Abstract：
PURPOSE OF REVIEW:The discovery of innate lymphoid cells (ILCs) over the past decade has reformed principles that were once thought to be exclusive to adaptive immunity. Here, we describe ILC nomenclature and function, and provide a survey of studies examining these cells in the context of HIV/SIV infections. Particular emphasis is placed on the ILC3 subset, important for proper functioning of the gastrointestinal tract barrier. RECENT FINDINGS:Studies in both humans and nonhuman primates have found ILCs to be rapidly and durably depleted in untreated HIV/SIV infections. Their depletion is most likely due to a number of bystander effects induced by viral replication. Given the number of associations observed between loss of ILCs and HIV-related GI damage, their impact on the GI tract is likely important. It may be informative to examine this subset in parallel with other immune cell types when assessing overall health of the GI tract in future studies.
journal_name
Curr HIV/AIDS Repjournal_title
Current HIV/AIDS reportsauthors
Mudd JC,Brenchley JMdoi
10.1007/s11904-019-00439-4subject
Has Abstractpub_date
2019-06-01 00:00:00pages
181-190issue
3eissn
1548-3568issn
1548-3576pii
10.1007/s11904-019-00439-4journal_volume
16pub_type
杂志文章,评审abstract：:Lipodystrophy and its two components lipo-accumulation and lipoatropy are very common among individuals with HIV infection on treatment, especially among those who started therapy in the late 1990s and early 2000s. This review discusses the current management of these complications of HIV and its treatment. For the pu...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-007-0013-x
更新日期：2007-05-01 00:00:00
abstract：:Roughly 10 % of HIV-positive individuals worldwide have concomitant chronic hepatitis B virus (HBV) infection, with large differences between geographical regions and/or risk groups. Hepatitis B is a preventable infection with vaccines. However, it cannot be eradicated once acquired, resembling HIV and in contrast wit...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-015-0275-7
更新日期：2015-09-01 00:00:00
abstract：:The HIV pandemic has disproportionately impacted sub-Saharan Africa and Southern Africa in particular. The concurrent presence of overlapping epidemic drivers likely underpins how and why the HIV epidemic is so explosive in this region, with implications for understanding approaches to reduce transmission. In this rev...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-016-0314-z
更新日期：2016-06-01 00:00:00
abstract：:With the introduction of potent combination antiretroviral therapy (cART) into clinical practice, HIV-infected patients have garnered much benefit. However, kidney disease continues to be a potential complication in this group. Whereas HIV-associated nephropathy (HIVAN) was the major renal complication prior to cART, ...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-014-0209-9
更新日期：2014-09-01 00:00:00
abstract：PURPOSE OF REVIEW:This review provides an overview of HCV resistance-associated substitutions (RASs) with a focus on NS3 protease and NS5A inhibitor resistance. Treatment approaches for managing resistance are also covered including the use of newly approved therapies with improved resistance profiles. RECENT FINDINGS...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-017-0369-5
更新日期：2017-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Mental health disorders, especially depression, are prevalent among people living with HIV (PLWH) and are associated with cognitive impairment (CI) among HIV-uninfected (HIV-) individuals. We conducted a comprehensive review of the link between depression and cognition among PLWH. RECENT FINDINGS:Stu...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-019-00421-0
更新日期：2019-02-01 00:00:00
abstract：:Bacterial infection is a major cause of morbidity and mortality among patients with HIV living in Africa. Broadening the scope of cotrimoxazole (CTX) prophylaxis to cover patients whose CD4 counts are above 200 cells/mm(3) has been suggested as a means of improving the control of infectious disease on the continent. C...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-007-0021-x
更新日期：2007-08-01 00:00:00
abstract：:Therapeutic drug monitoring (TDM) is the process by which a patient's dosing regimen is guided by repeated measures of plasma drug concentrations. An enormous challenge with regard to TDM of antiretroviral drugs (ARV) is that the concentration goals can be moving targets. Well-designed prospective studies demonstratin...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-005-0020-8
更新日期：2005-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Advances in short- and long-acting pre-exposure prophylaxis (PrEP) technologies have incentivized the need to understand how individuals make trade-offs and competing decisions regarding PrEP modalities. The purpose of this review was to examine how researchers have conceptualized and measured attribu...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00497-z
更新日期：2020-06-01 00:00:00
abstract：:The population of patients with HIV infection achieving viral suppression on combination antiretroviral therapy is growing, aging, and experiencing a widening spectrum of non-AIDS diseases. Concurrently, AIDS-defining conditions are becoming less common and are variably associated with outcome. Nonetheless, the spectr...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章
doi：10.1007/s11904-010-0041-9
更新日期：2010-05-01 00:00:00
abstract：PURPOSE OF THE REVIEW:Early diagnosis and treatment of HIV following seroconversion improves individual and population health. Using published data on pre-treatment CD4 cell counts, we benchmarked the level of immunodeficiency at HIV diagnosis and ART initiation in the "real world" against those of the treatment and co...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-019-00452-7
更新日期：2019-08-01 00:00:00
abstract：PURPOSE OF REVIEW:In the absence of antiretroviral therapy (ART), more than 50% of perinatally HIV-infected children die by 2 years of age. Early ART from infancy is therefore a global recommendation and significantly improves immune health, child survival, and disease outcome. However, even early treatment does not pr...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00495-1
更新日期：2020-06-01 00:00:00
abstract：:Vaccine recommendations for those with HIV require continual updating as additional research becomes available. Timing of vaccinations among HIV-infected individuals is a key area of uncertainty. This is particularly true for those who may soon initiate highly active antiretroviral therapy (HAART) because immune recon...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-009-0014-z
更新日期：2009-05-01 00:00:00
abstract：:HIV-infected individuals are at increased risk for most types of cancer, including those typically classified as non-AIDS-defining cancers (NADCs). This increased risk is likely multifactorial, but a prominent risk factor for the increased rate of some cancers is co-infection with oncogenic viruses. Anal cancer, hepat...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-015-0276-6
更新日期：2015-09-01 00:00:00
abstract：:Persons who inject drugs (PWID) are at high risk for infection with and poor outcomes from HIV and hepatitis C virus (HCV). Well-established interventions for HIV/HCV prevention among PWID include syringe access, opioid agonist maintenance treatment, and supervised injection facilities, yet these interventions remain ...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-014-0248-2
更新日期：2015-03-01 00:00:00
abstract：:While combination antiretroviral therapy allows HIV-infected patients to have life expectancies similar to that of the general population, it may also contribute to the development of co-morbidities, such as cardiovascular disease and osteoporosis. Such complications could compromise long-term quality of life, especia...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-016-0320-1
更新日期：2016-08-01 00:00:00
abstract：:The first association between HIV-1 infection and kidney disease was made in 1984 and much has been learned over the past 20 years. In recent years, more effective therapies for HIV-1 infection and its associated opportunistic infections have led to improved patient survival. However, with prolonged survival, morbidit...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-004-0016-9
更新日期：2004-09-01 00:00:00
abstract：:Several all-oral direct-acting antiviral (DAA) combination therapies including two fixed-dose combinations (FDCs) have been recently licensed for treatment of hepatitis C virus (HCV) genotype 1 infection. Results of pivotal trials with these new compounds are now also available in human immunodeficiency virus (HIV)/HC...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-015-0278-4
更新日期：2015-09-01 00:00:00
abstract：:The AIDS epidemic continues its unrelentless expansion. According to the Joint United Nations Programme on HIV/AIDS, there are more than 40 million people living with HIV, and more than 15,000 new infections occur every day. One approach to curbing HIV is the development of topical microbicidal agents or microbicides....
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-004-0004-0
更新日期：2004-04-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this paper is to provide a thorough overview of methods used for recruitment, network data collection, and network data management in a network-based study of rural people who use drugs (PWUD) and to offer methodological recommendations for future research on rural drug use. RECENT FIN...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-018-0391-2
更新日期：2018-04-01 00:00:00
abstract：:Pharmacy refill adherence has become an increasingly important measure of adherence to antiretroviral medications. It offers a simple, inexpensive, and valid method for measuring adherence. Over the past year, there have been several published developments in the use of pharmacy refill data to measure adherence. Given...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-007-0027-4
更新日期：2007-12-01 00:00:00
abstract：:Combined antiretroviral therapy (CART) has turned HIV-infection to a treatable chronic disease during which many patients survive to middle and older age. However, they prematurely develop non-AIDS comorbidities such as cardiovascular disease, metabolic syndrome, diabetes, and HIV-associated neurocognitive disorders (...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-016-0339-3
更新日期：2016-12-01 00:00:00
abstract：:HIV infection is one of the strongest risk factors for anal squamous cell cancer (ASCC). Most ASCC are caused by HPV, and most HPV-associated ASCC are caused by HPV-16. Anal HPV infections are very common in men who have sex with men (MSM), and nearly universal among HIV-infected MSM. High-grade anal intraepithelial n...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-014-0224-x
更新日期：2014-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Neurological conditions associated with HIV/AIDS including central nervous system (CNS), opportunistic infections (OI), chronic conditions including HIV-associated neurocognitive disorder, and cerebrospinal fluid (CSF) viral escape remain major contributors to morbidity and mortality worldwide. CNS in...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-020-00514-1
更新日期：2020-10-01 00:00:00
abstract：:HIV infection and antiretroviral therapy (ART) use are associated with perturbations in glucose and lipid metabolism. Increasing incidence of diabetes, cardiovascular disease, and obesity highlights the need for early identification and treatment of metabolic dysfunction. Newer ART regimens are less toxic for cellular...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-016-0330-z
更新日期：2016-10-01 00:00:00
abstract：:Neurocognitive compromise, a common sequela of HIV infection, ranges in severity from minor motor and information-processing speed decrements to severely incapacitating symptoms that affect functional independence. However, with the emergence of highly active antiretroviral therapy (HAART), neurocognitive phenotypes h...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-008-0029-x
更新日期：2008-11-01 00:00:00
abstract：:Substance users are at elevated risk for HIV. HIV researchers, particularly at the intersection of HIV and substance use, have requested new methods to better understand and address this important area. New technologies, such as social media and mobile applications, are increasingly being used as research tools in stu...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-015-0295-3
更新日期：2015-12-01 00:00:00
abstract：:HIV is a devastating worldwide epidemic that has had substantial social and economic impacts throughout the globe. Due to the presence of a small pool of latently infected cells that persists during antiretroviral therapy (ART), HIV is not curable. Because of the high cost of ART and the lack of reliable accessibility...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-016-0304-1
更新日期：2016-04-01 00:00:00
abstract：PURPOSE OF REVIEW:This narrative review summarizes recent data on factors associated with insulin resistance (IR) in adults with HIV, including contemporary antiretroviral therapy (ART). RECENT FINDINGS:IR remains common in persons with HIV, even those receiving contemporary ART. Generalized and abdominal obesity and ...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-018-0399-7
更新日期：2018-06-01 00:00:00
abstract：:Nine months of daily isoniazid is efficacious in treating latent M. tuberculosis infection, but completion rates are low, limiting treatment effectiveness. In 2011, three important studies were published involving novel regimens for the treatment of latent M. tuberculosis infection. At least 36 months of isoniazid was...
journal_title：Current HIV/AIDS reports
pub_type： 杂志文章,评审
doi：10.1007/s11904-012-0120-1
更新日期：2012-09-01 00:00:00
