thanks to their acute sense of smell....

journal_title：Journal of breath research

authors： Mazzola SM,Pirrone F,Sedda G,Gasparri R,Romano R,Spaggiari L,Mariangela A

更新日期：2020-03-11 00:00:00

abstract：:Wheeze is a common symptom in preschool children. The role of bacteria, regulatory T (T(reg)) cells and their association with airway inflammation in preschool wheeze is largely unknown. We evaluated inflammatory markers in exhaled breath condensate (EBC), bacterial colonization and circulating T(reg) cells in prescho...

journal_title：Journal of breath research

authors： van de Kant KD,Klaassen EM,van Aerde KJ,Damoiseaux J,Bruggeman CA,Stelma FF,Stobberingh EE,Muris JW,Jöbsis Q,van Schayck OC,Dompeling E

更新日期：2012-12-01 00:00:00

abstract：:Since the ancient discovery of the 'sweet odor' in human breath gas, pursuits of the breath analysis-based disease diagnostics have never stopped. Actually, the 'smell' of the breath, as one of three key disease diagnostic techniques, has been used in Eastern-Medicine for more than three thousand years. With advanceme...

journal_title：Journal of breath research

authors： Wang Z,Wang C

更新日期：2013-09-01 00:00:00

abstract：:The results of experiments are described in which a known quantity of sterile deuterated water is injected directly into the pulmonary circulation via the right internal jugular vein of several haemodialysis patients and the deuterium to hydrogen ratio, D/H, in the exhaled lung water was measured using the flowing aft...

journal_title：Journal of breath research

authors： Tan BK,Davies SJ,Spaněl P,Smith D

更新日期：2012-09-01 00:00:00

abstract：:Breath contains hundreds of volatile organic compounds (VOCs), the composition of which is altered in a wide variety of diseases. Bacteria are implicated in the formation of VOCs, but the biochemical mechanisms that lead to the formation of breath VOCs remain largely hypothetical. We hypothesized that bacterial DNA fr...

journal_title：Journal of breath research

authors： Bos LD,Meinardi S,Blake D,Whiteson K

更新日期：2016-12-17 00:00:00

abstract：:The lung just like all other organs is affected by age. The lung matures by the age of 20 and age-related changes start around middle age, at 40-50 years. Exhaled nitric oxide (FENO) has been shown to be age, height and gender dependent. We hypothesize that the nitric oxide (NO) parameters alveolar NO (CANO), airway f...

journal_title：Journal of breath research

authors： Högman M,Thornadtsson A,Liv P,Hua-Huy T,Dinh-Xuan AT,Tufvesson E,Dressel H,Janson C,Koskela K,Oksa P,Sauni R,Uitti J,Moilanen E,Lehtimäki L

更新日期：2017-09-13 00:00:00

abstract：:While there has been progress in making use of breath tests to guide clinical decision making, the full potential of exhaled breath analysis still remains to be exploited. Here we summarize some of the reasons why this is the case, what we have done so far to overcome some of the existing obstacles, and our vision of ...

journal_title：Journal of breath research

authors： Singh KD,Del Miguel GV,Gaugg MT,Ibañez AJ,Zenobi R,Kohler M,Frey U,Sinues PM

更新日期：2018-02-07 00:00:00

abstract：:Blood ammonia is routinely used in clinical settings to assess systemic ammonia in hepatic encephalopathy and urea cycle disorders. Despite its drawbacks, blood measurement is often used as a comparator in breath studies because it is a standard clinical test. We sought to evaluate sources of measurement error and pot...

journal_title：Journal of breath research

authors： Spacek LA,Mudalel M,Tittel F,Risby TH,Solga SF

更新日期：2015-12-14 00:00:00

abstract：:The discovery of nitric oxide (NO) as a signalling and regulatory molecule and its subsequent detection in the exhaled breath has not only yielded new mechanistic insights but also diagnostic opportunities and therapeutic targets in several important medical conditions. In diseases involving chronic pulmonary inflamma...

journal_title：Journal of breath research

authors： Boshier PR,Hanna GB,Marczin N

更新日期：2013-03-01 00:00:00

abstract：:The human genome is the counterpart to the human exposome with respect to the gene × environment interaction that describes health state and outcome. The genome has already been sequenced and is in the process of being assessed for specific functionality; to similarly decode the exposome will require the measurement a...

journal_title：Journal of breath research

authors： Pleil JD,Stiegel MA,Sobus JR

更新日期：2011-12-01 00:00:00

abstract：:Despite recent progress in Critical Care Medicine, sepsis is still a major medical problem with a high rate of mortality and morbidity especially in intensive care units. Oxidative stress induced by inflammation associated with sepsis causes degradation of heme protein, increases microsomal free heme content, promotes...

journal_title：Journal of breath research

authors： Morimatsu H,Takahashi T,Matsusaki T,Hayashi M,Matsumi J,Shimizu H,Matsumi M,Morita K

更新日期：2010-12-01 00:00:00

abstract：:Due to its high sensitivity, compact size and low cost ion mobility spectrometry (IMS) has the potential to become a point-of-care breath analyzer. Therefore, we developed a prototype of a compact, closed gas loop IMS with gas chromatographic (GC) pre-separation and high resolving power of R  =  90. In this study, we ...

journal_title：Journal of breath research

authors： Allers M,Langejuergen J,Gaida A,Holz O,Schuchardt S,Hohlfeld JM,Zimmermann S

更新日期：2016-04-08 00:00:00

abstract：:Exhaled breath acetone (BrAce) was investigated during and after submaximal aerobic exercise as a volatile biomarker for metabolic responsiveness in high and lower-fit individuals in a prospective cohort pilot-study. Twenty healthy adults (19-39 years) with different levels of cardiorespiratory fitness (VO2peak), dete...

journal_title：Journal of breath research

authors： Königstein K,Abegg S,Schorn AN,Weber IC,Derron N,Krebs A,Gerber PA,Schmidt-Trucksäss A,Güntner AT

更新日期：2020-10-31 00:00:00

abstract：:Breath gas analysis provides insight into human metabolism of healthy and ill individuals. As an innovative and non-invasive method, it opens up options to improve diagnostics, monitoring and treatment decisions. Mid-infrared laser absorption spectroscopy is utilized to detect CH(4), H(2)O, CO(2), NH(3) and CH(3)OH in...

journal_title：Journal of breath research

authors： Hannemann M,Antufjew A,Borgmann K,Hempel F,Ittermann T,Welzel S,Weltmann KD,Völzke H,Röpcke J

更新日期：2011-06-01 00:00:00

abstract：:Reactive oxygen species are associated with tissue inflammation and injury. Our laboratory has demonstrated that ethane, a stable product of lipid peroxidation, in exhaled breath can be used to measure total body oxidative stress. Herein patients were studied who underwent outpatient surgery, laproscopic bilateral tub...

journal_title：Journal of breath research

authors： Brown RH,Risby TH

更新日期：2009-03-01 00:00:00

abstract：:The forehead was studied as a possible sampling site for capturing changes in volatile organic compound (VOC) profiles associated with psychological-stress. Skin-VOCs were sampled with a polydimethylsilicone (PDMS)-coupon and the resulting VOCs were recovered and analysed with two-stage thermal desorption gas chromato...

journal_title：Journal of breath research

authors： Martin HJ,Turner MA,Bandelow S,Edwards L,Riazanskaia S,Thomas CL

更新日期：2016-11-21 00:00:00

abstract：:To investigate the premise that levels of endogenous volatile organic compounds (VOC) in breath reflect those in blood, the concentration of acetone and isoprene were measured in radial arterial blood, peripheral venous blood and breath samples from ten healthy volunteers. Coefficients of repeatability as a percentage...

journal_title：Journal of breath research

authors： O'Hara ME,Clutton-Brock TH,Green S,Mayhew CA

更新日期：2009-06-01 00:00:00

abstract：:Fractional exhaled NO (FeNO) is universally considered an indirect marker of eosinophilic airways inflammation, playing an important role in the physiopathology of childhood asthma. Advances in technology and standardization have allowed a wider use of FeNO in clinical practice in children from the age of four years. ...

journal_title：Journal of breath research

authors： Piacentini GL,Cattazzo E,Tezza G,Peroni DG

更新日期：2012-06-01 00:00:00