Review: Takagi-Sugeno fuzzy modeling of skin permeability.

Abstract:

:The skin is a major exposure route for many potentially toxic chemicals. It is, therefore, important to be able to predict the permeability of compounds through skin under a variety of conditions. Available skin permeability databases are often limited in scope and not conducive to developing effective models. This sparseness and ambiguity of available data prompted the use of fuzzy set theory to model and predict skin permeability. Using a previously published database containing 140 compounds, a rule-based Takagi-Sugeno fuzzy model is shown to predict skin permeability of compounds using octanol-water partition coefficient, molecular weight, and temperature as inputs. Model performance was estimated using a cross-validation approach. In addition, 10 data points were removed prior to model development for additional testing with new data. The fuzzy model is compared to a regression model for the same inputs using both R2 and root mean square error measures. The quality of the fuzzy model is also compared with previously published models. The statistical analysis demonstrates that the fuzzy model performs better than the regression model with identical data and validation protocols. The prediction quality for this model is similar to others that were published. The fuzzy model provides insights on the relationships between lipophilicity, molecular weight, and temperature on percutaneous penetration. This model can be used as a tool for rapid determination of initial estimates of skin permeability.

journal_name

Cutan Ocul Toxicol

authors

Keshwani DR,Jones DD,Brand RM

doi

10.1080/15569520500278690

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

149-63

issue

3

eissn

1556-9527

issn

1556-9535

pii

P3M43MX813747448

journal_volume

24

pub_type

杂志文章
  • Guinea pig maximization test assessment of hydrocortisone and tixocortol pivalate.

    abstract::The anti-inflammatory properties of topical corticosteroids are well documented; additionally, their sensitization potential is also known. We aimed to assess the relative sensitization potential of hydrocortisone and tixocortol pivalate in an animal assay as it relates to potential for sensitization in humans. Using ...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569520701662775

    authors: Mirshahpanah P,Maibach HI

    更新日期:2007-01-01 00:00:00

  • Terbinafine-induced lichenoid drug eruption.

    abstract::Drug-induced lichen planus has been induced by antibiotics, anticonvulsants, antidiabetics, antimalarials, antitubercular drugs, antihypertensives, psychiatric drugs, chemotherapeutic agents, diuretic, heavy metals, NSAIDs, etc. Terbinafine, an antifungal agent, is widely used for dermatophyte infections and onychomyc...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2016.1160101

    authors: Zheng Y,Zhang J,Chen H,Lai W,Maibach HI

    更新日期:2017-03-01 00:00:00

  • The vulva is relatively insensitive to menses-induced irritation.

    abstract::Skin patch testing of menses and venous blood on the vulva (labia majora) and the upper arm was performed to assess the potential contribution of these biological fluids to vulvar irritation during menstruation. After 24 and 48 hours of occlusive exposure, the skin of the labia majora was relatively unaffected by thes...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569520500371735

    authors: Farage M,Warren R,Wang-Weigand S

    更新日期:2005-01-01 00:00:00

  • Mystery of the disappearing allergen: published allergens rarely seen again.

    abstract::Patch testing is an important tool in the diagnosis of allergic contact dermatitis. Although this technique can be accurate, occasionally the results may be inconclusive. A previously positive result to an allergen may become negative upon repeat testing, and this may complicate the process of achieving a definitive d...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569520701856757

    authors: Zapolanski T,Maibach HI

    更新日期:2008-01-01 00:00:00

  • Targeted tumour therapy induced papulopustular rash and other dermatologic side effects: a retrospective study.

    abstract::Background: Papulopustular rash is the most common cutaneous adverse effect during targeted tumour therapy particularly with epidermal growth factor receptor inhibitors (EGFRIs). Objective: To evaluate the adverse skin reactions, mainly papulopustular rash, caused by targeted tumour therapy. Materials and methods: We ...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569527.2019.1594874

    authors: Yalici-Armagan B,Ayanoglu BT,Demirdag HG

    更新日期:2019-09-01 00:00:00

  • Efficacy of intravitreal dexamethasone implant for the treatment of macular oedema after pars plana vitrectomy for rhegmatogenous retinal detachment: long-term outcomes.

    abstract::Purpose: To investigate the efficacy and safety of intravitreal dexamethasone implant as initial and only treatment for macular oedema after pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD).Methods: This study included 14 patients, who were diagnosed with macular oedema after PPV for RRD and who...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569527.2019.1684315

    authors: Chatziralli I,Dimitriou E,Theodossiadis G,Kazantzis D,Alonistiotis D,Theodossiadis P

    更新日期:2020-03-01 00:00:00

  • Electroretinographic and optical coherence tomography findings in breast cancer patients using aromatase inhibitors.

    abstract:BACKGROUND:The present cross-sectional study has the purpose to investigate the impact of aromatase inhibitors (AIs) on retinal nerve fiber layer (RNFL) thickness, optic nerve and macular function in patients using AIs for breast cancer treatment. METHODS:Participants in our study were 41 hormone-receptor-positive ear...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2014.1003267

    authors: Moschos MM,Chatziralli IP,Sergentanis T,Zagouri F,Chrysikos D,Ladas I,Zografos G

    更新日期:2016-03-01 00:00:00

  • Long-term ocular consequences of sulfur mustard in seriously eye-injured war veterans.

    abstract:INTRODUCTION:Sulfur mustard (SM) has been used as a dangerous chemical warfare agent since the early 20th century. Although many descriptive studies about SM-induced ocular injuries are present in the medical literature, few of them have been conducted over a large group with serious ocular involvement. MATERIALS AND ...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569520902913936

    authors: Ghasemi H,Ghazanfari T,Ghassemi-Broumand M,Javadi MA,Babaei M,Soroush MR,Yaraee R,Faghihzadeh S,Poorfarzam S,Owlia P,Naghizadeh MM,Etezad-Razavi M,Jadidi K,Naderi M,Hassan ZM

    更新日期:2009-01-01 00:00:00

  • Paederus dermatitis in Southeastern Anatolia, Turkey: a report of 57 cases.

    abstract:BACKGROUND:Paederus dermatitis (PD), which is an irritant contact dermatitis, is common throughout the world and caused by rove beetles. OBJECTIVES:To assess the clinical features of PD and the level of knowledge of patients from the city of Batman and surrounding areas who presented with the condition. METHODS:We de...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2013.834499

    authors: Turan E

    更新日期:2014-09-01 00:00:00

  • Evaluation of thiol/disulfide homeostasis in patients with pityriasis rosea.

    abstract::Purpose: Pityriasis rosea (PR) is a common, self-limiting, inflammatory skin disease with an acute onset. The etiology of PR is not yet clearly known but the defect in the oxidation system involved in many papulosquamous skin diseases may play a role. Thiol/disulfide homeostasis is a new marker of oxidative stress and...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569527.2019.1616748

    authors: Yüksel M,Ülfer G

    更新日期:2019-12-01 00:00:00

  • Topical absorption and systemic toxicity.

    abstract::Dermal absorption of some chemicals and drugs can cause systemic toxicity. We evaluated several case reports from the past decade, which discuss the dermal absorption of a specific chemical and potential local and systemic effects. We focused on herbicide and pesticide exposure along with exposure to cutaneous medicat...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章,评审

    doi:10.3109/15569527.2011.560914

    authors: Alikhan FS,Maibach H

    更新日期:2011-09-01 00:00:00

  • Effects of cigarette smoking on choroidal and retinal thickness and ocular pulse amplitude.

    abstract:BACKGROUND:In our study, we aimed to show the effects of smoking on choroidal thickness and ocular pulse amplitude. It is known that the anatomy and physiologic functions of the choroid is important in ocular diseases like glaucoma and age-related macular degeneration. Choroidal thickness is measured by the spectral do...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2014.950380

    authors: Dervişoğulları MS,Totan Y,Tenlik A,Yuce A

    更新日期:2015-01-01 00:00:00

  • Taurine inhibits interleukin-6 expression and release induced by ultraviolet B exposure to human retinal pigment epithelium cells.

    abstract:BACKGROUND:The massive uptake of compatible osmolytes is a self-protective response shared by retina exposed to hypertonic stress and ultraviolet stress. OBJECTIVE:This study aimed to investigate the protective effects of taurine against ultraviolet damage in human retinal pigment epithelium cells. METHODS:Real-time ...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2014.944649

    authors: Dayang W,Jinsong Z

    更新日期:2015-01-01 00:00:00

  • Bilateral optic neuropathy following bite from brown recluse spider (Loxosceles reclusa).

    abstract::A 63-year-old female with history of a resected frontal lobe meningioma presented with bilaterally decreased vision after a bite from a brown recluse spider. The exam was significant for a left relative afferent pupillary defect, bilateral optic nerve pallor, decreased foveal sensitivity in the left eye and new bilate...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2015.1027906

    authors: Mantopoulos D,Hendershot AJ,Cebulla CM,Hirsh DK

    更新日期:2016-01-01 00:00:00

  • In vitro skin penetration of acetyl hexapeptide-8 from a cosmetic formulation.

    abstract::There is a concern that peptides in cosmetic creams marketed as anti-aging/anti-wrinkle may penetrate into the deep layers of the skin and potentially stimulate biological activity. Claims for one cosmetic peptide, acetyl hexapeptide-8 (Ac-EEMQRR-amide), suggest interference with neuromuscular signaling as its anti-wr...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2014.894521

    authors: Kraeling ME,Zhou W,Wang P,Ogunsola OA

    更新日期:2015-03-01 00:00:00

  • The role of CD4+ T cells in the induction of contact hypersensitivity to mercury in a murine model.

    abstract:BACKGROUND:The exact immunopathogenesis of contact hypersensitivity (CH) to mercury remains unclear. OBJECTIVE:The aim of the present study was to assess the role of CD4+ T cells in mercury-induced CH in mice. METHODS:Splenic CD4+ T cells obtained from nonsensitized and mercury-sensitized Balb/c mice were adoptively ...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569520903496746

    authors: Sumiwi YA,Soesatyo MH,Sosroseno W

    更新日期:2010-03-01 00:00:00

  • Hot dog? Toxicological concerns and The Hound of the Baskervilles.

    abstract::The terrifying dog in the Hound of the Baskervilles is described as having 'blazing eyes' and a 'luminous muzzle', appearances attributed by Watson and Holmes to the application of phosphorus. Review of the toxicity and flammability of white phosphorus make this improbable. It is suggested that Conan Doyle's descripti...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 历史文章,杂志文章

    doi:10.1080/15569520801900604

    authors: Dayan AD

    更新日期:2008-01-01 00:00:00

  • A paired comparison between human skin and hairless guinea pig skin in vitro permeability and lag time measurements for 6 industrial chemicals.

    abstract::The purpose of the present study was to measure and compare permeability coefficients (k(p)) and lag times (tau) in human skin and hairless guinea pig (HGP) skin. Paired experiments employed heat-separated epidermal membranes from human and HGP sources mounted on static in vitro diffusion cells. Infinite-dose, saturat...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569520902950474

    authors: Frasch HF,Barbero AM

    更新日期:2009-01-01 00:00:00

  • Comment on efficacy and safety of propranolol in the treatment of parotid hemangioma.

    abstract::A brief comment on efficacy and safety of propranolol in the treatment of parotid hemangioma is presented, with illustration of a typical case. ...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 评论,信件

    doi:10.3109/15569527.2011.584928

    authors: Zheng JW

    更新日期:2011-12-01 00:00:00

  • Extrapolating local lymph node assay EC3 values to estimate relative sensitizing potency.

    abstract::The assessment of the potency of a skin sensitizing chemical is a key starting point for its subsequent risk assessment/management. The Local Lymph Node Assay can provide information on the relative skin sensitizing potency of contact allergens by interpolation from the dose response curve the concentration of a chemi...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569520701212258

    authors: Ryan CA,Chaney JG,Gerberick GF,Kern PS,Dearman RJ,Kimber I,Basketter DA

    更新日期:2007-01-01 00:00:00

  • Ciliary body toxicities of systemic oxcarbazepine and valproic acid treatments: electron microscopic study.

    abstract::Ciliary body is responsible for humour aqueous production in posterior chamber. Valproic acid (VPA) has been widely used for the treatment of epilepsy and other neuropsychiatric diseases such as bipolar disease and major depression. Oxcarbazepine (OXC) is a new anti-epileptic agent that has been used recently for chil...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2014.930748

    authors: Göktaş G,Aktaş Z,Erdoğan D,Seymen CM,Karaca EE,Cansu A,Serdaroğlu A,Kaplanoğlu GT

    更新日期:2015-01-01 00:00:00

  • Evaluation of the effect of erythropoietin + corticosteroid versus corticosteroid alone in methanol-induced optic nerve neuropathy.

    abstract:PURPOSE:Following methanol intoxication, optic nerve neuropathy may occur, which is currently treated by different therapeutic regimens. Erythropoietin (EPO) has recently been introduced as a good therapeutic option in methanol-induced optic neuropathy. The aim of the current study was to evaluate the efficacy of EPO i...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569527.2017.1373121

    authors: Zamani N,Hassanian-Moghaddam H,Shojaei M,Rahimian S

    更新日期:2018-06-01 00:00:00

  • Spider bite-induced erythema multiforme.

    abstract::Erythema multiforme (EM) is an immune-mediated mucocutaneous eruption characterized by symmetrically distributed, polymorphic targetoid lesions, mostly on the distal parts of the extremities. It occurs mostly in the setting of an infection in certain predisposed individuals. A 30-year-old pregnant woman was presented ...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2012.751392

    authors: Özyurt S,Er O,Afsar FS,Ermete M

    更新日期:2013-09-01 00:00:00

  • Part 2. Comparison of emergency washing solutions in 70% hydrofluoric acid-burned human skin in an established ex vivo explants model.

    abstract:BACKGROUND:Hydrofluoric acid (HF) is a small and partially dissociated acid (pK(a) 3.2), able to deeply penetrate into human skin in addition to the corrosiveness of the hydrogen ion (H(+)) and the toxicity of the fluoride ion (F(-)). However, there has been a lack of experimental studies to objectively characterize th...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2010.534748

    authors: Burgher F,Mathieu L,Lati E,Gasser P,Peno-Mazzarino L,Blomet J,Hall AH,Maibach HI

    更新日期:2011-06-01 00:00:00

  • Ornidazole-induced fixed drug reaction on sole: case report and review of the literature.

    abstract:BACKGROUND:Fixed drug eruption (FDE) is a special variant of drug reaction seen on skin or mucous membrane, and typically recurs at the same location. Ornidazole-induced FDE cases have been reported extremely rare. CASE:The 48-year-old female patient was diagnosed for ornidazole-induced fixed drug reaction on the sole...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章,评审

    doi:10.1080/15569527.2016.1249796

    authors: Emre S,Ahsen H,Aktaş A

    更新日期:2017-09-01 00:00:00

  • Corneal perforation: another side effect of nicorandil.

    abstract:CONTEXT:Nicorandil is an antianginal drug used for 20 years in Japan and introduced in France in 1994. Since 1997, side effects such as mucocutaneous ulcerations have regularly been reported. OBJECTIVE:To describe the first case of a patient with a spontaneous corneal perforation associated with mucocutaneous ulcerati...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2013.812105

    authors: Campolmi N,Guy C,Cinotti E,Forest F,Gain P,Philippe-Zech C,Gauthier AS,Thuret G

    更新日期:2014-06-01 00:00:00

  • Toxic keratopathy due to abuse of topical anesthetic drugs.

    abstract:OBJECTIVE:To describe 8 cases of toxic keratopathy due to abuse of topical anesthetic drugs. METHODS:Clinical findings from patients with toxic keratopathy were investigated retrospectively. RESULTS:Two patients had toxic keratopathy bilaterally. Five of 8 patients had an ocular history of a corneal foreign body, 1 h...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569521003631752

    authors: Yeniad B,Canturk S,Esin Ozdemir F,Alparslan N,Akarcay K

    更新日期:2010-06-01 00:00:00

  • Long-term intraocular pressure changes after intravitreal injection of bevacizumab.

    abstract:PURPOSE:To assess the long-term intraocular pressure (IOP) changes after the intravitreal injection of bevacizumab (Avastin; Genentech, Inc., South San Francisco, CA) for treatment of age-related macular degeneration (AMD) and diabetic macular edema (DME) patients and evaluate the correlation factors. MATERIAL AND MET...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 临床试验,杂志文章

    doi:10.3109/15569527.2015.1124886

    authors: Baek SU,Park IW,Suh W

    更新日期:2016-12-01 00:00:00

  • Two synchronous periungual BCC treated with Mohs surgery. Nail polish related?

    abstract::Basal cell carcinoma (BCC), the most frequent malignant skin tumor observed in Caucasian adults, especially males, occurs mainly in sun-exposed areas of the body. BCC in the periungual tissues, such as proximal nail fold, nail matrix, nail bed and hyponychium, is rarely reported. We report a patient with two synchrono...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2012.708956

    authors: Dika E,Patrizi A,Fanti PA,Alessandrini A,Sorci R,Piraccini BM,Vaccari S,Misciali C,Maibach HI

    更新日期:2013-06-01 00:00:00

  • Comparison of the ocular surface changes following the use of two different prostaglandin F2α analogues containing benzalkonium chloride or polyquad in rabbit eyes.

    abstract:OBJECTIVE:The aim of this study is to compare the effect of prostaglandin analogues preserved with either 0.015% or 0.001% benzalkoium chloride (BAK); or 0.001% polyquad (PQ) on the ocular surface of rabbit eyes. METHODS:Forty white rabbits were randomized to receive four-times daily instillation of either 0.0015% taf...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2014.944650

    authors: Lee HJ,Jun RM,Cho MS,Choi KR

    更新日期:2015-01-01 00:00:00