Abstract:
OBJECTIVE:The aim of this study was to determine whether high fitness attenuates the defects in left ventricular (LV) structure, function and triglyceride (TG) content in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS:Patients (n = 74) with T2DM and ≥1 additional cardiac risk factor were recruited to participate in this cross-sectional study. Outcome measures of interest were LV structure and function by magnetic resonance imaging (MRI) and myocardial TG content by (1)H-magnetic resonance spectroscopy (MRS). The primary exposure variable was cardiorespiratory fitness defined by peak oxygen consumption scaled to fat-free mass (FFM; VO2peak-FFM). RESULTS:Mean age was 53.5 years; 42.9% were women and mean glycosylated haemoglobin (HbA1c) was 8.0% with the mean duration of T2DM 8.2 years. VO2peak-FFM was crudely associated with both LV end systolic (r = 0.35, p = 0.002) and diastolic volumes (r = 0.32, p = 0.004), but not with ejection fraction (r = -0.15, p = 0.206), myocardial TG (r = -0.04, p = 0.734) or early diastolic peak filling rate (PFR; r = -0.01, p = 0.887). In multiple linear regression analyses, among measures of LV structure/function, VO2peak-FFM was independently associated only with LV end-diastolic volume (EDV) (β = 1.037, p = 0.038). CONCLUSION:In individuals with T2DM at increased cardiovascular (CV) risk, cardiorespiratory fitness is not associated with LV morphology, function or myocardial TG content.
journal_name
Diab Vasc Dis Resjournal_title
Diabetes & vascular disease researchauthors
Sénéchal M,Ayers CR,Szczepaniak LS,Gore MO,See R,Abdullah SM,Berry JD,McGuire DK,McGavock JMdoi
10.1177/1479164114540924subject
Has Abstractpub_date
2014-09-01 00:00:00pages
343-51issue
5eissn
1479-1641issn
1752-8984pii
1479164114540924journal_volume
11pub_type
杂志文章abstract::While few dispute the existence of the metabolic syndrome as a clustering of factors indicative of poor metabolic health, its utility above that of its individual components in the clinical care of individual patients is questioned. This is likely a consequence of the failure of clinicians and scientists to agree on a...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164119827611
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:The effect of interarm blood pressure difference on the development of diabetic retinopathy, proteinuria and chronic kidney disease remains unknown. We investigated to determine the impact of interarm blood pressure difference on the prevalence of diabetic retinopathy, proteinuria and chronic kidney disease ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164120945910
更新日期:2020-07-01 00:00:00
abstract::The global prevalence of diabetes mellitus (DM) continues to climb, and is accompanied by an increase in DM associated complications, most often manifesting as coronary heart disease. Platelet dysfunction has been implicated as a central contributor to the increased risk of coronary artery disease in patients with DM,...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164111420890
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Continuous-wave Doppler is frequently used for detecting peripheral arterial disease in patients with diabetes; however, there is limited evidence investigating diagnostic accuracy. This study aimed to determine sensitivity and specificity of continuous-wave Doppler for detecting peripheral arterial disease ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164118782887
更新日期:2018-09-01 00:00:00
abstract::Adiponectin circulates in plasma as various isoforms. However, the biological activity of each isoform has not been firmly established. High molecular weight (HMW) adiponectin may be the active form of adiponectin, while a proteolytic cleavage product of adiponectin, known as globular adiponectin (gAd), has recently b...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.3132/dvdr.2008.020
更新日期:2008-06-01 00:00:00
abstract::We conducted a meta-analysis of cohort and case-control studies to evaluate all-cause and cardiovascular (CV) mortality of patients with type 2 diabetes mellitus (T2DM) who received sulphonylurea (SU) treatment, when compared to any other diabetes treatment. Only studies reporting raw data on mortality during SU treat...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,meta分析,评审
doi:10.1177/1479164112465442
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:Arterial stiffness has been associated with diabetic retinopathy; however, the information is limited in Asians. We aim to examine the association of central arterial stiffness with the presence and severity of diabetic retinopathy in type 2 diabetes mellitus patients in Singapore. METHODS:Arterial stiffness...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164119845904
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:Assess the effect of risk factors changes on risk for cardiovascular disease and mortality in patients with type 2 diabetes selected from the Swedish National Diabetes Register. METHODS:Observational study of 13,477 females and males aged 30-75 years, with baseline HbA1c 41-67 mmol/mol, systolic blood press...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164116637311
更新日期:2016-07-01 00:00:00
abstract::Antidiabetic thiazolidinediones (TZDs) improve endothelial function in patients with or without type 2 diabetes. The present randomised, placebo-controlled, double-blind study examined the time course of a single dose of rosiglitazone on flow-mediated endothelium-dependent vasodilation (FMD), metabolic parameters, and...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,随机对照试验
doi:10.1177/1479164110367812
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:Coronary atherosclerosis in patients with type 2 diabetes mellitus may be promoted by regional fat distribution. We investigated the association between anthropometric measures of obesity, truncal fat mass, epicardial adipose tissue and coronary atherosclerosis in asymptomatic patients and matched controls. ...
journal_title:Diabetes & vascular disease research
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abstract::Guidelines recommend aggressive goals for lipid and blood pressure reduction for high risk patients with diabetes mellitus and atherosclerotic coronary disease. However, it remains unclear how many patients achieve treatment goals versus the number of people merely placed on treatment. We conducted an observational st...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164111431471
更新日期:2012-04-01 00:00:00
abstract::Peripheral artery disease is a severe complication of diabetes. We have reported that the deletion of angiotensin type 2 receptor in diabetic mice promoted vascular angiogenesis in the ischaemic muscle 4 weeks following ischaemia. However, the angiotensin type 2 receptor deletion beneficial effects occurred 2 weeks po...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164119883978
更新日期:2020-01-01 00:00:00
abstract::Early studies showed nitric oxide as a pro-inflammatory-cytokine-induced toxin involved in pancreatic β-cell destruction during pathogenesis of type-1 diabetes. However, nitric oxide has both cytotoxic and cytoprotective effects on mammalian cells, depending on concentration and micro-environmental surroundings. Our s...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164117713947
更新日期:2017-09-01 00:00:00
abstract::The aim of this study was to evaluate changes in lipid profiles in patients with type 2 diabetes after treatment conversion from rosiglitazone to pioglitazone while maintaining stable statin and other lipid-altering therapies. A total of 305 patients were enrolled in this open-label study. Patients had been taking sta...
journal_title:Diabetes & vascular disease research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3132/dvdr.2006.005
更新日期:2006-05-01 00:00:00
abstract::The aim of this study was to characterise microvascular blood flow in the skin and to compare it with biomarkers of endothelial dysfunction and tissue inflammation in patients with type 2 diabetes with (n=20) or without (n=20) microvascular complications and 20 control subjects. Microvascular function was measured by ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.3132/dvdr.2008.006
更新日期:2008-03-01 00:00:00
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journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164115595523
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:The role of long non-coding RNA in diabetic retinopathy, a serious complication of diabetes mellitus, has attracted increasing attention in recent years. The purpose of this study was to explore whether long non-coding RNA nuclear paraspeckle assembly transcript 1 was involved in the context of diabetic reti...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164117749382
更新日期:2018-05-01 00:00:00
abstract::The complications of diabetes are myriad and represent a rising cause of morbidity and mortality, particularly in the Western world. The update of the Diabetes Control and Clinical Trials Group/Epidemiology of Diabetes Interventions and Complications Research Group (DCCT/EDIC) suggested that previous strict control of...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2004.001
更新日期:2004-05-01 00:00:00
abstract::Vascular complications associated with type 2 diabetes confer significant morbidity and mortality. Atherosclerosis develops much earlier and progresses more rapidly than in subjects without diabetes. The clustering of cardiovascular risk factors associated with type 2 diabetes is mainly responsible for accelerated ath...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2007.067
更新日期:2007-12-01 00:00:00
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journal_title:Diabetes & vascular disease research
pub_type: 临床试验,杂志文章
doi:10.1177/1479164109360470
更新日期:2010-04-01 00:00:00
abstract::Roux-en-Y bypass surgery is increasingly used for treatment of gross obesity due to the general inability of lifestyle change and existing drug treatments to counter the obesity epidemic. This common form of bariatric surgery involves bypass of the small intestine with significant reduction of body of weight that is i...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.3132/dvdr.2007.034
更新日期:2007-06-01 00:00:00
abstract:PURPOSE:Our objectives were to describe recent trends in the characteristics and in-hospital outcomes in diabetic as compared with non-diabetic patients hospitalized with ST-segment elevation myocardial infarction (STEMI). METHODS:We reviewed the medical records of 2537 persons with (n = 684) and without (n = 1853) a ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164114524235
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To investigate the long-term prognostic value of insulin-like growth factor-binding protein 1 in patients with acute myocardial infarction. METHODS:Patients ( n = 180) with admission glucose < 11 mmol/L without previously known diabetes admitted for an acute myocardial infarction in 1998-2000 were followed f...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164118781892
更新日期:2018-09-01 00:00:00
abstract::Insulin resistance typically reflects multiple defects of insulin receptor and post-receptor signalling that impair a diverse range of metabolic and vascular actions. Many potential intervention targets and compounds with therapeutic activity have been described. Proof of principle for a non-peptide insulin mimetic ha...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2007.002
更新日期:2007-03-01 00:00:00
abstract::More than 1 in 10 US adolescents have prediabetes or diabetes, and elevated glycosylated haemoglobin (HbA1C) in youth is associated with increased risk of death before the age of 55 years. We conducted a prospective, cross-sectional study of 31,546 consecutive volunteer blood donors, 16-19 years of age, who donated bl...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164115579799
更新日期:2015-07-01 00:00:00
abstract::We respond to the letter of Nadery and Shahsavari regarding our paper entitled 'Interobserver reliability of the ankle brachial index, toe -brachial index and distal pulse palpation in patients with diabetes. In this letter, we concluded that despite some limitations, the kappa coefficient is an informative measure of...
journal_title:Diabetes & vascular disease research
pub_type: 评论,信件
doi:10.1177/1479164118794901
更新日期:2018-11-01 00:00:00
abstract::Heart failure is now recognized as a progressive disease in which patients transition through the stages of being at risk of heart failure (stage A), to asymptomatic structural heart disease (stage B), to clinical manifestations of heart failure (stage C) and finally end-stage or refractory heart failure (stage D). Th...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164115579006
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To characterize copeptin levels and to explore its prognostic importance in patients with acute myocardial infarction with newly detected glucose abnormalities. METHODS:Copeptin was measured in 166 patients with acute myocardial infarction without known diabetes and in 168 age- and gender-matched controls. P...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究
doi:10.1177/1479164116664490
更新日期:2017-03-01 00:00:00
abstract::To assess the prevalence of metabolic syndrome (MS) and estimates of global risk by Framingham Risk Score in young subjects with acute myocardial infarction (MI), we assessed metabolic parameters and global risk assessment in 165 consecutive subjects who presented with myocardial infarction prior to 45 years of age. N...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.3132/dvdr.2006.012
更新日期:2006-09-01 00:00:00
abstract::Angiotensin II receptor blockers (ARB) are often co-administered with a calcium channel blocker (CCB) for treating hypertension. In this open-label randomised study, untreated diabetic hypertensive patients were randomised to receive either olmesartan 20 mg/day or candesartan 8 mg/day for 12 weeks. Patients with blood...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,随机对照试验
doi:10.1177/1479164112447310
更新日期:2012-10-01 00:00:00