Abstract:
OBJECTIVES:Coronary atherosclerosis in patients with type 2 diabetes mellitus may be promoted by regional fat distribution. We investigated the association between anthropometric measures of obesity, truncal fat mass, epicardial adipose tissue and coronary atherosclerosis in asymptomatic patients and matched controls. METHODS:We examined 44 patients and 59 controls [mean (standard deviation) age 64.4 ± 9.9 vs 61.8 ± 9.7, male 50% vs 47%, diabetes duration mean (standard deviation) 7.7 ± 1.5] with coronary computed tomography angiography. Coronary plaques were quantified as total, calcified, non-calcified and low-density non-calcified plaque volumes (mm3). Regional fat distribution was assessed by dual-energy X-ray absorptiometry, body mass index (kg/m2), waist circumference (cm) and epicardial fat volume (mm3). Endothelial function and systemic inflammation were evaluated by peripheral arterial tonometry (log transformed Reactive Hyperemia Index) and C-reactive protein (mg/L). RESULTS:Body mass index and waist circumference (p < 0.02) were associated with coronary plaque volumes. Body mass index was associated with low-density non-calcified plaque volume after adjustment for age, sex and diabetes status (p < 0.01). Truncal fat mass (p > 0.51), waist circumference (p > 0.06) and epicardial adipose tissue (p > 0.17) were not associated with coronary plaque volumes in adjusted analyses. CONCLUSION:Body mass index is associated with coronary plaque volumes in diabetic as well as non-diabetic individuals.
journal_name
Diab Vasc Dis Resjournal_title
Diabetes & vascular disease researchauthors
Gullaksen S,Funck KL,Laugesen E,Hansen TK,Dey D,Poulsen PLdoi
10.1177/1479164119825761subject
Has Abstractpub_date
2019-07-01 00:00:00pages
328-336issue
4eissn
1479-1641issn
1752-8984journal_volume
16pub_type
杂志文章abstract::Prehypertension is considered to be associated with increased cardiovascular disease (CVD), and some data suggest that insulin resistance is common in this group. The goal of this study was to quantify insulin action by determining the steady-state plasma glucose (SSPG) concentration during the insulin suppression tes...
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,多中心研究
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更新日期:2017-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-06-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2006-05-01 00:00:00
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更新日期:2013-07-01 00:00:00
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更新日期:2015-07-01 00:00:00
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