Abstract:
PURPOSE:The aim of this study was to examine the effects of long-term use of hydroxychloroquine (HQ) on the pachymetric, aberrometric, and densitometric values of the cornea and corneal endothelium in lupus patients. METHOD:Twenty-two eyes (study group) of 22 patients using HQ for treatment of lupus and 25 eyes (control group) of 25 healthy individuals were included in this prospective study. A specular microscopy was used to measure corneal endothelial cell density (ECD), percentage of hexagonal cells (HEX%), coefficient of variation of the cell size (CV). Then, a Pentacam® HR corneal tomography system was used to measure central corneal thickness (CCT), corneal aberrometry values in 6-mm pupil diameters and corneal densitometry values in 6-mm corneal zones (0-2 mm and 2-6 mm). RESULTS:While ECD was significantly lower in the study group than in the control group (p = 0.034), CCT was significantly higher in the study group (p = 0.032). The higher-order aberrations values and the anterior corneal densitometry values in the 0-2 mm and 2-6 mm corneal zones in the study group were found to be significantly higher than the control group (p = 0.021, p = 0.007 and p = 0.013). CONCLUSION:Prolonged use of HQ may cause some changes in the cornea. In the follow-up of these cases, detailed examination of the cornea as well as the macula may be important for the protection of corneal health.
journal_name
Cutan Ocul Toxicoljournal_title
Cutaneous and ocular toxicologyauthors
Çağlayan M,Akyol L,Balcı MA,Öncül H,Alakuş MF,Dağ Udoi
10.1080/15569527.2020.1861003subject
Has Abstractpub_date
2020-12-23 00:00:00pages
1-5eissn
1556-9527issn
1556-9535pub_type
杂志文章abstract:PURPOSES:To study the occurrence of ocular surface diseases on coal miners working under wells and to investigate the relation between xerophthalmia occurrence and coal dust contiguity. METHODS:To observe the influence of coal dust to ocular surface by using Schirmer to detect lacrimal gland secreting function, and br...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569520701212316
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
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journal_title:Cutaneous and ocular toxicology
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doi:10.3109/15569527.2013.812105
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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doi:10.3109/15569527.2010.485285
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abstract::Rapid decontamination is vital to alleviate adverse health effects following dermal exposure to hazardous materials. There is an abundance of materials and products which can be utilised to remove hazardous materials from the skin. In this study, a total of 15 products were evaluated, 10 of which were commercial or mi...
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journal_title:Cutaneous and ocular toxicology
pub_type: 临床试验,杂志文章
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