Sub-optimal achievement of guideline-derived lipid goals in management of diabetes patients with atherosclerotic cardiovascular disease, despite high use of evidence-based therapies.

abstract：:This study assessed the effects of tesaglitazar (0.5 or 1 mg/day), a dual peroxisome proliferator-activated receptor alpha/gamma agonist, when added to maximally tolerated metformin (2-2.5 g/day) in patients with poorly controlled type 2 diabetes. The primary end point of this 24-week, randomised, placebo-controlled s...

journal_title：Diabetes & vascular disease research

authors： Göke B,Gause-Nilsson I,Persson A,GALLANT 8 Study Group.

更新日期：2007-09-01 00:00:00

abstract：:The aim of this study was to evaluate changes in lipid profiles in patients with type 2 diabetes after treatment conversion from rosiglitazone to pioglitazone while maintaining stable statin and other lipid-altering therapies. A total of 305 patients were enrolled in this open-label study. Patients had been taking sta...

journal_title：Diabetes & vascular disease research

authors： Berhanu P,Kipnes MS,Khan MA,Perez AT,Kupfer SF,Spanheimer RC,Demissie S,Fleck PR

更新日期：2006-05-01 00:00:00

abstract：:Heart failure is now recognized as a progressive disease in which patients transition through the stages of being at risk of heart failure (stage A), to asymptomatic structural heart disease (stage B), to clinical manifestations of heart failure (stage C) and finally end-stage or refractory heart failure (stage D). Th...

journal_title：Diabetes & vascular disease research

authors： Lam CS

更新日期：2015-07-01 00:00:00

abstract：:Vascular complications associated with type 2 diabetes confer significant morbidity and mortality. Atherosclerosis develops much earlier and progresses more rapidly than in subjects without diabetes. The clustering of cardiovascular risk factors associated with type 2 diabetes is mainly responsible for accelerated ath...

journal_title：Diabetes & vascular disease research

authors： Steiner G

更新日期：2007-12-01 00:00:00

abstract：:The global prevalence of diabetes mellitus (DM) continues to climb, and is accompanied by an increase in DM associated complications, most often manifesting as coronary heart disease. Platelet dysfunction has been implicated as a central contributor to the increased risk of coronary artery disease in patients with DM,...

journal_title：Diabetes & vascular disease research

authors： Hall HM,Banerjee S,McGuire DK

更新日期：2011-10-01 00:00:00

abstract：:Insulin resistance has a broad pathogenic impact affecting metabolic, cardio-renal and other disease areas. Extensive studies to dissect the mechanisms of insulin resistance have provided valuable insights to shape current clinical awareness and advance therapeutic practice. However, the development of direct interven...

journal_title：Diabetes & vascular disease research

authors： Bailey CJ

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:Assess the effect of risk factors changes on risk for cardiovascular disease and mortality in patients with type 2 diabetes selected from the Swedish National Diabetes Register. METHODS:Observational study of 13,477 females and males aged 30-75 years, with baseline HbA1c 41-67 mmol/mol, systolic blood press...

journal_title：Diabetes & vascular disease research

authors： Eeg-Olofsson K,Zethelius B,Gudbjörnsdottir S,Eliasson B,Svensson AM,Cederholm J

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:C-type lectin receptors, including Dectin-2, are pattern recognition receptors on monocytes and macrophages that mainly recognize sugars and sugar-like structures present on fungi. Activation of C-type lectin receptors induces downstream CARD9 signalling, leading to the production of cytokines. We hypothesiz...

journal_title：Diabetes & vascular disease research

authors： Thiem K,Hoeke G,Zhou E,Hijmans A,Houben T,Boels MG,Mol IM,Lutgens E,Shiri-Sverdlov R,Bussink J,Kanneganti TD,Boon MR,Stienstra R,Tack CJ,Rensen PC,Netea MG,Berbée JF,van Diepen JA

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:To characterize copeptin levels and to explore its prognostic importance in patients with acute myocardial infarction with newly detected glucose abnormalities. METHODS:Copeptin was measured in 166 patients with acute myocardial infarction without known diabetes and in 168 age- and gender-matched controls. P...

journal_title：Diabetes & vascular disease research

authors： Smaradottir MI,Ritsinger V,Gyberg V,Norhammar A,Näsman P,Mellbin LG

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The role of long non-coding RNA in diabetic retinopathy, a serious complication of diabetes mellitus, has attracted increasing attention in recent years. The purpose of this study was to explore whether long non-coding RNA nuclear paraspeckle assembly transcript 1 was involved in the context of diabetic reti...

journal_title：Diabetes & vascular disease research

authors： Li XJ

更新日期：2018-05-01 00:00:00

abstract：:We conducted a meta-analysis of cohort and case-control studies to evaluate all-cause and cardiovascular (CV) mortality of patients with type 2 diabetes mellitus (T2DM) who received sulphonylurea (SU) treatment, when compared to any other diabetes treatment. Only studies reporting raw data on mortality during SU treat...

journal_title：Diabetes & vascular disease research

authors： Forst T,Hanefeld M,Jacob S,Moeser G,Schwenk G,Pfützner A,Haupt A

更新日期：2013-07-01 00:00:00

abstract：:Physical activity decreases risk for diabetes and cardiovascular disease morbidity and mortality; however, the specific impact of exercise on the diabetic vasculature is unexamined. We hypothesized that an acute, moderate exercise intervention in diabetic and hypertensive rats would induce mitochondrial biogenesis and...

journal_title：Diabetes & vascular disease research

authors： Knaub LA,McCune S,Chicco AJ,Miller M,Moore RL,Birdsey N,Lloyd MI,Villarreal J,Keller AC,Watson PA,Reusch JE

更新日期：2013-05-01 00:00:00

abstract：:While few dispute the existence of the metabolic syndrome as a clustering of factors indicative of poor metabolic health, its utility above that of its individual components in the clinical care of individual patients is questioned. This is likely a consequence of the failure of clinicians and scientists to agree on a...

journal_title：Diabetes & vascular disease research

authors： Nolan CJ,Prentki M

更新日期：2019-03-01 00:00:00

abstract：:More than 1 in 10 US adolescents have prediabetes or diabetes, and elevated glycosylated haemoglobin (HbA1C) in youth is associated with increased risk of death before the age of 55 years. We conducted a prospective, cross-sectional study of 31,546 consecutive volunteer blood donors, 16-19 years of age, who donated bl...

journal_title：Diabetes & vascular disease research

authors： Gore MO,Eason SJ,Ayers CR,Turer AT,Khera A,de Lemos JA,McGuire DK,Sayers M

更新日期：2015-07-01 00:00:00

abstract：:Cardiovascular disease is the most common complication of type 2 diabetes mellitus (type 2 DM), accounting for approximately 80% of deaths. While atherosclerotic vascular disease accounts for much of the cardiovascular morbidity and mortality among diabetic patients, congestive heart failure (CHF) is another key compl...

journal_title：Diabetes & vascular disease research

authors： Patel C,Wyne KL,McGuire DK

更新日期：2005-05-01 00:00:00

abstract：:The objective of this study was to evaluate the safety and tolerability of atorvastatin 10 mg compared with placebo in 2,838 patients with type 2 diabetes and no history of coronary heart disease who were enrolled in the Collaborative Atorvastatin Diabetes Study (CARDS) and followed for 3.9 years. The percentages of p...

journal_title：Diabetes & vascular disease research

authors： Newman CB,Szarek M,Colhoun HM,Betteridge DJ,Durrington PN,Hitman GA,Neil HA,Demicco DA,Auster S,Fuller JH,Cards Investigators.

更新日期：2008-09-01 00:00:00

abstract：:Insulin resistance typically reflects multiple defects of insulin receptor and post-receptor signalling that impair a diverse range of metabolic and vascular actions. Many potential intervention targets and compounds with therapeutic activity have been described. Proof of principle for a non-peptide insulin mimetic ha...

journal_title：Diabetes & vascular disease research

authors： Bailey CJ

更新日期：2007-03-01 00:00:00

abstract：:We investigated the effect of atorvastatin monotherapy and combined treatment with atorvastatin and pioglitazone on intima-media thickness, vascular function and the cardiovascular risk profile. In all, 148 patients (76 male, 72 female; aged 61.4+/-6.5 years; body mass index [BMI] 29.2+/-4.1 kg/m2; mean +/- SD) with i...

journal_title：Diabetes & vascular disease research

authors： Forst T,Wilhelm B,Pfützner A,Fuchs W,Lehmann U,Schaper F,Weber M,Müller J,Konrad T,Hanefeld M

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine whether high fitness attenuates the defects in left ventricular (LV) structure, function and triglyceride (TG) content in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS:Patients (n = 74) with T2DM and ≥1 additional cardiac risk factor were recruite...

journal_title：Diabetes & vascular disease research

authors： Sénéchal M,Ayers CR,Szczepaniak LS,Gore MO,See R,Abdullah SM,Berry JD,McGuire DK,McGavock JM

更新日期：2014-09-01 00:00:00

abstract：:Chronic diseases account for approximately 45% of all deaths in developed countries and are particularly prevalent in countries with the most sophisticated and robust public health systems. Chronic metabolic diseases, specifically lifestyle-related diseases pertaining to diet and exercise, continue to be difficult to ...

journal_title：Diabetes & vascular disease research

authors： Ackers I,Malgor R

更新日期：2018-01-01 00:00:00

abstract：:Sodium-glucose cotransporter 2 inhibitors are antihyperglycaemic medications with an emerging evidence base for cardiovascular and kidney disease risk reduction. Sodium-glucose cotransporter 2 inhibitors medications lower plasma glucose by inhibiting glucose reabsorption in the proximal tubule of the kidney independen...

journal_title：Diabetes & vascular disease research

authors： de Albuquerque Rocha N,Neeland IJ,McCullough PA,Toto RD,McGuire DK

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:Statins are extensively used for lowering LDL-cholesterol and reducing cardiovascular events. Recent studies have shown that statins have beneficial anti-inflammatory effects. We aimed to determine whether and how adipokines are regulated during statin treatment in type 2 diabetic patients. METHOD:In this st...

journal_title：Diabetes & vascular disease research

authors： Hu Y,Tong G,Xu W,Pan J,Ryan K,Yang R,Shuldiner AR,Gong DW,Zhu D

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:Reduced renal function and albuminuria predict cardiovascular (CV) events and mortality in type 2 diabetes (T2D). In addition, we evaluated the role of co-existing congestive heart failure (CHF) and other CV risk factors on CV events in a large observational population-based cohort of T2D patients. RESEARCH ...

journal_title：Diabetes & vascular disease research

authors： Svensson MK,Cederholm J,Eliasson B,Zethelius B,Gudbjörnsdottir S,Swedish National Diabetes Register.

更新日期：2013-11-01 00:00:00

abstract：:Flow-mediated dilatation evaluation using hand skin heating may possibly be more accurate than post-ischaemic hyperaemia to detect conduit artery endothelial dysfunction in type 1 diabetes. We measured in 24 type 1 diabetic patients (n=16 without microangiopathy) and 24 healthy matched subjects radial artery diameter ...

journal_title：Diabetes & vascular disease research

authors： Bellien J,Costentin A,Dutheil-Maillochaud B,Iacob M,Kuhn JM,Thuillez C,Joannides R

更新日期：2010-04-01 00:00:00

abstract：:Antidiabetic thiazolidinediones (TZDs) improve endothelial function in patients with or without type 2 diabetes. The present randomised, placebo-controlled, double-blind study examined the time course of a single dose of rosiglitazone on flow-mediated endothelium-dependent vasodilation (FMD), metabolic parameters, and...

journal_title：Diabetes & vascular disease research

authors： Walcher T,Walcher D,Hetzel J,Mielke C,Rau M,Rittig K,Balletshofer B,Schwedhelm E,Hombach V,Böger RH,Koenig W,Marx N

更新日期：2010-07-01 00:00:00

abstract：AIM:We examined eligibility and preventable cardiovascular disease events in US adults with diabetes mellitus from the Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME). METHODS:We identified adults with diabetes mellitus eligible for EMPA-REG OUTCOME based on tri...

journal_title：Diabetes & vascular disease research

authors： Wong ND,Fan W,Pak J

更新日期：2020-07-01 00:00:00

abstract：:We respond to the letter of Nadery and Shahsavari regarding our paper entitled 'Interobserver reliability of the ankle brachial index, toe -brachial index and distal pulse palpation in patients with diabetes. In this letter, we concluded that despite some limitations, the kappa coefficient is an informative measure of...

journal_title：Diabetes & vascular disease research

authors： Álvaro Afonso FJ,García-Morales E,Molines-Barroso RJ,García-Álvarez Y,Sanz-Corbalán I,Lázaro-Martínez JL

更新日期：2018-11-01 00:00:00

abstract：:Early studies showed nitric oxide as a pro-inflammatory-cytokine-induced toxin involved in pancreatic β-cell destruction during pathogenesis of type-1 diabetes. However, nitric oxide has both cytotoxic and cytoprotective effects on mammalian cells, depending on concentration and micro-environmental surroundings. Our s...

journal_title：Diabetes & vascular disease research

authors： Wong JC,Vo V,Gorjala P,Fiscus RR

更新日期：2017-09-01 00:00:00

abstract：:We aimed to study the association between fasting plasma glucose, diabetes incidence and cardiovascular burden after 10-12 years. We evaluated diabetes and cardiovascular events incidences, carotid intima-media thickness and coronary artery calcium scores in ELSA-Brasil (the Brazilian Longitudinal Study of Adult Healt...

journal_title：Diabetes & vascular disease research

authors： Sitnik D,Santos IS,Goulart AC,Staniak HL,Manson JE,Lotufo PA,Bensenor IM

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:The effect of interarm blood pressure difference on the development of diabetic retinopathy, proteinuria and chronic kidney disease remains unknown. We investigated to determine the impact of interarm blood pressure difference on the prevalence of diabetic retinopathy, proteinuria and chronic kidney disease ...

journal_title：Diabetes & vascular disease research

authors： Lee JH,Kim YA,Lee Y,Bang WD,Seo JH

更新日期：2020-07-01 00:00:00