Abstract:
PURPOSE OF REVIEW:End-stage organ disease prevalence is increasing among HIV-infected (HIV+) individuals. Trial and registry data confirm that solid organ transplantation (SOT) is efficacious in this population. Optimizing access to transplant and decreasing complications represent active frontiers. RECENT FINDINGS:HIV+ recipients historically experienced 2-4-fold higher rejection. Integrase strand transferase inhibitors (INSTIs) minimize drug interactions and may reduce rejection along with lymphodepleting induction immunosuppression. Hepatitis C virus (HCV) coinfection has been associated with inferior outcomes, yet direct-acting antivirals (DAAs) may mitigate this. Experience in South Africa and the US HIV Organ Policy Equity (HOPE) Act support HIV+ donor to HIV+ recipient (HIV D+/R+) transplantation. SOT is the optimal treatment for end-stage organ disease in HIV+ individuals. Recent advances include use of INSTIs and DAAs in transplant recipients; however, strategies to improve access to transplant are needed. HIV D+/R+ transplantation is under investigation and may improve access and provide insights for HIV cure and pathogenesis research.
journal_name
Curr HIV/AIDS Repjournal_title
Current HIV/AIDS reportsauthors
Werbel WA,Durand CMdoi
10.1007/s11904-019-00440-xsubject
Has Abstractpub_date
2019-06-01 00:00:00pages
191-203issue
3eissn
1548-3568issn
1548-3576pii
10.1007/s11904-019-00440-xjournal_volume
16pub_type
杂志文章,评审abstract::An emerging body of evidence suggests that intergenerational sexual partnerships may increase risk of HIV acquisition among young men who have sex with men (YMSM). However, no studies have comprehensively evaluated literature in this area. We applied a scoping review methodology to explore the relationships between ag...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-013-0187-3
更新日期:2013-12-01 00:00:00
abstract::Neurocognitive impairment is common in people living with HIV and AIDS. Prior to highly active antiretroviral therapy (HAART), cognitive impairment primarily affected patients with advanced disease, and was a more rapidly progressive illness. With the use of HAART, cognitive impairment improved, along with the overall...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-009-0020-1
更新日期:2009-08-01 00:00:00
abstract::While combination antiretroviral therapy allows HIV-infected patients to have life expectancies similar to that of the general population, it may also contribute to the development of co-morbidities, such as cardiovascular disease and osteoporosis. Such complications could compromise long-term quality of life, especia...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-016-0320-1
更新日期:2016-08-01 00:00:00
abstract:PURPOSE OF REVIEW:In the absence of antiretroviral therapy (ART), more than 50% of perinatally HIV-infected children die by 2 years of age. Early ART from infancy is therefore a global recommendation and significantly improves immune health, child survival, and disease outcome. However, even early treatment does not pr...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-020-00495-1
更新日期:2020-06-01 00:00:00
abstract::Substance users are at elevated risk for HIV. HIV researchers, particularly at the intersection of HIV and substance use, have requested new methods to better understand and address this important area. New technologies, such as social media and mobile applications, are increasingly being used as research tools in stu...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-015-0295-3
更新日期:2015-12-01 00:00:00
abstract::The first association between HIV-1 infection and kidney disease was made in 1984 and much has been learned over the past 20 years. In recent years, more effective therapies for HIV-1 infection and its associated opportunistic infections have led to improved patient survival. However, with prolonged survival, morbidit...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-004-0016-9
更新日期:2004-09-01 00:00:00
abstract::HIV infection is one of the strongest risk factors for anal squamous cell cancer (ASCC). Most ASCC are caused by HPV, and most HPV-associated ASCC are caused by HPV-16. Anal HPV infections are very common in men who have sex with men (MSM), and nearly universal among HIV-infected MSM. High-grade anal intraepithelial n...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0224-x
更新日期:2014-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe a small city/rural area HIV prevention project (the Cross Border Project) implemented in Ning Ming County, Guangxi Province, China, and Lang Son province, Vietnam, and consider its implications for addressing the opioid/heroin epidemic in small cities/rural areas in the USA. The descriptio...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-018-0405-0
更新日期:2018-08-01 00:00:00
abstract:PURPOSE OF REVIEW:In this report, we review the need for point-of-care (POC) or near real-time testing for antiretrovirals, progress in the field, evidence for guiding implementation of these tests globally, and future directions in objective antiretroviral therapy (ART) or pre-exposure prophylaxis (PrEP) adherence mon...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-020-00512-3
更新日期:2020-10-01 00:00:00
abstract::Neurocognitive compromise, a common sequela of HIV infection, ranges in severity from minor motor and information-processing speed decrements to severely incapacitating symptoms that affect functional independence. However, with the emergence of highly active antiretroviral therapy (HAART), neurocognitive phenotypes h...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-008-0029-x
更新日期:2008-11-01 00:00:00
abstract::Sustained retention represents an enduring and evolving challenge to HIV treatment programs in Africa. We present a theoretical framework for sustained retention borrowing from ecologic principles of sustainability and dynamic adaptation. We posit that sustained retention from the patient perspective is dependent on t...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-016-0317-9
更新日期:2016-06-01 00:00:00
abstract::Due to the rapid expansion of first-line antiretroviral therapy in resource-limited settings (RLS), increasing numbers of people are living with HIV for prolonged periods of time. Treatment programs must now decide how to balance monitoring costs necessary to maximize health benefits for those already on treatment wit...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-010-0046-4
更新日期:2010-08-01 00:00:00
abstract::With the introduction of potent combination antiretroviral therapy (cART) into clinical practice, HIV-infected patients have garnered much benefit. However, kidney disease continues to be a potential complication in this group. Whereas HIV-associated nephropathy (HIVAN) was the major renal complication prior to cART, ...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0209-9
更新日期:2014-09-01 00:00:00
abstract::Despite impressive decreases in mortality and morbidity, significant adverse events have surfaced as a result of combination antiretroviral therapy (ART). They include lipoatrophy, or subcutaneous fat wasting of the face, arms, buttocks, or legs, which can be associated with central fat accumulation. Although the unde...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-008-0010-8
更新日期:2008-05-01 00:00:00
abstract::For the last three decades, sub-Saharan Africa has been the epicentre of the HIV epidemic. Some key drivers of the epidemic are specific to this region and there is an urgent need to develop context-specific strategies to reduce HIV-related burden. Implementation frameworks should endeavour to combine structural, beha...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-015-0262-z
更新日期:2015-06-01 00:00:00
abstract::Therapeutic drug monitoring (TDM) is the process by which a patient's dosing regimen is guided by repeated measures of plasma drug concentrations. An enormous challenge with regard to TDM of antiretroviral drugs (ARV) is that the concentration goals can be moving targets. Well-designed prospective studies demonstratin...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-005-0020-8
更新日期:2005-06-01 00:00:00
abstract::The course of HIV research has led to a multitude of interventions to prevent and treat HIV. With the arrival of more effective interventions comes the need to end, or de-implement, less effective interventions. PURPOSE OF REVIEW: To describe the state of de-implementation research in HIV and provide a rationale for e...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-020-00517-y
更新日期:2020-10-01 00:00:00
abstract::Vaccine recommendations for those with HIV require continual updating as additional research becomes available. Timing of vaccinations among HIV-infected individuals is a key area of uncertainty. This is particularly true for those who may soon initiate highly active antiretroviral therapy (HAART) because immune recon...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-009-0014-z
更新日期:2009-05-01 00:00:00
abstract::The purpose of this meta-analytic study is to summarize the current science concerning the (a) prevalence of alcohol use, (b) prevalence of sexual risk behaviors, and (c) association between alcohol use and sexual risk behaviors among people livingwithHIV/AIDS (PLWHA). Studies were included if they sampled PLWHA, eval...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11904-013-0177-5
更新日期:2013-12-01 00:00:00
abstract::Recent policies, guidelines, and laws reflect promising preliminary outcomes among transplant recipients with HIV infection, and ethical analyses suggest that it is not justifiable to deny solid organ transplantation based solely on HIV-infection status. These studies consistently describe stable HIV disease following...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/BF02696657
更新日期:2006-09-01 00:00:00
abstract::Access to potent antiretroviral medications greatly reduces morbidity and mortality due to HIV/AIDS, but drug toxicity limits treatment success in many individuals. The field of pharmacogenomics strives to understand the influence of human genetic variants in response to medications. Investigators have begun to identi...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-006-0018-x
更新日期:2006-07-01 00:00:00
abstract:PURPOSE OF REVIEW:This narrative review summarizes recent data on factors associated with insulin resistance (IR) in adults with HIV, including contemporary antiretroviral therapy (ART). RECENT FINDINGS:IR remains common in persons with HIV, even those receiving contemporary ART. Generalized and abdominal obesity and ...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-018-0399-7
更新日期:2018-06-01 00:00:00
abstract::Self-reports are the most widely used method for measuring antiretroviral adherence. The association between self-reports and viral loads has been repeatedly demonstrated, but this association does not address how well self-reports measure actual medication-taking behaviors. Understanding adherence self-reports requir...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章
doi:10.1007/s11904-009-0024-x
更新日期:2009-11-01 00:00:00
abstract:PURPOSE OF REVIEW:This review aims to describe the epidemiology of HIV among female sex workers (FSWs) in China over the past decade, to summarize current gaps in knowledge regarding risk factors, and to identify new directions for HIV prevention strategies. RECENT FINDINGS:We summarized national and regional levels o...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00477-y
更新日期:2020-04-01 00:00:00
abstract::The availability of potent combination antiretroviral therapy has changed the long-term prognosis for people living with HIV/AIDS. There is increasing concern, however, about the effect of HIV therapy on lipid disorders and subsequent development of coronary artery disease. Virtually all classes of antiretroviral drug...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-005-0006-6
更新日期:2005-08-01 00:00:00
abstract::Due to the co-occurrence of sexual risk behaviors and substance use among HIV-positive individuals, there is often a need for HIV prevention efforts to target multiple behaviors. Motivational Interviewing (MI), a widely disseminated behavior change intervention, has demonstrated effectiveness in promoting behavior cha...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-012-0132-x
更新日期:2012-12-01 00:00:00
abstract:PURPOSE OF THE REVIEW:Early diagnosis and treatment of HIV following seroconversion improves individual and population health. Using published data on pre-treatment CD4 cell counts, we benchmarked the level of immunodeficiency at HIV diagnosis and ART initiation in the "real world" against those of the treatment and co...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00452-7
更新日期:2019-08-01 00:00:00
abstract::Combined antiretroviral therapy (CART) has turned HIV-infection to a treatable chronic disease during which many patients survive to middle and older age. However, they prematurely develop non-AIDS comorbidities such as cardiovascular disease, metabolic syndrome, diabetes, and HIV-associated neurocognitive disorders (...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-016-0339-3
更新日期:2016-12-01 00:00:00
abstract::Generation of memory T cells, which mediate immunity against microbes and cancers, relies, for optimal activity, on the interactions of multiple cell types that are highly regulated through the expression of soluble factors and negative and positive receptors. Their disruption will lead to aberrant immune responses, w...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-008-0003-7
更新日期:2008-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Glycoimmunology is an emerging field focused on understanding how immune responses are mediated by glycans (carbohydrates) and their interaction with glycan-binding proteins called lectins. How glycans influence immunological functions is increasingly well understood. In a parallel way, in the HIV fie...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00433-w
更新日期:2019-04-01 00:00:00