Abstract:
PURPOSE:Our objectives were to describe recent trends in the characteristics and in-hospital outcomes in diabetic as compared with non-diabetic patients hospitalized with ST-segment elevation myocardial infarction (STEMI). METHODS:We reviewed the medical records of 2537 persons with (n = 684) and without (n = 1853) a history of diabetes who were hospitalized for STEMI between 1997 and 2009 at 11 medical centres in Central Massachusetts. RESULTS:Diabetic patients were more likely to be older, female and to have a higher prevalence of previously diagnosed comorbidities. Diabetic patients were more likely to have developed important in-hospital complications and to have a longer hospital stay compared with non-diabetic patients. Between 1997 and 2009, there was a marked decline in hospital mortality in diabetic (20.0%-5.6%) and non-diabetic (18.6%-7.5%) patients. CONCLUSION:Despite reduced hospital mortality in patients hospitalized with STEMI, diabetic patients continue to experience significantly more adverse outcomes than non-diabetics.
journal_name
Diab Vasc Dis Resjournal_title
Diabetes & vascular disease researchauthors
Tisminetzky M,Joffe S,McManus DD,Darling C,Gore JM,Yarzebski J,Lessard D,Goldberg RJdoi
10.1177/1479164114524235subject
Has Abstractpub_date
2014-05-01 00:00:00pages
182-9issue
3eissn
1479-1641issn
1752-8984pii
1479164114524235journal_volume
11pub_type
杂志文章abstract::The aim of this study was to test the hypothesis that cardiovascular disease occurs to the greatest extent in persons with prediabetes mellitus who are also insulin resistant. In 2003, 664 non-diabetic women (n = 457) and men (n = 207), aged 52 ± 16 and 53 ± 15 years, were surveyed during a programme for cardiovascula...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164115610057
更新日期:2016-03-01 00:00:00
abstract::Prehypertension is considered to be associated with increased cardiovascular disease (CVD), and some data suggest that insulin resistance is common in this group. The goal of this study was to quantify insulin action by determining the steady-state plasma glucose (SSPG) concentration during the insulin suppression tes...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164110396919
更新日期:2011-01-01 00:00:00
abstract::Physical activity decreases risk for diabetes and cardiovascular disease morbidity and mortality; however, the specific impact of exercise on the diabetic vasculature is unexamined. We hypothesized that an acute, moderate exercise intervention in diabetic and hypertensive rats would induce mitochondrial biogenesis and...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
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journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,随机对照试验
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更新日期:2012-10-01 00:00:00
abstract::The first objective of this study was to determine the baseline prevalence of metabolic syndrome and its individual components using the NCEP-R/ATPIII criteria, IDF criteria for Europe, and IDF criteria for Africa: waist circumference of at least 94 cm for men and women. The second objective was to investigate the inc...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164109346362
更新日期:2010-01-01 00:00:00
abstract::Cardiovascular disease is the leading cause of morbidity and mortality in subjects with type 2 diabetes mellitus. Increased aortic stiffness, assessed with the carotid-femoral pulse wave velocity, is an independent risk factor for cardiovascular disease. Statins reduce effectively cardiovascular disease and mortality ...
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abstract::The objective of this study was to evaluate the safety and tolerability of atorvastatin 10 mg compared with placebo in 2,838 patients with type 2 diabetes and no history of coronary heart disease who were enrolled in the Collaborative Atorvastatin Diabetes Study (CARDS) and followed for 3.9 years. The percentages of p...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Antiretroviral therapy in HIV-positive patients leads to insulin resistance which is central to the pathogenesis of various metabolic abnormalities and cardiovascular disease seen in this patient group. We have investigated the dose-response relationship of telmisartan, an antihypertensive, on adipocytes in ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
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abstract::Insulin resistance has a broad pathogenic impact affecting metabolic, cardio-renal and other disease areas. Extensive studies to dissect the mechanisms of insulin resistance have provided valuable insights to shape current clinical awareness and advance therapeutic practice. However, the development of direct interven...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
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abstract::There are few data concerning the relationship between diabetes mellitus, the metabolic syndrome and inflammation following elective percutaneous coronary intervention (PCI). The purpose of this study was to assess basal and peak levels of candidate cytokines in 40 patients undergoing elective PCI. Patients were categ...
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pub_type: 临床试验,杂志文章
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更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:To characterize copeptin levels and to explore its prognostic importance in patients with acute myocardial infarction with newly detected glucose abnormalities. METHODS:Copeptin was measured in 166 patients with acute myocardial infarction without known diabetes and in 168 age- and gender-matched controls. P...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究
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journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
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更新日期:2015-07-01 00:00:00
abstract::Patients with diabetes mellitus (DM) have accelerated atherosclerosis, which is the main underlying factor contributing to the high risk of atherothrombotic events in these patients. Atherothrombotic complications are the leading cause of morbidity and mortality in patients with DM. Among factors contributing to the p...
journal_title:Diabetes & vascular disease research
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abstract::We respond to the letter of Nadery and Shahsavari regarding our paper entitled 'Interobserver reliability of the ankle brachial index, toe -brachial index and distal pulse palpation in patients with diabetes. In this letter, we concluded that despite some limitations, the kappa coefficient is an informative measure of...
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pub_type: 评论,信件
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更新日期:2018-11-01 00:00:00
abstract:PURPOSE:To examine the relationship between leisure-time physical activity (LTPA) and the metabolic syndrome in the U.S. adult population. METHODS:The sample (N=5,620) in this cross-sectional study included adults aged 20 years and older. Physical activity was measured in two ways: a six-level measure based upon those...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
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更新日期:2009-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:Arterial stiffness has been associated with diabetic retinopathy; however, the information is limited in Asians. We aim to examine the association of central arterial stiffness with the presence and severity of diabetic retinopathy in type 2 diabetes mellitus patients in Singapore. METHODS:Arterial stiffness...
journal_title:Diabetes & vascular disease research
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更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:The effect of interarm blood pressure difference on the development of diabetic retinopathy, proteinuria and chronic kidney disease remains unknown. We investigated to determine the impact of interarm blood pressure difference on the prevalence of diabetic retinopathy, proteinuria and chronic kidney disease ...
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更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:Assess the effect of risk factors changes on risk for cardiovascular disease and mortality in patients with type 2 diabetes selected from the Swedish National Diabetes Register. METHODS:Observational study of 13,477 females and males aged 30-75 years, with baseline HbA1c 41-67 mmol/mol, systolic blood press...
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更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:The main manifestation of hyperglycaemia during pregnancy is gestational diabetes mellitus. It can herald diabetes mellitus type 2 and its deleterious long-term effects, such as hypertension and cardiovascular disease. The aim of this study was to assess diastolic function in women with gestational diabetes ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Continuous-wave Doppler is frequently used for detecting peripheral arterial disease in patients with diabetes; however, there is limited evidence investigating diagnostic accuracy. This study aimed to determine sensitivity and specificity of continuous-wave Doppler for detecting peripheral arterial disease ...
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更新日期:2018-09-01 00:00:00
abstract::Sodium-glucose cotransporter 2 inhibitors are antihyperglycaemic medications with an emerging evidence base for cardiovascular and kidney disease risk reduction. Sodium-glucose cotransporter 2 inhibitors medications lower plasma glucose by inhibiting glucose reabsorption in the proximal tubule of the kidney independen...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
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更新日期:2018-09-01 00:00:00
abstract::Chronic diseases account for approximately 45% of all deaths in developed countries and are particularly prevalent in countries with the most sophisticated and robust public health systems. Chronic metabolic diseases, specifically lifestyle-related diseases pertaining to diet and exercise, continue to be difficult to ...
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更新日期:2018-01-01 00:00:00
abstract::Early studies showed nitric oxide as a pro-inflammatory-cytokine-induced toxin involved in pancreatic β-cell destruction during pathogenesis of type-1 diabetes. However, nitric oxide has both cytotoxic and cytoprotective effects on mammalian cells, depending on concentration and micro-environmental surroundings. Our s...
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更新日期:2017-09-01 00:00:00
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更新日期:2014-09-01 00:00:00
abstract::Flow-mediated dilatation evaluation using hand skin heating may possibly be more accurate than post-ischaemic hyperaemia to detect conduit artery endothelial dysfunction in type 1 diabetes. We measured in 24 type 1 diabetic patients (n=16 without microangiopathy) and 24 healthy matched subjects radial artery diameter ...
journal_title:Diabetes & vascular disease research
pub_type: 临床试验,杂志文章
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更新日期:2010-04-01 00:00:00