EMPACT syndrome.

Abstract:

:Phenytoin is commonly used an antiepileptic medication for seizure prophylaxis in patients with brain metastases. In these oncology patients group, phenytoin-induced severe adverse reactions may occur. Antiepileptic, particularly phenytoin-induced severe skin reactions including Stevens-Johnson syndrome (SJS) and bullous form of erythema multiforme have been reported in the patients treated with cranial irradiation due to brain metastasis. The acronym EMPACT (Erythema Multiforme associated with Phenytoin And Cranial radiation Therapy) was recently described as a clinical entity. Herein, we report a 36-year-old female with breast carcinoma, who developed EMPACT syndrome after treating with cranial radiation therapy for brain metastasis and phenytoin for seizure prophylaxis.

journal_name

Cutan Ocul Toxicol

authors

Bilgili SG,Calka O,Karadag AS,Burakgazi AZ

doi

10.3109/15569527.2011.588298

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

328-30

issue

4

eissn

1556-9527

issn

1556-9535

journal_volume

30

pub_type

杂志文章
  • Follow up of retinal nerve fiber layer thickness with optic coherence tomography in patients receiving anti-tubercular treatment may reveal early optic neuropathy.

    abstract:PURPOSE:To evaluate the effect of anti-tubercular treatment on retinal nerve fiber layer (RNFL) thickness and the efficiency of optic coherence tomography (OCT) on early diagnosis of optic neuropathy. METHODS:Twenty patients diagnosed with either pulmonary or extra-pulmonary tuberculosis which were treated with anti-t...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2014.954715

    authors: Gümüş A,Öner V

    更新日期:2015-01-01 00:00:00

  • Pustular irritant contact dermatitis caused by dexpanthenol in a child.

    abstract::Pustular irritant contact dermatitis is rare and unusual clinic form of contact dermatitis. Dexpanthenol is the stable alcoholic analogue of pantothenic acid. It is widely used in cosmetics and topical medical products for several purposes. We present the case of 8-year-old girl with pustules over erythematous and ecz...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2014.883405

    authors: Gulec AI,Albayrak H,Uslu E,Başkan E,Aliagaoglu C

    更新日期:2015-03-01 00:00:00

  • Epithelial healing in experimental corneal alkali wounds with nondiluted autologous serum eye drops.

    abstract:PURPOSE:To evaluate the effects of the topical application of nondiluted autologous serum on epithelial healing as an adjuvant therapy in rabbit corneal alkali wounds. METHODS:Central corneal alkali wounds were produced on the right eye of 16 rabbits, by a 60-second application of a 6-mm round filter paper soaked in 1...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569521003709558

    authors: Salman IA,Gündoğdu C

    更新日期:2010-06-01 00:00:00

  • Comparative dermal toxicity of dicyclohexylcarbodiimide and diisopropylcarbodiimide in rodents.

    abstract::Dicyclohexylcarbodiimide (DCC) and Diisopropylcarbodiimide (DIC) are two representative chemicals in the carbodiimide class of chemicals used in industry as stabilizing agents. There is a potential of dermal exposure to these agents in chemical, pharmaceutical and recombinant DNA industries. The National Toxicology Pr...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2011.629384

    authors: Surh I,Behl M,Elmore SA,Chhabra RS

    更新日期:2012-09-01 00:00:00

  • The effect of systemic isotretinoin on male fertility.

    abstract:BACKGROUND/OBJECTIVE:Acne vulgaris is one of the most common diseases of the youth. Systemic isotretinoin is the only drug which acts on all of the etiopathogenic mechanisms of acne. Isotretinoin has some well-known side effects. Besides these, there is a suspicion whether it causes infertility or not. In this study, w...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 临床试验,杂志文章

    doi:10.3109/15569527.2015.1119839

    authors: Çinar L,Kartal D,Ergin C,Aksoy H,Karadag MA,Aydin T,Cinar E,Borlu M

    更新日期:2016-12-01 00:00:00

  • Targeted tumour therapy induced papulopustular rash and other dermatologic side effects: a retrospective study.

    abstract::Background: Papulopustular rash is the most common cutaneous adverse effect during targeted tumour therapy particularly with epidermal growth factor receptor inhibitors (EGFRIs). Objective: To evaluate the adverse skin reactions, mainly papulopustular rash, caused by targeted tumour therapy. Materials and methods: We ...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569527.2019.1594874

    authors: Yalici-Armagan B,Ayanoglu BT,Demirdag HG

    更新日期:2019-09-01 00:00:00

  • A case of septal panniculitis secondary to interferon treatment.

    abstract::The most common side effects of interferon-beta therapy following subcutaneous administration include pain, inflammation and induration at the injection site, which occur in approximately 20-60% of patients. Besides, transient injection-site erythema is frequently seen in beta-interferon therapy. Less frequent reactio...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2013.875560

    authors: Ozuguz P,Kacar SD,Karaca S,Tokyol C

    更新日期:2014-12-01 00:00:00

  • Cutaneous changes in patients with chronic renal failure on hemodialysis.

    abstract:CONTEXT:A number of skin diseases can be observed in chronic renal failure (CRF). Their incidence have changed in different series. OBJECTIVE:To compare the prevalence of cutaneous changes in CRF undergoing hemodialysis (HD) with healthy persons and to study the potential relationship with various parameters in the pa...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2012.657726

    authors: Onelmis H,Sener S,Sasmaz S,Ozer A

    更新日期:2012-12-01 00:00:00

  • A patient with snakebite presenting with thrombophlebitis-like appearance and DIC.

    abstract::A snakebite is a serious and important problem in tropical and subtropical cities. A vast majority of snakebites are nonvenomous. However, venomous snakebites may cause local tissue destruction, neuroparalysis, systemic hemorrhage, generalized myotoxicity, and acute renal failure. A 10-year-old boy was brought to the ...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2011.573832

    authors: Ozkol HU,Karadag AS,Bilgili SG,Calka O

    更新日期:2011-12-01 00:00:00

  • A dynamic system for delivering controlled bromine and chlorine vapor exposures to weanling swine skin.

    abstract:CONTEXT:Assessing the hazards of accidental exposure to toxic industrial chemical (TIC) vapors and evaluating therapeutic compounds or treatment regimens require the development of appropriate animal models. OBJECTIVE:The objective of this project was to develop an exposure system for delivering controlled vapor conce...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2013.806524

    authors: Snider TH,Perry MR,Richter WR,Plahovinsak JL,Rogers J,Reid FM,Graham JS

    更新日期:2014-06-01 00:00:00

  • Acute corneal toxicity of latanoprost with different preservatives.

    abstract:PURPOSE:To investigate the corneal toxicity of Xalatan and three latanoprost generics using transepithelial electrical resistance (TER) and scanning electron microscopy (SEM). METHODS:Corneal TER changes after a 60-s exposure to Xalatan (latanoprost 0.005% preserved with 0.02% BAC), and latanoprost generics (Latanopro...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2015.1058272

    authors: Uematsu M,Mohamed YH,Onizuka N,Ueki R,Inoue D,Fujikawa A,Sasaki H,Kitaoka T

    更新日期:2016-01-01 00:00:00

  • A paired comparison between human skin and hairless guinea pig skin in vitro permeability and lag time measurements for 6 industrial chemicals.

    abstract::The purpose of the present study was to measure and compare permeability coefficients (k(p)) and lag times (tau) in human skin and hairless guinea pig (HGP) skin. Paired experiments employed heat-separated epidermal membranes from human and HGP sources mounted on static in vitro diffusion cells. Infinite-dose, saturat...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569520902950474

    authors: Frasch HF,Barbero AM

    更新日期:2009-01-01 00:00:00

  • Efficacy studies of Reactive Skin Decontamination Lotion, M291 Skin Decontamination Kit, 0.5% bleach, 1% soapy water, and Skin Exposure Reduction Paste Against Chemical Warfare Agents, part 2: guinea pigs challenged with soman.

    abstract:OBJECTIVE:This report, the second in a series of five, directly compares the efficacy of Reactive Skin Decontamination Lotion (RSDL), the M291 Skin Decontamination Kit (SDK), 0.5% bleach (sodium or calcium hypochlorite solution), 1% soapy water, and Skin Exposure Reduction Paste Against Chemical Warfare Agents (SERPACW...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2010.515281

    authors: Braue EH Jr,Smith KH,Doxzon BF,Lumpkin HL,Clarkson ED

    更新日期:2011-03-01 00:00:00

  • Evaluation of corneal safety in systemic lupus erythematosus patients undergoing long-term hydroxychloroquine treatment.

    abstract:PURPOSE:The aim of this study was to examine the effects of long-term use of hydroxychloroquine (HQ) on the pachymetric, aberrometric, and densitometric values of the cornea and corneal endothelium in lupus patients. METHOD:Twenty-two eyes (study group) of 22 patients using HQ for treatment of lupus and 25 eyes (contr...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569527.2020.1861003

    authors: Çağlayan M,Akyol L,Balcı MA,Öncül H,Alakuş MF,Dağ U

    更新日期:2020-12-23 00:00:00

  • Bullous hemorrhagic dermatosis induced by enoxaparin.

    abstract::The bullous hemorrhagic dermatosis induced by enoxaparin is a rare adverse reaction, which may be under-reported given its favorable evolution. We report a 71-year-old man who developed hemorrhagic bullae at sites distant from subcutaneous enoxaparin injections. It is important that clinicians be aware of the differen...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2015.1041033

    authors: Gouveia AI,Lopes L,Soares-Almeida L,Filipe P

    更新日期:2016-01-01 00:00:00

  • Paederus dermatitis in Southeastern Anatolia, Turkey: a report of 57 cases.

    abstract:BACKGROUND:Paederus dermatitis (PD), which is an irritant contact dermatitis, is common throughout the world and caused by rove beetles. OBJECTIVES:To assess the clinical features of PD and the level of knowledge of patients from the city of Batman and surrounding areas who presented with the condition. METHODS:We de...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2013.834499

    authors: Turan E

    更新日期:2014-09-01 00:00:00

  • Drug-induced psoriasis: an evidence-based overview and the introduction of psoriatic drug eruption probability score.

    abstract::Psoriasis is a common skin disorder that needs a long-term management, not only because, of its prevalence but also because of the profound impact it can have on patients quality of life. Drugs may result in exacerbation of a preexisting psoriasis, in induction of psoriatic lesions on clinically uninvolved skin in pat...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章,评审

    doi:10.1080/15569520500536568

    authors: Dika E,Varotti C,Bardazzi F,Maibach HI

    更新日期:2006-01-01 00:00:00

  • An in vitro method for detecting chemical sensitization using human reconstructed skin models and its applicability to cosmetic, pharmaceutical, and medical device safety testing.

    abstract::Chemical sensitization is a serious condition caused by small reactive molecules and is characterized by a delayed type hypersensitivity known as allergic contact dermatitis (ACD). Contact with these molecules via dermal exposure represent a significant concern for chemical manufacturers. Recent legislation in the EU ...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2012.667031

    authors: McKim JM Jr,Keller DJ 3rd,Gorski JR

    更新日期:2012-12-01 00:00:00

  • Why minimally invasive skin sampling techniques? A bright scientific future.

    abstract:BACKGROUND:There is increasing interest in minimally invasive skin sampling techniques to assay markers of molecular biology and biochemical processes. OBJECTIVE:This overview examines methodology strengths and limitations, and exciting developments pending in the scientific community. MATERIALS AND METHODS:Publicati...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章,评审

    doi:10.3109/15569527.2010.517230

    authors: Wang CY,Maibach HI

    更新日期:2011-03-01 00:00:00

  • Epileptic seizures induced by cycloplegic eye drops.

    abstract:OBJECTIVE:To assess the incidence of seizures induced by cycloplegic ophthalmic drops. MATERIALS AND METHODS:A survey among members of the American Association for Pediatric Ophthalmology and Strabismus yielded five patients who received cycloplegic eye drops between 1998 and 2010 and who consequently developed a seiz...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2013.808654

    authors: Wygnanski-Jaffe T,Nucci P,Goldchmit M,Mezer E

    更新日期:2014-06-01 00:00:00

  • Encapsulating contact allergens in liposomes, ethosomes, and polycaprolactone may affect their sensitizing properties.

    abstract::Attempts to improve formulation of topical products are a continuing process and the development of micro- and nanovesicular systems as well as polymeric microparticles has led to marketing of topical drugs and cosmetics using these technologies. Encapsulation of some well-known contact allergens in ethanolic liposome...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2010.540765

    authors: Madsen JT,Vogel S,Johansen JD,Andersen KE

    更新日期:2011-06-01 00:00:00

  • Antioxidant effects of vitamin D on lacrimal glands against high dose radioiodine-associated damage in an animal model.

    abstract:PURPOSE:To evaluate antioxidant effects of active vitamin D (calcitriol) against high-dose radioiodine (RAI) therapy-associated damage of lacrimal gland. MATERIALS AND METHODS:Wistar albino rats were used and divided into three groups randomly (n = 12/group). The first group was appointed as the negative control group...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569527.2018.1498507

    authors: Eksioglu U,Atilgan HI,Yakin M,Yazihan N,Altiparmak UE,Yumusak N,Korkmaz M,Demir A,Ornek F,Aribal Ayral P,Koca G

    更新日期:2019-03-01 00:00:00

  • Lichenoid drug eruption induced by colchicine: case report.

    abstract::Lichenoid drug eruption (LDE) is a common cutaneous side effect of drugs including antimalarials, antihypertensives, nonsteroids, anti-inflammatory drugs and diuretics. The physiopathologic relationship between colchicine treatment and LDE is unclear. There is very little documentation of LDE induced by colchicine in ...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569527.2016.1206556

    authors: An I,Demir V,Akdeniz S

    更新日期:2017-06-01 00:00:00

  • Guinea pig maximization test assessment of hydrocortisone and tixocortol pivalate.

    abstract::The anti-inflammatory properties of topical corticosteroids are well documented; additionally, their sensitization potential is also known. We aimed to assess the relative sensitization potential of hydrocortisone and tixocortol pivalate in an animal assay as it relates to potential for sensitization in humans. Using ...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.1080/15569520701662775

    authors: Mirshahpanah P,Maibach HI

    更新日期:2007-01-01 00:00:00

  • The new therapy schema of the various kinds of acne based on the mucosa-skin side effects of the retinoids.

    abstract::The most common adverse effects of oral isotretinoin (>1/10) are: cheilitis, skin dryness, erythema, itching, scaling, bruising, skin atopy, conjunctivitis, dry eyes and eyelid inflammation. The aim of this work was to define an optimal dose regime of the oral isotretinoin allowing for effective reduction of sebum pro...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2011.633949

    authors: Bergler-Czop B,Brzezińska-Wcisło L

    更新日期:2012-09-01 00:00:00

  • Dermatotoxicologic clinical solutions: textile dye dermatitis patch testing.

    abstract::The authors provide a framework for working up and counseling a patient with suspected textile dermatitis, focusing on identifying which textile materials are most likely to be the cause of the eczematous lesions, the current clinical guidelines, the utility and appropriateness of patch testing, the limitations of the...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2014.883403

    authors: Coman G,Blickenstaff N,Edwards A,Maibach H

    更新日期:2015-03-01 00:00:00

  • Erlotinib-induced trichomegaly in a male patient with pancreatic cancer.

    abstract::In this report we present a case of erlotinib-induced trichomegaly in a male patient who received erlotinib for his pancreatic cancer. Trichomegaly as a side effect of epidermal growth factor receptor (EGFR) inhibitor therapy is uncommon in male patients. Also, it has not been reported previously in a patient with pan...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569520903440058

    authors: Saif MW,Gnanaraj J

    更新日期:2010-03-01 00:00:00

  • Hot dog? Toxicological concerns and The Hound of the Baskervilles.

    abstract::The terrifying dog in the Hound of the Baskervilles is described as having 'blazing eyes' and a 'luminous muzzle', appearances attributed by Watson and Holmes to the application of phosphorus. Review of the toxicity and flammability of white phosphorus make this improbable. It is suggested that Conan Doyle's descripti...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 历史文章,杂志文章

    doi:10.1080/15569520801900604

    authors: Dayan AD

    更新日期:2008-01-01 00:00:00

  • Effects of cigarette smoking on choroidal and retinal thickness and ocular pulse amplitude.

    abstract:BACKGROUND:In our study, we aimed to show the effects of smoking on choroidal thickness and ocular pulse amplitude. It is known that the anatomy and physiologic functions of the choroid is important in ocular diseases like glaucoma and age-related macular degeneration. Choroidal thickness is measured by the spectral do...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章

    doi:10.3109/15569527.2014.950380

    authors: Dervişoğulları MS,Totan Y,Tenlik A,Yuce A

    更新日期:2015-01-01 00:00:00

  • Topical absorption and systemic toxicity.

    abstract::Dermal absorption of some chemicals and drugs can cause systemic toxicity. We evaluated several case reports from the past decade, which discuss the dermal absorption of a specific chemical and potential local and systemic effects. We focused on herbicide and pesticide exposure along with exposure to cutaneous medicat...

    journal_title:Cutaneous and ocular toxicology

    pub_type: 杂志文章,评审

    doi:10.3109/15569527.2011.560914

    authors: Alikhan FS,Maibach H

    更新日期:2011-09-01 00:00:00