Abstract:
:Since T cells express diverse sex steroid hormone receptors, they might be a good model to evaluate the effects of sex steroid hormones on immune modulation. Porcine testicular extract contains several sex steroid hormones and may be useful to study the effects of sex steroid hormones during T cell activation. We have examined the effects of the porcine testicular extract on T cell activation: proliferation and secretion of cytokines (IL-2 and IFN-γ) by activated T cells were severely decreased after treatment with porcine testicular extract. The extract produced an immunosuppressive effect and inhibited the proliferation of activated T cells by blocking the cell cycle transition from the G(1) phase to S phase. These effects were mediated by a decrease in the expression of cyclin D1 and cyclin E and constitutive expression of p27(KIP1) after T cell activation.
journal_name
Biotechnol Lettjournal_title
Biotechnology lettersauthors
Lee HH,Lee SJ,Kim S,Jeong S,Na M,Lee DM,Cheon YP,Lee KH,Choi I,Chun Tdoi
10.1007/s10529-012-0907-6subject
Has Abstractpub_date
2012-07-01 00:00:00pages
1225-33issue
7eissn
0141-5492issn
1573-6776journal_volume
34pub_type
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journal_title:Biotechnology letters
pub_type: 杂志文章,评审
doi:10.1007/s10529-012-0871-1
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journal_title:Biotechnology letters
pub_type: 杂志文章,评审
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journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1007/s10529-010-0227-7
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journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1007/s10529-013-1263-x
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journal_title:Biotechnology letters
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10529-007-9583-3
更新日期:2008-04-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1007/s10529-006-9172-x
更新日期:2006-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1007/s10529-012-0996-2
更新日期:2012-11-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1007/s10529-007-9606-0
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journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1007/s10529-013-1405-1
更新日期:2014-03-01 00:00:00
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更新日期:2008-03-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1007/s10529-015-1801-9
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pub_type: 杂志文章
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更新日期:2009-09-01 00:00:00
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journal_title:Biotechnology letters
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abstract::The exploded bast, branch and stem of cotton stalk were degraded by alkalophilic Bacillus NT-19, with weight losses of 24%, 20% and 14%, respectively, after 14 d. Compared with a white-rot fungus (Phanerochaete chrysosporium), Bacillus NT- 19 preferentially degraded the non-cellulose components of cotton stem. The rel...
journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1023/a:1026083827968
更新日期:2003-10-01 00:00:00
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doi:10.1007/s10529-009-0070-x
更新日期:2009-11-01 00:00:00
abstract::Excretion of 1,3-propanediol (1,3-PD) by K. pneumoniae was compared in ammonium- and phosphate-limited chemostat cultures running with an excess of glycerol. 59 and 43% catabolic flux were directed to 1,3-PD in ammonia-limited cultures and phosphate-limited cultures at dilution rate of 0.1 h(-1), respectively. Ammonia...
journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1007/s10529-009-0150-y
更新日期:2010-02-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 信件
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更新日期:2014-06-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章,评审
doi:10.1007/s10529-006-9111-x
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVES:Developing an effective HIV vaccine that stimulates the humoral and cellular immune responses is still challenging because of the diversity of HIV-1 virus, polymorphism of human HLA and lack of a suitable delivery system. RESULTS:Using bioinformatics tools, we designed a DNA construct encoding multiple epit...
journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1007/s10529-019-02734-x
更新日期:2019-11-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1007/s10529-008-9904-1
更新日期:2009-04-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1007/s10529-017-2371-9
更新日期:2017-09-01 00:00:00