Association of sulphonylurea treatment with all-cause and cardiovascular mortality: a systematic review and meta-analysis of observational studies.

Abstract:

:We conducted a meta-analysis of cohort and case-control studies to evaluate all-cause and cardiovascular (CV) mortality of patients with type 2 diabetes mellitus (T2DM) who received sulphonylurea (SU) treatment, when compared to any other diabetes treatment. Only studies reporting raw data on mortality during SU treatment were included. Data were combined using random-effects (RE) models. Unadjusted odds ratios (ORs) are presented. Of 4991 publication titles and abstracts reviewed, 20 studies (n = 551,912 patients) were included. For cohort studies (n = 276,050), patients receiving SU monotherapy or combination treatment had significantly higher all-cause and CV mortality risks compared to any non-SU treatment [all-cause, 13 studies: OR = 1.92, 95% confidence interval (CI) = 1.48-2.49; CV, 5 studies: OR = 2.72, 95% CI = 1.95-3.79]. Validity was limited by the high treatment group heterogeneity (I (2) > 90%) and study-inherent biases/design differences. In conclusion, patients receiving SU treatment had increased all-cause and CV mortality risks. However, the meta-analysis was limited by the high heterogeneity of non-randomized studies.

journal_name

Diab Vasc Dis Res

authors

Forst T,Hanefeld M,Jacob S,Moeser G,Schwenk G,Pfützner A,Haupt A

doi

10.1177/1479164112465442

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

302-14

issue

4

eissn

1479-1641

issn

1752-8984

pii

1479164112465442

journal_volume

10

pub_type

杂志文章,meta分析,评审
  • Respond to the letter on 'Interobserver reliability of the ankle brachial index, toe-brachial index and distal pulse palpation in patients with diabetes: a methodological issue'.

    abstract::We respond to the letter of Nadery and Shahsavari regarding our paper entitled 'Interobserver reliability of the ankle brachial index, toe -brachial index and distal pulse palpation in patients with diabetes. In this letter, we concluded that despite some limitations, the kappa coefficient is an informative measure of...

    journal_title:Diabetes & vascular disease research

    pub_type: 评论,信件

    doi:10.1177/1479164118794901

    authors: Álvaro Afonso FJ,García-Morales E,Molines-Barroso RJ,García-Álvarez Y,Sanz-Corbalán I,Lázaro-Martínez JL

    更新日期:2018-11-01 00:00:00

  • Association between interarm blood pressure differences and diabetic retinopathy in patients with type 2 diabetes.

    abstract:BACKGROUND:The effect of interarm blood pressure difference on the development of diabetic retinopathy, proteinuria and chronic kidney disease remains unknown. We investigated to determine the impact of interarm blood pressure difference on the prevalence of diabetic retinopathy, proteinuria and chronic kidney disease ...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.1177/1479164120945910

    authors: Lee JH,Kim YA,Lee Y,Bang WD,Seo JH

    更新日期:2020-07-01 00:00:00

  • Platelet abnormalities in diabetes mellitus.

    abstract::Patients with diabetes mellitus (DM) have accelerated atherosclerosis, which is the main underlying factor contributing to the high risk of atherothrombotic events in these patients. Atherothrombotic complications are the leading cause of morbidity and mortality in patients with DM. Among factors contributing to the p...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章,评审

    doi:10.1177/1479164110383994

    authors: Ferreiro JL,Gómez-Hospital JA,Angiolillo DJ

    更新日期:2010-10-01 00:00:00

  • Estimating the number of preventable cardiovascular disease events in the United States using the EMPA-REG OUTCOME trial results and National Health and Nutrition Examination Survey.

    abstract:AIM:We examined eligibility and preventable cardiovascular disease events in US adults with diabetes mellitus from the Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME). METHODS:We identified adults with diabetes mellitus eligible for EMPA-REG OUTCOME based on tri...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.1177/1479164120945674

    authors: Wong ND,Fan W,Pak J

    更新日期:2020-07-01 00:00:00

  • The effects of tesaglitazar as add-on treatment to metformin in patients with poorly controlled type 2 diabetes.

    abstract::This study assessed the effects of tesaglitazar (0.5 or 1 mg/day), a dual peroxisome proliferator-activated receptor alpha/gamma agonist, when added to maximally tolerated metformin (2-2.5 g/day) in patients with poorly controlled type 2 diabetes. The primary end point of this 24-week, randomised, placebo-controlled s...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.3132/dvdr.2007.041

    authors: Göke B,Gause-Nilsson I,Persson A,GALLANT 8 Study Group.

    更新日期:2007-09-01 00:00:00

  • Relationship between leisure-time physical activity and metabolic syndrome using varying definitions: 1999-2004 NHANES.

    abstract:PURPOSE:To examine the relationship between leisure-time physical activity (LTPA) and the metabolic syndrome in the U.S. adult population. METHODS:The sample (N=5,620) in this cross-sectional study included adults aged 20 years and older. Physical activity was measured in two ways: a six-level measure based upon those...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.1177/1479164109336040

    authors: Churilla JR,Fitzhugh EC

    更新日期:2009-04-01 00:00:00

  • Combination of the dipeptidyl peptidase-4 inhibitor linagliptin with insulin-based regimens in type 2 diabetes and chronic kidney disease.

    abstract::Glucose-lowering treatment options for type 2 diabetes mellitus patients with chronic kidney disease are limited. We evaluated the potential for linagliptin in combination with insulin in type 2 diabetes mellitus patients with mild-to-severe renal impairment. Data for participants in two phase 3 trials with linaglipti...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1479164115579001

    authors: McGill JB,Yki-Järvinen H,Crowe S,Woerle HJ,von Eynatten M

    更新日期:2015-07-01 00:00:00

  • Effects of pioglitazone on lipid and lipoprotein profiles in patients with type 2 diabetes and dyslipidaemia after treatment conversion from rosiglitazone while continuing stable statin therapy.

    abstract::The aim of this study was to evaluate changes in lipid profiles in patients with type 2 diabetes after treatment conversion from rosiglitazone to pioglitazone while maintaining stable statin and other lipid-altering therapies. A total of 305 patients were enrolled in this open-label study. Patients had been taking sta...

    journal_title:Diabetes & vascular disease research

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.3132/dvdr.2006.005

    authors: Berhanu P,Kipnes MS,Khan MA,Perez AT,Kupfer SF,Spanheimer RC,Demissie S,Fleck PR

    更新日期:2006-05-01 00:00:00

  • Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro.

    abstract:BACKGROUND:Antiretroviral therapy in HIV-positive patients leads to insulin resistance which is central to the pathogenesis of various metabolic abnormalities and cardiovascular disease seen in this patient group. We have investigated the dose-response relationship of telmisartan, an antihypertensive, on adipocytes in ...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.1177/1479164118757924

    authors: Pushpakom SP,Adaikalakoteswari A,Owen A,Back DJ,Tripathi G,Kumar S,McTernan P,Pirmohamed M

    更新日期:2018-05-01 00:00:00

  • Copeptin in patients with acute myocardial infarction and newly detected glucose abnormalities - A marker of increased stress susceptibility? A report from the Glucose in Acute Myocardial Infarction cohort.

    abstract:OBJECTIVE:To characterize copeptin levels and to explore its prognostic importance in patients with acute myocardial infarction with newly detected glucose abnormalities. METHODS:Copeptin was measured in 166 patients with acute myocardial infarction without known diabetes and in 168 age- and gender-matched controls. P...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章,多中心研究

    doi:10.1177/1479164116664490

    authors: Smaradottir MI,Ritsinger V,Gyberg V,Norhammar A,Näsman P,Mellbin LG

    更新日期:2017-03-01 00:00:00

  • Albuminuria and renal function as predictors of cardiovascular events and mortality in a general population of patients with type 2 diabetes: a nationwide observational study from the Swedish National Diabetes Register.

    abstract:OBJECTIVE:Reduced renal function and albuminuria predict cardiovascular (CV) events and mortality in type 2 diabetes (T2D). In addition, we evaluated the role of co-existing congestive heart failure (CHF) and other CV risk factors on CV events in a large observational population-based cohort of T2D patients. RESEARCH ...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.1177/1479164113500798

    authors: Svensson MK,Cederholm J,Eliasson B,Zethelius B,Gudbjörnsdottir S,Swedish National Diabetes Register.

    更新日期:2013-11-01 00:00:00

  • Raised natriuretic peptides, big-endothelin-1 and improved beta-cell function in type 2 diabetic males with hyperuricaemia.

    abstract::Urate, a naturally-occurring antioxidant, is a marker/factor for cardiovascular disease. Hyperuricaemia is associated with IR, MetS and endothelial dysfunction. We characterised the associations between neurohormones, uricaemia, and glucose homeostasis in type 2 diabetes mellitus (T2DM) males. Cross-sectional; 705 T2D...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.1177/1479164109336689

    authors: Hermans MP,Ahn SA,Rousseau MF

    更新日期:2009-07-01 00:00:00

  • Elevated levels of insulin-like growth factor-binding protein 1 predict outcome after acute myocardial infarction: A long-term follow-up of the glucose tolerance in patients with acute myocardial infarction (GAMI) cohort.

    abstract:OBJECTIVE:To investigate the long-term prognostic value of insulin-like growth factor-binding protein 1 in patients with acute myocardial infarction. METHODS:Patients ( n = 180) with admission glucose < 11 mmol/L without previously known diabetes admitted for an acute myocardial infarction in 1998-2000 were followed f...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.1177/1479164118781892

    authors: Ritsinger V,Brismar K,Mellbin L,Näsman P,Rydén L,Söderberg S,Norhammar A

    更新日期:2018-09-01 00:00:00

  • Fasting glucose levels, incident diabetes, subclinical atherosclerosis and cardiovascular events in apparently healthy adults: A 12-year longitudinal study.

    abstract::We aimed to study the association between fasting plasma glucose, diabetes incidence and cardiovascular burden after 10-12 years. We evaluated diabetes and cardiovascular events incidences, carotid intima-media thickness and coronary artery calcium scores in ELSA-Brasil (the Brazilian Longitudinal Study of Adult Healt...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.1177/1479164116653356

    authors: Sitnik D,Santos IS,Goulart AC,Staniak HL,Manson JE,Lotufo PA,Bensenor IM

    更新日期:2016-11-01 00:00:00

  • Effective surgical treatment of obesity may be mediated by ablation of the lipogenic gut hormone gastric inhibitory polypeptide (GIP): evidence and clinical opportunity for development of new obesity-diabetes drugs?

    abstract::Roux-en-Y bypass surgery is increasingly used for treatment of gross obesity due to the general inability of lifestyle change and existing drug treatments to counter the obesity epidemic. This common form of bariatric surgery involves bypass of the small intestine with significant reduction of body of weight that is i...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.3132/dvdr.2007.034

    authors: Flatt PR

    更新日期:2007-06-01 00:00:00

  • Insulin resistance: The linchpin between prediabetes and cardiovascular disease.

    abstract::The aim of this study was to test the hypothesis that cardiovascular disease occurs to the greatest extent in persons with prediabetes mellitus who are also insulin resistant. In 2003, 664 non-diabetic women (n = 457) and men (n = 207), aged 52 ± 16 and 53 ± 15 years, were surveyed during a programme for cardiovascula...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.1177/1479164115610057

    authors: Salazar MR,Carbajal HA,Espeche WG,Aizpurúa M,Leiva Sisnieguez CE,Leiva Sisnieguez BC,Stavile RN,March CE,Reaven GM

    更新日期:2016-03-01 00:00:00

  • Atherosclerosis in type 2 diabetes: a role for fibrate therapy?

    abstract::Vascular complications associated with type 2 diabetes confer significant morbidity and mortality. Atherosclerosis develops much earlier and progresses more rapidly than in subjects without diabetes. The clustering of cardiovascular risk factors associated with type 2 diabetes is mainly responsible for accelerated ath...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章,评审

    doi:10.3132/dvdr.2007.067

    authors: Steiner G

    更新日期:2007-12-01 00:00:00

  • Detection and characterisation of microcirculatory abnormalities in the skin of diabetic patients with microvascular complications.

    abstract::The aim of this study was to characterise microvascular blood flow in the skin and to compare it with biomarkers of endothelial dysfunction and tissue inflammation in patients with type 2 diabetes with (n=20) or without (n=20) microvascular complications and 20 control subjects. Microvascular function was measured by ...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.3132/dvdr.2008.006

    authors: Brooks BA,McLennan SV,Twigg SM,Yue DK

    更新日期:2008-03-01 00:00:00

  • Association of central arterial stiffness with the presence and severity of diabetic retinopathy in Asians with type 2 diabetes.

    abstract:OBJECTIVE:Arterial stiffness has been associated with diabetic retinopathy; however, the information is limited in Asians. We aim to examine the association of central arterial stiffness with the presence and severity of diabetic retinopathy in type 2 diabetes mellitus patients in Singapore. METHODS:Arterial stiffness...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.1177/1479164119845904

    authors: Zhang X,Lim SC,Tavintharan S,Yeoh LY,Sum CF,Ang K,Yeo D,Low S,Kumari N

    更新日期:2019-11-01 00:00:00

  • Diabetic cardiomyopathy: An expression of stage B heart failure with preserved ejection fraction.

    abstract::Heart failure is now recognized as a progressive disease in which patients transition through the stages of being at risk of heart failure (stage A), to asymptomatic structural heart disease (stage B), to clinical manifestations of heart failure (stage C) and finally end-stage or refractory heart failure (stage D). Th...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章,评审

    doi:10.1177/1479164115579006

    authors: Lam CS

    更新日期:2015-07-01 00:00:00

  • Interrelationship of canonical and non-canonical Wnt signalling pathways in chronic metabolic diseases.

    abstract::Chronic diseases account for approximately 45% of all deaths in developed countries and are particularly prevalent in countries with the most sophisticated and robust public health systems. Chronic metabolic diseases, specifically lifestyle-related diseases pertaining to diet and exercise, continue to be difficult to ...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章,评审

    doi:10.1177/1479164117738442

    authors: Ackers I,Malgor R

    更新日期:2018-01-01 00:00:00

  • Decade-long trends in the characteristics, management and hospital outcomes of diabetic patients with ST-segment elevation myocardial infarction.

    abstract:PURPOSE:Our objectives were to describe recent trends in the characteristics and in-hospital outcomes in diabetic as compared with non-diabetic patients hospitalized with ST-segment elevation myocardial infarction (STEMI). METHODS:We reviewed the medical records of 2537 persons with (n = 684) and without (n = 1853) a ...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.1177/1479164114524235

    authors: Tisminetzky M,Joffe S,McManus DD,Darling C,Gore JM,Yarzebski J,Lessard D,Goldberg RJ

    更新日期:2014-05-01 00:00:00

  • Thiazolidinediones, peripheral oedema and congestive heart failure: what is the evidence?

    abstract::Cardiovascular disease is the most common complication of type 2 diabetes mellitus (type 2 DM), accounting for approximately 80% of deaths. While atherosclerotic vascular disease accounts for much of the cardiovascular morbidity and mortality among diabetic patients, congestive heart failure (CHF) is another key compl...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章,评审

    doi:10.3132/dvdr.2005.010

    authors: Patel C,Wyne KL,McGuire DK

    更新日期:2005-05-01 00:00:00

  • Pancreatic-β-cell survival and proliferation are promoted by protein kinase G type Iα and downstream regulation of AKT/FOXO1.

    abstract::Early studies showed nitric oxide as a pro-inflammatory-cytokine-induced toxin involved in pancreatic β-cell destruction during pathogenesis of type-1 diabetes. However, nitric oxide has both cytotoxic and cytoprotective effects on mammalian cells, depending on concentration and micro-environmental surroundings. Our s...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.1177/1479164117713947

    authors: Wong JC,Vo V,Gorjala P,Fiscus RR

    更新日期:2017-09-01 00:00:00

  • Description of Doppler waveforms to detect lower extremity peripheral artery disease.

    abstract::Doppler waveforms analysis is a interesting to diagnose peripheral artery disease as suggested by the international recommendations. However as mentioned in the present letter, there is a lack of consensus about the terminology that should be used. ...

    journal_title:Diabetes & vascular disease research

    pub_type: 评论,信件

    doi:10.1177/1479164118809527

    authors: Lanéelle D,Stivalet O,Mahé G,Jaquinandi V,Omarjee L

    更新日期:2019-01-01 00:00:00

  • The safety and tolerability of atorvastatin 10 mg in the Collaborative Atorvastatin Diabetes Study (CARDS).

    abstract::The objective of this study was to evaluate the safety and tolerability of atorvastatin 10 mg compared with placebo in 2,838 patients with type 2 diabetes and no history of coronary heart disease who were enrolled in the Collaborative Atorvastatin Diabetes Study (CARDS) and followed for 3.9 years. The percentages of p...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.3132/dvdr.2008.029

    authors: Newman CB,Szarek M,Colhoun HM,Betteridge DJ,Durrington PN,Hitman GA,Neil HA,Demicco DA,Auster S,Fuller JH,Cards Investigators.

    更新日期:2008-09-01 00:00:00

  • Considerably decreased risk of cardiovascular disease with combined reductions in HbA1c, blood pressure and blood lipids in type 2 diabetes: Report from the Swedish National Diabetes Register.

    abstract:OBJECTIVES:Assess the effect of risk factors changes on risk for cardiovascular disease and mortality in patients with type 2 diabetes selected from the Swedish National Diabetes Register. METHODS:Observational study of 13,477 females and males aged 30-75 years, with baseline HbA1c 41-67 mmol/mol, systolic blood press...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.1177/1479164116637311

    authors: Eeg-Olofsson K,Zethelius B,Gudbjörnsdottir S,Eliasson B,Svensson AM,Cederholm J

    更新日期:2016-07-01 00:00:00

  • Assessment of structural cardiac abnormalities and diastolic function in women with gestational diabetes mellitus.

    abstract:BACKGROUND:The main manifestation of hyperglycaemia during pregnancy is gestational diabetes mellitus. It can herald diabetes mellitus type 2 and its deleterious long-term effects, such as hypertension and cardiovascular disease. The aim of this study was to assess diastolic function in women with gestational diabetes ...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.1177/1479164114563302

    authors: Oliveira AP,Calderon IM,Costa RA,Roscani MG,Magalhães CG,Borges VT

    更新日期:2015-05-01 00:00:00

  • Insulin resistance and cardiovascular disease risk factors in subjects with prehypertension.

    abstract::Prehypertension is considered to be associated with increased cardiovascular disease (CVD), and some data suggest that insulin resistance is common in this group. The goal of this study was to quantify insulin action by determining the steady-state plasma glucose (SSPG) concentration during the insulin suppression tes...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.1177/1479164110396919

    authors: Knobler H,Abbasi F,Lamendola C,Reaven GM

    更新日期:2011-01-01 00:00:00

  • Long non-coding RNA nuclear paraspeckle assembly transcript 1 inhibits the apoptosis of retina Müller cells after diabetic retinopathy through regulating miR-497/brain-derived neurotrophic factor axis.

    abstract:BACKGROUND:The role of long non-coding RNA in diabetic retinopathy, a serious complication of diabetes mellitus, has attracted increasing attention in recent years. The purpose of this study was to explore whether long non-coding RNA nuclear paraspeckle assembly transcript 1 was involved in the context of diabetic reti...

    journal_title:Diabetes & vascular disease research

    pub_type: 杂志文章

    doi:10.1177/1479164117749382

    authors: Li XJ

    更新日期:2018-05-01 00:00:00