Abstract:
:A 56-year-old white woman developed a distinctive skin eruption over her mammary, lumbosacral, and pubic areas 2 weeks after the start of esomeprazole therapy for dyspeptic symptoms. Skin biopsy disclosed a spongiotic dermatitis with predominantly lymphocytic dermal infiltrate. Treatment with a tapering dose of corticosteroid and withdrawal of the suspected drug led to a rapid resolution of the eruption without residual dyschromia. Patch testing with esomeprazole 2% in petrolatum was negative at 48 and 72 hours but became positive on day 6. Oral-controlled provocation test induced the reappearance of the lesions over the mammary areas, confirming the putative involvement of this drug. Therefore, the patient was diagnosed as having a nonpigmented fixed drug eruption associated with esomeprazole. This compound is a proton-pump inhibitor developed as the S-isomer of omeprazole to improve its pharmacokinetic properties. Reports of cutaneous reactions to proton-pump inhibitors are quite common, but reports of such reactions to esomeprazole are rare, which demonstrates the need for higher clinical awareness and knowledge of reactions to these drugs.
journal_name
Cutan Ocul Toxicoljournal_title
Cutaneous and ocular toxicologyauthors
Morais P,Baudrier T,Mota A,Cunha AP,Cadinha S,Barros AM,Azevedo Fdoi
10.3109/15569527.2010.484824subject
Has Abstractpub_date
2010-09-01 00:00:00pages
217-20issue
3eissn
1556-9527issn
1556-9535journal_volume
29pub_type
杂志文章abstract::The assessment of the potency of a skin sensitizing chemical is a key starting point for its subsequent risk assessment/management. The Local Lymph Node Assay can provide information on the relative skin sensitizing potency of contact allergens by interpolation from the dose response curve the concentration of a chemi...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569520701212258
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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doi:10.1080/15569520500371735
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journal_title:Cutaneous and ocular toxicology
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doi:10.3109/15569527.2015.1072546
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2014.930748
更新日期:2015-01-01 00:00:00
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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doi:10.3109/15569520903496746
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/15569527.2012.751392
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2012.657726
更新日期:2012-12-01 00:00:00
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journal_title:Cutaneous and ocular toxicology
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doi:10.3109/15569527.2015.1027906
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2016.1141417
更新日期:2017-03-01 00:00:00
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2013.796480
更新日期:2014-06-01 00:00:00
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journal_title:Cutaneous and ocular toxicology
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