Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta.

abstract：UNLABELLED:An overdose of acetaminophen (APAP) causes hepatotoxicity due to its metabolite, N-acetyl-p-benzoquinone imine. NAD(P)H:quinone oxidoreductase 1 (NQO1) is an important enzyme for detoxification, because it catabolizes endogenous/exogenous quinone to hydroquinone. Although various studies have suggested the ...

journal_title：Archives of toxicology

authors： Hwang JH,Kim YH,Noh JR,Gang GT,Kim KS,Chung HK,Tadi S,Yim YH,Shong M,Lee CH

更新日期：2015-11-01 00:00:00

abstract：:Liver disease is an escalating global health issue. While liver transplantation is an effective mode of therapy, patient mortality has increased due to the shortage of donor organs. Developing renewable sources of human liver tissue is therefore attractive. Pluripotent stem cell-derived liver tissue represents a poten...

journal_title：Archives of toxicology

authors： Rashidi H,Luu NT,Alwahsh SM,Ginai M,Alhaque S,Dong H,Tomaz RA,Vernay B,Vigneswara V,Hallett JM,Chandrashekran A,Dhawan A,Vallier L,Bradley M,Callanan A,Forbes SJ,Newsome PN,Hay DC

更新日期：2018-10-01 00:00:00

abstract：:Long-term exposure of rats to cadmium (Cd) resulted in a marked suppression of erythropoietin (Epo) mRNA expression in the kidneys and the development of severe anemia. A recent report revealed that Cd inhibited hypoxia-inducible factor 1 (HIF-1) binding activity and Epo mRNA expression and protein production. However...

journal_title：Archives of toxicology

authors： Obara N,Imagawa S,Nakano Y,Suzuki N,Yamamoto M,Nagasawa T

更新日期：2003-05-01 00:00:00

abstract：:Rhabdomyolysis has been reported in patients who abuse synthetic cannabinoids. However, no studies have yet assessed whether these cases reflect the direct cytotoxicity of synthetic cannabinoids on skeletal muscle, a possibility that the present study sought to address. Specifically, this study investigated the cytoto...

journal_title：Archives of toxicology

authors： Tomiyama KI,Funada M

更新日期：2020-11-10 00:00:00

abstract：:3-Chloro-1,2-propanediol (3-MCPD) fatty acid esters are formed upon thermal processing of fat-containing foods in the presence of chloride ions. Upon hydrolytic cleavage, these substances could release free 3-MCPD. This compound is toxicologically well characterised and displayed cancerogenic potential in rodent model...

journal_title：Archives of toxicology

authors： Buhrke T,Weisshaar R,Lampen A

更新日期：2011-10-01 00:00:00

abstract：:The reversibility of quinolone-induced cartilage lesions has not been studied in detail. We treated five groups of five to seven juvenile Wistar rats (male and female; age: 5 weeks) with 2 x 600 mg ofloxacin/kg by gastric intubation on 1 day only (9:00 a.m. and 5:00 p.m.) and studied the knee joints histologically 3 d...

journal_title：Archives of toxicology

authors： Förster C,Kociok K,Shakibaei M,Merker HJ,Stahlmann R

更新日期：1996-01-01 00:00:00

abstract：:The aim of this study was to investigate the electrophilic tissue burden (ETB) formation, assessed as covalent binding of the ultimate carcinogen benzo( a)pyrene diolepoxide (BaPDE) with cellular proteins, in liver, lung and heart, as well as with haemoglobin (Hb) following repeated exposure to binary mixtures of benz...

journal_title：Archives of toxicology

authors： Tzekova A,Leroux S,Viau C

更新日期：2004-02-01 00:00:00

abstract：:Previous human and experimental studies have demonstrated that lead exposure may modify the metabolism of lipids. Several studies have indicated that exposure to lead produces an increase in lipid peroxidation and inhibits blood superoxide dismutase activity. Recently, lipid peroxides have been shown to impair tissue ...

journal_title：Archives of toxicology

authors： Skoczyńska A,Smolik R,Jeleń M

更新日期：1993-01-01 00:00:00

abstract：:Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population. Treatment of OP poisoning is an ongoing challenge and burden for medical services. Standard drug treatment consists of atropine and an oxime as reactivator of OP-inhibited acetylcholinesterase and is virtually unchanged since more...

journal_title：Archives of toxicology

authors： Worek F,Thiermann H,Wille T

更新日期：2020-07-01 00:00:00

abstract：:Several structurally different metal chelating agents were screened for their relative efficacy in counteracting acute manganese intoxication in mice. Polyaminocarboxylic acids with nitrogen and oxygen as metal binding sites were more effective than certain sulfhydryl chelating agents and common drugs in preventing mo...

journal_title：Archives of toxicology

authors： Tandon SK,Khandelwal S

更新日期：1982-05-01 00:00:00

abstract：:Sotalol [4-(2-isopropylamino-1-hydroxyethyl)-methane-sulfonanilide hydrochloride] is a beta-adrenergic blocking agent. Despite the widespread use of these drugs, poisonings are not frequent. In this report the authors describe the first recorded case of fatal sotalol overdosage to their knowledge. The results of toxic...

journal_title：Archives of toxicology

authors： Montagna M,Groppi A

更新日期：1980-01-01 00:00:00

abstract：:Sodium diethyldithiocarbamate (DETC) is the main metabolite of disulfiram. Recently, we reported that mechanism of disulfiram cytotoxicity in V79 cells might be partially connected with thiol redox-state imbalance. Here, we examined the effect of DETC on the level of intracellular glutathione (GSH), protein oxidation ...

journal_title：Archives of toxicology

authors： Rahden-Staroń I,Grosicka-Maciąg E,Kurpios-Piec D,Czeczot H,Grzela T,Szumiło M

更新日期：2012-12-01 00:00:00

abstract：:Rats were exposed to black tea (2.5% w/v) as their sole drinking liquid for either 1 day or 1 month, while controls were maintained on water. After this treatment period, all animals received a single oral dose IQ (2-amino-3-methylimidazo-[4,5-f]quinoline), and urine was collected for 48 h. Mutagenic activity of the u...

journal_title：Archives of toxicology

authors： Yoxall VR,Parker DA,Kentish PA,Ioannides C

更新日期：2004-08-01 00:00:00

abstract：: ...

journal_title：Archives of toxicology

authors： Murad W,Abbass T,Seddek AL

更新日期：2018-11-01 00:00:00

abstract：:The use of nanotechnology is increasing exponentially, whereas the possible adverse health effects of engineered nanoparticles (NPs) are so far less known. Standardized mouse bioassay was used to study sensory and pulmonary irritation, airflow limitation, and inflammation potency of nanosized TiO(2). Single exposure (...

journal_title：Archives of toxicology

authors： Leppänen M,Korpi A,Miettinen M,Leskinen J,Torvela T,Rossi EM,Vanhala E,Wolff H,Alenius H,Kosma VM,Joutsensaari J,Jokiniemi J,Pasanen P

更新日期：2011-07-01 00:00:00

abstract：:Carbon tetrachloride-induced liver injury is a thoroughly studied model for regeneration and fibrosis in rodents. Nevertheless, its pattern of liver fibrosis is frequently misinterpreted as portal type. To clarify this, we show that collagen type IV+ "streets" and α-SMA+ cells accumulate pericentrally and extend to ne...

journal_title：Archives of toxicology

authors： Hammad S,Braeuning A,Meyer C,Mohamed FEZA,Hengstler JG,Dooley S

更新日期：2017-11-01 00:00:00

abstract：:pp'DDT (600 mg/kg, orally) produced an increase in the level of free ammonia and a decrease of acetylcholine in the corpus striatum of rats. These effects were maximal 5 h after the administration of pp'DDT. The animals showed tremors after 2 h, mild or moderate convulsions after 3.5 h and severe convulsions 5 h after...

journal_title：Archives of toxicology

authors： Matin MA,Jaffery FN,Kar PP

更新日期：1980-05-01 00:00:00

abstract：:The kinetic analysis of esterase inhibition by acylating compounds (organophosphorus carbamates and sulfonyl fluorides) is sometimes unable to yield consistent results by fitting simple inhibition kinetic models to experimental data of complex systems. In this work, kinetic data were obtained for phenylmethylsulfonyl ...

journal_title：Archives of toxicology

authors： Estévez J,Barril J,Vilanova E

更新日期：2012-05-01 00:00:00

abstract：:The mycotoxin deoxynivalenol (DON) has a high global prevalence in grain-based products. Biomarkers of exposure are detectable in most humans and farm animals. Considering the acute emetic and chronic anorexigenic toxicity of DON, maximum levels for food and feed have been implemented by food authorities. The tolerabl...

journal_title：Archives of toxicology

authors： Faeste CK,Pierre F,Ivanova L,Sayyari A,Massotte D

更新日期：2019-07-01 00:00:00

abstract：:Diet is directly related with physiological alterations occurring at a cell and subcellular level. However, the role of diet manipulation on mitochondrial physiology is still largely unexplored. Aiming at correlating diet with alterations of mitochondrial membrane composition and bioenergetics, Wistar-Han male rats we...

journal_title：Archives of toxicology

authors： Monteiro JP,Pereira CV,Silva AM,Maciel E,Baldeiras I,Peixoto F,Domingues MR,Jurado AS,Oliveira PJ

更新日期：2013-12-01 00:00:00

abstract：:This study aimed to investigate the effect of single and repeated administration of fenarimol on murine liver, kidney and lung microsomal CYP-catalyzed drug metabolism. The modulation of the regio- and stereo-selective hydroxylation of testosterone by fenarimol was considered in evaluating cocarcinogenic properties. I...

journal_title：Archives of toxicology

authors： Paolini M,Pozzetti L,Mesirca R,Sapone A,Cantelli-Forti G

更新日期：1996-01-01 00:00:00

abstract：:The metabolism of arsenic is generally accepted to proceed by repetitive reduction and oxidative methylation; the latter is mediated by arsenic methyltransferase (Cyt19). In human urine, the major metabolites of inorganic arsenicals such as arsenite (iAsIII) and arsenate (iAsV) are monomethylarsonic acid (MMA(V)) and ...

journal_title：Archives of toxicology

authors： Hayakawa T,Kobayashi Y,Cui X,Hirano S

更新日期：2005-04-01 00:00:00

abstract：:Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node ass...

journal_title：Archives of toxicology

authors： van der Veen JW,Gremmer ER,Vermeulen JP,van Loveren H,Ezendam J

更新日期：2013-04-01 00:00:00

abstract：:The toxicity of 60 micrograms/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) given IP in corn oil/5% acetone was examined in male Sprague-Dawley rats adapted to 25 degrees C or 4 degrees C ambient temperature. Cold exposure significantly reduced mean time to death and tended to increase mortality. Body weight at the ti...

journal_title：Archives of toxicology

authors： Rozman K,Greim H

更新日期：1986-12-01 00:00:00

abstract：:The objective of this study was to evaluate the role of apoptosis in the development of the newborn cochlear structures and hearing loss caused by prenatal cis-diaminedichloroplatinum (cisplatin) exposure. Pregnant albino guinea pigs were intraperitoneally injected with 1.5 mg/kg body weight cisplatin once a day for s...

journal_title：Archives of toxicology

authors： Hao S,Jiang X,Yan A,Yang B

更新日期：2011-01-01 00:00:00

abstract：:In the present study the toxicological potential of a tumor-inhibiting dinuclear platinum(II) complex (bis(acetato)diammine-bis-micro-acetato diplatinum(II) dihydrate (BAP)) was evaluated, utilizing in vitro models of nephrotoxicity, myelosuppression and neurotoxicity. Regarding the discrepancies between the hallmark ...

journal_title：Archives of toxicology

authors： Momekov G,Ferdinandov D,Bakalova A,Zaharieva M,Konstantinov S,Karaivanova M

更新日期：2006-09-01 00:00:00

abstract：:MDMA-induced impairments of memory performance have been reported in different human and animal studies. However, the correlation between spatial memory impairment, brain mitochondrial function, and concentrations of MDMA and its metabolites has not yet been investigated despite it being needed for comparison with hum...

journal_title：Archives of toxicology

authors： Taghizadeh G,Mehdizadeh H,Lavasani H,Hosseinzadeh Ardakani Y,Foroumadi A,Halvaei Khankahdani Z,Moshtagh A,Pourahmad J,Sharifzadeh M,Rouini MR

更新日期：2020-03-01 00:00:00

abstract：:4-Nonylphenol (para-nonylphenol, 4-NP), metabolites including linear and branched isoforms of nonylphenol (n-NP and t-NP, respectively), has been considered an endocrine disrupting substance resulting in reproductive dysfunction and increasing reactive oxygen species production in testis, liver, kidney, and brain. How...

journal_title：Archives of toxicology

authors： Hsieh CY,Miaw CL,Hsieh CC,Tseng HC,Yang YH,Yen CH

更新日期：2009-10-01 00:00:00

abstract：:Amoscanate, a substance which damages photoreceptors, was administered orally to Wistar rats in doses of 10, 40, and 125 mg/kg body weight once daily for 3 or 10 days. At both times electroretinographic, ophthalmological, and histopathological examinations of the retina were carried out to compare the sensitivity of c...

journal_title：Archives of toxicology

authors： Maertins T,Kroetlinger F,Sander E,Pauluhn J,Machemer L

更新日期：1993-01-01 00:00:00

abstract：:Increasing incidence of multidrug-resistant bacteria presents an imminent risk to global health. Polymyxins are 'last-resort' antibiotics against Gram-negative 'superbugs'; however, nephrotoxicity remains a key impediment in their clinical use. Molecular mechanisms underlying this nephrotoxicity remain poorly defined....

journal_title：Archives of toxicology

authors： Yun B,Zhang T,Azad MAK,Wang J,Nowell CJ,Kalitsis P,Velkov T,Hudson DF,Li J

更新日期：2018-07-01 00:00:00