Compartmentalization, Viral Evolution, and Viral Latency of HIV in the CNS.

abstract：:Neurocognitive compromise, a common sequela of HIV infection, ranges in severity from minor motor and information-processing speed decrements to severely incapacitating symptoms that affect functional independence. However, with the emergence of highly active antiretroviral therapy (HAART), neurocognitive phenotypes h...

journal_title：Current HIV/AIDS reports

authors： Foley J,Ettenhofer M,Wright M,Hinkin CH

更新日期：2008-11-01 00:00:00

abstract：:Substance users are at elevated risk for HIV. HIV researchers, particularly at the intersection of HIV and substance use, have requested new methods to better understand and address this important area. New technologies, such as social media and mobile applications, are increasingly being used as research tools in stu...

journal_title：Current HIV/AIDS reports

authors： Young SD,Swendeman D,Holloway IW,Reback CJ,Kao U

更新日期：2015-12-01 00:00:00

abstract：:The course of HIV research has led to a multitude of interventions to prevent and treat HIV. With the arrival of more effective interventions comes the need to end, or de-implement, less effective interventions. PURPOSE OF REVIEW: To describe the state of de-implementation research in HIV and provide a rationale for e...

journal_title：Current HIV/AIDS reports

authors： McKay VR,Tetteh EK,Reid MJ,Ingaiza LM

更新日期：2020-10-01 00:00:00

abstract：:While combination antiretroviral therapy allows HIV-infected patients to have life expectancies similar to that of the general population, it may also contribute to the development of co-morbidities, such as cardiovascular disease and osteoporosis. Such complications could compromise long-term quality of life, especia...

journal_title：Current HIV/AIDS reports

authors： Eckard AR,Fowler SL,Haston JC,Dixon TC

更新日期：2016-08-01 00:00:00

abstract：:Due to life-enhancing effects of antiretroviral therapy, HIV-positive persons have the potential for long life comparable to their uninfected peers. Older women (age 50+) living with HIV (OWLH) are often an under-recognized aging group. We conducted a systematic review to examine psychosocial factors that impact how O...

journal_title：Current HIV/AIDS reports

authors： Rubtsova AA,Kempf MC,Taylor TN,Konkle-Parker D,Wingood GM,Holstad MM

更新日期：2017-02-01 00:00:00

abstract：:With the introduction of potent combination antiretroviral therapy (cART) into clinical practice, HIV-infected patients have garnered much benefit. However, kidney disease continues to be a potential complication in this group. Whereas HIV-associated nephropathy (HIVAN) was the major renal complication prior to cART, ...

journal_title：Current HIV/AIDS reports

authors： Kumar N,Perazella MA

更新日期：2014-09-01 00:00:00

abstract：PURPOSE OF REVIEW:In this report, we review the need for point-of-care (POC) or near real-time testing for antiretrovirals, progress in the field, evidence for guiding implementation of these tests globally, and future directions in objective antiretroviral therapy (ART) or pre-exposure prophylaxis (PrEP) adherence mon...

journal_title：Current HIV/AIDS reports

authors： Drain PK,Bardon AR,Simoni JM,Cressey TR,Anderson P,Sevenler D,Olanrewaju AO,Gandhi M,Celum C

更新日期：2020-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This narrative review summarizes recent data on factors associated with insulin resistance (IR) in adults with HIV, including contemporary antiretroviral therapy (ART). RECENT FINDINGS:IR remains common in persons with HIV, even those receiving contemporary ART. Generalized and abdominal obesity and ...

journal_title：Current HIV/AIDS reports

authors： Hulgan T

更新日期：2018-06-01 00:00:00

abstract：:Increased access to testing and treatment means HIV can be managed as a chronic illness, though successful management requires continued engagement with the health care system. Most of the global HIV burden is in sub-Saharan Africa where rates of new infections are consistently higher in women versus men. Pregnancy is...

journal_title：Current HIV/AIDS reports

authors： Psaros C,Remmert JE,Bangsberg DR,Safren SA,Smit JA

更新日期：2015-03-01 00:00:00

abstract：:Combined antiretroviral therapy (CART) has turned HIV-infection to a treatable chronic disease during which many patients survive to middle and older age. However, they prematurely develop non-AIDS comorbidities such as cardiovascular disease, metabolic syndrome, diabetes, and HIV-associated neurocognitive disorders (...

journal_title：Current HIV/AIDS reports

authors： Monsuez JJ,Belin C,Bouchaud O

更新日期：2016-12-01 00:00:00

abstract：:T-cell activation has long been considered a central mediator of HIV pathogenesis. High T-cell activation levels predict more rapid disease progression in untreated patients and decreased treatment-mediated CD4+ T-cell gains during antiretroviral therapy, independent of plasma HIV RNA levels, and may be the primary fe...

journal_title：Current HIV/AIDS reports

authors： Hunt PW

更新日期：2007-02-01 00:00:00

abstract：:HIV is a devastating worldwide epidemic that has had substantial social and economic impacts throughout the globe. Due to the presence of a small pool of latently infected cells that persists during antiretroviral therapy (ART), HIV is not curable. Because of the high cost of ART and the lack of reliable accessibility...

journal_title：Current HIV/AIDS reports

authors： Barton KM,Palmer SE

更新日期：2016-04-01 00:00:00

abstract：:This article reviews the antiretroviral therapy (ART) initiation criteria from published national guidelines for 94 countries (representing 86 % of global HIV burden) and compares them with the 2013 World Health Organization (WHO) ART guidelines. As of 31st of July 2014, 19 countries have adopted the WHO-recommended C...

journal_title：Current HIV/AIDS reports

authors： Gupta S,Williams B,Montaner J

更新日期：2014-12-01 00:00:00

abstract：:Therapeutic drug monitoring (TDM) is the process by which a patient's dosing regimen is guided by repeated measures of plasma drug concentrations. An enormous challenge with regard to TDM of antiretroviral drugs (ARV) is that the concentration goals can be moving targets. Well-designed prospective studies demonstratin...

journal_title：Current HIV/AIDS reports

authors： Kiser JJ,Anderson PL,Gerber JG

更新日期：2005-06-01 00:00:00

abstract：:Vaccine recommendations for those with HIV require continual updating as additional research becomes available. Timing of vaccinations among HIV-infected individuals is a key area of uncertainty. This is particularly true for those who may soon initiate highly active antiretroviral therapy (HAART) because immune recon...

journal_title：Current HIV/AIDS reports

authors： Crane HM,Dhanireddy S,Kim HN,Ramers C,Dellit TH,Kitahata MM,Harrington RD

更新日期：2009-05-01 00:00:00

abstract：:This article reviews the magnitude and spectrum of ocular complications of HIV infection in sub-Sahara Africa. A literature search was done using PubMed, Google, and UpToDate and by talking to ophthalmologists and HIV experts working in the region. Ocular complications of HIV infection, mostly retinal, are seen in 29%...

journal_title：Current HIV/AIDS reports

authors： Nkomazana O,Tshitswana D

更新日期：2008-08-01 00:00:00

abstract：:The population of patients with HIV infection achieving viral suppression on combination antiretroviral therapy is growing, aging, and experiencing a widening spectrum of non-AIDS diseases. Concurrently, AIDS-defining conditions are becoming less common and are variably associated with outcome. Nonetheless, the spectr...

journal_title：Current HIV/AIDS reports

authors： Justice AC

更新日期：2010-05-01 00:00:00

abstract：:Neurocognitive impairment is common in people living with HIV and AIDS. Prior to highly active antiretroviral therapy (HAART), cognitive impairment primarily affected patients with advanced disease, and was a more rapidly progressive illness. With the use of HAART, cognitive impairment improved, along with the overall...

journal_title：Current HIV/AIDS reports

authors： Robinson-Papp J,Elliott KJ,Simpson DM

更新日期：2009-08-01 00:00:00

abstract：:The AIDS epidemic continues its unrelentless expansion. According to the Joint United Nations Programme on HIV/AIDS, there are more than 40 million people living with HIV, and more than 15,000 new infections occur every day. One approach to curbing HIV is the development of topical microbicidal agents or microbicides....

journal_title：Current HIV/AIDS reports

authors： Doncel G,Mauck C

更新日期：2004-04-01 00:00:00

abstract：:An emerging body of evidence suggests that intergenerational sexual partnerships may increase risk of HIV acquisition among young men who have sex with men (YMSM). However, no studies have comprehensively evaluated literature in this area. We applied a scoping review methodology to explore the relationships between ag...

journal_title：Current HIV/AIDS reports

authors： Anema A,Marshall BD,Stevenson B,Gurm J,Montaner G,Small W,Roth EA,Lima VD,Montaner JS,Moore D,Hogg RS

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent literature defining tissue-resident memory T cells (TRM) and discusses implications for HIV pathogenesis, vaccines, and eradication efforts. RECENT FINDINGS:Investigations using animal models and human tissues have identified a TRM transcriptional profile and elucidated ...

journal_title：Current HIV/AIDS reports

authors： Shacklett BL,Ferre AL,Kiniry BE

更新日期：2020-04-01 00:00:00

abstract：:Persons who inject drugs (PWID) are at high risk for infection with and poor outcomes from HIV and hepatitis C virus (HCV). Well-established interventions for HIV/HCV prevention among PWID include syringe access, opioid agonist maintenance treatment, and supervised injection facilities, yet these interventions remain ...

journal_title：Current HIV/AIDS reports

authors： Coffin PO,Rowe C,Santos GM

更新日期：2015-03-01 00:00:00

abstract：:Female sex workers (FSWs) continue to represent a high-risk population in need of targeted HIV prevention interventions. Targeting environmental risk factors should result in more sustainable behavior change than individual-level interventions alone. There are many types of FSWs who operate in and through a variety of...

journal_title：Current HIV/AIDS reports

authors： Pitpitan EV,Kalichman SC,Eaton LA,Strathdee SA,Patterson TL

更新日期：2013-03-01 00:00:00

abstract：:Lipodystrophy and its two components lipo-accumulation and lipoatropy are very common among individuals with HIV infection on treatment, especially among those who started therapy in the late 1990s and early 2000s. This review discusses the current management of these complications of HIV and its treatment. For the pu...

journal_title：Current HIV/AIDS reports

authors： Tebas P

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Aligning HIV treatment services with patient preferences can promote long-term engagement. A rising number of studies solicit such preferences using discrete choice experiments, but have not been systematically reviewed to seek generalizable insights. Using a systematic search, we identified eleven ch...

journal_title：Current HIV/AIDS reports

authors： Eshun-Wilson I,Kim HY,Schwartz S,Conte M,Glidden DV,Geng EH

更新日期：2020-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to describe the epidemiology of HIV among female sex workers (FSWs) in China over the past decade, to summarize current gaps in knowledge regarding risk factors, and to identify new directions for HIV prevention strategies. RECENT FINDINGS:We summarized national and regional levels o...

journal_title：Current HIV/AIDS reports

authors： Zhang H,Hsieh E,Wang L,Liao S

更新日期：2020-04-01 00:00:00

abstract：:Roughly 10 % of HIV-positive individuals worldwide have concomitant chronic hepatitis B virus (HBV) infection, with large differences between geographical regions and/or risk groups. Hepatitis B is a preventable infection with vaccines. However, it cannot be eradicated once acquired, resembling HIV and in contrast wit...

journal_title：Current HIV/AIDS reports

authors： Soriano V,Labarga P,de Mendoza C,Peña JM,Fernández-Montero JV,Benítez L,Esposito I,Barreiro P

更新日期：2015-09-01 00:00:00

abstract：:Bacterial infection is a major cause of morbidity and mortality among patients with HIV living in Africa. Broadening the scope of cotrimoxazole (CTX) prophylaxis to cover patients whose CD4 counts are above 200 cells/mm(3) has been suggested as a means of improving the control of infectious disease on the continent. C...

journal_title：Current HIV/AIDS reports

authors： Spencer DC

更新日期：2007-08-01 00:00:00

abstract：:HIV may cause several forms of peripheral neuropathy, the most common of which is distal symmetric polyneuropathy (DSP) characterized by pain and sensory deficits in a stocking-glove distribution. The pathophysiology of DSP remains largely unknown but is thought to be related both to the neurotoxicity of HIV-through i...

journal_title：Current HIV/AIDS reports

authors： Stavros K,Simpson DM

更新日期：2014-09-01 00:00:00

abstract：:Recent policies, guidelines, and laws reflect promising preliminary outcomes among transplant recipients with HIV infection, and ethical analyses suggest that it is not justifiable to deny solid organ transplantation based solely on HIV-infection status. These studies consistently describe stable HIV disease following...

journal_title：Current HIV/AIDS reports

authors： Roland ME,Stock PG

更新日期：2006-09-01 00:00:00