Metabolic syndrome-mediated inflammation following elective percutaneous coronary intervention.

Abstract:

:There are few data concerning the relationship between diabetes mellitus, the metabolic syndrome and inflammation following elective percutaneous coronary intervention (PCI). The purpose of this study was to assess basal and peak levels of candidate cytokines in 40 patients undergoing elective PCI. Patients were categorised as having diabetes mellitus, the metabolic syndrome, or neither. Patients with the metabolic syndrome exhibited significantly greater levels of tumour necrosis factor-alpha over the study period, although this was unrelated to PCI. There was a trend for increased levels of interleukin-6 following PCI, primarily among patients with metabolic syndrome. Basal levels of monocyte chemoattractant protein-1 (MCP-1) were not different among study groups; however, the metabolic syndrome cohort had a trend towards increased circulating levels of MCP-1 after PCI. In this patient population, the metabolic syndrome correlates with a heightened inflammatory response following elective PCI.

journal_name

Diab Vasc Dis Res

authors

Marso SP,Murphy JW,House JA,Safley DM,Harris WS

doi

10.3132/dvdr.2005.003

keywords:

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

31-6

issue

1

eissn

1479-1641

issn

1752-8984

journal_volume

2

pub_type

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