Abstract：
:While combination antiretroviral therapy allows HIV-infected patients to have life expectancies similar to that of the general population, it may also contribute to the development of co-morbidities, such as cardiovascular disease and osteoporosis. Such complications could compromise long-term quality of life, especially in HIV-infected youth whose lifetime cumulative exposure to antiretrovirals is likely to be many decades. Recent studies continue to demonstrate abnormalities associated with antiretroviral therapy, although clinical manifestations are rare in this younger population, especially with modern antiretrovirals. The purpose of this paper is to review the most recent literature on complications of treatment in youth with HIV.
journal_name
Curr HIV/AIDS Repjournal_title
Current HIV/AIDS reportsauthors
Eckard AR,Fowler SL,Haston JC,Dixon TCdoi
10.1007/s11904-016-0320-1subject
Has Abstractpub_date
2016-08-01 00:00:00pages
226-33issue
4eissn
1548-3568issn
1548-3576pii
10.1007/s11904-016-0320-1journal_volume
13pub_type
杂志文章,评审abstract：:Pharmacy refill adherence has become an increasingly important measure of adherence to antiretroviral medications. It offers a simple, inexpensive, and valid method for measuring adherence. Over the past year, there have been several published developments in the use of pharmacy refill data to measure adherence. Given...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-007-0027-4
更新日期：2007-12-01 00:00:00
abstract：:An emerging body of evidence suggests that intergenerational sexual partnerships may increase risk of HIV acquisition among young men who have sex with men (YMSM). However, no studies have comprehensively evaluated literature in this area. We applied a scoping review methodology to explore the relationships between ag...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-013-0187-3
更新日期：2013-12-01 00:00:00
abstract：:Combined antiretroviral therapy (CART) has turned HIV-infection to a treatable chronic disease during which many patients survive to middle and older age. However, they prematurely develop non-AIDS comorbidities such as cardiovascular disease, metabolic syndrome, diabetes, and HIV-associated neurocognitive disorders (...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-016-0339-3
更新日期：2016-12-01 00:00:00
abstract：:The role of voluntary counseling and testing (VCT)of HIV in resource-limited settings has recently broadened from primarily that of a prevention intervention to its identification as the key entry point into expanding access to life-saving antiretroviral therapy, additional HIV-specific medical care, and other support...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-004-0028-5
更新日期：2004-12-01 00:00:00
abstract：:The first association between HIV-1 infection and kidney disease was made in 1984 and much has been learned over the past 20 years. In recent years, more effective therapies for HIV-1 infection and its associated opportunistic infections have led to improved patient survival. However, with prolonged survival, morbidit...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-004-0016-9
更新日期：2004-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Aligning HIV treatment services with patient preferences can promote long-term engagement. A rising number of studies solicit such preferences using discrete choice experiments, but have not been systematically reviewed to seek generalizable insights. Using a systematic search, we identified eleven ch...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00520-3
更新日期：2020-10-01 00:00:00
abstract：:For the last three decades, sub-Saharan Africa has been the epicentre of the HIV epidemic. Some key drivers of the epidemic are specific to this region and there is an urgent need to develop context-specific strategies to reduce HIV-related burden. Implementation frameworks should endeavour to combine structural, beha...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-015-0262-z
更新日期：2015-06-01 00:00:00
abstract：:Therapeutic drug monitoring (TDM) is the process by which a patient's dosing regimen is guided by repeated measures of plasma drug concentrations. An enormous challenge with regard to TDM of antiretroviral drugs (ARV) is that the concentration goals can be moving targets. Well-designed prospective studies demonstratin...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-005-0020-8
更新日期：2005-06-01 00:00:00
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章
doi：10.1007/s11904-008-0019-z
更新日期：2008-08-01 00:00:00
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-019-00433-w
更新日期：2019-04-01 00:00:00
abstract：:Several all-oral direct-acting antiviral (DAA) combination therapies including two fixed-dose combinations (FDCs) have been recently licensed for treatment of hepatitis C virus (HCV) genotype 1 infection. Results of pivotal trials with these new compounds are now also available in human immunodeficiency virus (HIV)/HC...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-015-0278-4
更新日期：2015-09-01 00:00:00
abstract：:Lipodystrophy and its two components lipo-accumulation and lipoatropy are very common among individuals with HIV infection on treatment, especially among those who started therapy in the late 1990s and early 2000s. This review discusses the current management of these complications of HIV and its treatment. For the pu...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-007-0013-x
更新日期：2007-05-01 00:00:00
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-014-0211-2
更新日期：2014-09-01 00:00:00
abstract：:HIV-infected individuals are at increased risk for most types of cancer, including those typically classified as non-AIDS-defining cancers (NADCs). This increased risk is likely multifactorial, but a prominent risk factor for the increased rate of some cancers is co-infection with oncogenic viruses. Anal cancer, hepat...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-015-0276-6
更新日期：2015-09-01 00:00:00
abstract：:With the introduction of potent combination antiretroviral therapy (cART) into clinical practice, HIV-infected patients have garnered much benefit. However, kidney disease continues to be a potential complication in this group. Whereas HIV-associated nephropathy (HIVAN) was the major renal complication prior to cART, ...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-014-0209-9
更新日期：2014-09-01 00:00:00
abstract：:The global HIV pandemic began to expand rapidly in southern Africa a decade later than was noted in central Africa, Europe, the Caribbean, and North America. Multiple factors played a role in this rapid expansion which led Southern Africa to become the most heavily afflicted region for HIV/AIDS globally. In this issue...
journal_title：Current HIV/AIDS reports
pub_type：
doi：10.1007/s11904-015-0270-z
更新日期：2015-06-01 00:00:00
abstract：:The purpose of this meta-analytic study is to summarize the current science concerning the (a) prevalence of alcohol use, (b) prevalence of sexual risk behaviors, and (c) association between alcohol use and sexual risk behaviors among people livingwithHIV/AIDS (PLWHA). Studies were included if they sampled PLWHA, eval...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s11904-013-0177-5
更新日期：2013-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Advances in short- and long-acting pre-exposure prophylaxis (PrEP) technologies have incentivized the need to understand how individuals make trade-offs and competing decisions regarding PrEP modalities. The purpose of this review was to examine how researchers have conceptualized and measured attribu...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00497-z
更新日期：2020-06-01 00:00:00
abstract：:Generation of memory T cells, which mediate immunity against microbes and cancers, relies, for optimal activity, on the interactions of multiple cell types that are highly regulated through the expression of soluble factors and negative and positive receptors. Their disruption will lead to aberrant immune responses, w...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-008-0003-7
更新日期：2008-02-01 00:00:00
abstract：PURPOSE OF REVIEW:In the absence of antiretroviral therapy (ART), more than 50% of perinatally HIV-infected children die by 2 years of age. Early ART from infancy is therefore a global recommendation and significantly improves immune health, child survival, and disease outcome. However, even early treatment does not pr...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00495-1
更新日期：2020-06-01 00:00:00
abstract：:HIV research has identified approaches that can be combined to be more effective in transmission reduction than any 1 modality alone: delayed adolescent sexual debut, mutual monogamy or sexual partner reduction, correct and consistent condom use, pre-exposure prophylaxis with oral antiretroviral drugs or vaginal micro...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-013-0155-y
更新日期：2013-06-01 00:00:00
abstract：:HIV infection is one of the strongest risk factors for anal squamous cell cancer (ASCC). Most ASCC are caused by HPV, and most HPV-associated ASCC are caused by HPV-16. Anal HPV infections are very common in men who have sex with men (MSM), and nearly universal among HIV-infected MSM. High-grade anal intraepithelial n...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-014-0224-x
更新日期：2014-09-01 00:00:00
abstract：:Vaccine recommendations for those with HIV require continual updating as additional research becomes available. Timing of vaccinations among HIV-infected individuals is a key area of uncertainty. This is particularly true for those who may soon initiate highly active antiretroviral therapy (HAART) because immune recon...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-009-0014-z
更新日期：2009-05-01 00:00:00
abstract：:T-cell activation has long been considered a central mediator of HIV pathogenesis. High T-cell activation levels predict more rapid disease progression in untreated patients and decreased treatment-mediated CD4+ T-cell gains during antiretroviral therapy, independent of plasma HIV RNA levels, and may be the primary fe...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-007-0007-8
更新日期：2007-02-01 00:00:00
abstract：:Female sex workers (FSWs) continue to represent a high-risk population in need of targeted HIV prevention interventions. Targeting environmental risk factors should result in more sustainable behavior change than individual-level interventions alone. There are many types of FSWs who operate in and through a variety of...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-012-0142-8
更新日期：2013-03-01 00:00:00
abstract：PURPOSE OF REVIEW:This review summarizes recent literature defining tissue-resident memory T cells (TRM) and discusses implications for HIV pathogenesis, vaccines, and eradication efforts. RECENT FINDINGS:Investigations using animal models and human tissues have identified a TRM transcriptional profile and elucidated ...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00481-7
更新日期：2020-04-01 00:00:00
abstract：:The course of HIV research has led to a multitude of interventions to prevent and treat HIV. With the arrival of more effective interventions comes the need to end, or de-implement, less effective interventions. PURPOSE OF REVIEW: To describe the state of de-implementation research in HIV and provide a rationale for e...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00517-y
更新日期：2020-10-01 00:00:00
abstract：PURPOSE OF THE REVIEW:Early diagnosis and treatment of HIV following seroconversion improves individual and population health. Using published data on pre-treatment CD4 cell counts, we benchmarked the level of immunodeficiency at HIV diagnosis and ART initiation in the "real world" against those of the treatment and co...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-019-00452-7
更新日期：2019-08-01 00:00:00
abstract：PURPOSE OF REVIEW:To describe a small city/rural area HIV prevention project (the Cross Border Project) implemented in Ning Ming County, Guangxi Province, China, and Lang Son province, Vietnam, and consider its implications for addressing the opioid/heroin epidemic in small cities/rural areas in the USA. The descriptio...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-018-0405-0
更新日期：2018-08-01 00:00:00
abstract：:The availability of potent combination antiretroviral therapy has changed the long-term prognosis for people living with HIV/AIDS. There is increasing concern, however, about the effect of HIV therapy on lipid disorders and subsequent development of coronary artery disease. Virtually all classes of antiretroviral drug...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-005-0006-6
更新日期：2005-08-01 00:00:00
