Abstract:
:Insulin resistance typically reflects multiple defects of insulin receptor and post-receptor signalling that impair a diverse range of metabolic and vascular actions. Many potential intervention targets and compounds with therapeutic activity have been described. Proof of principle for a non-peptide insulin mimetic has been demonstrated by specific activation of the intracellular B-subunit of the insulin receptor. Potentiation of insulin action has been achieved with agents that enhance phosphorylation and prolong the tyrosine kinase activity of the insulin receptor and its protein substrates after activation by insulin. These include inhibitors of phosphatases and serine kinases that normally prevent or terminate tyrosine kinase signalling. Additional approaches involve increasing the activity of phosphatidylinositol 3-kinase and other downstream components of the insulin signalling pathways. Experimental interventions to remove signalling defects caused by cytokines, certain adipocyte hormones, excess fatty acids, glucotoxicity and negative feedback by distal signalling steps have also indicated therapeutic possibilities. Several hormones, metabolic enzymes, minerals, co-factors and transcription co-activators have shown insulin-sensitising potential. Since insulin resistance affects many metabolic and cardiovascular diseases, it provides an opportunity for simultaneous therapeutic attack on a broad front.
journal_name
Diab Vasc Dis Resjournal_title
Diabetes & vascular disease researchauthors
Bailey CJdoi
10.3132/dvdr.2007.002subject
Has Abstractpub_date
2007-03-01 00:00:00pages
20-31issue
1eissn
1479-1641issn
1752-8984pii
2661journal_volume
4pub_type
杂志文章,评审abstract::Cardiovascular disease is the most common complication of type 2 diabetes mellitus (type 2 DM), accounting for approximately 80% of deaths. While atherosclerotic vascular disease accounts for much of the cardiovascular morbidity and mortality among diabetic patients, congestive heart failure (CHF) is another key compl...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2005.010
更新日期:2005-05-01 00:00:00
abstract::We aimed to study the association between fasting plasma glucose, diabetes incidence and cardiovascular burden after 10-12 years. We evaluated diabetes and cardiovascular events incidences, carotid intima-media thickness and coronary artery calcium scores in ELSA-Brasil (the Brazilian Longitudinal Study of Adult Healt...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164116653356
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abstract::Diabetes contributes directly to the development of cardiovascular aortic valve disease. There is currently no drug therapy available for a dysfunctional valve and this urges the need for additional research to identify distinctive mechanisms of cardiovascular aortic valve disease evolution. The aim of this study was ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164119874469
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:Assess the effect of risk factors changes on risk for cardiovascular disease and mortality in patients with type 2 diabetes selected from the Swedish National Diabetes Register. METHODS:Observational study of 13,477 females and males aged 30-75 years, with baseline HbA1c 41-67 mmol/mol, systolic blood press...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164116637311
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:We have previously reported insignificant changes in HbA1c after exercise in patients with both type 2 diabetes and coronary artery disease. In this study, we investigated the effect of exercise on endothelial function and possible associations between changes in endothelial function and HbA1c. METHODS:Patie...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,随机对照试验
doi:10.1177/1479164116679077
更新日期:2017-03-01 00:00:00
abstract::The objective of this study was to evaluate the safety and tolerability of atorvastatin 10 mg compared with placebo in 2,838 patients with type 2 diabetes and no history of coronary heart disease who were enrolled in the Collaborative Atorvastatin Diabetes Study (CARDS) and followed for 3.9 years. The percentages of p...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3132/dvdr.2008.029
更新日期:2008-09-01 00:00:00
abstract::Flow-mediated dilatation evaluation using hand skin heating may possibly be more accurate than post-ischaemic hyperaemia to detect conduit artery endothelial dysfunction in type 1 diabetes. We measured in 24 type 1 diabetic patients (n=16 without microangiopathy) and 24 healthy matched subjects radial artery diameter ...
journal_title:Diabetes & vascular disease research
pub_type: 临床试验,杂志文章
doi:10.1177/1479164109360470
更新日期:2010-04-01 00:00:00
abstract::The aim of this study was to test the hypothesis that cardiovascular disease occurs to the greatest extent in persons with prediabetes mellitus who are also insulin resistant. In 2003, 664 non-diabetic women (n = 457) and men (n = 207), aged 52 ± 16 and 53 ± 15 years, were surveyed during a programme for cardiovascula...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164115610057
更新日期:2016-03-01 00:00:00
abstract::Patients with diabetes mellitus (DM) have accelerated atherosclerosis, which is the main underlying factor contributing to the high risk of atherothrombotic events in these patients. Atherothrombotic complications are the leading cause of morbidity and mortality in patients with DM. Among factors contributing to the p...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
abstract::To assess the prevalence of metabolic syndrome (MS) and estimates of global risk by Framingham Risk Score in young subjects with acute myocardial infarction (MI), we assessed metabolic parameters and global risk assessment in 165 consecutive subjects who presented with myocardial infarction prior to 45 years of age. N...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.3132/dvdr.2006.012
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:The effect of interarm blood pressure difference on the development of diabetic retinopathy, proteinuria and chronic kidney disease remains unknown. We investigated to determine the impact of interarm blood pressure difference on the prevalence of diabetic retinopathy, proteinuria and chronic kidney disease ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164120945910
更新日期:2020-07-01 00:00:00
abstract::Glucose-lowering treatment options for type 2 diabetes mellitus patients with chronic kidney disease are limited. We evaluated the potential for linagliptin in combination with insulin in type 2 diabetes mellitus patients with mild-to-severe renal impairment. Data for participants in two phase 3 trials with linaglipti...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,随机对照试验
doi:10.1177/1479164115579001
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:The role of long non-coding RNA in diabetic retinopathy, a serious complication of diabetes mellitus, has attracted increasing attention in recent years. The purpose of this study was to explore whether long non-coding RNA nuclear paraspeckle assembly transcript 1 was involved in the context of diabetic reti...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
abstract::Metabolic syndrome (MetS) is a clustering of atherosclerotic coronary heart disease risk factors. This post-hoc analysis compared the effects of switching to ezetimibe/simvastatin 10/20 mg or rosuvastatin 10 mg in a cohort of 618 high-risk hypercholesterolaemic patients with (n=368) and without (n=217) MetS who had pr...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/1479164111418136
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To characterize copeptin levels and to explore its prognostic importance in patients with acute myocardial infarction with newly detected glucose abnormalities. METHODS:Copeptin was measured in 166 patients with acute myocardial infarction without known diabetes and in 168 age- and gender-matched controls. P...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究
doi:10.1177/1479164116664490
更新日期:2017-03-01 00:00:00
abstract::Antidiabetic thiazolidinediones (TZDs) improve endothelial function in patients with or without type 2 diabetes. The present randomised, placebo-controlled, double-blind study examined the time course of a single dose of rosiglitazone on flow-mediated endothelium-dependent vasodilation (FMD), metabolic parameters, and...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,随机对照试验
doi:10.1177/1479164110367812
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine whether high fitness attenuates the defects in left ventricular (LV) structure, function and triglyceride (TG) content in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS:Patients (n = 74) with T2DM and ≥1 additional cardiac risk factor were recruite...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164114540924
更新日期:2014-09-01 00:00:00
abstract::Diabetes mellitus and angina pectoris are important conditions in older persons. The utility of pre-diabetes mellitus, diabetes mellitus and other risk factors as predictors of incident angina pectoris among older adults has not been characterized. We examined incident angina pectoris rates by sex and diabetes mellitu...
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pub_type: 杂志文章,多中心研究
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更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Statins are extensively used for lowering LDL-cholesterol and reducing cardiovascular events. Recent studies have shown that statins have beneficial anti-inflammatory effects. We aimed to determine whether and how adipokines are regulated during statin treatment in type 2 diabetic patients. METHOD:In this st...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,随机对照试验
doi:10.1177/1479164109339966
更新日期:2009-10-01 00:00:00
abstract::Peripheral artery disease is a severe complication of diabetes. We have reported that the deletion of angiotensin type 2 receptor in diabetic mice promoted vascular angiogenesis in the ischaemic muscle 4 weeks following ischaemia. However, the angiotensin type 2 receptor deletion beneficial effects occurred 2 weeks po...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
abstract::Guidelines recommend aggressive goals for lipid and blood pressure reduction for high risk patients with diabetes mellitus and atherosclerotic coronary disease. However, it remains unclear how many patients achieve treatment goals versus the number of people merely placed on treatment. We conducted an observational st...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164111431471
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The risk of major adverse cardiac and cerebrovascular events following acute coronary syndrome is increased in people with diabetes. Predicting out-of-hospital outcomes upon follow-up remains difficult, and no simple, well-validated tools exist for this population at present. We aim to evaluat...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究
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更新日期:2020-01-01 00:00:00
abstract::The global prevalence of diabetes mellitus (DM) continues to climb, and is accompanied by an increase in DM associated complications, most often manifesting as coronary heart disease. Platelet dysfunction has been implicated as a central contributor to the increased risk of coronary artery disease in patients with DM,...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164111420890
更新日期:2011-10-01 00:00:00
abstract::More than 1 in 10 US adolescents have prediabetes or diabetes, and elevated glycosylated haemoglobin (HbA1C) in youth is associated with increased risk of death before the age of 55 years. We conducted a prospective, cross-sectional study of 31,546 consecutive volunteer blood donors, 16-19 years of age, who donated bl...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164115579799
更新日期:2015-07-01 00:00:00
abstract::Telmisartan partially activates the peroxisome proliferator-activated receptor γ (PPARγ), which may ameliorate the accumulation of visceral adipose tissues and sensitise insulin action. Nineteen patients with essential hypertension and metabolic syndrome were randomly assigned to receive 40 mg of telmisartan (TELMI gr...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,随机对照试验
doi:10.1177/1479164112444640
更新日期:2013-01-01 00:00:00
abstract::The first objective of this study was to determine the baseline prevalence of metabolic syndrome and its individual components using the NCEP-R/ATPIII criteria, IDF criteria for Europe, and IDF criteria for Africa: waist circumference of at least 94 cm for men and women. The second objective was to investigate the inc...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164109346362
更新日期:2010-01-01 00:00:00
abstract::Heart failure is now recognized as a progressive disease in which patients transition through the stages of being at risk of heart failure (stage A), to asymptomatic structural heart disease (stage B), to clinical manifestations of heart failure (stage C) and finally end-stage or refractory heart failure (stage D). Th...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
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更新日期:2015-07-01 00:00:00
abstract::We investigated the effect of atorvastatin monotherapy and combined treatment with atorvastatin and pioglitazone on intima-media thickness, vascular function and the cardiovascular risk profile. In all, 148 patients (76 male, 72 female; aged 61.4+/-6.5 years; body mass index [BMI] 29.2+/-4.1 kg/m2; mean +/- SD) with i...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-11-01 00:00:00
abstract::This study assessed the effects of tesaglitazar (0.5 or 1 mg/day), a dual peroxisome proliferator-activated receptor alpha/gamma agonist, when added to maximally tolerated metformin (2-2.5 g/day) in patients with poorly controlled type 2 diabetes. The primary end point of this 24-week, randomised, placebo-controlled s...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3132/dvdr.2007.041
更新日期:2007-09-01 00:00:00
abstract::We investigated the usefulness of Holter monitoring to detect cardiac disease and predict future cardiovascular risk in asymptomatic diabetic patients. This is a multi-centre, prospective study in 406 asymptomatic diabetic patients. They were categorized into three groups based on findings of Holter monitoring. A tota...
journal_title:Diabetes & vascular disease research
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更新日期:2015-11-01 00:00:00