Abstract：
:Prehypertension is considered to be associated with increased cardiovascular disease (CVD), and some data suggest that insulin resistance is common in this group. The goal of this study was to quantify insulin action by determining the steady-state plasma glucose (SSPG) concentration during the insulin suppression test in apparently healthy individuals with prehypertension (n=126) and to elucidate the relationship between insulin action and CVD risk.We found a marked heterogeneity in insulin sensitivity in the prehypertension group, and when we divided the population into insulin-sensitive, insulin-resistant and intermediate groups, there were significant (p<0.01) increases in plasma glucose and triglyceride concentrations and decreases in high-density lipoprotein cholesterol concentrations with progressive degrees of insulin resistance. These data show that at least one-third of patients with prehypertension are insulin resistant, display the accompanying metabolic abnormalities, and merit enhanced surveillance and intensive efforts at therapeutic intervention to prevent CVD.
journal_name
Diab Vasc Dis Resjournal_title
Diabetes & vascular disease researchauthors
Knobler H,Abbasi F,Lamendola C,Reaven GMdoi
10.1177/1479164110396919subject
Has Abstractpub_date
2011-01-01 00:00:00pages
43-6issue
1eissn
1479-1641issn
1752-8984pii
8/1/43journal_volume
8pub_type
杂志文章abstract：:In order to discuss and establish a joint position on the treatment of low serum levels of high-density lipoprotein cholesterol (HDL-C), a group of experts involved in the care of people with dyslipidaemia and at risk of cardiovascular disease met in Miami, Florida, U.S., on 5th and 6th March 2005. The experts came fr...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章,实务指引
doi：10.3132/dvdr.2005.016
更新日期：2005-10-01 00:00:00
abstract：:There are few data concerning the relationship between diabetes mellitus, the metabolic syndrome and inflammation following elective percutaneous coronary intervention (PCI). The purpose of this study was to assess basal and peak levels of candidate cytokines in 40 patients undergoing elective PCI. Patients were categ...
journal_title：Diabetes & vascular disease research
pub_type： 临床试验,杂志文章
doi：10.3132/dvdr.2005.003
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND:The role of long non-coding RNA in diabetic retinopathy, a serious complication of diabetes mellitus, has attracted increasing attention in recent years. The purpose of this study was to explore whether long non-coding RNA nuclear paraspeckle assembly transcript 1 was involved in the context of diabetic reti...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章
doi：10.1177/1479164117749382
更新日期：2018-05-01 00:00:00
abstract：:Metabolic syndrome (MetS) is a clustering of atherosclerotic coronary heart disease risk factors. This post-hoc analysis compared the effects of switching to ezetimibe/simvastatin 10/20 mg or rosuvastatin 10 mg in a cohort of 618 high-risk hypercholesterolaemic patients with (n=368) and without (n=217) MetS who had pr...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1177/1479164111418136
更新日期：2011-10-01 00:00:00
abstract：:Telmisartan partially activates the peroxisome proliferator-activated receptor γ (PPARγ), which may ameliorate the accumulation of visceral adipose tissues and sensitise insulin action. Nineteen patients with essential hypertension and metabolic syndrome were randomly assigned to receive 40 mg of telmisartan (TELMI gr...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章,随机对照试验
doi：10.1177/1479164112444640
更新日期：2013-01-01 00:00:00
abstract：:While few dispute the existence of the metabolic syndrome as a clustering of factors indicative of poor metabolic health, its utility above that of its individual components in the clinical care of individual patients is questioned. This is likely a consequence of the failure of clinicians and scientists to agree on a...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章,评审
doi：10.1177/1479164119827611
更新日期：2019-03-01 00:00:00
abstract：:We investigated the usefulness of Holter monitoring to detect cardiac disease and predict future cardiovascular risk in asymptomatic diabetic patients. This is a multi-centre, prospective study in 406 asymptomatic diabetic patients. They were categorized into three groups based on findings of Holter monitoring. A tota...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章
doi：10.1177/1479164115595523
更新日期：2015-11-01 00:00:00
abstract：:Glucose-lowering treatment options for type 2 diabetes mellitus patients with chronic kidney disease are limited. We evaluated the potential for linagliptin in combination with insulin in type 2 diabetes mellitus patients with mild-to-severe renal impairment. Data for participants in two phase 3 trials with linaglipti...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章,随机对照试验
doi：10.1177/1479164115579001
更新日期：2015-07-01 00:00:00
abstract：:Roux-en-Y bypass surgery is increasingly used for treatment of gross obesity due to the general inability of lifestyle change and existing drug treatments to counter the obesity epidemic. This common form of bariatric surgery involves bypass of the small intestine with significant reduction of body of weight that is i...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章
doi：10.3132/dvdr.2007.034
更新日期：2007-06-01 00:00:00
abstract：:We respond to the letter of Nadery and Shahsavari regarding our paper entitled 'Interobserver reliability of the ankle brachial index, toe -brachial index and distal pulse palpation in patients with diabetes. In this letter, we concluded that despite some limitations, the kappa coefficient is an informative measure of...
journal_title：Diabetes & vascular disease research
pub_type： 评论,信件
doi：10.1177/1479164118794901
更新日期：2018-11-01 00:00:00
abstract：:Cardiovascular disease is the leading cause of morbidity and mortality in subjects with type 2 diabetes mellitus. Increased aortic stiffness, assessed with the carotid-femoral pulse wave velocity, is an independent risk factor for cardiovascular disease. Statins reduce effectively cardiovascular disease and mortality ...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章
doi：10.1177/1479164118805320
更新日期：2019-01-01 00:00:00
abstract：:Heart failure is now recognized as a progressive disease in which patients transition through the stages of being at risk of heart failure (stage A), to asymptomatic structural heart disease (stage B), to clinical manifestations of heart failure (stage C) and finally end-stage or refractory heart failure (stage D). Th...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章,评审
doi：10.1177/1479164115579006
更新日期：2015-07-01 00:00:00
abstract：:The complications of diabetes are myriad and represent a rising cause of morbidity and mortality, particularly in the Western world. The update of the Diabetes Control and Clinical Trials Group/Epidemiology of Diabetes Interventions and Complications Research Group (DCCT/EDIC) suggested that previous strict control of...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章,评审
doi：10.3132/dvdr.2004.001
更新日期：2004-05-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to determine whether high fitness attenuates the defects in left ventricular (LV) structure, function and triglyceride (TG) content in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS:Patients (n = 74) with T2DM and ≥1 additional cardiac risk factor were recruite...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章
doi：10.1177/1479164114540924
更新日期：2014-09-01 00:00:00
abstract：:We conducted a meta-analysis of cohort and case-control studies to evaluate all-cause and cardiovascular (CV) mortality of patients with type 2 diabetes mellitus (T2DM) who received sulphonylurea (SU) treatment, when compared to any other diabetes treatment. Only studies reporting raw data on mortality during SU treat...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章,meta分析,评审
doi：10.1177/1479164112465442
更新日期：2013-07-01 00:00:00
abstract：:We investigated the effect of atorvastatin monotherapy and combined treatment with atorvastatin and pioglitazone on intima-media thickness, vascular function and the cardiovascular risk profile. In all, 148 patients (76 male, 72 female; aged 61.4+/-6.5 years; body mass index [BMI] 29.2+/-4.1 kg/m2; mean +/- SD) with i...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.3132/dvdr.2008.043
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The risk of major adverse cardiac and cerebrovascular events following acute coronary syndrome is increased in people with diabetes. Predicting out-of-hospital outcomes upon follow-up remains difficult, and no simple, well-validated tools exist for this population at present. We aim to evaluat...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章,多中心研究
doi：10.1177/1479164119892137
更新日期：2020-01-01 00:00:00
abstract：:Guidelines recommend aggressive goals for lipid and blood pressure reduction for high risk patients with diabetes mellitus and atherosclerotic coronary disease. However, it remains unclear how many patients achieve treatment goals versus the number of people merely placed on treatment. We conducted an observational st...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章
doi：10.1177/1479164111431471
更新日期：2012-04-01 00:00:00
abstract：:The objective of this study was to evaluate the safety and tolerability of atorvastatin 10 mg compared with placebo in 2,838 patients with type 2 diabetes and no history of coronary heart disease who were enrolled in the Collaborative Atorvastatin Diabetes Study (CARDS) and followed for 3.9 years. The percentages of p...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.3132/dvdr.2008.029
更新日期：2008-09-01 00:00:00
abstract：:Diabetes mellitus and angina pectoris are important conditions in older persons. The utility of pre-diabetes mellitus, diabetes mellitus and other risk factors as predictors of incident angina pectoris among older adults has not been characterized. We examined incident angina pectoris rates by sex and diabetes mellitu...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章,多中心研究
doi：10.1177/1479164119888476
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:To examine the relationship between leisure-time physical activity (LTPA) and the metabolic syndrome in the U.S. adult population. METHODS:The sample (N=5,620) in this cross-sectional study included adults aged 20 years and older. Physical activity was measured in two ways: a six-level measure based upon those...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章
doi：10.1177/1479164109336040
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND:C-type lectin receptors, including Dectin-2, are pattern recognition receptors on monocytes and macrophages that mainly recognize sugars and sugar-like structures present on fungi. Activation of C-type lectin receptors induces downstream CARD9 signalling, leading to the production of cytokines. We hypothesiz...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章
doi：10.1177/1479164119892140
更新日期：2020-01-01 00:00:00
abstract：:Angiotensin II receptor blockers (ARB) are often co-administered with a calcium channel blocker (CCB) for treating hypertension. In this open-label randomised study, untreated diabetic hypertensive patients were randomised to receive either olmesartan 20 mg/day or candesartan 8 mg/day for 12 weeks. Patients with blood...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章,随机对照试验
doi：10.1177/1479164112447310
更新日期：2012-10-01 00:00:00
abstract：:Doppler waveforms analysis is a interesting to diagnose peripheral artery disease as suggested by the international recommendations. However as mentioned in the present letter, there is a lack of consensus about the terminology that should be used. ...
journal_title：Diabetes & vascular disease research
pub_type： 评论,信件
doi：10.1177/1479164118809527
更新日期：2019-01-01 00:00:00
abstract：:Chronic diseases account for approximately 45% of all deaths in developed countries and are particularly prevalent in countries with the most sophisticated and robust public health systems. Chronic metabolic diseases, specifically lifestyle-related diseases pertaining to diet and exercise, continue to be difficult to ...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章,评审
doi：10.1177/1479164117738442
更新日期：2018-01-01 00:00:00
abstract：:The global prevalence of diabetes mellitus (DM) continues to climb, and is accompanied by an increase in DM associated complications, most often manifesting as coronary heart disease. Platelet dysfunction has been implicated as a central contributor to the increased risk of coronary artery disease in patients with DM,...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章,评审
doi：10.1177/1479164111420890
更新日期：2011-10-01 00:00:00
abstract：:Antidiabetic thiazolidinediones (TZDs) improve endothelial function in patients with or without type 2 diabetes. The present randomised, placebo-controlled, double-blind study examined the time course of a single dose of rosiglitazone on flow-mediated endothelium-dependent vasodilation (FMD), metabolic parameters, and...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章,随机对照试验
doi：10.1177/1479164110367812
更新日期：2010-07-01 00:00:00
abstract：:Adiponectin circulates in plasma as various isoforms. However, the biological activity of each isoform has not been firmly established. High molecular weight (HMW) adiponectin may be the active form of adiponectin, while a proteolytic cleavage product of adiponectin, known as globular adiponectin (gAd), has recently b...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章
doi：10.3132/dvdr.2008.020
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:To characterize copeptin levels and to explore its prognostic importance in patients with acute myocardial infarction with newly detected glucose abnormalities. METHODS:Copeptin was measured in 166 patients with acute myocardial infarction without known diabetes and in 168 age- and gender-matched controls. P...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章,多中心研究
doi：10.1177/1479164116664490
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:Reduced renal function and albuminuria predict cardiovascular (CV) events and mortality in type 2 diabetes (T2D). In addition, we evaluated the role of co-existing congestive heart failure (CHF) and other CV risk factors on CV events in a large observational population-based cohort of T2D patients. RESEARCH ...
journal_title：Diabetes & vascular disease research
pub_type： 杂志文章
doi：10.1177/1479164113500798
更新日期：2013-11-01 00:00:00
