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The effects of tesaglitazar as add-on treatment to metformin in patients with poorly controlled type 2 diabetes.

Abstract：

:This study assessed the effects of tesaglitazar (0.5 or 1 mg/day), a dual peroxisome proliferator-activated receptor alpha/gamma agonist, when added to maximally tolerated metformin (2-2.5 g/day) in patients with poorly controlled type 2 diabetes. The primary end point of this 24-week, randomised, placebo-controlled study was the absolute change from baseline in glycosylated haemoglobin (HbA1C). Tesaglitazar significantly reduced HbA1C, fasting plasma glucose and insulin levels compared with placebo (p<0.0001 for all) when added to metformin. Triglycerides, high-density lipoprotein cholesterol (HDL-C) and non-HDL-C levels also improved with tesaglitazar treatment (p<0.0001 for all). Adverse events were generally similar across treatments, except for higher frequencies of peripheral oedema and weight gain in the tesaglitazar 1 mg group. Although reversibility was not fully evaluated, dose-dependent changes in mean serum creatinine levels and haematology measures tended to return towards baseline at follow-up. Despite the clinical discontinuation of tesaglitazar, this study has demonstrated the potential benefits of dual PPAR agonism as add-on therapy to metformin, in patients with poorly controlled type 2 diabetes.

journal_name

Diab Vasc Dis Res

journal_title

Diabetes & vascular disease research

authors

Göke B,Gause-Nilsson I,Persson A,GALLANT 8 Study Group.

doi

10.3132/dvdr.2007.041

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

204-13

issue

3

eissn

1479-1641

issn

1752-8984

pii

2825

journal_volume

4

pub_type

杂志文章,多中心研究,随机对照试验

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