Abstract:
BACKGROUND:To evaluate the effect of tolterodine on pupil diameter and anterior chamber parameters, including volume, depth, and angle, with the Pentacam. METHODS:The 56 eyes of 28 patients who were diagnosed as having overactive bladder and planned to be treated with tolterodine were followed up prospectively in the study. All the patients underwent full ophthalmic examination and scanning with the Pentacam (Oculus, Inc., Wetzlar, Germany) before and 4 weeks after the start date of tolterodine therapy. In addition, the 30 eyes of 15 healthy volunteers were analyzed twice as a control group for repeatability of the measurements. RESULTS:The quantitative descriptors of the anterior chamber before and after the treatment, respectively, were as follows: pupil diameter, 3.02 ± 0.56 mm and 3.01 ± 0.55 mm; anterior chamber depth, 2.74 ± 0.35 mm and 2.75 ± 0.34 mm; anterior chamber volume, 150.23 ± 33.95 mm(3) and 150.27 ± 34.48 mm(3); and anterior chamber angle, 34.56° ± 5.68° and 35.03° ± 5.99°. For all the measurements, the differences did not reach statistical significance (p > .05). Also, the comparison of the same parameters obtained from the first and second measurements of healthy volunteers was not statistically significant (p > .05). CONCLUSION:Our study demonstrates that tolterodine does not affect pupil diameter and anterior chamber parameters, including angle, volume, and depth. Most likely, it is an organ-selective agent, inhibiting muscarinic receptors in the bladder rather than in the anterior segment of the eye.
journal_name
Cutan Ocul Toxicoljournal_title
Cutaneous and ocular toxicologyauthors
Goktas Adoi
10.3109/15569527.2010.523036subject
Has Abstractpub_date
2011-03-01 00:00:00pages
61-3issue
1eissn
1556-9527issn
1556-9535journal_volume
30pub_type
杂志文章abstract:CONTEXT:Assessing the hazards of accidental exposure to toxic industrial chemical (TIC) vapors and evaluating therapeutic compounds or treatment regimens require the development of appropriate animal models. OBJECTIVE:The objective of this project was to develop an exposure system for delivering controlled vapor conce...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2013.806524
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:Evaluation of retinal and choroidal changes after energy drink consumption by optical coherence tomography and optical coherence tomography angiography. METHODS AND MATERIAL:Forty-two healthy volunteers with neither systemic nor ocular diseases were enrolled in the study. The energy drink (250 mL Red Bull ener...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569527.2020.1755977
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:To evaluate the effect of anti-tubercular treatment on retinal nerve fiber layer (RNFL) thickness and the efficiency of optic coherence tomography (OCT) on early diagnosis of optic neuropathy. METHODS:Twenty patients diagnosed with either pulmonary or extra-pulmonary tuberculosis which were treated with anti-t...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2014.954715
更新日期:2015-01-01 00:00:00
abstract::A snakebite is a serious and important problem in tropical and subtropical cities. A vast majority of snakebites are nonvenomous. However, venomous snakebites may cause local tissue destruction, neuroparalysis, systemic hemorrhage, generalized myotoxicity, and acute renal failure. A 10-year-old boy was brought to the ...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2011.573832
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:The aim of this study was to determine the effects of single-dose intravitreal bevacizumab on the levels of vascular endothelial growth factor (VEGF) in serum and distant organs. METHODS:Adult New Zealand albino rabbits (n = 40) were divided into experimental and control groups. Experimental rabbits received a...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2013.855227
更新日期:2014-12-01 00:00:00
abstract::Ciliary body is responsible for humour aqueous production in posterior chamber. Valproic acid (VPA) has been widely used for the treatment of epilepsy and other neuropsychiatric diseases such as bipolar disease and major depression. Oxcarbazepine (OXC) is a new anti-epileptic agent that has been used recently for chil...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2014.930748
更新日期:2015-01-01 00:00:00
abstract::In the EU, Methylisothiazolinone (MI) was approved as a preservative in cosmetics and household products in 2005. Since then, several cases of MI contact allergy have been reported. We studied the prevalence of MI sensitization in patients allergic to Methylchloroisothiazolinone/Methylisothiazolinone (MCI/MI). From a ...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2012.707266
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of heparin eye drops in the treatment of paraquat-induced ocular surface injury. DESIGN AND METHODS:In this retrospective study, we included 25 patients (31 eyes) with paraquat-induced ocular surface injury, who attended the Affiliated Hospital of Weifang Medical University between Oct...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569527.2017.1303706
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:The exact immunopathogenesis of contact hypersensitivity (CH) to mercury remains unclear. OBJECTIVE:The aim of the present study was to assess the role of CD4+ T cells in mercury-induced CH in mice. METHODS:Splenic CD4+ T cells obtained from nonsensitized and mercury-sensitized Balb/c mice were adoptively ...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569520903496746
更新日期:2010-03-01 00:00:00
abstract::Lichenoid drug eruption (LDE) is a common cutaneous side effect of drugs including antimalarials, antihypertensives, nonsteroids, anti-inflammatory drugs and diuretics. The physiopathologic relationship between colchicine treatment and LDE is unclear. There is very little documentation of LDE induced by colchicine in ...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569527.2016.1206556
更新日期:2017-06-01 00:00:00
abstract::Dicyclohexylcarbodiimide (DCC) and Diisopropylcarbodiimide (DIC) are two representative chemicals in the carbodiimide class of chemicals used in industry as stabilizing agents. There is a potential of dermal exposure to these agents in chemical, pharmaceutical and recombinant DNA industries. The National Toxicology Pr...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2011.629384
更新日期:2012-09-01 00:00:00
abstract::A 56-year-old white woman developed a distinctive skin eruption over her mammary, lumbosacral, and pubic areas 2 weeks after the start of esomeprazole therapy for dyspeptic symptoms. Skin biopsy disclosed a spongiotic dermatitis with predominantly lymphocytic dermal infiltrate. Treatment with a tapering dose of cortic...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2010.484824
更新日期:2010-09-01 00:00:00
abstract::Purpose: We have previously reported that skin barrier function is disrupted in mice with colonic tumours induced by azoxymethane (AOM) and dextran sodium sulphate (DSS). We postulated that the impaired skin barrier function was associated with reactive oxygen species derived from gp91phox. In this study, we investiga...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569527.2019.1622559
更新日期:2019-12-01 00:00:00
abstract::Dermal absorption of some chemicals and drugs can cause systemic toxicity. We evaluated several case reports from the past decade, which discuss the dermal absorption of a specific chemical and potential local and systemic effects. We focused on herbicide and pesticide exposure along with exposure to cutaneous medicat...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章,评审
doi:10.3109/15569527.2011.560914
更新日期:2011-09-01 00:00:00
abstract::Purpose: Pityriasis rosea (PR) is a common, self-limiting, inflammatory skin disease with an acute onset. The etiology of PR is not yet clearly known but the defect in the oxidation system involved in many papulosquamous skin diseases may play a role. Thiol/disulfide homeostasis is a new marker of oxidative stress and...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569527.2019.1616748
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:The aim of this study was to examine the effects of long-term use of hydroxychloroquine (HQ) on the pachymetric, aberrometric, and densitometric values of the cornea and corneal endothelium in lupus patients. METHOD:Twenty-two eyes (study group) of 22 patients using HQ for treatment of lupus and 25 eyes (contr...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569527.2020.1861003
更新日期:2020-12-23 00:00:00
abstract:PURPOSE:The aim of this study is to evaluate the effect of early amniotic membrane transplantation (AMT) in patients with topical proparacaine-related toxic keratopathy. MATERIALS AND METHODS:Between 2008 and 2011, eight eyes of seven patients with toxic keratopathy related to 0.5% proparacaine abuse underwent early A...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2012.759959
更新日期:2013-09-01 00:00:00
abstract::Rapid decontamination is vital to alleviate adverse health effects following dermal exposure to hazardous materials. There is an abundance of materials and products which can be utilised to remove hazardous materials from the skin. In this study, a total of 15 products were evaluated, 10 of which were commercial or mi...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2015.1072544
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:Delayed keratitis is the most dangerous ocular complication of sulfur mustard (SM) exposure. This study aimed to evaluate the role of tear and serum levels of interleukin-8 (IL-8) in SM exposed subjects. DESIGN AND METHODS:In this historical cohort study, the experimental group included 370 participants who ha...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2011.618940
更新日期:2012-06-01 00:00:00
abstract:CONTEXT:Nicorandil is an antianginal drug used for 20 years in Japan and introduced in France in 1994. Since 1997, side effects such as mucocutaneous ulcerations have regularly been reported. OBJECTIVE:To describe the first case of a patient with a spontaneous corneal perforation associated with mucocutaneous ulcerati...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2013.812105
更新日期:2014-06-01 00:00:00
abstract::The bullous hemorrhagic dermatosis induced by enoxaparin is a rare adverse reaction, which may be under-reported given its favorable evolution. We report a 71-year-old man who developed hemorrhagic bullae at sites distant from subcutaneous enoxaparin injections. It is important that clinicians be aware of the differen...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2015.1041033
更新日期:2016-01-01 00:00:00
abstract::Fixed drug eruption (FDE) is a rare form of drug allergies that recur at the same cutaneous or mucosal site in every usage of drug. Single or multiple round, sharply demarcated and dusky red plaques appear soon after drug exposure. Ursodeoxycholic acid (UDCA: 3α,7β-dihydroxy-5β-cholanic acid) is used for the treatment...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2013.838253
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:To assess the long-term intraocular pressure (IOP) changes after the intravitreal injection of bevacizumab (Avastin; Genentech, Inc., South San Francisco, CA) for treatment of age-related macular degeneration (AMD) and diabetic macular edema (DME) patients and evaluate the correlation factors. MATERIAL AND MET...
journal_title:Cutaneous and ocular toxicology
pub_type: 临床试验,杂志文章
doi:10.3109/15569527.2015.1124886
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:To assess the incidence of seizures induced by cycloplegic ophthalmic drops. MATERIALS AND METHODS:A survey among members of the American Association for Pediatric Ophthalmology and Strabismus yielded five patients who received cycloplegic eye drops between 1998 and 2010 and who consequently developed a seiz...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2013.808654
更新日期:2014-06-01 00:00:00
abstract::Background: Papulopustular rash is the most common cutaneous adverse effect during targeted tumour therapy particularly with epidermal growth factor receptor inhibitors (EGFRIs). Objective: To evaluate the adverse skin reactions, mainly papulopustular rash, caused by targeted tumour therapy. Materials and methods: We ...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569527.2019.1594874
更新日期:2019-09-01 00:00:00
abstract::Phenytoin is commonly used an antiepileptic medication for seizure prophylaxis in patients with brain metastases. In these oncology patients group, phenytoin-induced severe adverse reactions may occur. Antiepileptic, particularly phenytoin-induced severe skin reactions including Stevens-Johnson syndrome (SJS) and bull...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2011.588298
更新日期:2011-12-01 00:00:00
abstract::Basal cell carcinoma (BCC), the most frequent malignant skin tumor observed in Caucasian adults, especially males, occurs mainly in sun-exposed areas of the body. BCC in the periungual tissues, such as proximal nail fold, nail matrix, nail bed and hyponychium, is rarely reported. We report a patient with two synchrono...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2012.708956
更新日期:2013-06-01 00:00:00
abstract:CONTEXT:The acute effects of cigarette smoking on pupil size and ocular wavefront aberrations (OWA) have been previously documented. The accommodation status of the eye is well known to be related to ocular aberrations. No previous study has evaluated the impact of cigarette smoking on the accommodation status of the e...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2016.1141417
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:The purpose of this study was to compare the neovascularization inhibiting the effect of topical bevacizumab and sorafenib and to determine the effective dose of sorafenib. MATERIAL AND METHODS:Forty-two healthy Wistar albino rats were randomly divided into six groups. The right corneas of all rats except grou...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569527.2020.1760877
更新日期:2020-09-01 00:00:00
abstract::Psoriasis is a common skin disorder that needs a long-term management, not only because, of its prevalence but also because of the profound impact it can have on patients quality of life. Drugs may result in exacerbation of a preexisting psoriasis, in induction of psoriatic lesions on clinically uninvolved skin in pat...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章,评审
doi:10.1080/15569520500536568
更新日期:2006-01-01 00:00:00