Monitoring antiretroviral therapy in resource-limited settings: balancing clinical care, technology, and human resources.

abstract：:The course of HIV research has led to a multitude of interventions to prevent and treat HIV. With the arrival of more effective interventions comes the need to end, or de-implement, less effective interventions. PURPOSE OF REVIEW: To describe the state of de-implementation research in HIV and provide a rationale for e...

journal_title：Current HIV/AIDS reports

authors： McKay VR,Tetteh EK,Reid MJ,Ingaiza LM

更新日期：2020-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an overview of HCV resistance-associated substitutions (RASs) with a focus on NS3 protease and NS5A inhibitor resistance. Treatment approaches for managing resistance are also covered including the use of newly approved therapies with improved resistance profiles. RECENT FINDINGS...

journal_title：Current HIV/AIDS reports

authors： Wyles DL

更新日期：2017-12-01 00:00:00

abstract：:While combination antiretroviral therapy allows HIV-infected patients to have life expectancies similar to that of the general population, it may also contribute to the development of co-morbidities, such as cardiovascular disease and osteoporosis. Such complications could compromise long-term quality of life, especia...

journal_title：Current HIV/AIDS reports

authors： Eckard AR,Fowler SL,Haston JC,Dixon TC

更新日期：2016-08-01 00:00:00

abstract：:Access to potent antiretroviral medications greatly reduces morbidity and mortality due to HIV/AIDS, but drug toxicity limits treatment success in many individuals. The field of pharmacogenomics strives to understand the influence of human genetic variants in response to medications. Investigators have begun to identi...

journal_title：Current HIV/AIDS reports

authors： Haas DW

更新日期：2006-07-01 00:00:00

abstract：:This article reviews the magnitude and spectrum of ocular complications of HIV infection in sub-Sahara Africa. A literature search was done using PubMed, Google, and UpToDate and by talking to ophthalmologists and HIV experts working in the region. Ocular complications of HIV infection, mostly retinal, are seen in 29%...

journal_title：Current HIV/AIDS reports

authors： Nkomazana O,Tshitswana D

更新日期：2008-08-01 00:00:00

abstract：:Due to the co-occurrence of sexual risk behaviors and substance use among HIV-positive individuals, there is often a need for HIV prevention efforts to target multiple behaviors. Motivational Interviewing (MI), a widely disseminated behavior change intervention, has demonstrated effectiveness in promoting behavior cha...

journal_title：Current HIV/AIDS reports

authors： Naar-King S,Parsons JT,Johnson AM

更新日期：2012-12-01 00:00:00

abstract：:Despite impressive decreases in mortality and morbidity, significant adverse events have surfaced as a result of combination antiretroviral therapy (ART). They include lipoatrophy, or subcutaneous fat wasting of the face, arms, buttocks, or legs, which can be associated with central fat accumulation. Although the unde...

journal_title：Current HIV/AIDS reports

authors： Tungsiripat M,McComsey G

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Glycoimmunology is an emerging field focused on understanding how immune responses are mediated by glycans (carbohydrates) and their interaction with glycan-binding proteins called lectins. How glycans influence immunological functions is increasingly well understood. In a parallel way, in the HIV fie...

journal_title：Current HIV/AIDS reports

authors： Colomb F,Giron LB,Trbojevic-Akmacic I,Lauc G,Abdel-Mohsen M

更新日期：2019-04-01 00:00:00

abstract：:Neurocognitive compromise, a common sequela of HIV infection, ranges in severity from minor motor and information-processing speed decrements to severely incapacitating symptoms that affect functional independence. However, with the emergence of highly active antiretroviral therapy (HAART), neurocognitive phenotypes h...

journal_title：Current HIV/AIDS reports

authors： Foley J,Ettenhofer M,Wright M,Hinkin CH

更新日期：2008-11-01 00:00:00

abstract：:Generation of memory T cells, which mediate immunity against microbes and cancers, relies, for optimal activity, on the interactions of multiple cell types that are highly regulated through the expression of soluble factors and negative and positive receptors. Their disruption will lead to aberrant immune responses, w...

journal_title：Current HIV/AIDS reports

authors： El-Far M,Halwani R,Said E,Trautmann L,Doroudchi M,Janbazian L,Fonseca S,van Grevenynghe J,Yassine-Diab B,Sékaly RP,Haddad EK

更新日期：2008-02-01 00:00:00

abstract：:The first association between HIV-1 infection and kidney disease was made in 1984 and much has been learned over the past 20 years. In recent years, more effective therapies for HIV-1 infection and its associated opportunistic infections have led to improved patient survival. However, with prolonged survival, morbidit...

journal_title：Current HIV/AIDS reports

authors： Cho ME,Kopp JB

更新日期：2004-09-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Early diagnosis and treatment of HIV following seroconversion improves individual and population health. Using published data on pre-treatment CD4 cell counts, we benchmarked the level of immunodeficiency at HIV diagnosis and ART initiation in the "real world" against those of the treatment and co...

journal_title：Current HIV/AIDS reports

authors： Nash D,Robertson M

更新日期：2019-08-01 00:00:00

abstract：:HIV research has identified approaches that can be combined to be more effective in transmission reduction than any 1 modality alone: delayed adolescent sexual debut, mutual monogamy or sexual partner reduction, correct and consistent condom use, pre-exposure prophylaxis with oral antiretroviral drugs or vaginal micro...

journal_title：Current HIV/AIDS reports

authors： Vermund SH,Hayes RJ

更新日期：2013-06-01 00:00:00

abstract：:With the introduction of potent combination antiretroviral therapy (cART) into clinical practice, HIV-infected patients have garnered much benefit. However, kidney disease continues to be a potential complication in this group. Whereas HIV-associated nephropathy (HIVAN) was the major renal complication prior to cART, ...

journal_title：Current HIV/AIDS reports

authors： Kumar N,Perazella MA

更新日期：2014-09-01 00:00:00

abstract：:Substance users are at elevated risk for HIV. HIV researchers, particularly at the intersection of HIV and substance use, have requested new methods to better understand and address this important area. New technologies, such as social media and mobile applications, are increasingly being used as research tools in stu...

journal_title：Current HIV/AIDS reports

authors： Young SD,Swendeman D,Holloway IW,Reback CJ,Kao U

更新日期：2015-12-01 00:00:00

abstract：:Nine months of daily isoniazid is efficacious in treating latent M. tuberculosis infection, but completion rates are low, limiting treatment effectiveness. In 2011, three important studies were published involving novel regimens for the treatment of latent M. tuberculosis infection. At least 36 months of isoniazid was...

journal_title：Current HIV/AIDS reports

authors： Person AK,Sterling TR

更新日期：2012-09-01 00:00:00

abstract：:Sustained retention represents an enduring and evolving challenge to HIV treatment programs in Africa. We present a theoretical framework for sustained retention borrowing from ecologic principles of sustainability and dynamic adaptation. We posit that sustained retention from the patient perspective is dependent on t...

journal_title：Current HIV/AIDS reports

authors： Roy M,Czaicki N,Holmes C,Chavan S,Tsitsi A,Odeny T,Sikazwe I,Padian N,Geng E

更新日期：2016-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Advances in short- and long-acting pre-exposure prophylaxis (PrEP) technologies have incentivized the need to understand how individuals make trade-offs and competing decisions regarding PrEP modalities. The purpose of this review was to examine how researchers have conceptualized and measured attribu...

journal_title：Current HIV/AIDS reports

authors： Bauermeister JA,Downs JS,Krakower DS

更新日期：2020-06-01 00:00:00

abstract：:Pharmacy refill adherence has become an increasingly important measure of adherence to antiretroviral medications. It offers a simple, inexpensive, and valid method for measuring adherence. Over the past year, there have been several published developments in the use of pharmacy refill data to measure adherence. Given...

journal_title：Current HIV/AIDS reports

authors： Grossberg R,Gross R

更新日期：2007-12-01 00:00:00

abstract：:This article reviews the antiretroviral therapy (ART) initiation criteria from published national guidelines for 94 countries (representing 86 % of global HIV burden) and compares them with the 2013 World Health Organization (WHO) ART guidelines. As of 31st of July 2014, 19 countries have adopted the WHO-recommended C...

journal_title：Current HIV/AIDS reports

authors： Gupta S,Williams B,Montaner J

更新日期：2014-12-01 00:00:00

abstract：:HIV-infected individuals are at increased risk for most types of cancer, including those typically classified as non-AIDS-defining cancers (NADCs). This increased risk is likely multifactorial, but a prominent risk factor for the increased rate of some cancers is co-infection with oncogenic viruses. Anal cancer, hepat...

journal_title：Current HIV/AIDS reports

authors： Riedel DJ,Tang LS,Rositch AF

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Mental health disorders, especially depression, are prevalent among people living with HIV (PLWH) and are associated with cognitive impairment (CI) among HIV-uninfected (HIV-) individuals. We conducted a comprehensive review of the link between depression and cognition among PLWH. RECENT FINDINGS:Stu...

journal_title：Current HIV/AIDS reports

authors： Rubin LH,Maki PM

更新日期：2019-02-01 00:00:00

abstract：:Recent policies, guidelines, and laws reflect promising preliminary outcomes among transplant recipients with HIV infection, and ethical analyses suggest that it is not justifiable to deny solid organ transplantation based solely on HIV-infection status. These studies consistently describe stable HIV disease following...

journal_title：Current HIV/AIDS reports

authors： Roland ME,Stock PG

更新日期：2006-09-01 00:00:00

abstract：:The population of patients with HIV infection achieving viral suppression on combination antiretroviral therapy is growing, aging, and experiencing a widening spectrum of non-AIDS diseases. Concurrently, AIDS-defining conditions are becoming less common and are variably associated with outcome. Nonetheless, the spectr...

journal_title：Current HIV/AIDS reports

authors： Justice AC

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This narrative review summarizes recent data on factors associated with insulin resistance (IR) in adults with HIV, including contemporary antiretroviral therapy (ART). RECENT FINDINGS:IR remains common in persons with HIV, even those receiving contemporary ART. Generalized and abdominal obesity and ...

journal_title：Current HIV/AIDS reports

authors： Hulgan T

更新日期：2018-06-01 00:00:00

abstract：:HIV may cause several forms of peripheral neuropathy, the most common of which is distal symmetric polyneuropathy (DSP) characterized by pain and sensory deficits in a stocking-glove distribution. The pathophysiology of DSP remains largely unknown but is thought to be related both to the neurotoxicity of HIV-through i...

journal_title：Current HIV/AIDS reports

authors： Stavros K,Simpson DM

更新日期：2014-09-01 00:00:00

abstract：:The AIDS epidemic continues its unrelentless expansion. According to the Joint United Nations Programme on HIV/AIDS, there are more than 40 million people living with HIV, and more than 15,000 new infections occur every day. One approach to curbing HIV is the development of topical microbicidal agents or microbicides....

journal_title：Current HIV/AIDS reports

authors： Doncel G,Mauck C

更新日期：2004-04-01 00:00:00

abstract：:Adolescents are critical to efforts to end the AIDS epidemic. Few national AIDS strategies explicitly program for children in their second decade of life. Adolescents (aged 10-19 years) are therefore largely invisible in global, regional, and country HIV and AIDS reports making it difficult to assess progress in this ...

journal_title：Current HIV/AIDS reports

authors： Kasedde S,Luo C,McClure C,Chandan U

更新日期：2013-06-01 00:00:00

abstract：:T-cell activation has long been considered a central mediator of HIV pathogenesis. High T-cell activation levels predict more rapid disease progression in untreated patients and decreased treatment-mediated CD4+ T-cell gains during antiretroviral therapy, independent of plasma HIV RNA levels, and may be the primary fe...

journal_title：Current HIV/AIDS reports

authors： Hunt PW

更新日期：2007-02-01 00:00:00

abstract：:Neurocognitive impairment is common in people living with HIV and AIDS. Prior to highly active antiretroviral therapy (HAART), cognitive impairment primarily affected patients with advanced disease, and was a more rapidly progressive illness. With the use of HAART, cognitive impairment improved, along with the overall...

journal_title：Current HIV/AIDS reports

authors： Robinson-Papp J,Elliott KJ,Simpson DM

更新日期：2009-08-01 00:00:00