Topical absorption and systemic toxicity.

Abstract:

:Dermal absorption of some chemicals and drugs can cause systemic toxicity. We evaluated several case reports from the past decade, which discuss the dermal absorption of a specific chemical and potential local and systemic effects. We focused on herbicide and pesticide exposure along with exposure to cutaneous medication, occupational contact, and cosmeceutical exposure. Although causality cannot be established in most cases, it is critical to be aware of the possible effects of topical absorption that may not be immediately apparent. We recommended further studies on specific chemicals to ascertain causality and determine the highest exposure level with no observed adverse affect level (NOAEL) and the reference dose (RfD). Post-marketing epidemiology data in most geographical areas are markedly limited. A weak link in public health resides in the inadequate reporting and workup of alleged chemically related adverse effects. This arena mandates a re-thinking of how to increase this reporting, and workup, as a backup to our preclinical and clinical studies. Public awareness and funding will be rewarded by increased evidence to backup pre-approval pre-marketing studies.

journal_name

Cutan Ocul Toxicol

authors

Alikhan FS,Maibach H

doi

10.3109/15569527.2011.560914

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

175-86

issue

3

eissn

1556-9527

issn

1556-9535

journal_volume

30

pub_type

杂志文章,评审
  • The effect of systemic isotretinoin on male fertility.

    abstract:BACKGROUND/OBJECTIVE:Acne vulgaris is one of the most common diseases of the youth. Systemic isotretinoin is the only drug which acts on all of the etiopathogenic mechanisms of acne. Isotretinoin has some well-known side effects. Besides these, there is a suspicion whether it causes infertility or not. In this study, w...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 临床试验,杂志文章

    doi:10.3109/15569527.2015.1119839

    authors: Çinar L,Kartal D,Ergin C,Aksoy H,Karadag MA,Aydin T,Cinar E,Borlu M

    更新日期:2016-12-01 00:00:00

  • Impaired skin barrier function caused by reactive oxygen species in mice with colonic tumours.

    abstract::Purpose: We have previously reported that skin barrier function is disrupted in mice with colonic tumours induced by azoxymethane (AOM) and dextran sodium sulphate (DSS). We postulated that the impaired skin barrier function was associated with reactive oxygen species derived from gp91phox. In this study, we investiga...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569527.2019.1622559

    authors: Yokoyama S,Hiramoto K,Yamate Y

    更新日期:2019-12-01 00:00:00

  • Warfarin affects acute inflammatory response induced by subcutaneous polyvinyl sponge implantation in rats.

    abstract:PURPOSE:Warfarin (WF) is an anticoagulant which also affects physiological processes other than hemostasis. Our previous investigations showed the effect of WF which gained access to the organism via skin on resting peripheral blood granulocytes. Based on these data, the aim of the present study was to examine whether ...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569527.2016.1275664

    authors: Mirkov I,Popov Aleksandrov A,Demenesku J,Ninkov M,Mileusnic D,Kataranovski D,Kataranovski M

    更新日期:2017-09-01 00:00:00

  • Evaluation of the effect of energy drink consumption on retina and choroid: an optical coherence tomography and optical coherence tomography angiography study.

    abstract:PURPOSE:Evaluation of retinal and choroidal changes after energy drink consumption by optical coherence tomography and optical coherence tomography angiography. METHODS AND MATERIAL:Forty-two healthy volunteers with neither systemic nor ocular diseases were enrolled in the study. The energy drink (250 mL Red Bull ener...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569527.2020.1755977

    authors: Doğan M,Sabaner MC,Akar AT,Şenel M,Kaşikçi İ,Günal EŞ,Özbay AE,Şarman T,Gobeka HH,Cam Ö

    更新日期:2020-12-01 00:00:00

  • Efficacy studies of Reactive Skin Decontamination Lotion, M291 Skin Decontamination Kit, 0.5% bleach, 1% soapy water, and Skin Exposure Reduction Paste Against Chemical Warfare Agents, part 2: guinea pigs challenged with soman.

    abstract:OBJECTIVE:This report, the second in a series of five, directly compares the efficacy of Reactive Skin Decontamination Lotion (RSDL), the M291 Skin Decontamination Kit (SDK), 0.5% bleach (sodium or calcium hypochlorite solution), 1% soapy water, and Skin Exposure Reduction Paste Against Chemical Warfare Agents (SERPACW...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2010.515281

    authors: Braue EH Jr,Smith KH,Doxzon BF,Lumpkin HL,Clarkson ED

    更新日期:2011-03-01 00:00:00

  • Effects of selective serotonin reuptake inhibitors on intraocular pressure and anterior segment parameters in open angle eyes.

    abstract:PURPOSE:To evaluate the short- and long-term effects of selective serotonin reuptake inhibitors (SSRIs) on intraocular pressure (IOP) and anterior segment parameters in open angle eyes. MATERIALS AND METHODS:This cross-sectional study included 325 eyes of 166 subjects. Subjects were divided into three groups: Group 1 ...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569527.2017.1330270

    authors: Gündüz GU,Parmak Yener N,Kılınçel O,Gündüz C

    更新日期:2018-03-01 00:00:00

  • Human skin buffering capacity against a reference base sodium hydroxide: in vitro model.

    abstract::This study assesses the possibility of using an in vitro model as an introduction to clinical human models for evaluating the buffering capacity of skin when an irritant is topically applied. Sodium hydroxide (NaOH) was utilized as a model base with a view to elucidate information on preventing and/or treating base-in...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569520802326718

    authors: Ayer J,Maibach HI

    更新日期:2008-01-01 00:00:00

  • Toxicity assessment of six titanium dioxide nanoparticles in human epidermal keratinocytes.

    abstract:PURPOSE:The aim of this study was to evaluate and compare the toxicity of six different types of titanium dioxide (TiO2) nanoparticles (NP) on human epidermal keratinocytes (HEK). MATERIALS AND METHODS:Six TiO2 NP (A (10 nm), A*(32 nm), B (27.5 nm), C (200 nm), C*(30-40 nm), and D*(200-400 nm)) were suspended in water...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569527.2018.1527848

    authors: Zhang LW,Monteiro-Riviere NA

    更新日期:2019-03-01 00:00:00

  • Guinea pig maximization test assessment of hydrocortisone and tixocortol pivalate.

    abstract::The anti-inflammatory properties of topical corticosteroids are well documented; additionally, their sensitization potential is also known. We aimed to assess the relative sensitization potential of hydrocortisone and tixocortol pivalate in an animal assay as it relates to potential for sensitization in humans. Using ...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569520701662775

    authors: Mirshahpanah P,Maibach HI

    更新日期:2007-01-01 00:00:00

  • The vulva is relatively insensitive to menses-induced irritation.

    abstract::Skin patch testing of menses and venous blood on the vulva (labia majora) and the upper arm was performed to assess the potential contribution of these biological fluids to vulvar irritation during menstruation. After 24 and 48 hours of occlusive exposure, the skin of the labia majora was relatively unaffected by thes...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569520500371735

    authors: Farage M,Warren R,Wang-Weigand S

    更新日期:2005-01-01 00:00:00

  • Bullous hemorrhagic dermatosis induced by enoxaparin.

    abstract::The bullous hemorrhagic dermatosis induced by enoxaparin is a rare adverse reaction, which may be under-reported given its favorable evolution. We report a 71-year-old man who developed hemorrhagic bullae at sites distant from subcutaneous enoxaparin injections. It is important that clinicians be aware of the differen...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2015.1041033

    authors: Gouveia AI,Lopes L,Soares-Almeida L,Filipe P

    更新日期:2016-01-01 00:00:00

  • The role of CD4+ T cells in the induction of contact hypersensitivity to mercury in a murine model.

    abstract:BACKGROUND:The exact immunopathogenesis of contact hypersensitivity (CH) to mercury remains unclear. OBJECTIVE:The aim of the present study was to assess the role of CD4+ T cells in mercury-induced CH in mice. METHODS:Splenic CD4+ T cells obtained from nonsensitized and mercury-sensitized Balb/c mice were adoptively ...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569520903496746

    authors: Sumiwi YA,Soesatyo MH,Sosroseno W

    更新日期:2010-03-01 00:00:00

  • A dynamic system for delivering controlled bromine and chlorine vapor exposures to weanling swine skin.

    abstract:CONTEXT:Assessing the hazards of accidental exposure to toxic industrial chemical (TIC) vapors and evaluating therapeutic compounds or treatment regimens require the development of appropriate animal models. OBJECTIVE:The objective of this project was to develop an exposure system for delivering controlled vapor conce...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2013.806524

    authors: Snider TH,Perry MR,Richter WR,Plahovinsak JL,Rogers J,Reid FM,Graham JS

    更新日期:2014-06-01 00:00:00

  • Toxic anterior segment syndrome presenting as isolated cystoid macular edema after removal of entrapped ophthalmic ointment.

    abstract::We report a case of ophthalmic antibiotic ointment in the anterior chamber following uneventful phacoemulsification surgery. Antibiotic ointment was observed in the superior angle beneath the clear corneal wound one month later. The patient remained asymptomatic for 26 months after surgery until mild iritis developed....

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2010.485285

    authors: Ugurbas SC,Akova YA

    更新日期:2010-09-01 00:00:00

  • Ornidazole-induced fixed drug reaction on sole: case report and review of the literature.

    abstract:BACKGROUND:Fixed drug eruption (FDE) is a special variant of drug reaction seen on skin or mucous membrane, and typically recurs at the same location. Ornidazole-induced FDE cases have been reported extremely rare. CASE:The 48-year-old female patient was diagnosed for ornidazole-induced fixed drug reaction on the sole...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章,评审

    doi:10.1080/15569527.2016.1249796

    authors: Emre S,Ahsen H,Aktaş A

    更新日期:2017-09-01 00:00:00

  • Evaluation of the effect of erythropoietin + corticosteroid versus corticosteroid alone in methanol-induced optic nerve neuropathy.

    abstract:PURPOSE:Following methanol intoxication, optic nerve neuropathy may occur, which is currently treated by different therapeutic regimens. Erythropoietin (EPO) has recently been introduced as a good therapeutic option in methanol-induced optic neuropathy. The aim of the current study was to evaluate the efficacy of EPO i...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569527.2017.1373121

    authors: Zamani N,Hassanian-Moghaddam H,Shojaei M,Rahimian S

    更新日期:2018-06-01 00:00:00

  • Evaluation of thiol/disulfide homeostasis in patients with pityriasis rosea.

    abstract::Purpose: Pityriasis rosea (PR) is a common, self-limiting, inflammatory skin disease with an acute onset. The etiology of PR is not yet clearly known but the defect in the oxidation system involved in many papulosquamous skin diseases may play a role. Thiol/disulfide homeostasis is a new marker of oxidative stress and...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569527.2019.1616748

    authors: Yüksel M,Ülfer G

    更新日期:2019-12-01 00:00:00

  • Evaluation of the tear and serum levels of IL-8 in sulfur mustard intoxicated patients 20 years after exposure.

    abstract:PURPOSE:Delayed keratitis is the most dangerous ocular complication of sulfur mustard (SM) exposure. This study aimed to evaluate the role of tear and serum levels of interleukin-8 (IL-8) in SM exposed subjects. DESIGN AND METHODS:In this historical cohort study, the experimental group included 370 participants who ha...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2011.618940

    authors: Ghasemi H,Ghazanfari T,Yaraee R,Pourfarzam S,Soroush MR,Faghihzadeh S,Babaei M,Naghizadeh MM,Mohammad Hassan Z

    更新日期:2012-06-01 00:00:00

  • Comparing the ocular surface effects of topical vancomycin and linezolid for treating bacterial keratitis.

    abstract:BACKGROUND:Vancomycin is the gold standard in combination therapy for severe and resistant gram-positive keratitis and in particular for Methicillin-resistant Staphylococcus aureus (MRSA) infections. The aim of this study was to report the ocular surface toxicity and scoring in patients whose treatment shifted to topic...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2015.1058273

    authors: Akova Budak B,Baykara M,Kıvanç SA,Yilmaz H,Cicek S

    更新日期:2016-01-01 00:00:00

  • A case of septal panniculitis secondary to interferon treatment.

    abstract::The most common side effects of interferon-beta therapy following subcutaneous administration include pain, inflammation and induration at the injection site, which occur in approximately 20-60% of patients. Besides, transient injection-site erythema is frequently seen in beta-interferon therapy. Less frequent reactio...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2013.875560

    authors: Ozuguz P,Kacar SD,Karaca S,Tokyol C

    更新日期:2014-12-01 00:00:00

  • Development of phytophotodermatitis in two cases related to Plantago lanceolata.

    abstract::Plantago lanceolata, also known as snake's tongue, is a perennial herbaceous plant from the family Plantaginaceae. It is a species widely distributed both in Turkey and all over the world. Today, its fresh leaves are still used to soothe and suppress cough, externally for wound healing and draining abscesses. Phytopho...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2011.584232

    authors: Ozkol HU,Akdeniz N,Ozkol H,Bilgili SG,Calka O

    更新日期:2012-03-01 00:00:00

  • Epileptic seizures induced by cycloplegic eye drops.

    abstract:OBJECTIVE:To assess the incidence of seizures induced by cycloplegic ophthalmic drops. MATERIALS AND METHODS:A survey among members of the American Association for Pediatric Ophthalmology and Strabismus yielded five patients who received cycloplegic eye drops between 1998 and 2010 and who consequently developed a seiz...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2013.808654

    authors: Wygnanski-Jaffe T,Nucci P,Goldchmit M,Mezer E

    更新日期:2014-06-01 00:00:00

  • EMPACT syndrome.

    abstract::Phenytoin is commonly used an antiepileptic medication for seizure prophylaxis in patients with brain metastases. In these oncology patients group, phenytoin-induced severe adverse reactions may occur. Antiepileptic, particularly phenytoin-induced severe skin reactions including Stevens-Johnson syndrome (SJS) and bull...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2011.588298

    authors: Bilgili SG,Calka O,Karadag AS,Burakgazi AZ

    更新日期:2011-12-01 00:00:00

  • Extracts of different pollen species and their effect on human tear fluid and an epithelial cell line.

    abstract:PURPOSE:Hazelnut and birch pollen are known to destroy tear film components and attack ocular surface cells. We investigated further pollen species from different plant families, whether they show similar effects on human tear fluid and an epithelial cell line in vitro, to provide a broad basis for further research on ...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569527.2018.1530259

    authors: Rabensteiner DF,Rabensteiner J,Horwath-Winter J,Lang-Loidolt D,Wedrich A,Heidinger A,Schwantzer G,Schmut O

    更新日期:2019-03-01 00:00:00

  • High-resolution optical coherence tomography correlates in ischemic radiation retinopathy.

    abstract:PURPOSE:To find the abnormalities in various retinal layers caused by radiation retinopathy using spectral domain optical coherence tomography (SD-OCT). METHODS:We report a case of radiation retinopathy that was imaged using SD-OCT Copernicus (Optopol, Zawiercie, Poland). Analysis and synthesis of the OCT image were d...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569520903331674

    authors: Raman R,Pal SS,Krishnan T,Laxmi G,Radke N,Sharma T

    更新日期:2010-03-01 00:00:00

  • Drug-induced psoriasis: an evidence-based overview and the introduction of psoriatic drug eruption probability score.

    abstract::Psoriasis is a common skin disorder that needs a long-term management, not only because, of its prevalence but also because of the profound impact it can have on patients quality of life. Drugs may result in exacerbation of a preexisting psoriasis, in induction of psoriatic lesions on clinically uninvolved skin in pat...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章,评审

    doi:10.1080/15569520500536568

    authors: Dika E,Varotti C,Bardazzi F,Maibach HI

    更新日期:2006-01-01 00:00:00

  • Encapsulating contact allergens in liposomes, ethosomes, and polycaprolactone may affect their sensitizing properties.

    abstract::Attempts to improve formulation of topical products are a continuing process and the development of micro- and nanovesicular systems as well as polymeric microparticles has led to marketing of topical drugs and cosmetics using these technologies. Encapsulation of some well-known contact allergens in ethanolic liposome...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2010.540765

    authors: Madsen JT,Vogel S,Johansen JD,Andersen KE

    更新日期:2011-06-01 00:00:00

  • Poststeroid panniculitis: a rare complication of systemic corticosteroid therapy.

    abstract::We report a 9-month-old male patient with autoimmune enteropathy treated with intravenous methylprednisolone who developed firm, red, subcutaneous nodules 20 days after abrupt steroid interruption. The diagnosis of poststeroid panniculitis (PSP) was made based on clinical and histological grounds. PSP is an unusual co...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2011.623290

    authors: Peralta L,Morais P,Trindade E,Barreto F,Canelhas Á,Amil J

    更新日期:2012-06-01 00:00:00

  • Effectiveness of heparin eye drops in paraquat-induced ocular injury.

    abstract:PURPOSE:To evaluate the efficacy of heparin eye drops in the treatment of paraquat-induced ocular surface injury. DESIGN AND METHODS:In this retrospective study, we included 25 patients (31 eyes) with paraquat-induced ocular surface injury, who attended the Affiliated Hospital of Weifang Medical University between Oct...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569527.2017.1303706

    authors: Jian-Wei L,Xiu-Yun L,Ai-Jun D

    更新日期:2017-12-01 00:00:00

  • Erlotinib-induced trichomegaly in a male patient with pancreatic cancer.

    abstract::In this report we present a case of erlotinib-induced trichomegaly in a male patient who received erlotinib for his pancreatic cancer. Trichomegaly as a side effect of epidermal growth factor receptor (EGFR) inhibitor therapy is uncommon in male patients. Also, it has not been reported previously in a patient with pan...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569520903440058

    authors: Saif MW,Gnanaraj J

    更新日期:2010-03-01 00:00:00