Abstract:
:The first objective of this study was to determine the baseline prevalence of metabolic syndrome and its individual components using the NCEP-R/ATPIII criteria, IDF criteria for Europe, and IDF criteria for Africa: waist circumference of at least 94 cm for men and women. The second objective was to investigate the incidence and the determinants of type 2 diabetes in a prospective cohort of 807 non-diabetic Central Africans aged >or= 40 years from December 2004 to September 2008. During 3,156 person-years of median follow up, there were 93 type 2 diabetes cases (11.5%), corresponding to an incidence of 29 (95% CI 15-43) per 1,000 person-years. The independent predictors of incident type 2 diabetes were age >or= 45 years, physical inactivity, non-diabetic hyperglycaemia and metabolic syndrome regardless of criteria used. In conclusion, urgent prevention strategies are needed to curb the type 2 diabetes epidemic in Africa.
journal_name
Diab Vasc Dis Resjournal_title
Diabetes & vascular disease researchauthors
Longo-Mbenza B,On'kin JB,Okwe AN,Kabangu NK,Fuele SMdoi
10.1177/1479164109346362subject
Has Abstractpub_date
2010-01-01 00:00:00pages
28-39issue
1eissn
1479-1641issn
1752-8984pii
1479164109346362journal_volume
7pub_type
杂志文章abstract::The aim of this study was to test the hypothesis that cardiovascular disease occurs to the greatest extent in persons with prediabetes mellitus who are also insulin resistant. In 2003, 664 non-diabetic women (n = 457) and men (n = 207), aged 52 ± 16 and 53 ± 15 years, were surveyed during a programme for cardiovascula...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164115610057
更新日期:2016-03-01 00:00:00
abstract::The complications of diabetes are myriad and represent a rising cause of morbidity and mortality, particularly in the Western world. The update of the Diabetes Control and Clinical Trials Group/Epidemiology of Diabetes Interventions and Complications Research Group (DCCT/EDIC) suggested that previous strict control of...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2004.001
更新日期:2004-05-01 00:00:00
abstract::Physical activity decreases risk for diabetes and cardiovascular disease morbidity and mortality; however, the specific impact of exercise on the diabetic vasculature is unexamined. We hypothesized that an acute, moderate exercise intervention in diabetic and hypertensive rats would induce mitochondrial biogenesis and...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164112459664
更新日期:2013-05-01 00:00:00
abstract::Cardiovascular disease is the most common complication of type 2 diabetes mellitus (type 2 DM), accounting for approximately 80% of deaths. While atherosclerotic vascular disease accounts for much of the cardiovascular morbidity and mortality among diabetic patients, congestive heart failure (CHF) is another key compl...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2005.010
更新日期:2005-05-01 00:00:00
abstract:PURPOSE:To examine the relationship between leisure-time physical activity (LTPA) and the metabolic syndrome in the U.S. adult population. METHODS:The sample (N=5,620) in this cross-sectional study included adults aged 20 years and older. Physical activity was measured in two ways: a six-level measure based upon those...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164109336040
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine whether high fitness attenuates the defects in left ventricular (LV) structure, function and triglyceride (TG) content in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS:Patients (n = 74) with T2DM and ≥1 additional cardiac risk factor were recruite...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164114540924
更新日期:2014-09-01 00:00:00
abstract::Diabetes mellitus and angina pectoris are important conditions in older persons. The utility of pre-diabetes mellitus, diabetes mellitus and other risk factors as predictors of incident angina pectoris among older adults has not been characterized. We examined incident angina pectoris rates by sex and diabetes mellitu...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究
doi:10.1177/1479164119888476
更新日期:2020-01-01 00:00:00
abstract::Guidelines recommend aggressive goals for lipid and blood pressure reduction for high risk patients with diabetes mellitus and atherosclerotic coronary disease. However, it remains unclear how many patients achieve treatment goals versus the number of people merely placed on treatment. We conducted an observational st...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164111431471
更新日期:2012-04-01 00:00:00
abstract::Roux-en-Y bypass surgery is increasingly used for treatment of gross obesity due to the general inability of lifestyle change and existing drug treatments to counter the obesity epidemic. This common form of bariatric surgery involves bypass of the small intestine with significant reduction of body of weight that is i...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.3132/dvdr.2007.034
更新日期:2007-06-01 00:00:00
abstract::Prehypertension is considered to be associated with increased cardiovascular disease (CVD), and some data suggest that insulin resistance is common in this group. The goal of this study was to quantify insulin action by determining the steady-state plasma glucose (SSPG) concentration during the insulin suppression tes...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164110396919
更新日期:2011-01-01 00:00:00
abstract::We investigated the effect of atorvastatin monotherapy and combined treatment with atorvastatin and pioglitazone on intima-media thickness, vascular function and the cardiovascular risk profile. In all, 148 patients (76 male, 72 female; aged 61.4+/-6.5 years; body mass index [BMI] 29.2+/-4.1 kg/m2; mean +/- SD) with i...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3132/dvdr.2008.043
更新日期:2008-11-01 00:00:00
abstract::We aimed to study the association between fasting plasma glucose, diabetes incidence and cardiovascular burden after 10-12 years. We evaluated diabetes and cardiovascular events incidences, carotid intima-media thickness and coronary artery calcium scores in ELSA-Brasil (the Brazilian Longitudinal Study of Adult Healt...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164116653356
更新日期:2016-11-01 00:00:00
abstract::Sodium-glucose cotransporter 2 inhibitors are antihyperglycaemic medications with an emerging evidence base for cardiovascular and kidney disease risk reduction. Sodium-glucose cotransporter 2 inhibitors medications lower plasma glucose by inhibiting glucose reabsorption in the proximal tubule of the kidney independen...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164118783756
更新日期:2018-09-01 00:00:00
abstract::Early studies showed nitric oxide as a pro-inflammatory-cytokine-induced toxin involved in pancreatic β-cell destruction during pathogenesis of type-1 diabetes. However, nitric oxide has both cytotoxic and cytoprotective effects on mammalian cells, depending on concentration and micro-environmental surroundings. Our s...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164117713947
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To characterize copeptin levels and to explore its prognostic importance in patients with acute myocardial infarction with newly detected glucose abnormalities. METHODS:Copeptin was measured in 166 patients with acute myocardial infarction without known diabetes and in 168 age- and gender-matched controls. P...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究
doi:10.1177/1479164116664490
更新日期:2017-03-01 00:00:00
abstract::Chronic diseases account for approximately 45% of all deaths in developed countries and are particularly prevalent in countries with the most sophisticated and robust public health systems. Chronic metabolic diseases, specifically lifestyle-related diseases pertaining to diet and exercise, continue to be difficult to ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164117738442
更新日期:2018-01-01 00:00:00
abstract::There are few data concerning the relationship between diabetes mellitus, the metabolic syndrome and inflammation following elective percutaneous coronary intervention (PCI). The purpose of this study was to assess basal and peak levels of candidate cytokines in 40 patients undergoing elective PCI. Patients were categ...
journal_title:Diabetes & vascular disease research
pub_type: 临床试验,杂志文章
doi:10.3132/dvdr.2005.003
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVES:Assess the effect of risk factors changes on risk for cardiovascular disease and mortality in patients with type 2 diabetes selected from the Swedish National Diabetes Register. METHODS:Observational study of 13,477 females and males aged 30-75 years, with baseline HbA1c 41-67 mmol/mol, systolic blood press...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164116637311
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Musclin is a newly identified skeletal muscle-derived secretory factor, which has been recently characterized as a stimulator that induces insulin resistance in mice. However, the pathophysiological role of musclin in humans remains poorly understood. The aim of this study was to explore the potential correl...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164116675493
更新日期:2017-03-01 00:00:00
abstract::Inhibitors of the enzyme dipeptidyl peptidase IV (DPP IV) provide a strategy for the treatment of type 2 diabetes. DPP IV rapidly inactivates the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Inhibition of DPP IV prolongs and enhances the activity of endogeno...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2006.024
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:We conducted a prospective pilot study in patients with diabetes to analyse the interobserver reliability of the ankle-brachial index, toe-brachial index and distal pulse palpation depending on the training of the professional involved. MATERIALS AND METHODS:The ankle-brachial index, toe-brachial index and d...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164118767599
更新日期:2018-07-01 00:00:00
abstract::We investigated the usefulness of Holter monitoring to detect cardiac disease and predict future cardiovascular risk in asymptomatic diabetic patients. This is a multi-centre, prospective study in 406 asymptomatic diabetic patients. They were categorized into three groups based on findings of Holter monitoring. A tota...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164115595523
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:The effect of interarm blood pressure difference on the development of diabetic retinopathy, proteinuria and chronic kidney disease remains unknown. We investigated to determine the impact of interarm blood pressure difference on the prevalence of diabetic retinopathy, proteinuria and chronic kidney disease ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164120945910
更新日期:2020-07-01 00:00:00
abstract::The aim of this study was to characterise microvascular blood flow in the skin and to compare it with biomarkers of endothelial dysfunction and tissue inflammation in patients with type 2 diabetes with (n=20) or without (n=20) microvascular complications and 20 control subjects. Microvascular function was measured by ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.3132/dvdr.2008.006
更新日期:2008-03-01 00:00:00
abstract::Cardiovascular disease is the leading cause of morbidity and mortality in subjects with type 2 diabetes mellitus. Increased aortic stiffness, assessed with the carotid-femoral pulse wave velocity, is an independent risk factor for cardiovascular disease. Statins reduce effectively cardiovascular disease and mortality ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164118805320
更新日期:2019-01-01 00:00:00
abstract::Adiponectin circulates in plasma as various isoforms. However, the biological activity of each isoform has not been firmly established. High molecular weight (HMW) adiponectin may be the active form of adiponectin, while a proteolytic cleavage product of adiponectin, known as globular adiponectin (gAd), has recently b...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.3132/dvdr.2008.020
更新日期:2008-06-01 00:00:00
abstract::Vascular complications associated with type 2 diabetes confer significant morbidity and mortality. Atherosclerosis develops much earlier and progresses more rapidly than in subjects without diabetes. The clustering of cardiovascular risk factors associated with type 2 diabetes is mainly responsible for accelerated ath...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2007.067
更新日期:2007-12-01 00:00:00
abstract::Diabetes contributes directly to the development of cardiovascular aortic valve disease. There is currently no drug therapy available for a dysfunctional valve and this urges the need for additional research to identify distinctive mechanisms of cardiovascular aortic valve disease evolution. The aim of this study was ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164119874469
更新日期:2019-11-01 00:00:00
abstract::A cross-sectional analysis of ethnic differences in dietary intake, insulin sensitivity and beta-cell function, using the intravenous glucose tolerance test (IVGTT), was conducted on 497 healthy adult participants of the 'Reading, Imperial, Surrey, Cambridge, and Kings' (RISCK) study. Insulin sensitivity (Si) was sign...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164112467545
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:The role of long non-coding RNA in diabetic retinopathy, a serious complication of diabetes mellitus, has attracted increasing attention in recent years. The purpose of this study was to explore whether long non-coding RNA nuclear paraspeckle assembly transcript 1 was involved in the context of diabetic reti...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164117749382
更新日期:2018-05-01 00:00:00