Abstract：
:Despite impressive decreases in mortality and morbidity, significant adverse events have surfaced as a result of combination antiretroviral therapy (ART). They include lipoatrophy, or subcutaneous fat wasting of the face, arms, buttocks, or legs, which can be associated with central fat accumulation. Although the underlying mechanism of ART-related body fat abnormalities has not been definitively established, mitochondrial toxicity is increasingly implicated in the lipoatrophy component of these fat abnormalities. Several studies evaluating switches off of nucleoside analogues have showed modest but statistically significant increases in limb fat. Because ART switches result in slow and small improvements and are not an option in many patients, other therapeutic interventions are needed. Although peroxisome proliferator-activated receptor chi agonist thiazolidinediones would be expected to have positive effects on lipoatrophy, initial clinical studies are conflicting. Other interventions of uridine, pravastatin, and facial fillers have been evaluated in small studies.
journal_name
Curr HIV/AIDS Repjournal_title
Current HIV/AIDS reportsauthors
Tungsiripat M,McComsey Gdoi
10.1007/s11904-008-0010-8subject
Has Abstractpub_date
2008-05-01 00:00:00pages
55-63issue
2eissn
1548-3568issn
1548-3576journal_volume
5pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:In the absence of antiretroviral therapy (ART), more than 50% of perinatally HIV-infected children die by 2 years of age. Early ART from infancy is therefore a global recommendation and significantly improves immune health, child survival, and disease outcome. However, even early treatment does not pr...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00495-1
更新日期：2020-06-01 00:00:00
abstract：PURPOSE OF REVIEW:This review summarizes recent literature defining tissue-resident memory T cells (TRM) and discusses implications for HIV pathogenesis, vaccines, and eradication efforts. RECENT FINDINGS:Investigations using animal models and human tissues have identified a TRM transcriptional profile and elucidated ...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00481-7
更新日期：2020-04-01 00:00:00
abstract：:The first association between HIV-1 infection and kidney disease was made in 1984 and much has been learned over the past 20 years. In recent years, more effective therapies for HIV-1 infection and its associated opportunistic infections have led to improved patient survival. However, with prolonged survival, morbidit...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-004-0016-9
更新日期：2004-09-01 00:00:00
abstract：PURPOSE OF REVIEW:To describe a small city/rural area HIV prevention project (the Cross Border Project) implemented in Ning Ming County, Guangxi Province, China, and Lang Son province, Vietnam, and consider its implications for addressing the opioid/heroin epidemic in small cities/rural areas in the USA. The descriptio...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-018-0405-0
更新日期：2018-08-01 00:00:00
abstract：:The global HIV pandemic began to expand rapidly in southern Africa a decade later than was noted in central Africa, Europe, the Caribbean, and North America. Multiple factors played a role in this rapid expansion which led Southern Africa to become the most heavily afflicted region for HIV/AIDS globally. In this issue...
journal_title：Current HIV/AIDS reports
pub_type：
doi：10.1007/s11904-015-0270-z
更新日期：2015-06-01 00:00:00
abstract：:Female sex workers (FSWs) continue to represent a high-risk population in need of targeted HIV prevention interventions. Targeting environmental risk factors should result in more sustainable behavior change than individual-level interventions alone. There are many types of FSWs who operate in and through a variety of...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-012-0142-8
更新日期：2013-03-01 00:00:00
abstract：:Roughly 10 % of HIV-positive individuals worldwide have concomitant chronic hepatitis B virus (HBV) infection, with large differences between geographical regions and/or risk groups. Hepatitis B is a preventable infection with vaccines. However, it cannot be eradicated once acquired, resembling HIV and in contrast wit...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-015-0275-7
更新日期：2015-09-01 00:00:00
abstract：:Due to the rapid expansion of first-line antiretroviral therapy in resource-limited settings (RLS), increasing numbers of people are living with HIV for prolonged periods of time. Treatment programs must now decide how to balance monitoring costs necessary to maximize health benefits for those already on treatment wit...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-010-0046-4
更新日期：2010-08-01 00:00:00
abstract：:Persons who inject drugs (PWID) are at high risk for infection with and poor outcomes from HIV and hepatitis C virus (HCV). Well-established interventions for HIV/HCV prevention among PWID include syringe access, opioid agonist maintenance treatment, and supervised injection facilities, yet these interventions remain ...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-014-0248-2
更新日期：2015-03-01 00:00:00
abstract：:The AIDS epidemic continues its unrelentless expansion. According to the Joint United Nations Programme on HIV/AIDS, there are more than 40 million people living with HIV, and more than 15,000 new infections occur every day. One approach to curbing HIV is the development of topical microbicidal agents or microbicides....
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-004-0004-0
更新日期：2004-04-01 00:00:00
abstract：PURPOSE OF REVIEW:Neurological conditions associated with HIV/AIDS including central nervous system (CNS), opportunistic infections (OI), chronic conditions including HIV-associated neurocognitive disorder, and cerebrospinal fluid (CSF) viral escape remain major contributors to morbidity and mortality worldwide. CNS in...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00514-1
更新日期：2020-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Advances in short- and long-acting pre-exposure prophylaxis (PrEP) technologies have incentivized the need to understand how individuals make trade-offs and competing decisions regarding PrEP modalities. The purpose of this review was to examine how researchers have conceptualized and measured attribu...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00497-z
更新日期：2020-06-01 00:00:00
abstract：:The HIV pandemic has disproportionately impacted sub-Saharan Africa and Southern Africa in particular. The concurrent presence of overlapping epidemic drivers likely underpins how and why the HIV epidemic is so explosive in this region, with implications for understanding approaches to reduce transmission. In this rev...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-016-0314-z
更新日期：2016-06-01 00:00:00
abstract：:Pharmacy refill adherence has become an increasingly important measure of adherence to antiretroviral medications. It offers a simple, inexpensive, and valid method for measuring adherence. Over the past year, there have been several published developments in the use of pharmacy refill data to measure adherence. Given...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-007-0027-4
更新日期：2007-12-01 00:00:00
abstract：PURPOSE OF REVIEW:The discovery of innate lymphoid cells (ILCs) over the past decade has reformed principles that were once thought to be exclusive to adaptive immunity. Here, we describe ILC nomenclature and function, and provide a survey of studies examining these cells in the context of HIV/SIV infections. Particula...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-019-00439-4
更新日期：2019-06-01 00:00:00
abstract：:For the last three decades, sub-Saharan Africa has been the epicentre of the HIV epidemic. Some key drivers of the epidemic are specific to this region and there is an urgent need to develop context-specific strategies to reduce HIV-related burden. Implementation frameworks should endeavour to combine structural, beha...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-015-0262-z
更新日期：2015-06-01 00:00:00
abstract：:With the introduction of potent combination antiretroviral therapy (cART) into clinical practice, HIV-infected patients have garnered much benefit. However, kidney disease continues to be a potential complication in this group. Whereas HIV-associated nephropathy (HIVAN) was the major renal complication prior to cART, ...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-014-0209-9
更新日期：2014-09-01 00:00:00
abstract：:HIV may cause several forms of peripheral neuropathy, the most common of which is distal symmetric polyneuropathy (DSP) characterized by pain and sensory deficits in a stocking-glove distribution. The pathophysiology of DSP remains largely unknown but is thought to be related both to the neurotoxicity of HIV-through i...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-014-0211-2
更新日期：2014-09-01 00:00:00
abstract：:Self-reports are the most widely used method for measuring antiretroviral adherence. The association between self-reports and viral loads has been repeatedly demonstrated, but this association does not address how well self-reports measure actual medication-taking behaviors. Understanding adherence self-reports requir...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章
doi：10.1007/s11904-009-0024-x
更新日期：2009-11-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this paper is to provide a thorough overview of methods used for recruitment, network data collection, and network data management in a network-based study of rural people who use drugs (PWUD) and to offer methodological recommendations for future research on rural drug use. RECENT FIN...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-018-0391-2
更新日期：2018-04-01 00:00:00
abstract：:This article reviews the magnitude and spectrum of ocular complications of HIV infection in sub-Sahara Africa. A literature search was done using PubMed, Google, and UpToDate and by talking to ophthalmologists and HIV experts working in the region. Ocular complications of HIV infection, mostly retinal, are seen in 29%...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章
doi：10.1007/s11904-008-0019-z
更新日期：2008-08-01 00:00:00
abstract：PURPOSE OF REVIEW:In this report, we review the need for point-of-care (POC) or near real-time testing for antiretrovirals, progress in the field, evidence for guiding implementation of these tests globally, and future directions in objective antiretroviral therapy (ART) or pre-exposure prophylaxis (PrEP) adherence mon...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00512-3
更新日期：2020-10-01 00:00:00
abstract：:Combined antiretroviral therapy (CART) has turned HIV-infection to a treatable chronic disease during which many patients survive to middle and older age. However, they prematurely develop non-AIDS comorbidities such as cardiovascular disease, metabolic syndrome, diabetes, and HIV-associated neurocognitive disorders (...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-016-0339-3
更新日期：2016-12-01 00:00:00
abstract：:Generation of memory T cells, which mediate immunity against microbes and cancers, relies, for optimal activity, on the interactions of multiple cell types that are highly regulated through the expression of soluble factors and negative and positive receptors. Their disruption will lead to aberrant immune responses, w...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-008-0003-7
更新日期：2008-02-01 00:00:00
abstract：:HIV-infected individuals are at increased risk for most types of cancer, including those typically classified as non-AIDS-defining cancers (NADCs). This increased risk is likely multifactorial, but a prominent risk factor for the increased rate of some cancers is co-infection with oncogenic viruses. Anal cancer, hepat...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-015-0276-6
更新日期：2015-09-01 00:00:00
abstract：:Neurocognitive impairment is common in people living with HIV and AIDS. Prior to highly active antiretroviral therapy (HAART), cognitive impairment primarily affected patients with advanced disease, and was a more rapidly progressive illness. With the use of HAART, cognitive impairment improved, along with the overall...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-009-0020-1
更新日期：2009-08-01 00:00:00
abstract：:The population of patients with HIV infection achieving viral suppression on combination antiretroviral therapy is growing, aging, and experiencing a widening spectrum of non-AIDS diseases. Concurrently, AIDS-defining conditions are becoming less common and are variably associated with outcome. Nonetheless, the spectr...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章
doi：10.1007/s11904-010-0041-9
更新日期：2010-05-01 00:00:00
abstract：:While combination antiretroviral therapy allows HIV-infected patients to have life expectancies similar to that of the general population, it may also contribute to the development of co-morbidities, such as cardiovascular disease and osteoporosis. Such complications could compromise long-term quality of life, especia...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-016-0320-1
更新日期：2016-08-01 00:00:00
abstract：:HIV is a devastating worldwide epidemic that has had substantial social and economic impacts throughout the globe. Due to the presence of a small pool of latently infected cells that persists during antiretroviral therapy (ART), HIV is not curable. Because of the high cost of ART and the lack of reliable accessibility...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-016-0304-1
更新日期：2016-04-01 00:00:00
abstract：PURPOSE OF REVIEW:End-stage organ disease prevalence is increasing among HIV-infected (HIV+) individuals. Trial and registry data confirm that solid organ transplantation (SOT) is efficacious in this population. Optimizing access to transplant and decreasing complications represent active frontiers. RECENT FINDINGS:HI...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-019-00440-x
更新日期：2019-06-01 00:00:00
