Abstract:
:HIV infection is one of the strongest risk factors for anal squamous cell cancer (ASCC). Most ASCC are caused by HPV, and most HPV-associated ASCC are caused by HPV-16. Anal HPV infections are very common in men who have sex with men (MSM), and nearly universal among HIV-infected MSM. High-grade anal intraepithelial neoplasia (HGAIN), the precursor for ASCC, is present in about 30 % of HIV+ MSM, but neither the progression rate to ASCC nor the regression rate are known. The incidence rate of ASCC among HIV-infected people has risen in the first decade after cART became available, but appears to be plateauing recently. Anal cytology has poor sensitivity and specificity. High resolution anoscopy (HRA) is advocated by some as a screening tool in high-risk groups, but is cumbersome and time-consuming and it is unknown whether HRA followed by treatment of HGAIN prevents ASCC. More research is needed on progression and regression rates of HGAIN, on effective therapy of HGAIN, and on biomarkers that predict HGAIN or anal cancer. HPV vaccination and earlier start of cART may prevent most anal cancers in the long run.
journal_name
Curr HIV/AIDS Repjournal_title
Current HIV/AIDS reportsauthors
Schim van der Loeff MF,Mooij SH,Richel O,de Vries HJ,Prins JMdoi
10.1007/s11904-014-0224-xsubject
Has Abstractpub_date
2014-09-01 00:00:00pages
250-62issue
3eissn
1548-3568issn
1548-3576journal_volume
11pub_type
杂志文章,评审abstract::Due to the rapid expansion of first-line antiretroviral therapy in resource-limited settings (RLS), increasing numbers of people are living with HIV for prolonged periods of time. Treatment programs must now decide how to balance monitoring costs necessary to maximize health benefits for those already on treatment wit...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-010-0046-4
更新日期:2010-08-01 00:00:00
abstract::Substance users are at elevated risk for HIV. HIV researchers, particularly at the intersection of HIV and substance use, have requested new methods to better understand and address this important area. New technologies, such as social media and mobile applications, are increasingly being used as research tools in stu...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-015-0295-3
更新日期:2015-12-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-017-0369-5
更新日期:2017-12-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-016-0330-z
更新日期:2016-10-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-007-0021-x
更新日期:2007-08-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-013-0187-3
更新日期:2013-12-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-020-00512-3
更新日期:2020-10-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-007-0027-4
更新日期:2007-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-06-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
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更新日期:2006-11-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00421-0
更新日期:2019-02-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type:
doi:10.1007/s11904-015-0270-z
更新日期:2015-06-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-005-0020-8
更新日期:2005-06-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/BF02696657
更新日期:2006-09-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-008-0010-8
更新日期:2008-05-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章
doi:10.1007/s11904-008-0019-z
更新日期:2008-08-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-015-0276-6
更新日期:2015-09-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00452-7
更新日期:2019-08-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-008-0003-7
更新日期:2008-02-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-016-0339-3
更新日期:2016-12-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,meta分析,评审
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更新日期:2013-12-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-019-00439-4
更新日期:2019-06-01 00:00:00
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journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-004-0004-0
更新日期:2004-04-01 00:00:00
abstract::Increased access to testing and treatment means HIV can be managed as a chronic illness, though successful management requires continued engagement with the health care system. Most of the global HIV burden is in sub-Saharan Africa where rates of new infections are consistently higher in women versus men. Pregnancy is...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0252-6
更新日期:2015-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe a small city/rural area HIV prevention project (the Cross Border Project) implemented in Ning Ming County, Guangxi Province, China, and Lang Son province, Vietnam, and consider its implications for addressing the opioid/heroin epidemic in small cities/rural areas in the USA. The descriptio...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-018-0405-0
更新日期:2018-08-01 00:00:00
abstract::Sustained retention represents an enduring and evolving challenge to HIV treatment programs in Africa. We present a theoretical framework for sustained retention borrowing from ecologic principles of sustainability and dynamic adaptation. We posit that sustained retention from the patient perspective is dependent on t...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-016-0317-9
更新日期:2016-06-01 00:00:00
abstract::Lipodystrophy and its two components lipo-accumulation and lipoatropy are very common among individuals with HIV infection on treatment, especially among those who started therapy in the late 1990s and early 2000s. This review discusses the current management of these complications of HIV and its treatment. For the pu...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-007-0013-x
更新日期:2007-05-01 00:00:00
abstract::Due to life-enhancing effects of antiretroviral therapy, HIV-positive persons have the potential for long life comparable to their uninfected peers. Older women (age 50+) living with HIV (OWLH) are often an under-recognized aging group. We conducted a systematic review to examine psychosocial factors that impact how O...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-017-0347-y
更新日期:2017-02-01 00:00:00
abstract::With the introduction of potent combination antiretroviral therapy (cART) into clinical practice, HIV-infected patients have garnered much benefit. However, kidney disease continues to be a potential complication in this group. Whereas HIV-associated nephropathy (HIVAN) was the major renal complication prior to cART, ...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-014-0209-9
更新日期:2014-09-01 00:00:00
abstract::The HIV pandemic has disproportionately impacted sub-Saharan Africa and Southern Africa in particular. The concurrent presence of overlapping epidemic drivers likely underpins how and why the HIV epidemic is so explosive in this region, with implications for understanding approaches to reduce transmission. In this rev...
journal_title:Current HIV/AIDS reports
pub_type: 杂志文章,评审
doi:10.1007/s11904-016-0314-z
更新日期:2016-06-01 00:00:00