Investigation of the vascular and pleiotropic effects of atorvastatin and pioglitazone in a population at high cardiovascular risk.

abstract：:Antidiabetic thiazolidinediones (TZDs) improve endothelial function in patients with or without type 2 diabetes. The present randomised, placebo-controlled, double-blind study examined the time course of a single dose of rosiglitazone on flow-mediated endothelium-dependent vasodilation (FMD), metabolic parameters, and...

journal_title：Diabetes & vascular disease research

authors： Walcher T,Walcher D,Hetzel J,Mielke C,Rau M,Rittig K,Balletshofer B,Schwedhelm E,Hombach V,Böger RH,Koenig W,Marx N

更新日期：2010-07-01 00:00:00

abstract：:Insulin resistance has a broad pathogenic impact affecting metabolic, cardio-renal and other disease areas. Extensive studies to dissect the mechanisms of insulin resistance have provided valuable insights to shape current clinical awareness and advance therapeutic practice. However, the development of direct interven...

journal_title：Diabetes & vascular disease research

authors： Bailey CJ

更新日期：2019-03-01 00:00:00

abstract：:More than 1 in 10 US adolescents have prediabetes or diabetes, and elevated glycosylated haemoglobin (HbA1C) in youth is associated with increased risk of death before the age of 55 years. We conducted a prospective, cross-sectional study of 31,546 consecutive volunteer blood donors, 16-19 years of age, who donated bl...

journal_title：Diabetes & vascular disease research

authors： Gore MO,Eason SJ,Ayers CR,Turer AT,Khera A,de Lemos JA,McGuire DK,Sayers M

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:The development of disturbances in skin microcirculation in type 1 diabetes is not well characterised. We assessed skin microcirculation longitudinally from the onset of diabetes up to 29 years of duration to investigate when such disturbances start. MATERIAL AND METHODS:Seventeen adult patients with type 1...

journal_title：Diabetes & vascular disease research

authors： Santesson P,Lins PE,Kalani M,Adamson U,Lelic I,von Wendt G,Fagrell B,Jörneskog G

更新日期：2017-05-01 00:00:00

abstract：:There are few data concerning the relationship between diabetes mellitus, the metabolic syndrome and inflammation following elective percutaneous coronary intervention (PCI). The purpose of this study was to assess basal and peak levels of candidate cytokines in 40 patients undergoing elective PCI. Patients were categ...

journal_title：Diabetes & vascular disease research

authors： Marso SP,Murphy JW,House JA,Safley DM,Harris WS

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVES:Assess the effect of risk factors changes on risk for cardiovascular disease and mortality in patients with type 2 diabetes selected from the Swedish National Diabetes Register. METHODS:Observational study of 13,477 females and males aged 30-75 years, with baseline HbA1c 41-67 mmol/mol, systolic blood press...

journal_title：Diabetes & vascular disease research

authors： Eeg-Olofsson K,Zethelius B,Gudbjörnsdottir S,Eliasson B,Svensson AM,Cederholm J

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:To examine the relationship between leisure-time physical activity (LTPA) and the metabolic syndrome in the U.S. adult population. METHODS:The sample (N=5,620) in this cross-sectional study included adults aged 20 years and older. Physical activity was measured in two ways: a six-level measure based upon those...

journal_title：Diabetes & vascular disease research

authors： Churilla JR,Fitzhugh EC

更新日期：2009-04-01 00:00:00

abstract：:Prehypertension is considered to be associated with increased cardiovascular disease (CVD), and some data suggest that insulin resistance is common in this group. The goal of this study was to quantify insulin action by determining the steady-state plasma glucose (SSPG) concentration during the insulin suppression tes...

journal_title：Diabetes & vascular disease research

authors： Knobler H,Abbasi F,Lamendola C,Reaven GM

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Antiretroviral therapy in HIV-positive patients leads to insulin resistance which is central to the pathogenesis of various metabolic abnormalities and cardiovascular disease seen in this patient group. We have investigated the dose-response relationship of telmisartan, an antihypertensive, on adipocytes in ...

journal_title：Diabetes & vascular disease research

authors： Pushpakom SP,Adaikalakoteswari A,Owen A,Back DJ,Tripathi G,Kumar S,McTernan P,Pirmohamed M

更新日期：2018-05-01 00:00:00

abstract：:Telmisartan partially activates the peroxisome proliferator-activated receptor γ (PPARγ), which may ameliorate the accumulation of visceral adipose tissues and sensitise insulin action. Nineteen patients with essential hypertension and metabolic syndrome were randomly assigned to receive 40 mg of telmisartan (TELMI gr...

journal_title：Diabetes & vascular disease research

authors： Murakami K,Wada J,Ogawa D,Horiguchi CS,Miyoshi T,Sasaki M,Uchida HA,Nakamura Y,Makino H

更新日期：2013-01-01 00:00:00

abstract：:With the growing prevalence of childhood obesity and type 2 diabetes mellitus (T2DM) in youth, the challenge of cardiovascular disease risk management has entered the paediatric realm, affecting specialists, family physicians and allied healthcare professionals alike. Currently, there is little evidence to support opt...

journal_title：Diabetes & vascular disease research

authors： McGavock J,Sellers E,Dean H

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:The role of long non-coding RNA in diabetic retinopathy, a serious complication of diabetes mellitus, has attracted increasing attention in recent years. The purpose of this study was to explore whether long non-coding RNA nuclear paraspeckle assembly transcript 1 was involved in the context of diabetic reti...

journal_title：Diabetes & vascular disease research

authors： Li XJ

更新日期：2018-05-01 00:00:00

abstract：:While few dispute the existence of the metabolic syndrome as a clustering of factors indicative of poor metabolic health, its utility above that of its individual components in the clinical care of individual patients is questioned. This is likely a consequence of the failure of clinicians and scientists to agree on a...

journal_title：Diabetes & vascular disease research

authors： Nolan CJ,Prentki M

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:We conducted a prospective pilot study in patients with diabetes to analyse the interobserver reliability of the ankle-brachial index, toe-brachial index and distal pulse palpation depending on the training of the professional involved. MATERIALS AND METHODS:The ankle-brachial index, toe-brachial index and d...

journal_title：Diabetes & vascular disease research

authors： Álvaro-Afonso FJ,García-Morales E,Molines-Barroso RJ,García-Álvarez Y,Sanz-Corbalán I,Lázaro-Martínez JL

更新日期：2018-07-01 00:00:00

abstract：:We investigated the usefulness of Holter monitoring to detect cardiac disease and predict future cardiovascular risk in asymptomatic diabetic patients. This is a multi-centre, prospective study in 406 asymptomatic diabetic patients. They were categorized into three groups based on findings of Holter monitoring. A tota...

journal_title：Diabetes & vascular disease research

authors： Nakao YM,Ueshima K,Nohara R,Mizunuma Y,Segawa I,Tanaka-Mizuno S,Yasuno S,Nakao K,Hiramori K,Kihara Y

更新日期：2015-11-01 00:00:00

abstract：:To assess the prevalence of metabolic syndrome (MS) and estimates of global risk by Framingham Risk Score in young subjects with acute myocardial infarction (MI), we assessed metabolic parameters and global risk assessment in 165 consecutive subjects who presented with myocardial infarction prior to 45 years of age. N...

journal_title：Diabetes & vascular disease research

authors： Zarich S,Luciano C,Hulford J,Abdullah A

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Musclin is a newly identified skeletal muscle-derived secretory factor, which has been recently characterized as a stimulator that induces insulin resistance in mice. However, the pathophysiological role of musclin in humans remains poorly understood. The aim of this study was to explore the potential correl...

journal_title：Diabetes & vascular disease research

authors： Chen WJ,Liu Y,Sui YB,Zhang B,Zhang XH,Yin XH

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVES:Coronary atherosclerosis in patients with type 2 diabetes mellitus may be promoted by regional fat distribution. We investigated the association between anthropometric measures of obesity, truncal fat mass, epicardial adipose tissue and coronary atherosclerosis in asymptomatic patients and matched controls. ...

journal_title：Diabetes & vascular disease research

authors： Gullaksen S,Funck KL,Laugesen E,Hansen TK,Dey D,Poulsen PL

更新日期：2019-07-01 00:00:00

abstract：:The aim of this study was to characterise microvascular blood flow in the skin and to compare it with biomarkers of endothelial dysfunction and tissue inflammation in patients with type 2 diabetes with (n=20) or without (n=20) microvascular complications and 20 control subjects. Microvascular function was measured by ...

journal_title：Diabetes & vascular disease research

authors： Brooks BA,McLennan SV,Twigg SM,Yue DK

更新日期：2008-03-01 00:00:00

abstract：:Roux-en-Y bypass surgery is increasingly used for treatment of gross obesity due to the general inability of lifestyle change and existing drug treatments to counter the obesity epidemic. This common form of bariatric surgery involves bypass of the small intestine with significant reduction of body of weight that is i...

journal_title：Diabetes & vascular disease research

authors： Flatt PR

更新日期：2007-06-01 00:00:00

abstract：:Patients with diabetes mellitus (DM) have accelerated atherosclerosis, which is the main underlying factor contributing to the high risk of atherothrombotic events in these patients. Atherothrombotic complications are the leading cause of morbidity and mortality in patients with DM. Among factors contributing to the p...

journal_title：Diabetes & vascular disease research

authors： Ferreiro JL,Gómez-Hospital JA,Angiolillo DJ

更新日期：2010-10-01 00:00:00

abstract：:Vascular complications associated with type 2 diabetes confer significant morbidity and mortality. Atherosclerosis develops much earlier and progresses more rapidly than in subjects without diabetes. The clustering of cardiovascular risk factors associated with type 2 diabetes is mainly responsible for accelerated ath...

journal_title：Diabetes & vascular disease research

authors： Steiner G

更新日期：2007-12-01 00:00:00

abstract：:Glucose-lowering treatment options for type 2 diabetes mellitus patients with chronic kidney disease are limited. We evaluated the potential for linagliptin in combination with insulin in type 2 diabetes mellitus patients with mild-to-severe renal impairment. Data for participants in two phase 3 trials with linaglipti...

journal_title：Diabetes & vascular disease research

authors： McGill JB,Yki-Järvinen H,Crowe S,Woerle HJ,von Eynatten M

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Reduced renal function and albuminuria predict cardiovascular (CV) events and mortality in type 2 diabetes (T2D). In addition, we evaluated the role of co-existing congestive heart failure (CHF) and other CV risk factors on CV events in a large observational population-based cohort of T2D patients. RESEARCH ...

journal_title：Diabetes & vascular disease research

authors： Svensson MK,Cederholm J,Eliasson B,Zethelius B,Gudbjörnsdottir S,Swedish National Diabetes Register.

更新日期：2013-11-01 00:00:00

abstract：:Doppler waveforms analysis is a interesting to diagnose peripheral artery disease as suggested by the international recommendations. However as mentioned in the present letter, there is a lack of consensus about the terminology that should be used. ...

journal_title：Diabetes & vascular disease research

authors： Lanéelle D,Stivalet O,Mahé G,Jaquinandi V,Omarjee L

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To characterize copeptin levels and to explore its prognostic importance in patients with acute myocardial infarction with newly detected glucose abnormalities. METHODS:Copeptin was measured in 166 patients with acute myocardial infarction without known diabetes and in 168 age- and gender-matched controls. P...

journal_title：Diabetes & vascular disease research

authors： Smaradottir MI,Ritsinger V,Gyberg V,Norhammar A,Näsman P,Mellbin LG

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The main manifestation of hyperglycaemia during pregnancy is gestational diabetes mellitus. It can herald diabetes mellitus type 2 and its deleterious long-term effects, such as hypertension and cardiovascular disease. The aim of this study was to assess diastolic function in women with gestational diabetes ...

journal_title：Diabetes & vascular disease research

authors： Oliveira AP,Calderon IM,Costa RA,Roscani MG,Magalhães CG,Borges VT

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:C-type lectin receptors, including Dectin-2, are pattern recognition receptors on monocytes and macrophages that mainly recognize sugars and sugar-like structures present on fungi. Activation of C-type lectin receptors induces downstream CARD9 signalling, leading to the production of cytokines. We hypothesiz...

journal_title：Diabetes & vascular disease research

authors： Thiem K,Hoeke G,Zhou E,Hijmans A,Houben T,Boels MG,Mol IM,Lutgens E,Shiri-Sverdlov R,Bussink J,Kanneganti TD,Boon MR,Stienstra R,Tack CJ,Rensen PC,Netea MG,Berbée JF,van Diepen JA

更新日期：2020-01-01 00:00:00

abstract：:The global prevalence of diabetes mellitus (DM) continues to climb, and is accompanied by an increase in DM associated complications, most often manifesting as coronary heart disease. Platelet dysfunction has been implicated as a central contributor to the increased risk of coronary artery disease in patients with DM,...

journal_title：Diabetes & vascular disease research

authors： Hall HM,Banerjee S,McGuire DK

更新日期：2011-10-01 00:00:00

abstract：:Adiponectin circulates in plasma as various isoforms. However, the biological activity of each isoform has not been firmly established. High molecular weight (HMW) adiponectin may be the active form of adiponectin, while a proteolytic cleavage product of adiponectin, known as globular adiponectin (gAd), has recently b...

journal_title：Diabetes & vascular disease research

authors： Tomizawa A,Hattori Y,Kasai K,Nakano Y

更新日期：2008-06-01 00:00:00