Abstract:
:Persons who inject drugs (PWID) are at high risk for infection with and poor outcomes from HIV and hepatitis C virus (HCV). Well-established interventions for HIV/HCV prevention among PWID include syringe access, opioid agonist maintenance treatment, and supervised injection facilities, yet these interventions remain unavailable or inadequately resourced in much of the world. We review recent literature on biomedical and behavioral interventions to reduce the burden of HIV/HCV among PWID, with an emphasis on randomized controlled trials and quasi-experimental studies. Since 2013, there have been significant advancements in utilizing antiviral therapy and behavioral interventions for prevention among PWID, including approaches that address the unique needs of couples and sex workers. In addition, there have been significant developments in pharmacotherapies for substance use and the implementation of naloxone for opioid overdose prevention. Notwithstanding multiple ongoing structural challenges in delivering HIV/HCV prevention interventions to PWID, these emerging and rigorously evaluated interventions expand possibilities for prevention among PWID.
journal_name
Curr HIV/AIDS Repjournal_title
Current HIV/AIDS reportsauthors
Coffin PO,Rowe C,Santos GMdoi
10.1007/s11904-014-0248-2subject
Has Abstractpub_date
2015-03-01 00:00:00pages
145-63issue
1eissn
1548-3568issn
1548-3576journal_volume
12pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:This narrative review summarizes recent data on factors associated with insulin resistance (IR) in adults with HIV, including contemporary antiretroviral therapy (ART). RECENT FINDINGS:IR remains common in persons with HIV, even those receiving contemporary ART. Generalized and abdominal obesity and ...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-018-0399-7
更新日期:2018-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Mental health disorders, especially depression, are prevalent among people living with HIV (PLWH) and are associated with cognitive impairment (CI) among HIV-uninfected (HIV-) individuals. We conducted a comprehensive review of the link between depression and cognition among PLWH. RECENT FINDINGS:Stu...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00421-0
更新日期:2019-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Aligning HIV treatment services with patient preferences can promote long-term engagement. A rising number of studies solicit such preferences using discrete choice experiments, but have not been systematically reviewed to seek generalizable insights. Using a systematic search, we identified eleven ch...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-020-00520-3
更新日期:2020-10-01 00:00:00
abstract::Substance users are at elevated risk for HIV. HIV researchers, particularly at the intersection of HIV and substance use, have requested new methods to better understand and address this important area. New technologies, such as social media and mobile applications, are increasingly being used as research tools in stu...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-015-0295-3
更新日期:2015-12-01 00:00:00
abstract::Due to life-enhancing effects of antiretroviral therapy, HIV-positive persons have the potential for long life comparable to their uninfected peers. Older women (age 50+) living with HIV (OWLH) are often an under-recognized aging group. We conducted a systematic review to examine psychosocial factors that impact how O...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-017-0347-y
更新日期:2017-02-01 00:00:00
abstract::HIV is a devastating worldwide epidemic that has had substantial social and economic impacts throughout the globe. Due to the presence of a small pool of latently infected cells that persists during antiretroviral therapy (ART), HIV is not curable. Because of the high cost of ART and the lack of reliable accessibility...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-016-0304-1
更新日期:2016-04-01 00:00:00
abstract:PURPOSE OF REVIEW:End-stage organ disease prevalence is increasing among HIV-infected (HIV+) individuals. Trial and registry data confirm that solid organ transplantation (SOT) is efficacious in this population. Optimizing access to transplant and decreasing complications represent active frontiers. RECENT FINDINGS:HI...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00440-x
更新日期:2019-06-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) infection occurs throughout the body and can have dramatic physical effects, such as neurocognitive impairment in the central nervous system (CNS). Furthermore, examining the virus that resides in the CNS is challenging due to its location and can only be done using samples ...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-015-0265-9
更新日期:2015-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This review provides an overview of HCV resistance-associated substitutions (RASs) with a focus on NS3 protease and NS5A inhibitor resistance. Treatment approaches for managing resistance are also covered including the use of newly approved therapies with improved resistance profiles. RECENT FINDINGS...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-017-0369-5
更新日期:2017-12-01 00:00:00
abstract::HIV research has identified approaches that can be combined to be more effective in transmission reduction than any 1 modality alone: delayed adolescent sexual debut, mutual monogamy or sexual partner reduction, correct and consistent condom use, pre-exposure prophylaxis with oral antiretroviral drugs or vaginal micro...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-013-0155-y
更新日期:2013-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This review summarizes recent literature defining tissue-resident memory T cells (TRM) and discusses implications for HIV pathogenesis, vaccines, and eradication efforts. RECENT FINDINGS:Investigations using animal models and human tissues have identified a TRM transcriptional profile and elucidated ...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-020-00481-7
更新日期:2020-04-01 00:00:00
abstract::Neurocognitive impairment is common in people living with HIV and AIDS. Prior to highly active antiretroviral therapy (HAART), cognitive impairment primarily affected patients with advanced disease, and was a more rapidly progressive illness. With the use of HAART, cognitive impairment improved, along with the overall...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-009-0020-1
更新日期:2009-08-01 00:00:00
abstract::Generation of memory T cells, which mediate immunity against microbes and cancers, relies, for optimal activity, on the interactions of multiple cell types that are highly regulated through the expression of soluble factors and negative and positive receptors. Their disruption will lead to aberrant immune responses, w...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-008-0003-7
更新日期:2008-02-01 00:00:00
abstract::The HIV pandemic has disproportionately impacted sub-Saharan Africa and Southern Africa in particular. The concurrent presence of overlapping epidemic drivers likely underpins how and why the HIV epidemic is so explosive in this region, with implications for understanding approaches to reduce transmission. In this rev...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-016-0314-z
更新日期:2016-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Glycoimmunology is an emerging field focused on understanding how immune responses are mediated by glycans (carbohydrates) and their interaction with glycan-binding proteins called lectins. How glycans influence immunological functions is increasingly well understood. In a parallel way, in the HIV fie...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00433-w
更新日期:2019-04-01 00:00:00
abstract::Adolescents are critical to efforts to end the AIDS epidemic. Few national AIDS strategies explicitly program for children in their second decade of life. Adolescents (aged 10-19 years) are therefore largely invisible in global, regional, and country HIV and AIDS reports making it difficult to assess progress in this ...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-013-0159-7
更新日期:2013-06-01 00:00:00
abstract::The availability of potent combination antiretroviral therapy has changed the long-term prognosis for people living with HIV/AIDS. There is increasing concern, however, about the effect of HIV therapy on lipid disorders and subsequent development of coronary artery disease. Virtually all classes of antiretroviral drug...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-005-0006-6
更新日期:2005-08-01 00:00:00
abstract::Bacterial infection is a major cause of morbidity and mortality among patients with HIV living in Africa. Broadening the scope of cotrimoxazole (CTX) prophylaxis to cover patients whose CD4 counts are above 200 cells/mm(3) has been suggested as a means of improving the control of infectious disease on the continent. C...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-007-0021-x
更新日期:2007-08-01 00:00:00
abstract::Neurocognitive compromise, a common sequela of HIV infection, ranges in severity from minor motor and information-processing speed decrements to severely incapacitating symptoms that affect functional independence. However, with the emergence of highly active antiretroviral therapy (HAART), neurocognitive phenotypes h...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-008-0029-x
更新日期:2008-11-01 00:00:00
abstract::The population of patients with HIV infection achieving viral suppression on combination antiretroviral therapy is growing, aging, and experiencing a widening spectrum of non-AIDS diseases. Concurrently, AIDS-defining conditions are becoming less common and are variably associated with outcome. Nonetheless, the spectr...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章
doi:10.1007/s11904-010-0041-9
更新日期:2010-05-01 00:00:00
abstract::Access to potent antiretroviral medications greatly reduces morbidity and mortality due to HIV/AIDS, but drug toxicity limits treatment success in many individuals. The field of pharmacogenomics strives to understand the influence of human genetic variants in response to medications. Investigators have begun to identi...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-006-0018-x
更新日期:2006-07-01 00:00:00
abstract::The global HIV pandemic began to expand rapidly in southern Africa a decade later than was noted in central Africa, Europe, the Caribbean, and North America. Multiple factors played a role in this rapid expansion which led Southern Africa to become the most heavily afflicted region for HIV/AIDS globally. In this issue...
journal_title:Current HIV/AIDS reports
pub_type:
doi:10.1007/s11904-015-0270-z
更新日期:2015-06-01 00:00:00
abstract::Lipodystrophy and its two components lipo-accumulation and lipoatropy are very common among individuals with HIV infection on treatment, especially among those who started therapy in the late 1990s and early 2000s. This review discusses the current management of these complications of HIV and its treatment. For the pu...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-007-0013-x
更新日期:2007-05-01 00:00:00
abstract:PURPOSE OF THE REVIEW:Early diagnosis and treatment of HIV following seroconversion improves individual and population health. Using published data on pre-treatment CD4 cell counts, we benchmarked the level of immunodeficiency at HIV diagnosis and ART initiation in the "real world" against those of the treatment and co...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00452-7
更新日期:2019-08-01 00:00:00
abstract::Therapeutic drug monitoring (TDM) is the process by which a patient's dosing regimen is guided by repeated measures of plasma drug concentrations. An enormous challenge with regard to TDM of antiretroviral drugs (ARV) is that the concentration goals can be moving targets. Well-designed prospective studies demonstratin...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-005-0020-8
更新日期:2005-06-01 00:00:00
abstract::Due to the co-occurrence of sexual risk behaviors and substance use among HIV-positive individuals, there is often a need for HIV prevention efforts to target multiple behaviors. Motivational Interviewing (MI), a widely disseminated behavior change intervention, has demonstrated effectiveness in promoting behavior cha...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-012-0132-x
更新日期:2012-12-01 00:00:00
abstract::Pharmacy refill adherence has become an increasingly important measure of adherence to antiretroviral medications. It offers a simple, inexpensive, and valid method for measuring adherence. Over the past year, there have been several published developments in the use of pharmacy refill data to measure adherence. Given...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-007-0027-4
更新日期:2007-12-01 00:00:00
abstract::HIV may cause several forms of peripheral neuropathy, the most common of which is distal symmetric polyneuropathy (DSP) characterized by pain and sensory deficits in a stocking-glove distribution. The pathophysiology of DSP remains largely unknown but is thought to be related both to the neurotoxicity of HIV-through i...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0211-2
更新日期:2014-09-01 00:00:00
abstract::For the last three decades, sub-Saharan Africa has been the epicentre of the HIV epidemic. Some key drivers of the epidemic are specific to this region and there is an urgent need to develop context-specific strategies to reduce HIV-related burden. Implementation frameworks should endeavour to combine structural, beha...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-015-0262-z
更新日期:2015-06-01 00:00:00
abstract::While combination antiretroviral therapy allows HIV-infected patients to have life expectancies similar to that of the general population, it may also contribute to the development of co-morbidities, such as cardiovascular disease and osteoporosis. Such complications could compromise long-term quality of life, especia...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-016-0320-1
更新日期:2016-08-01 00:00:00