Abstract：
:The first association between HIV-1 infection and kidney disease was made in 1984 and much has been learned over the past 20 years. In recent years, more effective therapies for HIV-1 infection and its associated opportunistic infections have led to improved patient survival. However, with prolonged survival, morbidity associated with renal disease has also increased. Among the multiple glomerulopathies that can affect patients with HIV, focal segmental glomerulosclerosis (FSGS) is most common and frequently leads to end-stage renal disease. Although the precise mechanisms of HIV-associated FSGS remain to be elucidated, it appears that host genetic susceptibility, direct infection of the renal epithelium, and toxicity of one or more viral accessory protein contribute. Therapy for HIV-associated FSGS includes control of blood pressure and the use of angiotensin antagonist therapy. A randomized trial of angiotensin receptor blocker will be initiated shortly. Drug-related nephropathies are also common, manifesting as acute renal failure, nephrolithiasis, and interstitial nephritis. Tenofovir, a newer nucleoside analogue, has recently been implicated in causing tubular toxicity, although the incidence is low. Appropriate screening for renal dysfunction can minimize the likelihood of progressive renal injury in all patients with HIV-1 infection.
journal_name
Curr HIV/AIDS Repjournal_title
Current HIV/AIDS reportsauthors
Cho ME,Kopp JBdoi
10.1007/s11904-004-0016-9keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
109-15issue
3eissn
1548-3568issn
1548-3576journal_volume
1pub_type
杂志文章,评审abstract：:This article reviews the magnitude and spectrum of ocular complications of HIV infection in sub-Sahara Africa. A literature search was done using PubMed, Google, and UpToDate and by talking to ophthalmologists and HIV experts working in the region. Ocular complications of HIV infection, mostly retinal, are seen in 29%...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章
doi：10.1007/s11904-008-0019-z
更新日期：2008-08-01 00:00:00
abstract：:HIV-infected individuals are at increased risk for most types of cancer, including those typically classified as non-AIDS-defining cancers (NADCs). This increased risk is likely multifactorial, but a prominent risk factor for the increased rate of some cancers is co-infection with oncogenic viruses. Anal cancer, hepat...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-015-0276-6
更新日期：2015-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Neurological conditions associated with HIV/AIDS including central nervous system (CNS), opportunistic infections (OI), chronic conditions including HIV-associated neurocognitive disorder, and cerebrospinal fluid (CSF) viral escape remain major contributors to morbidity and mortality worldwide. CNS in...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00514-1
更新日期：2020-10-01 00:00:00
abstract：:Neurocognitive impairment is common in people living with HIV and AIDS. Prior to highly active antiretroviral therapy (HAART), cognitive impairment primarily affected patients with advanced disease, and was a more rapidly progressive illness. With the use of HAART, cognitive impairment improved, along with the overall...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-009-0020-1
更新日期：2009-08-01 00:00:00
abstract：PURPOSE OF REVIEW:This review summarizes recent literature defining tissue-resident memory T cells (TRM) and discusses implications for HIV pathogenesis, vaccines, and eradication efforts. RECENT FINDINGS:Investigations using animal models and human tissues have identified a TRM transcriptional profile and elucidated ...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00481-7
更新日期：2020-04-01 00:00:00
abstract：:HIV infection is one of the strongest risk factors for anal squamous cell cancer (ASCC). Most ASCC are caused by HPV, and most HPV-associated ASCC are caused by HPV-16. Anal HPV infections are very common in men who have sex with men (MSM), and nearly universal among HIV-infected MSM. High-grade anal intraepithelial n...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-014-0224-x
更新日期：2014-09-01 00:00:00
abstract：:Lipodystrophy and its two components lipo-accumulation and lipoatropy are very common among individuals with HIV infection on treatment, especially among those who started therapy in the late 1990s and early 2000s. This review discusses the current management of these complications of HIV and its treatment. For the pu...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-007-0013-x
更新日期：2007-05-01 00:00:00
abstract：PURPOSE OF REVIEW:Mental health disorders, especially depression, are prevalent among people living with HIV (PLWH) and are associated with cognitive impairment (CI) among HIV-uninfected (HIV-) individuals. We conducted a comprehensive review of the link between depression and cognition among PLWH. RECENT FINDINGS:Stu...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-019-00421-0
更新日期：2019-02-01 00:00:00
abstract：PURPOSE OF REVIEW:In this report, we review the need for point-of-care (POC) or near real-time testing for antiretrovirals, progress in the field, evidence for guiding implementation of these tests globally, and future directions in objective antiretroviral therapy (ART) or pre-exposure prophylaxis (PrEP) adherence mon...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00512-3
更新日期：2020-10-01 00:00:00
abstract：PURPOSE OF REVIEW:End-stage organ disease prevalence is increasing among HIV-infected (HIV+) individuals. Trial and registry data confirm that solid organ transplantation (SOT) is efficacious in this population. Optimizing access to transplant and decreasing complications represent active frontiers. RECENT FINDINGS:HI...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-019-00440-x
更新日期：2019-06-01 00:00:00
abstract：:HIV is a devastating worldwide epidemic that has had substantial social and economic impacts throughout the globe. Due to the presence of a small pool of latently infected cells that persists during antiretroviral therapy (ART), HIV is not curable. Because of the high cost of ART and the lack of reliable accessibility...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-016-0304-1
更新日期：2016-04-01 00:00:00
abstract：:The HIV pandemic has disproportionately impacted sub-Saharan Africa and Southern Africa in particular. The concurrent presence of overlapping epidemic drivers likely underpins how and why the HIV epidemic is so explosive in this region, with implications for understanding approaches to reduce transmission. In this rev...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-016-0314-z
更新日期：2016-06-01 00:00:00
abstract：:T-cell activation has long been considered a central mediator of HIV pathogenesis. High T-cell activation levels predict more rapid disease progression in untreated patients and decreased treatment-mediated CD4+ T-cell gains during antiretroviral therapy, independent of plasma HIV RNA levels, and may be the primary fe...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-007-0007-8
更新日期：2007-02-01 00:00:00
abstract：:The role of voluntary counseling and testing (VCT)of HIV in resource-limited settings has recently broadened from primarily that of a prevention intervention to its identification as the key entry point into expanding access to life-saving antiretroviral therapy, additional HIV-specific medical care, and other support...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-004-0028-5
更新日期：2004-12-01 00:00:00
abstract：:Recent policies, guidelines, and laws reflect promising preliminary outcomes among transplant recipients with HIV infection, and ethical analyses suggest that it is not justifiable to deny solid organ transplantation based solely on HIV-infection status. These studies consistently describe stable HIV disease following...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/BF02696657
更新日期：2006-09-01 00:00:00
abstract：:HIV may cause several forms of peripheral neuropathy, the most common of which is distal symmetric polyneuropathy (DSP) characterized by pain and sensory deficits in a stocking-glove distribution. The pathophysiology of DSP remains largely unknown but is thought to be related both to the neurotoxicity of HIV-through i...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-014-0211-2
更新日期：2014-09-01 00:00:00
abstract：:Substance users are at elevated risk for HIV. HIV researchers, particularly at the intersection of HIV and substance use, have requested new methods to better understand and address this important area. New technologies, such as social media and mobile applications, are increasingly being used as research tools in stu...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-015-0295-3
更新日期：2015-12-01 00:00:00
abstract：PURPOSE OF REVIEW:To describe a small city/rural area HIV prevention project (the Cross Border Project) implemented in Ning Ming County, Guangxi Province, China, and Lang Son province, Vietnam, and consider its implications for addressing the opioid/heroin epidemic in small cities/rural areas in the USA. The descriptio...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-018-0405-0
更新日期：2018-08-01 00:00:00
abstract：:Human immunodeficiency virus type 1 (HIV-1) infection occurs throughout the body and can have dramatic physical effects, such as neurocognitive impairment in the central nervous system (CNS). Furthermore, examining the virus that resides in the CNS is challenging due to its location and can only be done using samples ...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-015-0265-9
更新日期：2015-06-01 00:00:00
abstract：:Due to life-enhancing effects of antiretroviral therapy, HIV-positive persons have the potential for long life comparable to their uninfected peers. Older women (age 50+) living with HIV (OWLH) are often an under-recognized aging group. We conducted a systematic review to examine psychosocial factors that impact how O...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-017-0347-y
更新日期：2017-02-01 00:00:00
abstract：:Pharmacy refill adherence has become an increasingly important measure of adherence to antiretroviral medications. It offers a simple, inexpensive, and valid method for measuring adherence. Over the past year, there have been several published developments in the use of pharmacy refill data to measure adherence. Given...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-007-0027-4
更新日期：2007-12-01 00:00:00
abstract：:The purpose of this meta-analytic study is to summarize the current science concerning the (a) prevalence of alcohol use, (b) prevalence of sexual risk behaviors, and (c) association between alcohol use and sexual risk behaviors among people livingwithHIV/AIDS (PLWHA). Studies were included if they sampled PLWHA, eval...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s11904-013-0177-5
更新日期：2013-12-01 00:00:00
abstract：:Neurocognitive compromise, a common sequela of HIV infection, ranges in severity from minor motor and information-processing speed decrements to severely incapacitating symptoms that affect functional independence. However, with the emergence of highly active antiretroviral therapy (HAART), neurocognitive phenotypes h...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-008-0029-x
更新日期：2008-11-01 00:00:00
abstract：PURPOSE OF REVIEW:Advances in short- and long-acting pre-exposure prophylaxis (PrEP) technologies have incentivized the need to understand how individuals make trade-offs and competing decisions regarding PrEP modalities. The purpose of this review was to examine how researchers have conceptualized and measured attribu...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00497-z
更新日期：2020-06-01 00:00:00
abstract：:Access to potent antiretroviral medications greatly reduces morbidity and mortality due to HIV/AIDS, but drug toxicity limits treatment success in many individuals. The field of pharmacogenomics strives to understand the influence of human genetic variants in response to medications. Investigators have begun to identi...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-006-0018-x
更新日期：2006-07-01 00:00:00
abstract：PURPOSE OF THE REVIEW:Early diagnosis and treatment of HIV following seroconversion improves individual and population health. Using published data on pre-treatment CD4 cell counts, we benchmarked the level of immunodeficiency at HIV diagnosis and ART initiation in the "real world" against those of the treatment and co...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-019-00452-7
更新日期：2019-08-01 00:00:00
abstract：:Sustained retention represents an enduring and evolving challenge to HIV treatment programs in Africa. We present a theoretical framework for sustained retention borrowing from ecologic principles of sustainability and dynamic adaptation. We posit that sustained retention from the patient perspective is dependent on t...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-016-0317-9
更新日期：2016-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Aligning HIV treatment services with patient preferences can promote long-term engagement. A rising number of studies solicit such preferences using discrete choice experiments, but have not been systematically reviewed to seek generalizable insights. Using a systematic search, we identified eleven ch...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00520-3
更新日期：2020-10-01 00:00:00
abstract：:While combination antiretroviral therapy allows HIV-infected patients to have life expectancies similar to that of the general population, it may also contribute to the development of co-morbidities, such as cardiovascular disease and osteoporosis. Such complications could compromise long-term quality of life, especia...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-016-0320-1
更新日期：2016-08-01 00:00:00
abstract：:The AIDS epidemic continues its unrelentless expansion. According to the Joint United Nations Programme on HIV/AIDS, there are more than 40 million people living with HIV, and more than 15,000 new infections occur every day. One approach to curbing HIV is the development of topical microbicidal agents or microbicides....
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-004-0004-0
更新日期：2004-04-01 00:00:00
