A paired comparison between human skin and hairless guinea pig skin in vitro permeability and lag time measurements for 6 industrial chemicals.

abstract：:The Organisation for Economic Co-operation and Development (OECD) Test Guideline 429 for the local lymph node assay (LLNA) indicates a minimum of 4 mice per dose group, or of 5 mice if statistics are required. Recent discussions at the Interagency Coordinating Committee for the Validation of Alternative Methods (ICCVA...

journal_title：Cutaneous and ocular toxicology

authors： Basketter DA,Dearman RJ,Kimber I,Gerberick GF,Ryan CA

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:To evaluate the effects of the topical application of nondiluted autologous serum on epithelial healing as an adjuvant therapy in rabbit corneal alkali wounds. METHODS:Central corneal alkali wounds were produced on the right eye of 16 rabbits, by a 60-second application of a 6-mm round filter paper soaked in 1...

journal_title：Cutaneous and ocular toxicology

authors： Salman IA,Gündoğdu C

更新日期：2010-06-01 00:00:00

abstract：:Plantago lanceolata, also known as snake's tongue, is a perennial herbaceous plant from the family Plantaginaceae. It is a species widely distributed both in Turkey and all over the world. Today, its fresh leaves are still used to soothe and suppress cough, externally for wound healing and draining abscesses. Phytopho...

journal_title：Cutaneous and ocular toxicology

authors： Ozkol HU,Akdeniz N,Ozkol H,Bilgili SG,Calka O

更新日期：2012-03-01 00:00:00

abstract：:The anti-inflammatory properties of topical corticosteroids are well documented; additionally, their sensitization potential is also known. We aimed to assess the relative sensitization potential of hydrocortisone and tixocortol pivalate in an animal assay as it relates to potential for sensitization in humans. Using ...

journal_title：Cutaneous and ocular toxicology

authors： Mirshahpanah P,Maibach HI

更新日期：2007-01-01 00:00:00

abstract：:Erlotinib is a tyrosine kinase inhibitor of the epidermal growth factor receptor. Since there is a wide expression of the epidermal growth factor receptors in the epithelial tissues of ocular surface and adnexa, ocular adverse reactions may happen during systemic administration of erlotinib. Previously reported ocular...

journal_title：Cutaneous and ocular toxicology

authors： Kau HC,Tsai CC

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of heparin eye drops in the treatment of paraquat-induced ocular surface injury. DESIGN AND METHODS:In this retrospective study, we included 25 patients (31 eyes) with paraquat-induced ocular surface injury, who attended the Affiliated Hospital of Weifang Medical University between Oct...

journal_title：Cutaneous and ocular toxicology

authors： Jian-Wei L,Xiu-Yun L,Ai-Jun D

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:To describe 8 cases of toxic keratopathy due to abuse of topical anesthetic drugs. METHODS:Clinical findings from patients with toxic keratopathy were investigated retrospectively. RESULTS:Two patients had toxic keratopathy bilaterally. Five of 8 patients had an ocular history of a corneal foreign body, 1 h...

journal_title：Cutaneous and ocular toxicology

authors： Yeniad B,Canturk S,Esin Ozdemir F,Alparslan N,Akarcay K

更新日期：2010-06-01 00:00:00

abstract：:Skin patch testing of menses and venous blood on the vulva (labia majora) and the upper arm was performed to assess the potential contribution of these biological fluids to vulvar irritation during menstruation. After 24 and 48 hours of occlusive exposure, the skin of the labia majora was relatively unaffected by thes...

journal_title：Cutaneous and ocular toxicology

authors： Farage M,Warren R,Wang-Weigand S

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to compare the effect of prostaglandin analogues preserved with either 0.015% or 0.001% benzalkoium chloride (BAK); or 0.001% polyquad (PQ) on the ocular surface of rabbit eyes. METHODS:Forty white rabbits were randomized to receive four-times daily instillation of either 0.0015% taf...

journal_title：Cutaneous and ocular toxicology

authors： Lee HJ,Jun RM,Cho MS,Choi KR

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To evaluate the effect of anti-tubercular treatment on retinal nerve fiber layer (RNFL) thickness and the efficiency of optic coherence tomography (OCT) on early diagnosis of optic neuropathy. METHODS:Twenty patients diagnosed with either pulmonary or extra-pulmonary tuberculosis which were treated with anti-t...

journal_title：Cutaneous and ocular toxicology

authors： Gümüş A,Öner V

更新日期：2015-01-01 00:00:00

abstract：CONTEXT:The acute effects of cigarette smoking on pupil size and ocular wavefront aberrations (OWA) have been previously documented. The accommodation status of the eye is well known to be related to ocular aberrations. No previous study has evaluated the impact of cigarette smoking on the accommodation status of the e...

journal_title：Cutaneous and ocular toxicology

authors： Bardak H,Gunay M,Bardak Y,Ercalik Y,Imamoglu S,Yildiz E,Gunay BO

更新日期：2017-03-01 00:00:00

abstract：:Rapid decontamination is vital to alleviate adverse health effects following dermal exposure to hazardous materials. There is an abundance of materials and products which can be utilised to remove hazardous materials from the skin. In this study, a total of 15 products were evaluated, 10 of which were commercial or mi...

journal_title：Cutaneous and ocular toxicology

authors： Matar H,Guerreiro A,Piletsky SA,Price SC,Chilcott RP

更新日期：2016-01-01 00:00:00

abstract：:The most common side effects of interferon-beta therapy following subcutaneous administration include pain, inflammation and induration at the injection site, which occur in approximately 20-60% of patients. Besides, transient injection-site erythema is frequently seen in beta-interferon therapy. Less frequent reactio...

journal_title：Cutaneous and ocular toxicology

authors： Ozuguz P,Kacar SD,Karaca S,Tokyol C

更新日期：2014-12-01 00:00:00

abstract：CONTEXT:Nicorandil is an antianginal drug used for 20 years in Japan and introduced in France in 1994. Since 1997, side effects such as mucocutaneous ulcerations have regularly been reported. OBJECTIVE:To describe the first case of a patient with a spontaneous corneal perforation associated with mucocutaneous ulcerati...

journal_title：Cutaneous and ocular toxicology

authors： Campolmi N,Guy C,Cinotti E,Forest F,Gain P,Philippe-Zech C,Gauthier AS,Thuret G

更新日期：2014-06-01 00:00:00

abstract：:The assessment of the potency of a skin sensitizing chemical is a key starting point for its subsequent risk assessment/management. The Local Lymph Node Assay can provide information on the relative skin sensitizing potency of contact allergens by interpolation from the dose response curve the concentration of a chemi...

journal_title：Cutaneous and ocular toxicology

authors： Ryan CA,Chaney JG,Gerberick GF,Kern PS,Dearman RJ,Kimber I,Basketter DA

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:To find the abnormalities in various retinal layers caused by radiation retinopathy using spectral domain optical coherence tomography (SD-OCT). METHODS:We report a case of radiation retinopathy that was imaged using SD-OCT Copernicus (Optopol, Zawiercie, Poland). Analysis and synthesis of the OCT image were d...

journal_title：Cutaneous and ocular toxicology

authors： Raman R,Pal SS,Krishnan T,Laxmi G,Radke N,Sharma T

更新日期：2010-03-01 00:00:00

abstract：:A snakebite is a serious and important problem in tropical and subtropical cities. A vast majority of snakebites are nonvenomous. However, venomous snakebites may cause local tissue destruction, neuroparalysis, systemic hemorrhage, generalized myotoxicity, and acute renal failure. A 10-year-old boy was brought to the ...

journal_title：Cutaneous and ocular toxicology

authors： Ozkol HU,Karadag AS,Bilgili SG,Calka O

更新日期：2011-12-01 00:00:00

abstract：:Pustular irritant contact dermatitis is rare and unusual clinic form of contact dermatitis. Dexpanthenol is the stable alcoholic analogue of pantothenic acid. It is widely used in cosmetics and topical medical products for several purposes. We present the case of 8-year-old girl with pustules over erythematous and ecz...

journal_title：Cutaneous and ocular toxicology

authors： Gulec AI,Albayrak H,Uslu E,Başkan E,Aliagaoglu C

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:Following methanol intoxication, optic nerve neuropathy may occur, which is currently treated by different therapeutic regimens. Erythropoietin (EPO) has recently been introduced as a good therapeutic option in methanol-induced optic neuropathy. The aim of the current study was to evaluate the efficacy of EPO i...

journal_title：Cutaneous and ocular toxicology

authors： Zamani N,Hassanian-Moghaddam H,Shojaei M,Rahimian S

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Systemic isotretinoin (13-cis-retinoic acid) is effective in the treatment of acne vulgaris. The most common side effects are mucocutaneous ones. Hematuria seen secondary to isotretinoin treatment is thought to be due to mucosal dryness in the urinary system. This study aims to determine the frequency of hem...

journal_title：Cutaneous and ocular toxicology

authors： Yesilkaya B,Alli N,Artuz RF,Ulu E,Kartal D,Cinar SL

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The present cross-sectional study has the purpose to investigate the impact of aromatase inhibitors (AIs) on retinal nerve fiber layer (RNFL) thickness, optic nerve and macular function in patients using AIs for breast cancer treatment. METHODS:Participants in our study were 41 hormone-receptor-positive ear...

journal_title：Cutaneous and ocular toxicology

authors： Moschos MM,Chatziralli IP,Sergentanis T,Zagouri F,Chrysikos D,Ladas I,Zografos G

更新日期：2016-03-01 00:00:00

abstract：:The authors provide a framework for working up and counseling a patient with suspected textile dermatitis, focusing on identifying which textile materials are most likely to be the cause of the eczematous lesions, the current clinical guidelines, the utility and appropriateness of patch testing, the limitations of the...

journal_title：Cutaneous and ocular toxicology

authors： Coman G,Blickenstaff N,Edwards A,Maibach H

更新日期：2015-03-01 00:00:00

abstract：:Background: Papulopustular rash is the most common cutaneous adverse effect during targeted tumour therapy particularly with epidermal growth factor receptor inhibitors (EGFRIs). Objective: To evaluate the adverse skin reactions, mainly papulopustular rash, caused by targeted tumour therapy. Materials and methods: We ...

journal_title：Cutaneous and ocular toxicology

authors： Yalici-Armagan B,Ayanoglu BT,Demirdag HG

更新日期：2019-09-01 00:00:00

abstract：:We report a case of ophthalmic antibiotic ointment in the anterior chamber following uneventful phacoemulsification surgery. Antibiotic ointment was observed in the superior angle beneath the clear corneal wound one month later. The patient remained asymptomatic for 26 months after surgery until mild iritis developed....

journal_title：Cutaneous and ocular toxicology

authors： Ugurbas SC,Akova YA

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to examine the effects of long-term use of hydroxychloroquine (HQ) on the pachymetric, aberrometric, and densitometric values of the cornea and corneal endothelium in lupus patients. METHOD:Twenty-two eyes (study group) of 22 patients using HQ for treatment of lupus and 25 eyes (contr...

journal_title：Cutaneous and ocular toxicology

authors： Çağlayan M,Akyol L,Balcı MA,Öncül H,Alakuş MF,Dağ U

更新日期：2020-12-23 00:00:00

abstract：:Phenytoin is commonly used an antiepileptic medication for seizure prophylaxis in patients with brain metastases. In these oncology patients group, phenytoin-induced severe adverse reactions may occur. Antiepileptic, particularly phenytoin-induced severe skin reactions including Stevens-Johnson syndrome (SJS) and bull...

journal_title：Cutaneous and ocular toxicology

authors： Bilgili SG,Calka O,Karadag AS,Burakgazi AZ

更新日期：2011-12-01 00:00:00

abstract：:Attempts to improve formulation of topical products are a continuing process and the development of micro- and nanovesicular systems as well as polymeric microparticles has led to marketing of topical drugs and cosmetics using these technologies. Encapsulation of some well-known contact allergens in ethanolic liposome...

journal_title：Cutaneous and ocular toxicology

authors： Madsen JT,Vogel S,Johansen JD,Andersen KE

更新日期：2011-06-01 00:00:00

abstract：:The skin is a major exposure route for many potentially toxic chemicals. It is, therefore, important to be able to predict the permeability of compounds through skin under a variety of conditions. Available skin permeability databases are often limited in scope and not conducive to developing effective models. This sp...

journal_title：Cutaneous and ocular toxicology

authors： Keshwani DR,Jones DD,Brand RM

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Hazelnut and birch pollen are known to destroy tear film components and attack ocular surface cells. We investigated further pollen species from different plant families, whether they show similar effects on human tear fluid and an epithelial cell line in vitro, to provide a broad basis for further research on ...

journal_title：Cutaneous and ocular toxicology

authors： Rabensteiner DF,Rabensteiner J,Horwath-Winter J,Lang-Loidolt D,Wedrich A,Heidinger A,Schwantzer G,Schmut O

更新日期：2019-03-01 00:00:00

abstract：:Purpose: To investigate the efficacy and safety of intravitreal dexamethasone implant as initial and only treatment for macular oedema after pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD).Methods: This study included 14 patients, who were diagnosed with macular oedema after PPV for RRD and who...

journal_title：Cutaneous and ocular toxicology

authors： Chatziralli I,Dimitriou E,Theodossiadis G,Kazantzis D,Alonistiotis D,Theodossiadis P

更新日期：2020-03-01 00:00:00