Defining T Cell Tissue Residency in Humans: Implications for HIV Pathogenesis and Vaccine Design.


PURPOSE OF REVIEW:This review summarizes recent literature defining tissue-resident memory T cells (TRM) and discusses implications for HIV pathogenesis, vaccines, and eradication efforts. RECENT FINDINGS:Investigations using animal models and human tissues have identified a TRM transcriptional profile and elucidated signals within the tissue microenvironment leading to TRM development and maintenance. TRM are major contributors to host response in infectious diseases and cancer; in addition, TRM contribute to pathogenic inflammation in a variety of settings. Although TRM are daunting to study in HIV infection, recent work has helped define their molecular signatures and effector functions and tested strategies for their mobilization. Exclusive reliance on blood sampling to gain an understanding of host immunity overlooks the contribution of TRM, which differ in significant ways from their counterparts in circulation. It is hoped that greater understanding of these cells will lead to novel approaches to prevent and/or eradicate HIV infection.




Current HIV/AIDS reports


Shacklett BL,Ferre AL,Kiniry BE




Has Abstract


2020-04-01 00:00:00














  • Preventing bacterial disease in the HIV-infected of sub-Saharan Africa: the role of cotrimoxazole and the pneumococcal vaccines.

    abstract::Bacterial infection is a major cause of morbidity and mortality among patients with HIV living in Africa. Broadening the scope of cotrimoxazole (CTX) prophylaxis to cover patients whose CD4 counts are above 200 cells/mm(3) has been suggested as a means of improving the control of infectious disease on the continent. C...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Spencer DC

    更新日期:2007-08-01 00:00:00

  • Emerging issues in the neuropsychology of HIV infection.

    abstract::Neurocognitive compromise, a common sequela of HIV infection, ranges in severity from minor motor and information-processing speed decrements to severely incapacitating symptoms that affect functional independence. However, with the emergence of highly active antiretroviral therapy (HAART), neurocognitive phenotypes h...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Foley J,Ettenhofer M,Wright M,Hinkin CH

    更新日期:2008-11-01 00:00:00

  • How to Define the Latent Reservoir: Tools of the Trade.

    abstract::HIV is a devastating worldwide epidemic that has had substantial social and economic impacts throughout the globe. Due to the presence of a small pool of latently infected cells that persists during antiretroviral therapy (ART), HIV is not curable. Because of the high cost of ART and the lack of reliable accessibility...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Barton KM,Palmer SE

    更新日期:2016-04-01 00:00:00

  • PrEP Product Acceptability and Dual Process Decision-Making Among Men Who Have Sex with Men.

    abstract:PURPOSE OF REVIEW:Advances in short- and long-acting pre-exposure prophylaxis (PrEP) technologies have incentivized the need to understand how individuals make trade-offs and competing decisions regarding PrEP modalities. The purpose of this review was to examine how researchers have conceptualized and measured attribu...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Bauermeister JA,Downs JS,Krakower DS

    更新日期:2020-06-01 00:00:00

  • Pathogenesis and management of lipoatrophy.

    abstract::Despite impressive decreases in mortality and morbidity, significant adverse events have surfaced as a result of combination antiretroviral therapy (ART). They include lipoatrophy, or subcutaneous fat wasting of the face, arms, buttocks, or legs, which can be associated with central fat accumulation. Although the unde...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Tungsiripat M,McComsey G

    更新日期:2008-05-01 00:00:00

  • Adherence to HIV care after pregnancy among women in sub-Saharan Africa: falling off the cliff of the treatment cascade.

    abstract::Increased access to testing and treatment means HIV can be managed as a chronic illness, though successful management requires continued engagement with the health care system. Most of the global HIV burden is in sub-Saharan Africa where rates of new infections are consistently higher in women versus men. Pregnancy is...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Psaros C,Remmert JE,Bangsberg DR,Safren SA,Smit JA

    更新日期:2015-03-01 00:00:00

  • Treatment of chronic HCV genotype 1 coinfection.

    abstract::Several all-oral direct-acting antiviral (DAA) combination therapies including two fixed-dose combinations (FDCs) have been recently licensed for treatment of hepatitis C virus (HCV) genotype 1 infection. Results of pivotal trials with these new compounds are now also available in human immunodeficiency virus (HIV)/HC...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Boesecke C,Rockstroh JK

    更新日期:2015-09-01 00:00:00

  • Factors Associated With Insulin Resistance in Adults With HIV Receiving Contemporary Antiretroviral Therapy: a Brief Update.

    abstract:PURPOSE OF REVIEW:This narrative review summarizes recent data on factors associated with insulin resistance (IR) in adults with HIV, including contemporary antiretroviral therapy (ART). RECENT FINDINGS:IR remains common in persons with HIV, even those receiving contemporary ART. Generalized and abdominal obesity and ...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Hulgan T

    更新日期:2018-06-01 00:00:00

  • Understanding Sustained Retention in HIV/AIDS Care and Treatment: a Synthetic Review.

    abstract::Sustained retention represents an enduring and evolving challenge to HIV treatment programs in Africa. We present a theoretical framework for sustained retention borrowing from ecologic principles of sustainability and dynamic adaptation. We posit that sustained retention from the patient perspective is dependent on t...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Roy M,Czaicki N,Holmes C,Chavan S,Tsitsi A,Odeny T,Sikazwe I,Padian N,Geng E

    更新日期:2016-06-01 00:00:00

  • Solid organ transplantation is a reality for patients with HIV infection.

    abstract::Recent policies, guidelines, and laws reflect promising preliminary outcomes among transplant recipients with HIV infection, and ethical analyses suggest that it is not justifiable to deny solid organ transplantation based solely on HIV-infection status. These studies consistently describe stable HIV disease following...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Roland ME,Stock PG

    更新日期:2006-09-01 00:00:00

  • The evolving role of HIV counseling and testing in resource-limited settings: HIV prevention and linkage to expanding HIV care access.

    abstract::The role of voluntary counseling and testing (VCT)of HIV in resource-limited settings has recently broadened from primarily that of a prevention intervention to its identification as the key entry point into expanding access to life-saving antiretroviral therapy, additional HIV-specific medical care, and other support...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Liechty CA

    更新日期:2004-12-01 00:00:00

  • Differentiating HIV-associated nephropathy from antiretroviral drug-induced nephropathy: a clinical challenge.

    abstract::With the introduction of potent combination antiretroviral therapy (cART) into clinical practice, HIV-infected patients have garnered much benefit. However, kidney disease continues to be a potential complication in this group. Whereas HIV-associated nephropathy (HIVAN) was the major renal complication prior to cART, ...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Kumar N,Perazella MA

    更新日期:2014-09-01 00:00:00

  • Therapeutic drug monitoring: pharmacologic considerations for antiretroviral drugs.

    abstract::Therapeutic drug monitoring (TDM) is the process by which a patient's dosing regimen is guided by repeated measures of plasma drug concentrations. An enormous challenge with regard to TDM of antiretroviral drugs (ARV) is that the concentration goals can be moving targets. Well-designed prospective studies demonstratin...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Kiser JJ,Anderson PL,Gerber JG

    更新日期:2005-06-01 00:00:00

  • Network-Based Research on Rural Opioid Use: an Overview of Methods and Lessons Learned.

    abstract:PURPOSE OF REVIEW:The purpose of this paper is to provide a thorough overview of methods used for recruitment, network data collection, and network data management in a network-based study of rural people who use drugs (PWUD) and to offer methodological recommendations for future research on rural drug use. RECENT FIN...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Young AM,Rudolph AE,Havens JR

    更新日期:2018-04-01 00:00:00

  • The role of viral co-infection in HIV-associated non-AIDS-related cancers.

    abstract::HIV-infected individuals are at increased risk for most types of cancer, including those typically classified as non-AIDS-defining cancers (NADCs). This increased risk is likely multifactorial, but a prominent risk factor for the increased rate of some cancers is co-infection with oncogenic viruses. Anal cancer, hepat...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Riedel DJ,Tang LS,Rositch AF

    更新日期:2015-09-01 00:00:00

  • HIV-related neurocognitive impairment in the HAART era.

    abstract::Neurocognitive impairment is common in people living with HIV and AIDS. Prior to highly active antiretroviral therapy (HAART), cognitive impairment primarily affected patients with advanced disease, and was a more rapidly progressive illness. With the use of HAART, cognitive impairment improved, along with the overall...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Robinson-Papp J,Elliott KJ,Simpson DM

    更新日期:2009-08-01 00:00:00

  • HIV/AIDS Among Female Sex Workers in China: Epidemiology and Recent Prevention Strategies.

    abstract:PURPOSE OF REVIEW:This review aims to describe the epidemiology of HIV among female sex workers (FSWs) in China over the past decade, to summarize current gaps in knowledge regarding risk factors, and to identify new directions for HIV prevention strategies. RECENT FINDINGS:We summarized national and regional levels o...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Zhang H,Hsieh E,Wang L,Liao S

    更新日期:2020-04-01 00:00:00

  • Improving the self-report of HIV antiretroviral medication adherence: is the glass half full or half empty?

    abstract::Self-reports are the most widely used method for measuring antiretroviral adherence. The association between self-reports and viral loads has been repeatedly demonstrated, but this association does not address how well self-reports measure actual medication-taking behaviors. Understanding adherence self-reports requir...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章


    authors: Wilson IB,Carter AE,Berg KM

    更新日期:2009-11-01 00:00:00

  • Factors Driving the HIV Epidemic in Southern Africa.

    abstract::The HIV pandemic has disproportionately impacted sub-Saharan Africa and Southern Africa in particular. The concurrent presence of overlapping epidemic drivers likely underpins how and why the HIV epidemic is so explosive in this region, with implications for understanding approaches to reduce transmission. In this rev...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: McKinnon LR,Karim QA

    更新日期:2016-06-01 00:00:00

  • Optimal timing of routine vaccination in HIV-infected persons.

    abstract::Vaccine recommendations for those with HIV require continual updating as additional research becomes available. Timing of vaccinations among HIV-infected individuals is a key area of uncertainty. This is particularly true for those who may soon initiate highly active antiretroviral therapy (HAART) because immune recon...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Crane HM,Dhanireddy S,Kim HN,Ramers C,Dellit TH,Kitahata MM,Harrington RD

    更新日期:2009-05-01 00:00:00

  • Point-of-care and Near Real-time Testing for Antiretroviral Adherence Monitoring to HIV Treatment and Prevention.

    abstract:PURPOSE OF REVIEW:In this report, we review the need for point-of-care (POC) or near real-time testing for antiretrovirals, progress in the field, evidence for guiding implementation of these tests globally, and future directions in objective antiretroviral therapy (ART) or pre-exposure prophylaxis (PrEP) adherence mon...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Drain PK,Bardon AR,Simoni JM,Cressey TR,Anderson P,Sevenler D,Olanrewaju AO,Gandhi M,Celum C

    更新日期:2020-10-01 00:00:00

  • HIV/STI risk among venue-based female sex workers across the globe: a look back and the way forward.

    abstract::Female sex workers (FSWs) continue to represent a high-risk population in need of targeted HIV prevention interventions. Targeting environmental risk factors should result in more sustainable behavior change than individual-level interventions alone. There are many types of FSWs who operate in and through a variety of...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Pitpitan EV,Kalichman SC,Eaton LA,Strathdee SA,Patterson TL

    更新日期:2013-03-01 00:00:00

  • Resistance to DAAs: When to Look and When It Matters.

    abstract:PURPOSE OF REVIEW:This review provides an overview of HCV resistance-associated substitutions (RASs) with a focus on NS3 protease and NS5A inhibitor resistance. Treatment approaches for managing resistance are also covered including the use of newly approved therapies with improved resistance profiles. RECENT FINDINGS...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Wyles DL

    更新日期:2017-12-01 00:00:00

  • Better Service by Doing Less: Introducing De-implementation Research in HIV.

    abstract::The course of HIV research has led to a multitude of interventions to prevent and treat HIV. With the arrival of more effective interventions comes the need to end, or de-implement, less effective interventions. PURPOSE OF REVIEW: To describe the state of de-implementation research in HIV and provide a rationale for e...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: McKay VR,Tetteh EK,Reid MJ,Ingaiza LM

    更新日期:2020-10-01 00:00:00

  • Vaginal microbicides: a novel approach to preventing sexual transmission of HIV.

    abstract::The AIDS epidemic continues its unrelentless expansion. According to the Joint United Nations Programme on HIV/AIDS, there are more than 40 million people living with HIV, and more than 15,000 new infections occur every day. One approach to curbing HIV is the development of topical microbicidal agents or microbicides....

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Doncel G,Mauck C

    更新日期:2004-04-01 00:00:00

  • HIV, Depression, and Cognitive Impairment in the Era of Effective Antiretroviral Therapy.

    abstract:PURPOSE OF REVIEW:Mental health disorders, especially depression, are prevalent among people living with HIV (PLWH) and are associated with cognitive impairment (CI) among HIV-uninfected (HIV-) individuals. We conducted a comprehensive review of the link between depression and cognition among PLWH. RECENT FINDINGS:Stu...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Rubin LH,Maki PM

    更新日期:2019-02-01 00:00:00

  • Exploring Relative Preferences for HIV Service Features Using Discrete Choice Experiments: a Synthetic Review.

    abstract:PURPOSE OF REVIEW:Aligning HIV treatment services with patient preferences can promote long-term engagement. A rising number of studies solicit such preferences using discrete choice experiments, but have not been systematically reviewed to seek generalizable insights. Using a systematic search, we identified eleven ch...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Eshun-Wilson I,Kim HY,Schwartz S,Conte M,Glidden DV,Geng EH

    更新日期:2020-10-01 00:00:00

  • Treatment of latent tuberculosis infection in HIV: shorter or longer?

    abstract::Nine months of daily isoniazid is efficacious in treating latent M. tuberculosis infection, but completion rates are low, limiting treatment effectiveness. In 2011, three important studies were published involving novel regimens for the treatment of latent M. tuberculosis infection. At least 36 months of isoniazid was...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Person AK,Sterling TR

    更新日期:2012-09-01 00:00:00

  • HIV and aging: time for a new paradigm.

    abstract::The population of patients with HIV infection achieving viral suppression on combination antiretroviral therapy is growing, aging, and experiencing a widening spectrum of non-AIDS diseases. Concurrently, AIDS-defining conditions are becoming less common and are variably associated with outcome. Nonetheless, the spectr...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章


    authors: Justice AC

    更新日期:2010-05-01 00:00:00

  • Lipids, metabolic syndrome, and risk factors for future cardiovascular disease among HIV-infected patients.

    abstract::The availability of potent combination antiretroviral therapy has changed the long-term prognosis for people living with HIV/AIDS. There is increasing concern, however, about the effect of HIV therapy on lipid disorders and subsequent development of coronary artery disease. Virtually all classes of antiretroviral drug...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Umeh OC,Currier JS

    更新日期:2005-08-01 00:00:00