Abstract:
:We conducted a meta-analysis of cohort and case-control studies to evaluate all-cause and cardiovascular (CV) mortality of patients with type 2 diabetes mellitus (T2DM) who received sulphonylurea (SU) treatment, when compared to any other diabetes treatment. Only studies reporting raw data on mortality during SU treatment were included. Data were combined using random-effects (RE) models. Unadjusted odds ratios (ORs) are presented. Of 4991 publication titles and abstracts reviewed, 20 studies (n = 551,912 patients) were included. For cohort studies (n = 276,050), patients receiving SU monotherapy or combination treatment had significantly higher all-cause and CV mortality risks compared to any non-SU treatment [all-cause, 13 studies: OR = 1.92, 95% confidence interval (CI) = 1.48-2.49; CV, 5 studies: OR = 2.72, 95% CI = 1.95-3.79]. Validity was limited by the high treatment group heterogeneity (I (2) > 90%) and study-inherent biases/design differences. In conclusion, patients receiving SU treatment had increased all-cause and CV mortality risks. However, the meta-analysis was limited by the high heterogeneity of non-randomized studies.
journal_name
Diab Vasc Dis Resjournal_title
Diabetes & vascular disease researchauthors
Forst T,Hanefeld M,Jacob S,Moeser G,Schwenk G,Pfützner A,Haupt Adoi
10.1177/1479164112465442subject
Has Abstractpub_date
2013-07-01 00:00:00pages
302-14issue
4eissn
1479-1641issn
1752-8984pii
1479164112465442journal_volume
10pub_type
杂志文章,meta分析,评审abstract::We respond to the letter of Nadery and Shahsavari regarding our paper entitled 'Interobserver reliability of the ankle brachial index, toe -brachial index and distal pulse palpation in patients with diabetes. In this letter, we concluded that despite some limitations, the kappa coefficient is an informative measure of...
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pub_type: 杂志文章,多中心研究,随机对照试验
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