Abstract:
:Patients with diabetes mellitus (DM) have accelerated atherosclerosis, which is the main underlying factor contributing to the high risk of atherothrombotic events in these patients. Atherothrombotic complications are the leading cause of morbidity and mortality in patients with DM. Among factors contributing to the prothrombotic condition which characterise patients with DM, platelet hyperreactivity plays a pivotal role. Platelets of DM patients are characterised by dysregulation of several signalling pathways leading to intensified adhesion, activation and aggregation. Multiple mechanisms are involved in platelet dysfunction of patients with DM, which can be categorised as follows: a) hyperglycaemia, b) insulin deficiency and resistance, c) associated metabolic conditions, and d) other cellular abnormalities.The present manuscript aims to provide an overview on the current status of knowledge on platelet abnormalities that characterise patients with DM.
journal_name
Diab Vasc Dis Resjournal_title
Diabetes & vascular disease researchauthors
Ferreiro JL,Gómez-Hospital JA,Angiolillo DJdoi
10.1177/1479164110383994subject
Has Abstractpub_date
2010-10-01 00:00:00pages
251-9issue
4eissn
1479-1641issn
1752-8984pii
1479164110383994journal_volume
7pub_type
杂志文章,评审abstract:OBJECTIVE:To investigate the long-term prognostic value of insulin-like growth factor-binding protein 1 in patients with acute myocardial infarction. METHODS:Patients ( n = 180) with admission glucose < 11 mmol/L without previously known diabetes admitted for an acute myocardial infarction in 1998-2000 were followed f...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164118781892
更新日期:2018-09-01 00:00:00
abstract::Sodium-glucose cotransporter 2 inhibitors are antihyperglycaemic medications with an emerging evidence base for cardiovascular and kidney disease risk reduction. Sodium-glucose cotransporter 2 inhibitors medications lower plasma glucose by inhibiting glucose reabsorption in the proximal tubule of the kidney independen...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
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abstract::We conducted a meta-analysis of cohort and case-control studies to evaluate all-cause and cardiovascular (CV) mortality of patients with type 2 diabetes mellitus (T2DM) who received sulphonylurea (SU) treatment, when compared to any other diabetes treatment. Only studies reporting raw data on mortality during SU treat...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,meta分析,评审
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abstract::In order to discuss and establish a joint position on the treatment of low serum levels of high-density lipoprotein cholesterol (HDL-C), a group of experts involved in the care of people with dyslipidaemia and at risk of cardiovascular disease met in Miami, Florida, U.S., on 5th and 6th March 2005. The experts came fr...
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pub_type: 杂志文章,实务指引
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abstract::We aimed to study the association between fasting plasma glucose, diabetes incidence and cardiovascular burden after 10-12 years. We evaluated diabetes and cardiovascular events incidences, carotid intima-media thickness and coronary artery calcium scores in ELSA-Brasil (the Brazilian Longitudinal Study of Adult Healt...
journal_title:Diabetes & vascular disease research
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abstract:BACKGROUND:The role of long non-coding RNA in diabetic retinopathy, a serious complication of diabetes mellitus, has attracted increasing attention in recent years. The purpose of this study was to explore whether long non-coding RNA nuclear paraspeckle assembly transcript 1 was involved in the context of diabetic reti...
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abstract::Heart failure is now recognized as a progressive disease in which patients transition through the stages of being at risk of heart failure (stage A), to asymptomatic structural heart disease (stage B), to clinical manifestations of heart failure (stage C) and finally end-stage or refractory heart failure (stage D). Th...
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abstract:AIM:We examined eligibility and preventable cardiovascular disease events in US adults with diabetes mellitus from the Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME). METHODS:We identified adults with diabetes mellitus eligible for EMPA-REG OUTCOME based on tri...
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-03-01 00:00:00
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journal_title:Diabetes & vascular disease research
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-07-01 00:00:00
abstract::More than 1 in 10 US adolescents have prediabetes or diabetes, and elevated glycosylated haemoglobin (HbA1C) in youth is associated with increased risk of death before the age of 55 years. We conducted a prospective, cross-sectional study of 31,546 consecutive volunteer blood donors, 16-19 years of age, who donated bl...
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更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:The development of disturbances in skin microcirculation in type 1 diabetes is not well characterised. We assessed skin microcirculation longitudinally from the onset of diabetes up to 29 years of duration to investigate when such disturbances start. MATERIAL AND METHODS:Seventeen adult patients with type 1...
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abstract::Flow-mediated dilatation evaluation using hand skin heating may possibly be more accurate than post-ischaemic hyperaemia to detect conduit artery endothelial dysfunction in type 1 diabetes. We measured in 24 type 1 diabetic patients (n=16 without microangiopathy) and 24 healthy matched subjects radial artery diameter ...
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-11-01 00:00:00