Abstract:
:Roux-en-Y bypass surgery is increasingly used for treatment of gross obesity due to the general inability of lifestyle change and existing drug treatments to counter the obesity epidemic. This common form of bariatric surgery involves bypass of the small intestine with significant reduction of body of weight that is independent of malabsorption. Strikingly, obesity-related diabetes is also cured by the procedure but prior to body weight loss. This is due to rapid improvement of insulin resistance and associated pancreatic beta-cell function. Several hypotheses have been proposed to account for this phenomenon, but the most attractive concerns surgical ablation of gastric inhibitory polypetide (GIP)-secreting intestinal K-cells. Thus, circulating GIP levels are decreased after Roux-en-Y bypass surgery and GIP is known to play a key role in lipid metabolism and fat deposition. Further, both genetic and chemical ablation of GIP in animal models has been shown to protect against obesity and associated metabolic disturbances. These observations in animals and man suggest that GIP receptor antagonism may afford an alternative therapeutic option for treatment of obesity-diabetes.
journal_name
Diab Vasc Dis Resjournal_title
Diabetes & vascular disease researchauthors
Flatt PRdoi
10.3132/dvdr.2007.034subject
Has Abstractpub_date
2007-06-01 00:00:00pages
151-3issue
2eissn
1479-1641issn
1752-8984pii
2767journal_volume
4pub_type
杂志文章abstract:BACKGROUND:The main manifestation of hyperglycaemia during pregnancy is gestational diabetes mellitus. It can herald diabetes mellitus type 2 and its deleterious long-term effects, such as hypertension and cardiovascular disease. The aim of this study was to assess diastolic function in women with gestational diabetes ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164114563302
更新日期:2015-05-01 00:00:00
abstract::Cardiovascular disease is the most common complication of type 2 diabetes mellitus (type 2 DM), accounting for approximately 80% of deaths. While atherosclerotic vascular disease accounts for much of the cardiovascular morbidity and mortality among diabetic patients, congestive heart failure (CHF) is another key compl...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2005.010
更新日期:2005-05-01 00:00:00
abstract::Sodium-glucose cotransporter 2 inhibitors are antihyperglycaemic medications with an emerging evidence base for cardiovascular and kidney disease risk reduction. Sodium-glucose cotransporter 2 inhibitors medications lower plasma glucose by inhibiting glucose reabsorption in the proximal tubule of the kidney independen...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164118783756
更新日期:2018-09-01 00:00:00
abstract::Adiponectin circulates in plasma as various isoforms. However, the biological activity of each isoform has not been firmly established. High molecular weight (HMW) adiponectin may be the active form of adiponectin, while a proteolytic cleavage product of adiponectin, known as globular adiponectin (gAd), has recently b...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.3132/dvdr.2008.020
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Continuous-wave Doppler is frequently used for detecting peripheral arterial disease in patients with diabetes; however, there is limited evidence investigating diagnostic accuracy. This study aimed to determine sensitivity and specificity of continuous-wave Doppler for detecting peripheral arterial disease ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164118782887
更新日期:2018-09-01 00:00:00
abstract::Insulin resistance has a broad pathogenic impact affecting metabolic, cardio-renal and other disease areas. Extensive studies to dissect the mechanisms of insulin resistance have provided valuable insights to shape current clinical awareness and advance therapeutic practice. However, the development of direct interven...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164119827570
更新日期:2019-03-01 00:00:00
abstract::Insulin resistance typically reflects multiple defects of insulin receptor and post-receptor signalling that impair a diverse range of metabolic and vascular actions. Many potential intervention targets and compounds with therapeutic activity have been described. Proof of principle for a non-peptide insulin mimetic ha...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2007.002
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The risk of major adverse cardiac and cerebrovascular events following acute coronary syndrome is increased in people with diabetes. Predicting out-of-hospital outcomes upon follow-up remains difficult, and no simple, well-validated tools exist for this population at present. We aim to evaluat...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究
doi:10.1177/1479164119892137
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:We conducted a prospective pilot study in patients with diabetes to analyse the interobserver reliability of the ankle-brachial index, toe-brachial index and distal pulse palpation depending on the training of the professional involved. MATERIALS AND METHODS:The ankle-brachial index, toe-brachial index and d...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164118767599
更新日期:2018-07-01 00:00:00
abstract::The complications of diabetes are myriad and represent a rising cause of morbidity and mortality, particularly in the Western world. The update of the Diabetes Control and Clinical Trials Group/Epidemiology of Diabetes Interventions and Complications Research Group (DCCT/EDIC) suggested that previous strict control of...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2004.001
更新日期:2004-05-01 00:00:00
abstract::Peripheral artery disease is a severe complication of diabetes. We have reported that the deletion of angiotensin type 2 receptor in diabetic mice promoted vascular angiogenesis in the ischaemic muscle 4 weeks following ischaemia. However, the angiotensin type 2 receptor deletion beneficial effects occurred 2 weeks po...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164119883978
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine whether high fitness attenuates the defects in left ventricular (LV) structure, function and triglyceride (TG) content in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS:Patients (n = 74) with T2DM and ≥1 additional cardiac risk factor were recruite...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164114540924
更新日期:2014-09-01 00:00:00
abstract::Early studies showed nitric oxide as a pro-inflammatory-cytokine-induced toxin involved in pancreatic β-cell destruction during pathogenesis of type-1 diabetes. However, nitric oxide has both cytotoxic and cytoprotective effects on mammalian cells, depending on concentration and micro-environmental surroundings. Our s...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164117713947
更新日期:2017-09-01 00:00:00
abstract::Flow-mediated dilatation evaluation using hand skin heating may possibly be more accurate than post-ischaemic hyperaemia to detect conduit artery endothelial dysfunction in type 1 diabetes. We measured in 24 type 1 diabetic patients (n=16 without microangiopathy) and 24 healthy matched subjects radial artery diameter ...
journal_title:Diabetes & vascular disease research
pub_type: 临床试验,杂志文章
doi:10.1177/1479164109360470
更新日期:2010-04-01 00:00:00
abstract::This study assessed the effects of tesaglitazar (0.5 or 1 mg/day), a dual peroxisome proliferator-activated receptor alpha/gamma agonist, when added to maximally tolerated metformin (2-2.5 g/day) in patients with poorly controlled type 2 diabetes. The primary end point of this 24-week, randomised, placebo-controlled s...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3132/dvdr.2007.041
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:Coronary atherosclerosis in patients with type 2 diabetes mellitus may be promoted by regional fat distribution. We investigated the association between anthropometric measures of obesity, truncal fat mass, epicardial adipose tissue and coronary atherosclerosis in asymptomatic patients and matched controls. ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164119825761
更新日期:2019-07-01 00:00:00
abstract::The objective of this study was to evaluate the safety and tolerability of atorvastatin 10 mg compared with placebo in 2,838 patients with type 2 diabetes and no history of coronary heart disease who were enrolled in the Collaborative Atorvastatin Diabetes Study (CARDS) and followed for 3.9 years. The percentages of p...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3132/dvdr.2008.029
更新日期:2008-09-01 00:00:00
abstract::Urate, a naturally-occurring antioxidant, is a marker/factor for cardiovascular disease. Hyperuricaemia is associated with IR, MetS and endothelial dysfunction. We characterised the associations between neurohormones, uricaemia, and glucose homeostasis in type 2 diabetes mellitus (T2DM) males. Cross-sectional; 705 T2D...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164109336689
更新日期:2009-07-01 00:00:00
abstract::Heart failure is now recognized as a progressive disease in which patients transition through the stages of being at risk of heart failure (stage A), to asymptomatic structural heart disease (stage B), to clinical manifestations of heart failure (stage C) and finally end-stage or refractory heart failure (stage D). Th...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164115579006
更新日期:2015-07-01 00:00:00
abstract::The global prevalence of diabetes mellitus (DM) continues to climb, and is accompanied by an increase in DM associated complications, most often manifesting as coronary heart disease. Platelet dysfunction has been implicated as a central contributor to the increased risk of coronary artery disease in patients with DM,...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164111420890
更新日期:2011-10-01 00:00:00
abstract::We investigated the effect of atorvastatin monotherapy and combined treatment with atorvastatin and pioglitazone on intima-media thickness, vascular function and the cardiovascular risk profile. In all, 148 patients (76 male, 72 female; aged 61.4+/-6.5 years; body mass index [BMI] 29.2+/-4.1 kg/m2; mean +/- SD) with i...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3132/dvdr.2008.043
更新日期:2008-11-01 00:00:00
abstract::Diabetes mellitus and angina pectoris are important conditions in older persons. The utility of pre-diabetes mellitus, diabetes mellitus and other risk factors as predictors of incident angina pectoris among older adults has not been characterized. We examined incident angina pectoris rates by sex and diabetes mellitu...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究
doi:10.1177/1479164119888476
更新日期:2020-01-01 00:00:00
abstract::Patients with diabetes mellitus (DM) have accelerated atherosclerosis, which is the main underlying factor contributing to the high risk of atherothrombotic events in these patients. Atherothrombotic complications are the leading cause of morbidity and mortality in patients with DM. Among factors contributing to the p...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164110383994
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:Our objectives were to describe recent trends in the characteristics and in-hospital outcomes in diabetic as compared with non-diabetic patients hospitalized with ST-segment elevation myocardial infarction (STEMI). METHODS:We reviewed the medical records of 2537 persons with (n = 684) and without (n = 1853) a ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164114524235
更新日期:2014-05-01 00:00:00
abstract::We aimed to study the association between fasting plasma glucose, diabetes incidence and cardiovascular burden after 10-12 years. We evaluated diabetes and cardiovascular events incidences, carotid intima-media thickness and coronary artery calcium scores in ELSA-Brasil (the Brazilian Longitudinal Study of Adult Healt...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164116653356
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:The development of disturbances in skin microcirculation in type 1 diabetes is not well characterised. We assessed skin microcirculation longitudinally from the onset of diabetes up to 29 years of duration to investigate when such disturbances start. MATERIAL AND METHODS:Seventeen adult patients with type 1...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164117694463
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:Assess the effect of risk factors changes on risk for cardiovascular disease and mortality in patients with type 2 diabetes selected from the Swedish National Diabetes Register. METHODS:Observational study of 13,477 females and males aged 30-75 years, with baseline HbA1c 41-67 mmol/mol, systolic blood press...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164116637311
更新日期:2016-07-01 00:00:00
abstract::Angiotensin II receptor blockers (ARB) are often co-administered with a calcium channel blocker (CCB) for treating hypertension. In this open-label randomised study, untreated diabetic hypertensive patients were randomised to receive either olmesartan 20 mg/day or candesartan 8 mg/day for 12 weeks. Patients with blood...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,随机对照试验
doi:10.1177/1479164112447310
更新日期:2012-10-01 00:00:00
abstract::Inhibitors of the enzyme dipeptidyl peptidase IV (DPP IV) provide a strategy for the treatment of type 2 diabetes. DPP IV rapidly inactivates the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Inhibition of DPP IV prolongs and enhances the activity of endogeno...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2006.024
更新日期:2006-12-01 00:00:00
abstract:AIM:We examined eligibility and preventable cardiovascular disease events in US adults with diabetes mellitus from the Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME). METHODS:We identified adults with diabetes mellitus eligible for EMPA-REG OUTCOME based on tri...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164120945674
更新日期:2020-07-01 00:00:00