Abstract：
PURPOSE OF REVIEW:In the absence of antiretroviral therapy (ART), more than 50% of perinatally HIV-infected children die by 2 years of age. Early ART from infancy is therefore a global recommendation and significantly improves immune health, child survival, and disease outcome. However, even early treatment does not prevent or eradicate the latent reservoir necessitating life-long ART. Adherence to life-long ART is challenging for children and longstanding ART during chronic HIV infection led to higher risks of non-AIDS co-morbidities and virologic failure in infected children. Thus, HIV-infected children are an important population for consideration for immune-based interventions to achieve ART-free remission and functional cure. This review summarizes how the uniqueness of the early life immune system can be harnessed for the development of ART-free remission and functional cure, which means complete virus control in absence of ART. In addition, recent advances in therapeutics in the HIV cure field and their potential for the treatment of pediatric HIV infections are discussed. RECENT FINDINGS:Preclinical studies and clinical trials demonstrated that immune-based interventions target HIV replication, limit size of virus reservoir, maintain virus suppression, and delay time to virus rebound. However, these studies have been performed so far only in carefully selected HIV-infected adults, highlighting the need to evaluate the efficacy of immune-based therapeutics in HIV-infected children and to design interventions tailored to the early life maturing immune system. Immune-based therapeutics alone or in combination with ART should be actively explored as potential strategies to achieve viral remission and functional cure in HIV-infected pediatric populations.
journal_name
Curr HIV/AIDS Repjournal_title
Current HIV/AIDS reportsauthors
Berendam SJ,Nelson AN,Goswami R,Persaud D,Haigwood NL,Chahroudi A,Fouda GG,Permar SRdoi
10.1007/s11904-020-00495-1subject
Has Abstractpub_date
2020-06-01 00:00:00pages
237-248issue
3eissn
1548-3568issn
1548-3576pii
10.1007/s11904-020-00495-1journal_volume
17pub_type
杂志文章,评审abstract：:An emerging body of evidence suggests that intergenerational sexual partnerships may increase risk of HIV acquisition among young men who have sex with men (YMSM). However, no studies have comprehensively evaluated literature in this area. We applied a scoping review methodology to explore the relationships between ag...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-013-0187-3
更新日期：2013-12-01 00:00:00
abstract：:HIV-infected individuals are at increased risk for most types of cancer, including those typically classified as non-AIDS-defining cancers (NADCs). This increased risk is likely multifactorial, but a prominent risk factor for the increased rate of some cancers is co-infection with oncogenic viruses. Anal cancer, hepat...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-015-0276-6
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abstract：:Female sex workers (FSWs) continue to represent a high-risk population in need of targeted HIV prevention interventions. Targeting environmental risk factors should result in more sustainable behavior change than individual-level interventions alone. There are many types of FSWs who operate in and through a variety of...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-012-0142-8
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章
doi：10.1007/s11904-009-0024-x
更新日期：2009-11-01 00:00:00
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-015-0295-3
更新日期：2015-12-01 00:00:00
abstract：PURPOSE OF REVIEW:To describe a small city/rural area HIV prevention project (the Cross Border Project) implemented in Ning Ming County, Guangxi Province, China, and Lang Son province, Vietnam, and consider its implications for addressing the opioid/heroin epidemic in small cities/rural areas in the USA. The descriptio...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-018-0405-0
更新日期：2018-08-01 00:00:00
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-017-0347-y
更新日期：2017-02-01 00:00:00
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,meta分析,评审
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更新日期：2013-12-01 00:00:00
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
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journal_title：Current HIV/AIDS reports
pub_type：
doi：10.1007/s11904-015-0270-z
更新日期：2015-06-01 00:00:00
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
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更新日期：2006-07-01 00:00:00
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journal_title：Current HIV/AIDS reports
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-009-0014-z
更新日期：2009-05-01 00:00:00
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-006-0016-z
更新日期：2006-11-01 00:00:00
abstract：:HIV infection is one of the strongest risk factors for anal squamous cell cancer (ASCC). Most ASCC are caused by HPV, and most HPV-associated ASCC are caused by HPV-16. Anal HPV infections are very common in men who have sex with men (MSM), and nearly universal among HIV-infected MSM. High-grade anal intraepithelial n...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
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journal_title：Current HIV/AIDS reports
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journal_title：Current HIV/AIDS reports
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
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journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
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更新日期：2014-09-01 00:00:00
abstract：:Pharmacy refill adherence has become an increasingly important measure of adherence to antiretroviral medications. It offers a simple, inexpensive, and valid method for measuring adherence. Over the past year, there have been several published developments in the use of pharmacy refill data to measure adherence. Given...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-007-0027-4
更新日期：2007-12-01 00:00:00
