Abstract:
:HIV may cause several forms of peripheral neuropathy, the most common of which is distal symmetric polyneuropathy (DSP) characterized by pain and sensory deficits in a stocking-glove distribution. The pathophysiology of DSP remains largely unknown but is thought to be related both to the neurotoxicity of HIV-through indirect immunomodulatory mechanisms-and to the neurotoxic effects of anti-retroviral therapies, most notably the dideoxynucleoside reverse transcription inhibitors or so-called d-drugs. Determining whether symptoms arise from the virus or the treatment poses a challenge to the clinician who must decide if a patient's HAART regimen should be altered. Treatment of symptoms related to HIV-DSP is a difficult task and there is no evidence that the traditional agents used in chronic neuropathic pain are efficacious in the HIV-DSP population. Indeed few pharmacologic agents have proven efficacy in HIV-DSP - these include cannabis and the capsaicin 8 % dermal patch. As such, alternative, non-pharmacologic therapies are being investigated. More research is needed to further elucidate the complex pathophysiology of HIV-DSP which may yield additional therapies for these patients.
journal_name
Curr HIV/AIDS Repjournal_title
Current HIV/AIDS reportsauthors
Stavros K,Simpson DMdoi
10.1007/s11904-014-0211-2subject
Has Abstractpub_date
2014-09-01 00:00:00pages
195-201issue
3eissn
1548-3568issn
1548-3576journal_volume
11pub_type
杂志文章,评审abstract::Lipodystrophy and its two components lipo-accumulation and lipoatropy are very common among individuals with HIV infection on treatment, especially among those who started therapy in the late 1990s and early 2000s. This review discusses the current management of these complications of HIV and its treatment. For the pu...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-007-0013-x
更新日期:2007-05-01 00:00:00
abstract::The availability of potent combination antiretroviral therapy has changed the long-term prognosis for people living with HIV/AIDS. There is increasing concern, however, about the effect of HIV therapy on lipid disorders and subsequent development of coronary artery disease. Virtually all classes of antiretroviral drug...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-005-0006-6
更新日期:2005-08-01 00:00:00
abstract::The purpose of this meta-analytic study is to summarize the current science concerning the (a) prevalence of alcohol use, (b) prevalence of sexual risk behaviors, and (c) association between alcohol use and sexual risk behaviors among people livingwithHIV/AIDS (PLWHA). Studies were included if they sampled PLWHA, eval...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11904-013-0177-5
更新日期:2013-12-01 00:00:00
abstract::Due to life-enhancing effects of antiretroviral therapy, HIV-positive persons have the potential for long life comparable to their uninfected peers. Older women (age 50+) living with HIV (OWLH) are often an under-recognized aging group. We conducted a systematic review to examine psychosocial factors that impact how O...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-017-0347-y
更新日期:2017-02-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) infection occurs throughout the body and can have dramatic physical effects, such as neurocognitive impairment in the central nervous system (CNS). Furthermore, examining the virus that resides in the CNS is challenging due to its location and can only be done using samples ...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-015-0265-9
更新日期:2015-06-01 00:00:00
abstract::An emerging body of evidence suggests that intergenerational sexual partnerships may increase risk of HIV acquisition among young men who have sex with men (YMSM). However, no studies have comprehensively evaluated literature in this area. We applied a scoping review methodology to explore the relationships between ag...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-013-0187-3
更新日期:2013-12-01 00:00:00
abstract::Roughly 10 % of HIV-positive individuals worldwide have concomitant chronic hepatitis B virus (HBV) infection, with large differences between geographical regions and/or risk groups. Hepatitis B is a preventable infection with vaccines. However, it cannot be eradicated once acquired, resembling HIV and in contrast wit...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-015-0275-7
更新日期:2015-09-01 00:00:00
abstract:PURPOSE OF REVIEW:In the absence of antiretroviral therapy (ART), more than 50% of perinatally HIV-infected children die by 2 years of age. Early ART from infancy is therefore a global recommendation and significantly improves immune health, child survival, and disease outcome. However, even early treatment does not pr...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-020-00495-1
更新日期:2020-06-01 00:00:00
abstract::Persons who inject drugs (PWID) are at high risk for infection with and poor outcomes from HIV and hepatitis C virus (HCV). Well-established interventions for HIV/HCV prevention among PWID include syringe access, opioid agonist maintenance treatment, and supervised injection facilities, yet these interventions remain ...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0248-2
更新日期:2015-03-01 00:00:00
abstract::For the last three decades, sub-Saharan Africa has been the epicentre of the HIV epidemic. Some key drivers of the epidemic are specific to this region and there is an urgent need to develop context-specific strategies to reduce HIV-related burden. Implementation frameworks should endeavour to combine structural, beha...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-015-0262-z
更新日期:2015-06-01 00:00:00
abstract::The AIDS epidemic continues its unrelentless expansion. According to the Joint United Nations Programme on HIV/AIDS, there are more than 40 million people living with HIV, and more than 15,000 new infections occur every day. One approach to curbing HIV is the development of topical microbicidal agents or microbicides....
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-004-0004-0
更新日期:2004-04-01 00:00:00
abstract::Generation of memory T cells, which mediate immunity against microbes and cancers, relies, for optimal activity, on the interactions of multiple cell types that are highly regulated through the expression of soluble factors and negative and positive receptors. Their disruption will lead to aberrant immune responses, w...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-008-0003-7
更新日期:2008-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this paper is to provide a thorough overview of methods used for recruitment, network data collection, and network data management in a network-based study of rural people who use drugs (PWUD) and to offer methodological recommendations for future research on rural drug use. RECENT FIN...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-018-0391-2
更新日期:2018-04-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe a small city/rural area HIV prevention project (the Cross Border Project) implemented in Ning Ming County, Guangxi Province, China, and Lang Son province, Vietnam, and consider its implications for addressing the opioid/heroin epidemic in small cities/rural areas in the USA. The descriptio...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-018-0405-0
更新日期:2018-08-01 00:00:00
abstract::HIV infection and antiretroviral therapy (ART) use are associated with perturbations in glucose and lipid metabolism. Increasing incidence of diabetes, cardiovascular disease, and obesity highlights the need for early identification and treatment of metabolic dysfunction. Newer ART regimens are less toxic for cellular...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-016-0330-z
更新日期:2016-10-01 00:00:00
abstract::Neurocognitive compromise, a common sequela of HIV infection, ranges in severity from minor motor and information-processing speed decrements to severely incapacitating symptoms that affect functional independence. However, with the emergence of highly active antiretroviral therapy (HAART), neurocognitive phenotypes h...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-008-0029-x
更新日期:2008-11-01 00:00:00
abstract::HIV infection is one of the strongest risk factors for anal squamous cell cancer (ASCC). Most ASCC are caused by HPV, and most HPV-associated ASCC are caused by HPV-16. Anal HPV infections are very common in men who have sex with men (MSM), and nearly universal among HIV-infected MSM. High-grade anal intraepithelial n...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0224-x
更新日期:2014-09-01 00:00:00
abstract:PURPOSE OF THE REVIEW:Early diagnosis and treatment of HIV following seroconversion improves individual and population health. Using published data on pre-treatment CD4 cell counts, we benchmarked the level of immunodeficiency at HIV diagnosis and ART initiation in the "real world" against those of the treatment and co...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00452-7
更新日期:2019-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Mental health disorders, especially depression, are prevalent among people living with HIV (PLWH) and are associated with cognitive impairment (CI) among HIV-uninfected (HIV-) individuals. We conducted a comprehensive review of the link between depression and cognition among PLWH. RECENT FINDINGS:Stu...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00421-0
更新日期:2019-02-01 00:00:00
abstract:PURPOSE OF REVIEW:This review provides an overview of HCV resistance-associated substitutions (RASs) with a focus on NS3 protease and NS5A inhibitor resistance. Treatment approaches for managing resistance are also covered including the use of newly approved therapies with improved resistance profiles. RECENT FINDINGS...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-017-0369-5
更新日期:2017-12-01 00:00:00
abstract::HIV-infected individuals are at increased risk for most types of cancer, including those typically classified as non-AIDS-defining cancers (NADCs). This increased risk is likely multifactorial, but a prominent risk factor for the increased rate of some cancers is co-infection with oncogenic viruses. Anal cancer, hepat...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-015-0276-6
更新日期:2015-09-01 00:00:00
abstract::With the introduction of potent combination antiretroviral therapy (cART) into clinical practice, HIV-infected patients have garnered much benefit. However, kidney disease continues to be a potential complication in this group. Whereas HIV-associated nephropathy (HIVAN) was the major renal complication prior to cART, ...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0209-9
更新日期:2014-09-01 00:00:00
abstract::Increased access to testing and treatment means HIV can be managed as a chronic illness, though successful management requires continued engagement with the health care system. Most of the global HIV burden is in sub-Saharan Africa where rates of new infections are consistently higher in women versus men. Pregnancy is...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0252-6
更新日期:2015-03-01 00:00:00
abstract::Combined antiretroviral therapy (CART) has turned HIV-infection to a treatable chronic disease during which many patients survive to middle and older age. However, they prematurely develop non-AIDS comorbidities such as cardiovascular disease, metabolic syndrome, diabetes, and HIV-associated neurocognitive disorders (...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-016-0339-3
更新日期:2016-12-01 00:00:00
abstract::The first association between HIV-1 infection and kidney disease was made in 1984 and much has been learned over the past 20 years. In recent years, more effective therapies for HIV-1 infection and its associated opportunistic infections have led to improved patient survival. However, with prolonged survival, morbidit...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-004-0016-9
更新日期:2004-09-01 00:00:00
abstract::This article reviews the antiretroviral therapy (ART) initiation criteria from published national guidelines for 94 countries (representing 86 % of global HIV burden) and compares them with the 2013 World Health Organization (WHO) ART guidelines. As of 31st of July 2014, 19 countries have adopted the WHO-recommended C...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0230-z
更新日期:2014-12-01 00:00:00
abstract:PURPOSE OF REVIEW:In this report, we review the need for point-of-care (POC) or near real-time testing for antiretrovirals, progress in the field, evidence for guiding implementation of these tests globally, and future directions in objective antiretroviral therapy (ART) or pre-exposure prophylaxis (PrEP) adherence mon...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-020-00512-3
更新日期:2020-10-01 00:00:00
abstract::The global HIV pandemic began to expand rapidly in southern Africa a decade later than was noted in central Africa, Europe, the Caribbean, and North America. Multiple factors played a role in this rapid expansion which led Southern Africa to become the most heavily afflicted region for HIV/AIDS globally. In this issue...
journal_title:Current HIV/AIDS reports
pub_type:
doi:10.1007/s11904-015-0270-z
更新日期:2015-06-01 00:00:00
abstract::This article reviews the magnitude and spectrum of ocular complications of HIV infection in sub-Sahara Africa. A literature search was done using PubMed, Google, and UpToDate and by talking to ophthalmologists and HIV experts working in the region. Ocular complications of HIV infection, mostly retinal, are seen in 29%...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章
doi:10.1007/s11904-008-0019-z
更新日期:2008-08-01 00:00:00
abstract:PURPOSE OF REVIEW:This review summarizes recent literature defining tissue-resident memory T cells (TRM) and discusses implications for HIV pathogenesis, vaccines, and eradication efforts. RECENT FINDINGS:Investigations using animal models and human tissues have identified a TRM transcriptional profile and elucidated ...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-020-00481-7
更新日期:2020-04-01 00:00:00