Abstract:
:The availability of potent combination antiretroviral therapy has changed the long-term prognosis for people living with HIV/AIDS. There is increasing concern, however, about the effect of HIV therapy on lipid disorders and subsequent development of coronary artery disease. Virtually all classes of antiretroviral drugs have been associated with some aspect of atherogenic changes in the lipid profiles. This article reviews the current literature on HIV-associated dyslipidemias and the metabolic syndrome, their potential effect on future coronary heart disease, and reviews strategies for management.
journal_name
Curr HIV/AIDS Repjournal_title
Current HIV/AIDS reportsauthors
Umeh OC,Currier JSdoi
10.1007/s11904-005-0006-6keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
132-9issue
3eissn
1548-3568issn
1548-3576journal_volume
2pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Aligning HIV treatment services with patient preferences can promote long-term engagement. A rising number of studies solicit such preferences using discrete choice experiments, but have not been systematically reviewed to seek generalizable insights. Using a systematic search, we identified eleven ch...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-020-00520-3
更新日期:2020-10-01 00:00:00
abstract::Increased access to testing and treatment means HIV can be managed as a chronic illness, though successful management requires continued engagement with the health care system. Most of the global HIV burden is in sub-Saharan Africa where rates of new infections are consistently higher in women versus men. Pregnancy is...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0252-6
更新日期:2015-03-01 00:00:00
abstract::Neurocognitive compromise, a common sequela of HIV infection, ranges in severity from minor motor and information-processing speed decrements to severely incapacitating symptoms that affect functional independence. However, with the emergence of highly active antiretroviral therapy (HAART), neurocognitive phenotypes h...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-008-0029-x
更新日期:2008-11-01 00:00:00
abstract::T-cell activation has long been considered a central mediator of HIV pathogenesis. High T-cell activation levels predict more rapid disease progression in untreated patients and decreased treatment-mediated CD4+ T-cell gains during antiretroviral therapy, independent of plasma HIV RNA levels, and may be the primary fe...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-007-0007-8
更新日期:2007-02-01 00:00:00
abstract::The course of HIV research has led to a multitude of interventions to prevent and treat HIV. With the arrival of more effective interventions comes the need to end, or de-implement, less effective interventions. PURPOSE OF REVIEW: To describe the state of de-implementation research in HIV and provide a rationale for e...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-020-00517-y
更新日期:2020-10-01 00:00:00
abstract::Pharmacy refill adherence has become an increasingly important measure of adherence to antiretroviral medications. It offers a simple, inexpensive, and valid method for measuring adherence. Over the past year, there have been several published developments in the use of pharmacy refill data to measure adherence. Given...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-007-0027-4
更新日期:2007-12-01 00:00:00
abstract::Persons who inject drugs (PWID) are at high risk for infection with and poor outcomes from HIV and hepatitis C virus (HCV). Well-established interventions for HIV/HCV prevention among PWID include syringe access, opioid agonist maintenance treatment, and supervised injection facilities, yet these interventions remain ...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0248-2
更新日期:2015-03-01 00:00:00
abstract::HIV research has identified approaches that can be combined to be more effective in transmission reduction than any 1 modality alone: delayed adolescent sexual debut, mutual monogamy or sexual partner reduction, correct and consistent condom use, pre-exposure prophylaxis with oral antiretroviral drugs or vaginal micro...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-013-0155-y
更新日期:2013-06-01 00:00:00
abstract::Roughly 10 % of HIV-positive individuals worldwide have concomitant chronic hepatitis B virus (HBV) infection, with large differences between geographical regions and/or risk groups. Hepatitis B is a preventable infection with vaccines. However, it cannot be eradicated once acquired, resembling HIV and in contrast wit...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-015-0275-7
更新日期:2015-09-01 00:00:00
abstract::Lipodystrophy and its two components lipo-accumulation and lipoatropy are very common among individuals with HIV infection on treatment, especially among those who started therapy in the late 1990s and early 2000s. This review discusses the current management of these complications of HIV and its treatment. For the pu...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-007-0013-x
更新日期:2007-05-01 00:00:00
abstract::This article reviews the antiretroviral therapy (ART) initiation criteria from published national guidelines for 94 countries (representing 86 % of global HIV burden) and compares them with the 2013 World Health Organization (WHO) ART guidelines. As of 31st of July 2014, 19 countries have adopted the WHO-recommended C...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0230-z
更新日期:2014-12-01 00:00:00
abstract::The AIDS epidemic continues its unrelentless expansion. According to the Joint United Nations Programme on HIV/AIDS, there are more than 40 million people living with HIV, and more than 15,000 new infections occur every day. One approach to curbing HIV is the development of topical microbicidal agents or microbicides....
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-004-0004-0
更新日期:2004-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Glycoimmunology is an emerging field focused on understanding how immune responses are mediated by glycans (carbohydrates) and their interaction with glycan-binding proteins called lectins. How glycans influence immunological functions is increasingly well understood. In a parallel way, in the HIV fie...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00433-w
更新日期:2019-04-01 00:00:00
abstract::Vaccine recommendations for those with HIV require continual updating as additional research becomes available. Timing of vaccinations among HIV-infected individuals is a key area of uncertainty. This is particularly true for those who may soon initiate highly active antiretroviral therapy (HAART) because immune recon...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-009-0014-z
更新日期:2009-05-01 00:00:00
abstract::Despite impressive decreases in mortality and morbidity, significant adverse events have surfaced as a result of combination antiretroviral therapy (ART). They include lipoatrophy, or subcutaneous fat wasting of the face, arms, buttocks, or legs, which can be associated with central fat accumulation. Although the unde...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-008-0010-8
更新日期:2008-05-01 00:00:00
abstract::HIV may cause several forms of peripheral neuropathy, the most common of which is distal symmetric polyneuropathy (DSP) characterized by pain and sensory deficits in a stocking-glove distribution. The pathophysiology of DSP remains largely unknown but is thought to be related both to the neurotoxicity of HIV-through i...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0211-2
更新日期:2014-09-01 00:00:00
abstract::Combined antiretroviral therapy (CART) has turned HIV-infection to a treatable chronic disease during which many patients survive to middle and older age. However, they prematurely develop non-AIDS comorbidities such as cardiovascular disease, metabolic syndrome, diabetes, and HIV-associated neurocognitive disorders (...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-016-0339-3
更新日期:2016-12-01 00:00:00
abstract::Substance users are at elevated risk for HIV. HIV researchers, particularly at the intersection of HIV and substance use, have requested new methods to better understand and address this important area. New technologies, such as social media and mobile applications, are increasingly being used as research tools in stu...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-015-0295-3
更新日期:2015-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this paper is to provide a thorough overview of methods used for recruitment, network data collection, and network data management in a network-based study of rural people who use drugs (PWUD) and to offer methodological recommendations for future research on rural drug use. RECENT FIN...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-018-0391-2
更新日期:2018-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This review provides an overview of HCV resistance-associated substitutions (RASs) with a focus on NS3 protease and NS5A inhibitor resistance. Treatment approaches for managing resistance are also covered including the use of newly approved therapies with improved resistance profiles. RECENT FINDINGS...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-017-0369-5
更新日期:2017-12-01 00:00:00
abstract::Several all-oral direct-acting antiviral (DAA) combination therapies including two fixed-dose combinations (FDCs) have been recently licensed for treatment of hepatitis C virus (HCV) genotype 1 infection. Results of pivotal trials with these new compounds are now also available in human immunodeficiency virus (HIV)/HC...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-015-0278-4
更新日期:2015-09-01 00:00:00
abstract::The role of voluntary counseling and testing (VCT)of HIV in resource-limited settings has recently broadened from primarily that of a prevention intervention to its identification as the key entry point into expanding access to life-saving antiretroviral therapy, additional HIV-specific medical care, and other support...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-004-0028-5
更新日期:2004-12-01 00:00:00
abstract::Due to the rapid expansion of first-line antiretroviral therapy in resource-limited settings (RLS), increasing numbers of people are living with HIV for prolonged periods of time. Treatment programs must now decide how to balance monitoring costs necessary to maximize health benefits for those already on treatment wit...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-010-0046-4
更新日期:2010-08-01 00:00:00
abstract::This article reviews the magnitude and spectrum of ocular complications of HIV infection in sub-Sahara Africa. A literature search was done using PubMed, Google, and UpToDate and by talking to ophthalmologists and HIV experts working in the region. Ocular complications of HIV infection, mostly retinal, are seen in 29%...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章
doi:10.1007/s11904-008-0019-z
更新日期:2008-08-01 00:00:00
abstract::HIV is a devastating worldwide epidemic that has had substantial social and economic impacts throughout the globe. Due to the presence of a small pool of latently infected cells that persists during antiretroviral therapy (ART), HIV is not curable. Because of the high cost of ART and the lack of reliable accessibility...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-016-0304-1
更新日期:2016-04-01 00:00:00
abstract::Female sex workers (FSWs) continue to represent a high-risk population in need of targeted HIV prevention interventions. Targeting environmental risk factors should result in more sustainable behavior change than individual-level interventions alone. There are many types of FSWs who operate in and through a variety of...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-012-0142-8
更新日期:2013-03-01 00:00:00
abstract::Injecting drug use is a common mode of transmission among persons with HIV/AIDS. Many HIV-infected patients meet diagnostic criteria for opioid dependence, a chronic and relapsing brain disorder. Most HIV providers, however, receive little training in substance use disorders. Opioid agonist therapy (OAT) has a stabili...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-006-0016-z
更新日期:2006-11-01 00:00:00
abstract::Nine months of daily isoniazid is efficacious in treating latent M. tuberculosis infection, but completion rates are low, limiting treatment effectiveness. In 2011, three important studies were published involving novel regimens for the treatment of latent M. tuberculosis infection. At least 36 months of isoniazid was...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-012-0120-1
更新日期:2012-09-01 00:00:00
abstract:PURPOSE OF THE REVIEW:Early diagnosis and treatment of HIV following seroconversion improves individual and population health. Using published data on pre-treatment CD4 cell counts, we benchmarked the level of immunodeficiency at HIV diagnosis and ART initiation in the "real world" against those of the treatment and co...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00452-7
更新日期:2019-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe a small city/rural area HIV prevention project (the Cross Border Project) implemented in Ning Ming County, Guangxi Province, China, and Lang Son province, Vietnam, and consider its implications for addressing the opioid/heroin epidemic in small cities/rural areas in the USA. The descriptio...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-018-0405-0
更新日期:2018-08-01 00:00:00