Insulin resistance: Impact on therapeutic developments in diabetes.

abstract：OBJECTIVES:Assess the effect of risk factors changes on risk for cardiovascular disease and mortality in patients with type 2 diabetes selected from the Swedish National Diabetes Register. METHODS:Observational study of 13,477 females and males aged 30-75 years, with baseline HbA1c 41-67 mmol/mol, systolic blood press...

journal_title：Diabetes & vascular disease research

authors： Eeg-Olofsson K,Zethelius B,Gudbjörnsdottir S,Eliasson B,Svensson AM,Cederholm J

更新日期：2016-07-01 00:00:00

abstract：:Telmisartan partially activates the peroxisome proliferator-activated receptor γ (PPARγ), which may ameliorate the accumulation of visceral adipose tissues and sensitise insulin action. Nineteen patients with essential hypertension and metabolic syndrome were randomly assigned to receive 40 mg of telmisartan (TELMI gr...

journal_title：Diabetes & vascular disease research

authors： Murakami K,Wada J,Ogawa D,Horiguchi CS,Miyoshi T,Sasaki M,Uchida HA,Nakamura Y,Makino H

更新日期：2013-01-01 00:00:00

abstract：:Guidelines recommend aggressive goals for lipid and blood pressure reduction for high risk patients with diabetes mellitus and atherosclerotic coronary disease. However, it remains unclear how many patients achieve treatment goals versus the number of people merely placed on treatment. We conducted an observational st...

journal_title：Diabetes & vascular disease research

authors： DeGuzman PB,Akosah KO,Simpson AG,Barbieri KE,Megginson GC,Goldberg RI,Beller GA

更新日期：2012-04-01 00:00:00

abstract：:Urate, a naturally-occurring antioxidant, is a marker/factor for cardiovascular disease. Hyperuricaemia is associated with IR, MetS and endothelial dysfunction. We characterised the associations between neurohormones, uricaemia, and glucose homeostasis in type 2 diabetes mellitus (T2DM) males. Cross-sectional; 705 T2D...

journal_title：Diabetes & vascular disease research

authors： Hermans MP,Ahn SA,Rousseau MF

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:We have previously reported insignificant changes in HbA1c after exercise in patients with both type 2 diabetes and coronary artery disease. In this study, we investigated the effect of exercise on endothelial function and possible associations between changes in endothelial function and HbA1c. METHODS:Patie...

journal_title：Diabetes & vascular disease research

authors： Byrkjeland R,Njerve IU,Arnesen H,Seljeflot I,Solheim S

更新日期：2017-03-01 00:00:00

abstract：:While few dispute the existence of the metabolic syndrome as a clustering of factors indicative of poor metabolic health, its utility above that of its individual components in the clinical care of individual patients is questioned. This is likely a consequence of the failure of clinicians and scientists to agree on a...

journal_title：Diabetes & vascular disease research

authors： Nolan CJ,Prentki M

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:Statins are extensively used for lowering LDL-cholesterol and reducing cardiovascular events. Recent studies have shown that statins have beneficial anti-inflammatory effects. We aimed to determine whether and how adipokines are regulated during statin treatment in type 2 diabetic patients. METHOD:In this st...

journal_title：Diabetes & vascular disease research

authors： Hu Y,Tong G,Xu W,Pan J,Ryan K,Yang R,Shuldiner AR,Gong DW,Zhu D

更新日期：2009-10-01 00:00:00

abstract：:We aimed to study the association between fasting plasma glucose, diabetes incidence and cardiovascular burden after 10-12 years. We evaluated diabetes and cardiovascular events incidences, carotid intima-media thickness and coronary artery calcium scores in ELSA-Brasil (the Brazilian Longitudinal Study of Adult Healt...

journal_title：Diabetes & vascular disease research

authors： Sitnik D,Santos IS,Goulart AC,Staniak HL,Manson JE,Lotufo PA,Bensenor IM

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:The development of disturbances in skin microcirculation in type 1 diabetes is not well characterised. We assessed skin microcirculation longitudinally from the onset of diabetes up to 29 years of duration to investigate when such disturbances start. MATERIAL AND METHODS:Seventeen adult patients with type 1...

journal_title：Diabetes & vascular disease research

authors： Santesson P,Lins PE,Kalani M,Adamson U,Lelic I,von Wendt G,Fagrell B,Jörneskog G

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:Coronary atherosclerosis in patients with type 2 diabetes mellitus may be promoted by regional fat distribution. We investigated the association between anthropometric measures of obesity, truncal fat mass, epicardial adipose tissue and coronary atherosclerosis in asymptomatic patients and matched controls. ...

journal_title：Diabetes & vascular disease research

authors： Gullaksen S,Funck KL,Laugesen E,Hansen TK,Dey D,Poulsen PL

更新日期：2019-07-01 00:00:00

abstract：:Prehypertension is considered to be associated with increased cardiovascular disease (CVD), and some data suggest that insulin resistance is common in this group. The goal of this study was to quantify insulin action by determining the steady-state plasma glucose (SSPG) concentration during the insulin suppression tes...

journal_title：Diabetes & vascular disease research

authors： Knobler H,Abbasi F,Lamendola C,Reaven GM

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:Our objectives were to describe recent trends in the characteristics and in-hospital outcomes in diabetic as compared with non-diabetic patients hospitalized with ST-segment elevation myocardial infarction (STEMI). METHODS:We reviewed the medical records of 2537 persons with (n = 684) and without (n = 1853) a ...

journal_title：Diabetes & vascular disease research

authors： Tisminetzky M,Joffe S,McManus DD,Darling C,Gore JM,Yarzebski J,Lessard D,Goldberg RJ

更新日期：2014-05-01 00:00:00

abstract：:We conducted a meta-analysis of cohort and case-control studies to evaluate all-cause and cardiovascular (CV) mortality of patients with type 2 diabetes mellitus (T2DM) who received sulphonylurea (SU) treatment, when compared to any other diabetes treatment. Only studies reporting raw data on mortality during SU treat...

journal_title：Diabetes & vascular disease research

authors： Forst T,Hanefeld M,Jacob S,Moeser G,Schwenk G,Pfützner A,Haupt A

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Musclin is a newly identified skeletal muscle-derived secretory factor, which has been recently characterized as a stimulator that induces insulin resistance in mice. However, the pathophysiological role of musclin in humans remains poorly understood. The aim of this study was to explore the potential correl...

journal_title：Diabetes & vascular disease research

authors： Chen WJ,Liu Y,Sui YB,Zhang B,Zhang XH,Yin XH

更新日期：2017-03-01 00:00:00

abstract：:The aim of this study was to test the hypothesis that cardiovascular disease occurs to the greatest extent in persons with prediabetes mellitus who are also insulin resistant. In 2003, 664 non-diabetic women (n = 457) and men (n = 207), aged 52 ± 16 and 53 ± 15 years, were surveyed during a programme for cardiovascula...

journal_title：Diabetes & vascular disease research

authors： Salazar MR,Carbajal HA,Espeche WG,Aizpurúa M,Leiva Sisnieguez CE,Leiva Sisnieguez BC,Stavile RN,March CE,Reaven GM

更新日期：2016-03-01 00:00:00

abstract：:Inhibitors of the enzyme dipeptidyl peptidase IV (DPP IV) provide a strategy for the treatment of type 2 diabetes. DPP IV rapidly inactivates the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Inhibition of DPP IV prolongs and enhances the activity of endogeno...

journal_title：Diabetes & vascular disease research

authors： Green BD,Flatt PR,Bailey CJ

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The risk of major adverse cardiac and cerebrovascular events following acute coronary syndrome is increased in people with diabetes. Predicting out-of-hospital outcomes upon follow-up remains difficult, and no simple, well-validated tools exist for this population at present. We aim to evaluat...

journal_title：Diabetes & vascular disease research

authors： Baluja A,Rodríguez-Mañero M,Cordero A,Kreidieh B,Iglesias-Alvarez D,García-Acuña JM,Martínez-Gómez A,Agra-Bermejo R,Alvarez-Rodríguez L,Abou-Jokh C,López-Ratón M,Gude-Sampedro F,Alvarez-Escudero J,González-Juanatey JR

更新日期：2020-01-01 00:00:00

abstract：:Cardiovascular disease is the most common complication of type 2 diabetes mellitus (type 2 DM), accounting for approximately 80% of deaths. While atherosclerotic vascular disease accounts for much of the cardiovascular morbidity and mortality among diabetic patients, congestive heart failure (CHF) is another key compl...

journal_title：Diabetes & vascular disease research

authors： Patel C,Wyne KL,McGuire DK

更新日期：2005-05-01 00:00:00

abstract：:Adiponectin circulates in plasma as various isoforms. However, the biological activity of each isoform has not been firmly established. High molecular weight (HMW) adiponectin may be the active form of adiponectin, while a proteolytic cleavage product of adiponectin, known as globular adiponectin (gAd), has recently b...

journal_title：Diabetes & vascular disease research

authors： Tomizawa A,Hattori Y,Kasai K,Nakano Y

更新日期：2008-06-01 00:00:00

abstract：:Early studies showed nitric oxide as a pro-inflammatory-cytokine-induced toxin involved in pancreatic β-cell destruction during pathogenesis of type-1 diabetes. However, nitric oxide has both cytotoxic and cytoprotective effects on mammalian cells, depending on concentration and micro-environmental surroundings. Our s...

journal_title：Diabetes & vascular disease research

authors： Wong JC,Vo V,Gorjala P,Fiscus RR

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:To examine the relationship between leisure-time physical activity (LTPA) and the metabolic syndrome in the U.S. adult population. METHODS:The sample (N=5,620) in this cross-sectional study included adults aged 20 years and older. Physical activity was measured in two ways: a six-level measure based upon those...

journal_title：Diabetes & vascular disease research

authors： Churilla JR,Fitzhugh EC

更新日期：2009-04-01 00:00:00

abstract：:Doppler waveforms analysis is a interesting to diagnose peripheral artery disease as suggested by the international recommendations. However as mentioned in the present letter, there is a lack of consensus about the terminology that should be used. ...

journal_title：Diabetes & vascular disease research

authors： Lanéelle D,Stivalet O,Mahé G,Jaquinandi V,Omarjee L

更新日期：2019-01-01 00:00:00

abstract：:The objective of this study was to evaluate the safety and tolerability of atorvastatin 10 mg compared with placebo in 2,838 patients with type 2 diabetes and no history of coronary heart disease who were enrolled in the Collaborative Atorvastatin Diabetes Study (CARDS) and followed for 3.9 years. The percentages of p...

journal_title：Diabetes & vascular disease research

authors： Newman CB,Szarek M,Colhoun HM,Betteridge DJ,Durrington PN,Hitman GA,Neil HA,Demicco DA,Auster S,Fuller JH,Cards Investigators.

更新日期：2008-09-01 00:00:00

abstract：:The aim of this study was to evaluate changes in lipid profiles in patients with type 2 diabetes after treatment conversion from rosiglitazone to pioglitazone while maintaining stable statin and other lipid-altering therapies. A total of 305 patients were enrolled in this open-label study. Patients had been taking sta...

journal_title：Diabetes & vascular disease research

authors： Berhanu P,Kipnes MS,Khan MA,Perez AT,Kupfer SF,Spanheimer RC,Demissie S,Fleck PR

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:The main manifestation of hyperglycaemia during pregnancy is gestational diabetes mellitus. It can herald diabetes mellitus type 2 and its deleterious long-term effects, such as hypertension and cardiovascular disease. The aim of this study was to assess diastolic function in women with gestational diabetes ...

journal_title：Diabetes & vascular disease research

authors： Oliveira AP,Calderon IM,Costa RA,Roscani MG,Magalhães CG,Borges VT

更新日期：2015-05-01 00:00:00

abstract：:Antidiabetic thiazolidinediones (TZDs) improve endothelial function in patients with or without type 2 diabetes. The present randomised, placebo-controlled, double-blind study examined the time course of a single dose of rosiglitazone on flow-mediated endothelium-dependent vasodilation (FMD), metabolic parameters, and...

journal_title：Diabetes & vascular disease research

authors： Walcher T,Walcher D,Hetzel J,Mielke C,Rau M,Rittig K,Balletshofer B,Schwedhelm E,Hombach V,Böger RH,Koenig W,Marx N

更新日期：2010-07-01 00:00:00

abstract：:The aim of this study was to characterise microvascular blood flow in the skin and to compare it with biomarkers of endothelial dysfunction and tissue inflammation in patients with type 2 diabetes with (n=20) or without (n=20) microvascular complications and 20 control subjects. Microvascular function was measured by ...

journal_title：Diabetes & vascular disease research

authors： Brooks BA,McLennan SV,Twigg SM,Yue DK

更新日期：2008-03-01 00:00:00

abstract：:To assess the non-LDL-C-related dyslipidaemia risk of MI, 823 men aged 23 to 65 with a first MI were compared with 823 MI-free PROCAM controls matched for sex, age, smoking, DM, BP and LDL-C. Overall, the odds of MI in men with HDL-C < 1.15 mmol/L were 2.6 times those of men with HDL-C >or= 1.15 mmol/L, and the odds o...

journal_title：Diabetes & vascular disease research

authors： Assmann G,Cullen P,Schulte H

更新日期：2010-07-01 00:00:00

abstract：:Metabolic syndrome (MetS) is a clustering of atherosclerotic coronary heart disease risk factors. This post-hoc analysis compared the effects of switching to ezetimibe/simvastatin 10/20 mg or rosuvastatin 10 mg in a cohort of 618 high-risk hypercholesterolaemic patients with (n=368) and without (n=217) MetS who had pr...

journal_title：Diabetes & vascular disease research

authors： Averna M,Missault L,Vaverkova H,Farnier M,Viigimaa M,Dong Q,Shah A,Johnson-Levonas AO,Taggart W,Brudi P

更新日期：2011-10-01 00:00:00

abstract：:In order to discuss and establish a joint position on the treatment of low serum levels of high-density lipoprotein cholesterol (HDL-C), a group of experts involved in the care of people with dyslipidaemia and at risk of cardiovascular disease met in Miami, Florida, U.S., on 5th and 6th March 2005. The experts came fr...

journal_title：Diabetes & vascular disease research

authors： Espinosa-Larrañaga F,Vejar-Jalaf M,Medina-Santillán R,Latin American Group.

更新日期：2005-10-01 00:00:00