Abstract:
PURPOSE:To assess the long-term intraocular pressure (IOP) changes after the intravitreal injection of bevacizumab (Avastin; Genentech, Inc., South San Francisco, CA) for treatment of age-related macular degeneration (AMD) and diabetic macular edema (DME) patients and evaluate the correlation factors. MATERIAL AND METHODS:Patients with neovascular AMD or DME underwent treat-and-extended anti-VEGF regimen in one eye and followed more than 12 months were enrolled in this study. We set three criteria of IOP elevation: (1) the IOP of the treated eye increased above the contralateral eye for at least two consecutive visits; (2) the IOP of the treated eye increased above the pre-injection IOP for at least two consecutive visits; (3) and the IOP of the treated eye increased more than 5 mmHg above the baseline IOP for at least two consecutive visits. We used mixed model univariate and multivariate analysis to assess the association between IOP elevation and independent parameters including age, sex, lens status, the number of injections, and underlying disease. RESULTS:In total 152 patients, 83 patients with AMD and 69 patients with DME, were included in this study. Mean follow-up time was 18.7 months, with a maximum of 50 months. In IOP elevation, 54 eyes (35.6%) showed an IOP increase above that of the contralateral eye (criteria 1), 50 eyes (33.4%) showed an IOP increase above the baseline IOP (criteria 2), and an IOP increase greater than 5 mmHg above the baseline IOP observed in nine eyes (5.9%) (criteria 3). In the univariate analysis, lens status and total number of injections were statistically significant for criteria 2 and 3 (all ps < 0.05). However, in the multivariable analysis, only the number of intravitreal injections was statistically correlated with sustained IOP elevation for criteria 2 and 3 (p < 0.001 and p = 0.039, respectively). CONCLUSIONS:Our results suggest that under long-term monitoring, with a treat-and-extended regimen, intravitreal bevacizumab injections were associated with sustained IOP elevation. In particular, multiple intravitreal injections could be associated with sustained IOP elevation.
journal_name
Cutan Ocul Toxicoljournal_title
Cutaneous and ocular toxicologyauthors
Baek SU,Park IW,Suh Wdoi
10.3109/15569527.2015.1124886subject
Has Abstractpub_date
2016-12-01 00:00:00pages
310-4issue
4eissn
1556-9527issn
1556-9535journal_volume
35pub_type
临床试验,杂志文章abstract::This study assesses the possibility of using an in vitro model as an introduction to clinical human models for evaluating the buffering capacity of skin when an irritant is topically applied. Sodium hydroxide (NaOH) was utilized as a model base with a view to elucidate information on preventing and/or treating base-in...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569520802326718
更新日期:2008-01-01 00:00:00
abstract::In the EU, Methylisothiazolinone (MI) was approved as a preservative in cosmetics and household products in 2005. Since then, several cases of MI contact allergy have been reported. We studied the prevalence of MI sensitization in patients allergic to Methylchloroisothiazolinone/Methylisothiazolinone (MCI/MI). From a ...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2012.707266
更新日期:2013-06-01 00:00:00
abstract::In this report we present a case of erlotinib-induced trichomegaly in a male patient who received erlotinib for his pancreatic cancer. Trichomegaly as a side effect of epidermal growth factor receptor (EGFR) inhibitor therapy is uncommon in male patients. Also, it has not been reported previously in a patient with pan...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569520903440058
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Fixed drug eruption (FDE) is a special variant of drug reaction seen on skin or mucous membrane, and typically recurs at the same location. Ornidazole-induced FDE cases have been reported extremely rare. CASE:The 48-year-old female patient was diagnosed for ornidazole-induced fixed drug reaction on the sole...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章,评审
doi:10.1080/15569527.2016.1249796
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To find the abnormalities in various retinal layers caused by radiation retinopathy using spectral domain optical coherence tomography (SD-OCT). METHODS:We report a case of radiation retinopathy that was imaged using SD-OCT Copernicus (Optopol, Zawiercie, Poland). Analysis and synthesis of the OCT image were d...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569520903331674
更新日期:2010-03-01 00:00:00
abstract:INTRODUCTION:Sulfur mustard (SM) has been used as a dangerous chemical warfare agent since the early 20th century. Although many descriptive studies about SM-induced ocular injuries are present in the medical literature, few of them have been conducted over a large group with serious ocular involvement. MATERIALS AND ...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569520902913936
更新日期:2009-01-01 00:00:00
abstract::The anti-inflammatory properties of topical corticosteroids are well documented; additionally, their sensitization potential is also known. We aimed to assess the relative sensitization potential of hydrocortisone and tixocortol pivalate in an animal assay as it relates to potential for sensitization in humans. Using ...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569520701662775
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of heparin eye drops in the treatment of paraquat-induced ocular surface injury. DESIGN AND METHODS:In this retrospective study, we included 25 patients (31 eyes) with paraquat-induced ocular surface injury, who attended the Affiliated Hospital of Weifang Medical University between Oct...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569527.2017.1303706
更新日期:2017-12-01 00:00:00
abstract:CONTEXT:Assessing the hazards of accidental exposure to toxic industrial chemical (TIC) vapors and evaluating therapeutic compounds or treatment regimens require the development of appropriate animal models. OBJECTIVE:The objective of this project was to develop an exposure system for delivering controlled vapor conce...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2013.806524
更新日期:2014-06-01 00:00:00
abstract::Context Incontinence-associated dermatitis (IAD) is a type of moisture-associated dermatitis caused by repeated skin exposure to urine or stool. A product that could mitigate such symptoms would have a significant impact on cost of care and patients' quality of life. Objective This study compared the clinical efficacy...
journal_title:Cutaneous and ocular toxicology
pub_type: 临床试验,杂志文章
doi:10.1080/15569527.2016.1257637
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of topiramate on choroidal thickness and anterior chamber parameters using optical coherence tomography in the treatment of patients with migraine. METHODS:A total of 22 eyes of 22 adults (12 females, 10 males) diagnosed with migraine and scheduled to topiramate treatment for pain ...
journal_title:Cutaneous and ocular toxicology
pub_type: 临床试验,杂志文章
doi:10.1080/15569527.2017.1311337
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Acne vulgaris is one of the most common diseases of the youth. Systemic isotretinoin is the only drug which acts on all of the etiopathogenic mechanisms of acne. Isotretinoin has some well-known side effects. Besides these, there is a suspicion whether it causes infertility or not. In this study, w...
journal_title:Cutaneous and ocular toxicology
pub_type: 临床试验,杂志文章
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abstract:PURPOSE:Delayed keratitis is the most dangerous ocular complication of sulfur mustard (SM) exposure. This study aimed to evaluate the role of tear and serum levels of interleukin-8 (IL-8) in SM exposed subjects. DESIGN AND METHODS:In this historical cohort study, the experimental group included 370 participants who ha...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2011.618940
更新日期:2012-06-01 00:00:00
abstract::A 56-year-old white woman developed a distinctive skin eruption over her mammary, lumbosacral, and pubic areas 2 weeks after the start of esomeprazole therapy for dyspeptic symptoms. Skin biopsy disclosed a spongiotic dermatitis with predominantly lymphocytic dermal infiltrate. Treatment with a tapering dose of cortic...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2010.484824
更新日期:2010-09-01 00:00:00
abstract::Basal cell carcinoma (BCC), the most frequent malignant skin tumor observed in Caucasian adults, especially males, occurs mainly in sun-exposed areas of the body. BCC in the periungual tissues, such as proximal nail fold, nail matrix, nail bed and hyponychium, is rarely reported. We report a patient with two synchrono...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2012.708956
更新日期:2013-06-01 00:00:00
abstract::The most common adverse effects of oral isotretinoin (>1/10) are: cheilitis, skin dryness, erythema, itching, scaling, bruising, skin atopy, conjunctivitis, dry eyes and eyelid inflammation. The aim of this work was to define an optimal dose regime of the oral isotretinoin allowing for effective reduction of sebum pro...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2011.633949
更新日期:2012-09-01 00:00:00
abstract::A brief comment on efficacy and safety of propranolol in the treatment of parotid hemangioma is presented, with illustration of a typical case. ...
journal_title:Cutaneous and ocular toxicology
pub_type: 评论,信件
doi:10.3109/15569527.2011.584928
更新日期:2011-12-01 00:00:00
abstract::The Organisation for Economic Co-operation and Development (OECD) Test Guideline 429 for the local lymph node assay (LLNA) indicates a minimum of 4 mice per dose group, or of 5 mice if statistics are required. Recent discussions at the Interagency Coordinating Committee for the Validation of Alternative Methods (ICCVA...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章,评审
doi:10.1080/15569520802636280
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abstract::Background: Papulopustular rash is the most common cutaneous adverse effect during targeted tumour therapy particularly with epidermal growth factor receptor inhibitors (EGFRIs). Objective: To evaluate the adverse skin reactions, mainly papulopustular rash, caused by targeted tumour therapy. Materials and methods: We ...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569527.2019.1594874
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569527.2016.1206556
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2011.623290
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2014.1003267
更新日期:2016-03-01 00:00:00
abstract:PURPOSES:To study the occurrence of ocular surface diseases on coal miners working under wells and to investigate the relation between xerophthalmia occurrence and coal dust contiguity. METHODS:To observe the influence of coal dust to ocular surface by using Schirmer to detect lacrimal gland secreting function, and br...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569520701212316
更新日期:2007-01-01 00:00:00
abstract::Psoriasis is a common skin disorder that needs a long-term management, not only because, of its prevalence but also because of the profound impact it can have on patients quality of life. Drugs may result in exacerbation of a preexisting psoriasis, in induction of psoriatic lesions on clinically uninvolved skin in pat...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章,评审
doi:10.1080/15569520500536568
更新日期:2006-01-01 00:00:00
abstract::Purpose: We have previously reported that skin barrier function is disrupted in mice with colonic tumours induced by azoxymethane (AOM) and dextran sodium sulphate (DSS). We postulated that the impaired skin barrier function was associated with reactive oxygen species derived from gp91phox. In this study, we investiga...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569527.2019.1622559
更新日期:2019-12-01 00:00:00
abstract::The skin is a major exposure route for many potentially toxic chemicals. It is, therefore, important to be able to predict the permeability of compounds through skin under a variety of conditions. Available skin permeability databases are often limited in scope and not conducive to developing effective models. This sp...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569520500278690
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abstract::The terrifying dog in the Hound of the Baskervilles is described as having 'blazing eyes' and a 'luminous muzzle', appearances attributed by Watson and Holmes to the application of phosphorus. Review of the toxicity and flammability of white phosphorus make this improbable. It is suggested that Conan Doyle's descripti...
journal_title:Cutaneous and ocular toxicology
pub_type: 历史文章,杂志文章
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更新日期:2008-01-01 00:00:00
abstract::A 63-year-old female with history of a resected frontal lobe meningioma presented with bilaterally decreased vision after a bite from a brown recluse spider. The exam was significant for a left relative afferent pupillary defect, bilateral optic nerve pallor, decreased foveal sensitivity in the left eye and new bilate...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2015.1027906
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:Welding workers' ophthalmic problems resulting from their professions are frequently observed in ophthalmic emergencies and can cause severe visual impairment. We aimed to investigate the use of topical anesthetic and non-medical alternatives of this population regarding ophthalmic problems in this study. MATE...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2013.796480
更新日期:2014-06-01 00:00:00
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2014.930748
更新日期:2015-01-01 00:00:00