HPV and anal cancer in HIV-infected individuals: a review.

Abstract:

:HIV infection is one of the strongest risk factors for anal squamous cell cancer (ASCC). Most ASCC are caused by HPV, and most HPV-associated ASCC are caused by HPV-16. Anal HPV infections are very common in men who have sex with men (MSM), and nearly universal among HIV-infected MSM. High-grade anal intraepithelial neoplasia (HGAIN), the precursor for ASCC, is present in about 30 % of HIV+ MSM, but neither the progression rate to ASCC nor the regression rate are known. The incidence rate of ASCC among HIV-infected people has risen in the first decade after cART became available, but appears to be plateauing recently. Anal cytology has poor sensitivity and specificity. High resolution anoscopy (HRA) is advocated by some as a screening tool in high-risk groups, but is cumbersome and time-consuming and it is unknown whether HRA followed by treatment of HGAIN prevents ASCC. More research is needed on progression and regression rates of HGAIN, on effective therapy of HGAIN, and on biomarkers that predict HGAIN or anal cancer. HPV vaccination and earlier start of cART may prevent most anal cancers in the long run.

journal_name

Curr HIV/AIDS Rep

journal_title

Current HIV/AIDS reports

authors

Schim van der Loeff MF,Mooij SH,Richel O,de Vries HJ,Prins JM

doi

10.1007/s11904-014-0224-x

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

250-62

issue

3

eissn

1548-3568

issn

1548-3576

journal_volume

11

pub_type

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