Defining T Cell Tissue Residency in Humans: Implications for HIV Pathogenesis and Vaccine Design.


PURPOSE OF REVIEW:This review summarizes recent literature defining tissue-resident memory T cells (TRM) and discusses implications for HIV pathogenesis, vaccines, and eradication efforts. RECENT FINDINGS:Investigations using animal models and human tissues have identified a TRM transcriptional profile and elucidated signals within the tissue microenvironment leading to TRM development and maintenance. TRM are major contributors to host response in infectious diseases and cancer; in addition, TRM contribute to pathogenic inflammation in a variety of settings. Although TRM are daunting to study in HIV infection, recent work has helped define their molecular signatures and effector functions and tested strategies for their mobilization. Exclusive reliance on blood sampling to gain an understanding of host immunity overlooks the contribution of TRM, which differ in significant ways from their counterparts in circulation. It is hoped that greater understanding of these cells will lead to novel approaches to prevent and/or eradicate HIV infection.




Current HIV/AIDS reports


Shacklett BL,Ferre AL,Kiniry BE




Has Abstract


2020-04-01 00:00:00














  • Optimal timing of routine vaccination in HIV-infected persons.

    abstract::Vaccine recommendations for those with HIV require continual updating as additional research becomes available. Timing of vaccinations among HIV-infected individuals is a key area of uncertainty. This is particularly true for those who may soon initiate highly active antiretroviral therapy (HAART) because immune recon...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Crane HM,Dhanireddy S,Kim HN,Ramers C,Dellit TH,Kitahata MM,Harrington RD

    更新日期:2009-05-01 00:00:00

  • Novel interventions to prevent HIV and HCV among persons who inject drugs.

    abstract::Persons who inject drugs (PWID) are at high risk for infection with and poor outcomes from HIV and hepatitis C virus (HCV). Well-established interventions for HIV/HCV prevention among PWID include syringe access, opioid agonist maintenance treatment, and supervised injection facilities, yet these interventions remain ...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Coffin PO,Rowe C,Santos GM

    更新日期:2015-03-01 00:00:00

  • How to Define the Latent Reservoir: Tools of the Trade.

    abstract::HIV is a devastating worldwide epidemic that has had substantial social and economic impacts throughout the globe. Due to the presence of a small pool of latently infected cells that persists during antiretroviral therapy (ART), HIV is not curable. Because of the high cost of ART and the lack of reliable accessibility...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Barton KM,Palmer SE

    更新日期:2016-04-01 00:00:00

  • Lipids, metabolic syndrome, and risk factors for future cardiovascular disease among HIV-infected patients.

    abstract::The availability of potent combination antiretroviral therapy has changed the long-term prognosis for people living with HIV/AIDS. There is increasing concern, however, about the effect of HIV therapy on lipid disorders and subsequent development of coronary artery disease. Virtually all classes of antiretroviral drug...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Umeh OC,Currier JS

    更新日期:2005-08-01 00:00:00

  • Pediatric HIV: the Potential of Immune Therapeutics to Achieve Viral Remission and Functional Cure.

    abstract:PURPOSE OF REVIEW:In the absence of antiretroviral therapy (ART), more than 50% of perinatally HIV-infected children die by 2 years of age. Early ART from infancy is therefore a global recommendation and significantly improves immune health, child survival, and disease outcome. However, even early treatment does not pr...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Berendam SJ,Nelson AN,Goswami R,Persaud D,Haigwood NL,Chahroudi A,Fouda GG,Permar SR

    更新日期:2020-06-01 00:00:00

  • Differentiating HIV-associated nephropathy from antiretroviral drug-induced nephropathy: a clinical challenge.

    abstract::With the introduction of potent combination antiretroviral therapy (cART) into clinical practice, HIV-infected patients have garnered much benefit. However, kidney disease continues to be a potential complication in this group. Whereas HIV-associated nephropathy (HIVAN) was the major renal complication prior to cART, ...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Kumar N,Perazella MA

    更新日期:2014-09-01 00:00:00

  • The role of viral co-infection in HIV-associated non-AIDS-related cancers.

    abstract::HIV-infected individuals are at increased risk for most types of cancer, including those typically classified as non-AIDS-defining cancers (NADCs). This increased risk is likely multifactorial, but a prominent risk factor for the increased rate of some cancers is co-infection with oncogenic viruses. Anal cancer, hepat...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Riedel DJ,Tang LS,Rositch AF

    更新日期:2015-09-01 00:00:00

  • How to Evolve the Response to the Global HIV Epidemic With New Metrics and Targets Based on Pre-Treatment CD4 Counts.

    abstract:PURPOSE OF THE REVIEW:Early diagnosis and treatment of HIV following seroconversion improves individual and population health. Using published data on pre-treatment CD4 cell counts, we benchmarked the level of immunodeficiency at HIV diagnosis and ART initiation in the "real world" against those of the treatment and co...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Nash D,Robertson M

    更新日期:2019-08-01 00:00:00

  • Treatment of latent tuberculosis infection in HIV: shorter or longer?

    abstract::Nine months of daily isoniazid is efficacious in treating latent M. tuberculosis infection, but completion rates are low, limiting treatment effectiveness. In 2011, three important studies were published involving novel regimens for the treatment of latent M. tuberculosis infection. At least 36 months of isoniazid was...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Person AK,Sterling TR

    更新日期:2012-09-01 00:00:00

  • The evolving role of HIV counseling and testing in resource-limited settings: HIV prevention and linkage to expanding HIV care access.

    abstract::The role of voluntary counseling and testing (VCT)of HIV in resource-limited settings has recently broadened from primarily that of a prevention intervention to its identification as the key entry point into expanding access to life-saving antiretroviral therapy, additional HIV-specific medical care, and other support...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Liechty CA

    更新日期:2004-12-01 00:00:00

  • Solid Organ Transplantation in HIV-Infected Recipients: History, Progress, and Frontiers.

    abstract:PURPOSE OF REVIEW:End-stage organ disease prevalence is increasing among HIV-infected (HIV+) individuals. Trial and registry data confirm that solid organ transplantation (SOT) is efficacious in this population. Optimizing access to transplant and decreasing complications represent active frontiers. RECENT FINDINGS:HI...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Werbel WA,Durand CM

    更新日期:2019-06-01 00:00:00

  • Metabolic Complications and Glucose Metabolism in HIV Infection: A Review of the Evidence.

    abstract::HIV infection and antiretroviral therapy (ART) use are associated with perturbations in glucose and lipid metabolism. Increasing incidence of diabetes, cardiovascular disease, and obesity highlights the need for early identification and treatment of metabolic dysfunction. Newer ART regimens are less toxic for cellular...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Willig AL,Overton ET

    更新日期:2016-10-01 00:00:00

  • T-cell exhaustion in HIV infection.

    abstract::Generation of memory T cells, which mediate immunity against microbes and cancers, relies, for optimal activity, on the interactions of multiple cell types that are highly regulated through the expression of soluble factors and negative and positive receptors. Their disruption will lead to aberrant immune responses, w...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: El-Far M,Halwani R,Said E,Trautmann L,Doroudchi M,Janbazian L,Fonseca S,van Grevenynghe J,Yassine-Diab B,Sékaly RP,Haddad EK

    更新日期:2008-02-01 00:00:00

  • Vaginal microbicides: a novel approach to preventing sexual transmission of HIV.

    abstract::The AIDS epidemic continues its unrelentless expansion. According to the Joint United Nations Programme on HIV/AIDS, there are more than 40 million people living with HIV, and more than 15,000 new infections occur every day. One approach to curbing HIV is the development of topical microbicidal agents or microbicides....

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Doncel G,Mauck C

    更新日期:2004-04-01 00:00:00

  • Motivational interviewing targeting risk reduction for people with HIV: a systematic review.

    abstract::Due to the co-occurrence of sexual risk behaviors and substance use among HIV-positive individuals, there is often a need for HIV prevention efforts to target multiple behaviors. Motivational Interviewing (MI), a widely disseminated behavior change intervention, has demonstrated effectiveness in promoting behavior cha...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Naar-King S,Parsons JT,Johnson AM

    更新日期:2012-12-01 00:00:00

  • Combination prevention: new hope for stopping the epidemic.

    abstract::HIV research has identified approaches that can be combined to be more effective in transmission reduction than any 1 modality alone: delayed adolescent sexual debut, mutual monogamy or sexual partner reduction, correct and consistent condom use, pre-exposure prophylaxis with oral antiretroviral drugs or vaginal micro...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Vermund SH,Hayes RJ

    更新日期:2013-06-01 00:00:00

  • Monitoring antiretroviral therapy in resource-limited settings: balancing clinical care, technology, and human resources.

    abstract::Due to the rapid expansion of first-line antiretroviral therapy in resource-limited settings (RLS), increasing numbers of people are living with HIV for prolonged periods of time. Treatment programs must now decide how to balance monitoring costs necessary to maximize health benefits for those already on treatment wit...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Hosseinipour MC,Schechter M

    更新日期:2010-08-01 00:00:00

  • HPV and anal cancer in HIV-infected individuals: a review.

    abstract::HIV infection is one of the strongest risk factors for anal squamous cell cancer (ASCC). Most ASCC are caused by HPV, and most HPV-associated ASCC are caused by HPV-16. Anal HPV infections are very common in men who have sex with men (MSM), and nearly universal among HIV-infected MSM. High-grade anal intraepithelial n...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Schim van der Loeff MF,Mooij SH,Richel O,de Vries HJ,Prins JM

    更新日期:2014-09-01 00:00:00

  • Treatment of chronic HCV genotype 1 coinfection.

    abstract::Several all-oral direct-acting antiviral (DAA) combination therapies including two fixed-dose combinations (FDCs) have been recently licensed for treatment of hepatitis C virus (HCV) genotype 1 infection. Results of pivotal trials with these new compounds are now also available in human immunodeficiency virus (HIV)/HC...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Boesecke C,Rockstroh JK

    更新日期:2015-09-01 00:00:00

  • Complications of Treatment in Youth with HIV.

    abstract::While combination antiretroviral therapy allows HIV-infected patients to have life expectancies similar to that of the general population, it may also contribute to the development of co-morbidities, such as cardiovascular disease and osteoporosis. Such complications could compromise long-term quality of life, especia...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Eckard AR,Fowler SL,Haston JC,Dixon TC

    更新日期:2016-08-01 00:00:00

  • Microvascular Function in Aging Among Women Living with HIV.

    abstract::Combined antiretroviral therapy (CART) has turned HIV-infection to a treatable chronic disease during which many patients survive to middle and older age. However, they prematurely develop non-AIDS comorbidities such as cardiovascular disease, metabolic syndrome, diabetes, and HIV-associated neurocognitive disorders (...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Monsuez JJ,Belin C,Bouchaud O

    更新日期:2016-12-01 00:00:00

  • The medical management of opioid dependence in HIV primary care settings.

    abstract::Injecting drug use is a common mode of transmission among persons with HIV/AIDS. Many HIV-infected patients meet diagnostic criteria for opioid dependence, a chronic and relapsing brain disorder. Most HIV providers, however, receive little training in substance use disorders. Opioid agonist therapy (OAT) has a stabili...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Lum PJ,Tulsky JP

    更新日期:2006-11-01 00:00:00

  • HIV-related neurocognitive impairment in the HAART era.

    abstract::Neurocognitive impairment is common in people living with HIV and AIDS. Prior to highly active antiretroviral therapy (HAART), cognitive impairment primarily affected patients with advanced disease, and was a more rapidly progressive illness. With the use of HAART, cognitive impairment improved, along with the overall...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Robinson-Papp J,Elliott KJ,Simpson DM

    更新日期:2009-08-01 00:00:00

  • HIV and aging: time for a new paradigm.

    abstract::The population of patients with HIV infection achieving viral suppression on combination antiretroviral therapy is growing, aging, and experiencing a widening spectrum of non-AIDS diseases. Concurrently, AIDS-defining conditions are becoming less common and are variably associated with outcome. Nonetheless, the spectr...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章


    authors: Justice AC

    更新日期:2010-05-01 00:00:00

  • Interventions for body habitus changes associated with HIV infection and its treatment.

    abstract::Lipodystrophy and its two components lipo-accumulation and lipoatropy are very common among individuals with HIV infection on treatment, especially among those who started therapy in the late 1990s and early 2000s. This review discusses the current management of these complications of HIV and its treatment. For the pu...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Tebas P

    更新日期:2007-05-01 00:00:00

  • Application of Pathogen Discovery/Metagenomic Sequencing in CNS HIV.

    abstract:PURPOSE OF REVIEW:Neurological conditions associated with HIV/AIDS including central nervous system (CNS), opportunistic infections (OI), chronic conditions including HIV-associated neurocognitive disorder, and cerebrospinal fluid (CSF) viral escape remain major contributors to morbidity and mortality worldwide. CNS in...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Thakur KT

    更新日期:2020-10-01 00:00:00

  • Innate Lymphoid Cells: Their Contributions to Gastrointestinal Tissue Homeostasis and HIV/SIV Disease Pathology.

    abstract:PURPOSE OF REVIEW:The discovery of innate lymphoid cells (ILCs) over the past decade has reformed principles that were once thought to be exclusive to adaptive immunity. Here, we describe ILC nomenclature and function, and provide a survey of studies examining these cells in the context of HIV/SIV infections. Particula...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Mudd JC,Brenchley JM

    更新日期:2019-06-01 00:00:00

  • Use of pharmacy refill data as a measure of antiretroviral adherence.

    abstract::Pharmacy refill adherence has become an increasingly important measure of adherence to antiretroviral medications. It offers a simple, inexpensive, and valid method for measuring adherence. Over the past year, there have been several published developments in the use of pharmacy refill data to measure adherence. Given...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Grossberg R,Gross R

    更新日期:2007-12-01 00:00:00

  • Realizing the potential of treatment as prevention: global ART policy and treatment coverage.

    abstract::This article reviews the antiretroviral therapy (ART) initiation criteria from published national guidelines for 94 countries (representing 86 % of global HIV burden) and compares them with the 2013 World Health Organization (WHO) ART guidelines. As of 31st of July 2014, 19 countries have adopted the WHO-recommended C...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Gupta S,Williams B,Montaner J

    更新日期:2014-12-01 00:00:00

  • Use of Technology to Address Substance Use in the Context of HIV: A Systematic Review.

    abstract::Substance users are at elevated risk for HIV. HIV researchers, particularly at the intersection of HIV and substance use, have requested new methods to better understand and address this important area. New technologies, such as social media and mobile applications, are increasingly being used as research tools in stu...

    journal_title:Current HIV/AIDS reports

    pub_type: 杂志文章,评审


    authors: Young SD,Swendeman D,Holloway IW,Reback CJ,Kao U

    更新日期:2015-12-01 00:00:00