Defining T Cell Tissue Residency in Humans: Implications for HIV Pathogenesis and Vaccine Design.

Abstract:

PURPOSE OF REVIEW:This review summarizes recent literature defining tissue-resident memory T cells (TRM) and discusses implications for HIV pathogenesis, vaccines, and eradication efforts. RECENT FINDINGS:Investigations using animal models and human tissues have identified a TRM transcriptional profile and elucidated signals within the tissue microenvironment leading to TRM development and maintenance. TRM are major contributors to host response in infectious diseases and cancer; in addition, TRM contribute to pathogenic inflammation in a variety of settings. Although TRM are daunting to study in HIV infection, recent work has helped define their molecular signatures and effector functions and tested strategies for their mobilization. Exclusive reliance on blood sampling to gain an understanding of host immunity overlooks the contribution of TRM, which differ in significant ways from their counterparts in circulation. It is hoped that greater understanding of these cells will lead to novel approaches to prevent and/or eradicate HIV infection.

journal_name

Curr HIV/AIDS Rep

journal_title

Current HIV/AIDS reports

authors

Shacklett BL,Ferre AL,Kiniry BE

doi

10.1007/s11904-020-00481-7

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

109-117

issue

2

eissn

1548-3568

issn

1548-3576

pii

10.1007/s11904-020-00481-7

journal_volume

17

pub_type

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