Platelet abnormalities in diabetes mellitus.

Abstract:

:Patients with diabetes mellitus (DM) have accelerated atherosclerosis, which is the main underlying factor contributing to the high risk of atherothrombotic events in these patients. Atherothrombotic complications are the leading cause of morbidity and mortality in patients with DM. Among factors contributing to the prothrombotic condition which characterise patients with DM, platelet hyperreactivity plays a pivotal role. Platelets of DM patients are characterised by dysregulation of several signalling pathways leading to intensified adhesion, activation and aggregation. Multiple mechanisms are involved in platelet dysfunction of patients with DM, which can be categorised as follows: a) hyperglycaemia, b) insulin deficiency and resistance, c) associated metabolic conditions, and d) other cellular abnormalities.The present manuscript aims to provide an overview on the current status of knowledge on platelet abnormalities that characterise patients with DM.

journal_name

Diab Vasc Dis Res

authors

Ferreiro JL,Gómez-Hospital JA,Angiolillo DJ

doi

10.1177/1479164110383994

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

251-9

issue

4

eissn

1479-1641

issn

1752-8984

pii

1479164110383994

journal_volume

7

pub_type

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