Abstract:
:Attempts to improve formulation of topical products are a continuing process and the development of micro- and nanovesicular systems as well as polymeric microparticles has led to marketing of topical drugs and cosmetics using these technologies. Encapsulation of some well-known contact allergens in ethanolic liposomes have been reported to enhance allergenicity compared with the allergens in similar vehicles without liposomes. The present report includes data on more sensitization studies using the mouse local lymph node assay with three contact allergens encapsulated in different dermal drug-delivery systems: liposomes, ethosomes, and polycaprolactone particles. The results show that the drug-delivery systems are not sensitizers in themselves. Encapsulating the hydrophilic contact allergen potassium dichromate in all three drug-delivery systems did not affect the sensitizing capacity of potassium dichromate compared with control solutions. However, encapsulating the lipophilic contact allergen dinitrochlorobenzene (DNCB) in polycaprolactone reduced the sensitizing capacity to 1211 ± 449 compared with liposomes (7602 ± 2658) and in acetone:olive oil (4:1) (5633 ± 666). The same trend was observed for encapsulating isoeugenol in polycaprolactone (1100 ± 406) compared with a formulation in acetone:olive oil (4491 ± 819) and in liposomes (3668 ± 950). Further, the size of DNCB-loaded liposomes did not affect the sensitizing properties. These results suggest that modern dermal drug-delivery systems may in some cases magnify or decrease the sensitizing capacity of the encapsulated contact allergen.
journal_name
Cutan Ocul Toxicoljournal_title
Cutaneous and ocular toxicologyauthors
Madsen JT,Vogel S,Johansen JD,Andersen KEdoi
10.3109/15569527.2010.540765subject
Has Abstractpub_date
2011-06-01 00:00:00pages
116-23issue
2eissn
1556-9527issn
1556-9535journal_volume
30pub_type
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.3109/15569527.2014.954715
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
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journal_title:Cutaneous and ocular toxicology
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