Realizing the potential of treatment as prevention: global ART policy and treatment coverage.

abstract：:The population of patients with HIV infection achieving viral suppression on combination antiretroviral therapy is growing, aging, and experiencing a widening spectrum of non-AIDS diseases. Concurrently, AIDS-defining conditions are becoming less common and are variably associated with outcome. Nonetheless, the spectr...

journal_title：Current HIV/AIDS reports

authors： Justice AC

更新日期：2010-05-01 00:00:00

abstract：:Neurocognitive impairment is common in people living with HIV and AIDS. Prior to highly active antiretroviral therapy (HAART), cognitive impairment primarily affected patients with advanced disease, and was a more rapidly progressive illness. With the use of HAART, cognitive impairment improved, along with the overall...

journal_title：Current HIV/AIDS reports

authors： Robinson-Papp J,Elliott KJ,Simpson DM

更新日期：2009-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This narrative review summarizes recent data on factors associated with insulin resistance (IR) in adults with HIV, including contemporary antiretroviral therapy (ART). RECENT FINDINGS:IR remains common in persons with HIV, even those receiving contemporary ART. Generalized and abdominal obesity and ...

journal_title：Current HIV/AIDS reports

authors： Hulgan T

更新日期：2018-06-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection occurs throughout the body and can have dramatic physical effects, such as neurocognitive impairment in the central nervous system (CNS). Furthermore, examining the virus that resides in the CNS is challenging due to its location and can only be done using samples ...

journal_title：Current HIV/AIDS reports

authors： Bednar MM,Sturdevant CB,Tompkins LA,Arrildt KT,Dukhovlinova E,Kincer LP,Swanstrom R

更新日期：2015-06-01 00:00:00

abstract：:Several all-oral direct-acting antiviral (DAA) combination therapies including two fixed-dose combinations (FDCs) have been recently licensed for treatment of hepatitis C virus (HCV) genotype 1 infection. Results of pivotal trials with these new compounds are now also available in human immunodeficiency virus (HIV)/HC...

journal_title：Current HIV/AIDS reports

authors： Boesecke C,Rockstroh JK

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Neurological conditions associated with HIV/AIDS including central nervous system (CNS), opportunistic infections (OI), chronic conditions including HIV-associated neurocognitive disorder, and cerebrospinal fluid (CSF) viral escape remain major contributors to morbidity and mortality worldwide. CNS in...

journal_title：Current HIV/AIDS reports

authors： Thakur KT

更新日期：2020-10-01 00:00:00

abstract：:Despite impressive decreases in mortality and morbidity, significant adverse events have surfaced as a result of combination antiretroviral therapy (ART). They include lipoatrophy, or subcutaneous fat wasting of the face, arms, buttocks, or legs, which can be associated with central fat accumulation. Although the unde...

journal_title：Current HIV/AIDS reports

authors： Tungsiripat M,McComsey G

更新日期：2008-05-01 00:00:00

abstract：:The HIV pandemic has disproportionately impacted sub-Saharan Africa and Southern Africa in particular. The concurrent presence of overlapping epidemic drivers likely underpins how and why the HIV epidemic is so explosive in this region, with implications for understanding approaches to reduce transmission. In this rev...

journal_title：Current HIV/AIDS reports

authors： McKinnon LR,Karim QA

更新日期：2016-06-01 00:00:00

abstract：:The global HIV pandemic began to expand rapidly in southern Africa a decade later than was noted in central Africa, Europe, the Caribbean, and North America. Multiple factors played a role in this rapid expansion which led Southern Africa to become the most heavily afflicted region for HIV/AIDS globally. In this issue...

journal_title：Current HIV/AIDS reports

authors： Vermund SH,Sheldon EK,Sidat M

更新日期：2015-06-01 00:00:00

abstract：:Due to the co-occurrence of sexual risk behaviors and substance use among HIV-positive individuals, there is often a need for HIV prevention efforts to target multiple behaviors. Motivational Interviewing (MI), a widely disseminated behavior change intervention, has demonstrated effectiveness in promoting behavior cha...

journal_title：Current HIV/AIDS reports

authors： Naar-King S,Parsons JT,Johnson AM

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:End-stage organ disease prevalence is increasing among HIV-infected (HIV+) individuals. Trial and registry data confirm that solid organ transplantation (SOT) is efficacious in this population. Optimizing access to transplant and decreasing complications represent active frontiers. RECENT FINDINGS:HI...

journal_title：Current HIV/AIDS reports

authors： Werbel WA,Durand CM

更新日期：2019-06-01 00:00:00

abstract：:Vaccine recommendations for those with HIV require continual updating as additional research becomes available. Timing of vaccinations among HIV-infected individuals is a key area of uncertainty. This is particularly true for those who may soon initiate highly active antiretroviral therapy (HAART) because immune recon...

journal_title：Current HIV/AIDS reports

authors： Crane HM,Dhanireddy S,Kim HN,Ramers C,Dellit TH,Kitahata MM,Harrington RD

更新日期：2009-05-01 00:00:00

abstract：:Lipodystrophy and its two components lipo-accumulation and lipoatropy are very common among individuals with HIV infection on treatment, especially among those who started therapy in the late 1990s and early 2000s. This review discusses the current management of these complications of HIV and its treatment. For the pu...

journal_title：Current HIV/AIDS reports

authors： Tebas P

更新日期：2007-05-01 00:00:00

abstract：:Access to potent antiretroviral medications greatly reduces morbidity and mortality due to HIV/AIDS, but drug toxicity limits treatment success in many individuals. The field of pharmacogenomics strives to understand the influence of human genetic variants in response to medications. Investigators have begun to identi...

journal_title：Current HIV/AIDS reports

authors： Haas DW

更新日期：2006-07-01 00:00:00

abstract：:Due to the rapid expansion of first-line antiretroviral therapy in resource-limited settings (RLS), increasing numbers of people are living with HIV for prolonged periods of time. Treatment programs must now decide how to balance monitoring costs necessary to maximize health benefits for those already on treatment wit...

journal_title：Current HIV/AIDS reports

authors： Hosseinipour MC,Schechter M

更新日期：2010-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Aligning HIV treatment services with patient preferences can promote long-term engagement. A rising number of studies solicit such preferences using discrete choice experiments, but have not been systematically reviewed to seek generalizable insights. Using a systematic search, we identified eleven ch...

journal_title：Current HIV/AIDS reports

authors： Eshun-Wilson I,Kim HY,Schwartz S,Conte M,Glidden DV,Geng EH

更新日期：2020-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe a small city/rural area HIV prevention project (the Cross Border Project) implemented in Ning Ming County, Guangxi Province, China, and Lang Son province, Vietnam, and consider its implications for addressing the opioid/heroin epidemic in small cities/rural areas in the USA. The descriptio...

journal_title：Current HIV/AIDS reports

authors： Des Jarlais DC,Hammett TM,Kieu B,Chen Y,Feelemyer J

更新日期：2018-08-01 00:00:00

abstract：:With the introduction of potent combination antiretroviral therapy (cART) into clinical practice, HIV-infected patients have garnered much benefit. However, kidney disease continues to be a potential complication in this group. Whereas HIV-associated nephropathy (HIVAN) was the major renal complication prior to cART, ...

journal_title：Current HIV/AIDS reports

authors： Kumar N,Perazella MA

更新日期：2014-09-01 00:00:00

abstract：:HIV-infected individuals are at increased risk for most types of cancer, including those typically classified as non-AIDS-defining cancers (NADCs). This increased risk is likely multifactorial, but a prominent risk factor for the increased rate of some cancers is co-infection with oncogenic viruses. Anal cancer, hepat...

journal_title：Current HIV/AIDS reports

authors： Riedel DJ,Tang LS,Rositch AF

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Early diagnosis and treatment of HIV following seroconversion improves individual and population health. Using published data on pre-treatment CD4 cell counts, we benchmarked the level of immunodeficiency at HIV diagnosis and ART initiation in the "real world" against those of the treatment and co...

journal_title：Current HIV/AIDS reports

authors： Nash D,Robertson M

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this paper is to provide a thorough overview of methods used for recruitment, network data collection, and network data management in a network-based study of rural people who use drugs (PWUD) and to offer methodological recommendations for future research on rural drug use. RECENT FIN...

journal_title：Current HIV/AIDS reports

authors： Young AM,Rudolph AE,Havens JR

更新日期：2018-04-01 00:00:00

abstract：:The role of voluntary counseling and testing (VCT)of HIV in resource-limited settings has recently broadened from primarily that of a prevention intervention to its identification as the key entry point into expanding access to life-saving antiretroviral therapy, additional HIV-specific medical care, and other support...

journal_title：Current HIV/AIDS reports

authors： Liechty CA

更新日期：2004-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to describe the epidemiology of HIV among female sex workers (FSWs) in China over the past decade, to summarize current gaps in knowledge regarding risk factors, and to identify new directions for HIV prevention strategies. RECENT FINDINGS:We summarized national and regional levels o...

journal_title：Current HIV/AIDS reports

authors： Zhang H,Hsieh E,Wang L,Liao S

更新日期：2020-04-01 00:00:00

abstract：:HIV infection is one of the strongest risk factors for anal squamous cell cancer (ASCC). Most ASCC are caused by HPV, and most HPV-associated ASCC are caused by HPV-16. Anal HPV infections are very common in men who have sex with men (MSM), and nearly universal among HIV-infected MSM. High-grade anal intraepithelial n...

journal_title：Current HIV/AIDS reports

authors： Schim van der Loeff MF,Mooij SH,Richel O,de Vries HJ,Prins JM

更新日期：2014-09-01 00:00:00

abstract：PURPOSE OF REVIEW:In the absence of antiretroviral therapy (ART), more than 50% of perinatally HIV-infected children die by 2 years of age. Early ART from infancy is therefore a global recommendation and significantly improves immune health, child survival, and disease outcome. However, even early treatment does not pr...

journal_title：Current HIV/AIDS reports

authors： Berendam SJ,Nelson AN,Goswami R,Persaud D,Haigwood NL,Chahroudi A,Fouda GG,Permar SR

更新日期：2020-06-01 00:00:00

abstract：:HIV infection and antiretroviral therapy (ART) use are associated with perturbations in glucose and lipid metabolism. Increasing incidence of diabetes, cardiovascular disease, and obesity highlights the need for early identification and treatment of metabolic dysfunction. Newer ART regimens are less toxic for cellular...

journal_title：Current HIV/AIDS reports

authors： Willig AL,Overton ET

更新日期：2016-10-01 00:00:00

abstract：:HIV is a devastating worldwide epidemic that has had substantial social and economic impacts throughout the globe. Due to the presence of a small pool of latently infected cells that persists during antiretroviral therapy (ART), HIV is not curable. Because of the high cost of ART and the lack of reliable accessibility...

journal_title：Current HIV/AIDS reports

authors： Barton KM,Palmer SE

更新日期：2016-04-01 00:00:00

abstract：:The first association between HIV-1 infection and kidney disease was made in 1984 and much has been learned over the past 20 years. In recent years, more effective therapies for HIV-1 infection and its associated opportunistic infections have led to improved patient survival. However, with prolonged survival, morbidit...

journal_title：Current HIV/AIDS reports

authors： Cho ME,Kopp JB

更新日期：2004-09-01 00:00:00

abstract：:Persons who inject drugs (PWID) are at high risk for infection with and poor outcomes from HIV and hepatitis C virus (HCV). Well-established interventions for HIV/HCV prevention among PWID include syringe access, opioid agonist maintenance treatment, and supervised injection facilities, yet these interventions remain ...

journal_title：Current HIV/AIDS reports

authors： Coffin PO,Rowe C,Santos GM

更新日期：2015-03-01 00:00:00

abstract：:HIV may cause several forms of peripheral neuropathy, the most common of which is distal symmetric polyneuropathy (DSP) characterized by pain and sensory deficits in a stocking-glove distribution. The pathophysiology of DSP remains largely unknown but is thought to be related both to the neurotoxicity of HIV-through i...

journal_title：Current HIV/AIDS reports

authors： Stavros K,Simpson DM

更新日期：2014-09-01 00:00:00