Abstract:
:Ciliary body is responsible for humour aqueous production in posterior chamber. Valproic acid (VPA) has been widely used for the treatment of epilepsy and other neuropsychiatric diseases such as bipolar disease and major depression. Oxcarbazepine (OXC) is a new anti-epileptic agent that has been used recently for childhood epilepsies such as VPA. In this study, we aimed to investigate the effects of VPA and OXC treatments used as antiepileptic in ciliary body by electron microscopy. In our study, 40 Wistar rats (21 days old) were divided equally into four groups which were applied saline (group 1), VPA (group 2), OXC (group 3) and VPA + OXC (group 4). The as-prepared ocular tissues were characterized by transmission electron microscopy (TEM) technique in scanning and transmission electron microscopy (SEM-TEM) (Carl Zeiss EVO LS10). The results confirmed that VPA caused dense ciliary body degeneration. Additionally, ciliary body degeneration in group 4 was supposed to be due to VPA treatment. Ciliary body damage and secondary outcomes should be considered in patients with long-term VPA therapy.
journal_name
Cutan Ocul Toxicoljournal_title
Cutaneous and ocular toxicologyauthors
Göktaş G,Aktaş Z,Erdoğan D,Seymen CM,Karaca EE,Cansu A,Serdaroğlu A,Kaplanoğlu GTdoi
10.3109/15569527.2014.930748subject
Has Abstractpub_date
2015-01-01 00:00:00pages
156-60issue
2eissn
1556-9527issn
1556-9535journal_volume
34pub_type
杂志文章abstract::Erythema multiforme (EM) is an immune-mediated mucocutaneous eruption characterized by symmetrically distributed, polymorphic targetoid lesions, mostly on the distal parts of the extremities. It occurs mostly in the setting of an infection in certain predisposed individuals. A 30-year-old pregnant woman was presented ...
journal_title:Cutaneous and ocular toxicology
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pub_type: 临床试验,杂志文章
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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doi:10.3109/15569527.2016.1155595
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2013.875560
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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