Abstract:
:The AIDS epidemic continues its unrelentless expansion. According to the Joint United Nations Programme on HIV/AIDS, there are more than 40 million people living with HIV, and more than 15,000 new infections occur every day. One approach to curbing HIV is the development of topical microbicidal agents or microbicides. These are compounds designed to protect the body's mucosal surfaces from infection by sexually transmitted disease-causing pathogens, including HIV. Several candidates are in preclinical stages; however, only a handful have been tested in humans for safety, and even fewer are ready for clinical efficacy trials. In this update, we describe microbicide research and development, including preclinical screening algorithms, ideal properties, compounds in the pipeline, and future prospects. This review is based on a previous work, which has been updated to contain new information, especially regarding microbicide candidates in preclinical and clinical stages of development.
journal_name
Curr HIV/AIDS Repjournal_title
Current HIV/AIDS reportsauthors
Doncel G,Mauck Cdoi
10.1007/s11904-004-0004-0keywords:
subject
Has Abstractpub_date
2004-04-01 00:00:00pages
25-32issue
1eissn
1548-3568issn
1548-3576journal_volume
1pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:The purpose of this paper is to provide a thorough overview of methods used for recruitment, network data collection, and network data management in a network-based study of rural people who use drugs (PWUD) and to offer methodological recommendations for future research on rural drug use. RECENT FIN...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-018-0391-2
更新日期:2018-04-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe a small city/rural area HIV prevention project (the Cross Border Project) implemented in Ning Ming County, Guangxi Province, China, and Lang Son province, Vietnam, and consider its implications for addressing the opioid/heroin epidemic in small cities/rural areas in the USA. The descriptio...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-018-0405-0
更新日期:2018-08-01 00:00:00
abstract::HIV infection is one of the strongest risk factors for anal squamous cell cancer (ASCC). Most ASCC are caused by HPV, and most HPV-associated ASCC are caused by HPV-16. Anal HPV infections are very common in men who have sex with men (MSM), and nearly universal among HIV-infected MSM. High-grade anal intraepithelial n...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0224-x
更新日期:2014-09-01 00:00:00
abstract::This article reviews the magnitude and spectrum of ocular complications of HIV infection in sub-Sahara Africa. A literature search was done using PubMed, Google, and UpToDate and by talking to ophthalmologists and HIV experts working in the region. Ocular complications of HIV infection, mostly retinal, are seen in 29%...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章
doi:10.1007/s11904-008-0019-z
更新日期:2008-08-01 00:00:00
abstract::Bacterial infection is a major cause of morbidity and mortality among patients with HIV living in Africa. Broadening the scope of cotrimoxazole (CTX) prophylaxis to cover patients whose CD4 counts are above 200 cells/mm(3) has been suggested as a means of improving the control of infectious disease on the continent. C...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-007-0021-x
更新日期:2007-08-01 00:00:00
abstract:PURPOSE OF REVIEW:This review aims to describe the epidemiology of HIV among female sex workers (FSWs) in China over the past decade, to summarize current gaps in knowledge regarding risk factors, and to identify new directions for HIV prevention strategies. RECENT FINDINGS:We summarized national and regional levels o...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00477-y
更新日期:2020-04-01 00:00:00
abstract::Female sex workers (FSWs) continue to represent a high-risk population in need of targeted HIV prevention interventions. Targeting environmental risk factors should result in more sustainable behavior change than individual-level interventions alone. There are many types of FSWs who operate in and through a variety of...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-012-0142-8
更新日期:2013-03-01 00:00:00
abstract::Due to the rapid expansion of first-line antiretroviral therapy in resource-limited settings (RLS), increasing numbers of people are living with HIV for prolonged periods of time. Treatment programs must now decide how to balance monitoring costs necessary to maximize health benefits for those already on treatment wit...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-010-0046-4
更新日期:2010-08-01 00:00:00
abstract::Due to life-enhancing effects of antiretroviral therapy, HIV-positive persons have the potential for long life comparable to their uninfected peers. Older women (age 50+) living with HIV (OWLH) are often an under-recognized aging group. We conducted a systematic review to examine psychosocial factors that impact how O...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-017-0347-y
更新日期:2017-02-01 00:00:00
abstract::Access to potent antiretroviral medications greatly reduces morbidity and mortality due to HIV/AIDS, but drug toxicity limits treatment success in many individuals. The field of pharmacogenomics strives to understand the influence of human genetic variants in response to medications. Investigators have begun to identi...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-006-0018-x
更新日期:2006-07-01 00:00:00
abstract::Recent policies, guidelines, and laws reflect promising preliminary outcomes among transplant recipients with HIV infection, and ethical analyses suggest that it is not justifiable to deny solid organ transplantation based solely on HIV-infection status. These studies consistently describe stable HIV disease following...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/BF02696657
更新日期:2006-09-01 00:00:00
abstract::Therapeutic drug monitoring (TDM) is the process by which a patient's dosing regimen is guided by repeated measures of plasma drug concentrations. An enormous challenge with regard to TDM of antiretroviral drugs (ARV) is that the concentration goals can be moving targets. Well-designed prospective studies demonstratin...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-005-0020-8
更新日期:2005-06-01 00:00:00
abstract:PURPOSE OF REVIEW:End-stage organ disease prevalence is increasing among HIV-infected (HIV+) individuals. Trial and registry data confirm that solid organ transplantation (SOT) is efficacious in this population. Optimizing access to transplant and decreasing complications represent active frontiers. RECENT FINDINGS:HI...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00440-x
更新日期:2019-06-01 00:00:00
abstract::This article reviews the antiretroviral therapy (ART) initiation criteria from published national guidelines for 94 countries (representing 86 % of global HIV burden) and compares them with the 2013 World Health Organization (WHO) ART guidelines. As of 31st of July 2014, 19 countries have adopted the WHO-recommended C...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0230-z
更新日期:2014-12-01 00:00:00
abstract::HIV research has identified approaches that can be combined to be more effective in transmission reduction than any 1 modality alone: delayed adolescent sexual debut, mutual monogamy or sexual partner reduction, correct and consistent condom use, pre-exposure prophylaxis with oral antiretroviral drugs or vaginal micro...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-013-0155-y
更新日期:2013-06-01 00:00:00
abstract::Increased access to testing and treatment means HIV can be managed as a chronic illness, though successful management requires continued engagement with the health care system. Most of the global HIV burden is in sub-Saharan Africa where rates of new infections are consistently higher in women versus men. Pregnancy is...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0252-6
更新日期:2015-03-01 00:00:00
abstract::Sustained retention represents an enduring and evolving challenge to HIV treatment programs in Africa. We present a theoretical framework for sustained retention borrowing from ecologic principles of sustainability and dynamic adaptation. We posit that sustained retention from the patient perspective is dependent on t...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-016-0317-9
更新日期:2016-06-01 00:00:00
abstract::An emerging body of evidence suggests that intergenerational sexual partnerships may increase risk of HIV acquisition among young men who have sex with men (YMSM). However, no studies have comprehensively evaluated literature in this area. We applied a scoping review methodology to explore the relationships between ag...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-013-0187-3
更新日期:2013-12-01 00:00:00
abstract::Injecting drug use is a common mode of transmission among persons with HIV/AIDS. Many HIV-infected patients meet diagnostic criteria for opioid dependence, a chronic and relapsing brain disorder. Most HIV providers, however, receive little training in substance use disorders. Opioid agonist therapy (OAT) has a stabili...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-006-0016-z
更新日期:2006-11-01 00:00:00
abstract:PURPOSE OF THE REVIEW:Early diagnosis and treatment of HIV following seroconversion improves individual and population health. Using published data on pre-treatment CD4 cell counts, we benchmarked the level of immunodeficiency at HIV diagnosis and ART initiation in the "real world" against those of the treatment and co...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00452-7
更新日期:2019-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Neurological conditions associated with HIV/AIDS including central nervous system (CNS), opportunistic infections (OI), chronic conditions including HIV-associated neurocognitive disorder, and cerebrospinal fluid (CSF) viral escape remain major contributors to morbidity and mortality worldwide. CNS in...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-020-00514-1
更新日期:2020-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Aligning HIV treatment services with patient preferences can promote long-term engagement. A rising number of studies solicit such preferences using discrete choice experiments, but have not been systematically reviewed to seek generalizable insights. Using a systematic search, we identified eleven ch...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-020-00520-3
更新日期:2020-10-01 00:00:00
abstract::Roughly 10 % of HIV-positive individuals worldwide have concomitant chronic hepatitis B virus (HBV) infection, with large differences between geographical regions and/or risk groups. Hepatitis B is a preventable infection with vaccines. However, it cannot be eradicated once acquired, resembling HIV and in contrast wit...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-015-0275-7
更新日期:2015-09-01 00:00:00
abstract::HIV is a devastating worldwide epidemic that has had substantial social and economic impacts throughout the globe. Due to the presence of a small pool of latently infected cells that persists during antiretroviral therapy (ART), HIV is not curable. Because of the high cost of ART and the lack of reliable accessibility...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-016-0304-1
更新日期:2016-04-01 00:00:00
abstract::Nine months of daily isoniazid is efficacious in treating latent M. tuberculosis infection, but completion rates are low, limiting treatment effectiveness. In 2011, three important studies were published involving novel regimens for the treatment of latent M. tuberculosis infection. At least 36 months of isoniazid was...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-012-0120-1
更新日期:2012-09-01 00:00:00
abstract::The course of HIV research has led to a multitude of interventions to prevent and treat HIV. With the arrival of more effective interventions comes the need to end, or de-implement, less effective interventions. PURPOSE OF REVIEW: To describe the state of de-implementation research in HIV and provide a rationale for e...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-020-00517-y
更新日期:2020-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Glycoimmunology is an emerging field focused on understanding how immune responses are mediated by glycans (carbohydrates) and their interaction with glycan-binding proteins called lectins. How glycans influence immunological functions is increasingly well understood. In a parallel way, in the HIV fie...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00433-w
更新日期:2019-04-01 00:00:00
abstract::HIV may cause several forms of peripheral neuropathy, the most common of which is distal symmetric polyneuropathy (DSP) characterized by pain and sensory deficits in a stocking-glove distribution. The pathophysiology of DSP remains largely unknown but is thought to be related both to the neurotoxicity of HIV-through i...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0211-2
更新日期:2014-09-01 00:00:00
abstract::The population of patients with HIV infection achieving viral suppression on combination antiretroviral therapy is growing, aging, and experiencing a widening spectrum of non-AIDS diseases. Concurrently, AIDS-defining conditions are becoming less common and are variably associated with outcome. Nonetheless, the spectr...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章
doi:10.1007/s11904-010-0041-9
更新日期:2010-05-01 00:00:00
abstract:PURPOSE OF REVIEW:This narrative review summarizes recent data on factors associated with insulin resistance (IR) in adults with HIV, including contemporary antiretroviral therapy (ART). RECENT FINDINGS:IR remains common in persons with HIV, even those receiving contemporary ART. Generalized and abdominal obesity and ...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-018-0399-7
更新日期:2018-06-01 00:00:00