Adiponectin induces NF-kappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells: globular adiponectin vs. high molecular weight adiponectin.

abstract：BACKGROUND:The development of disturbances in skin microcirculation in type 1 diabetes is not well characterised. We assessed skin microcirculation longitudinally from the onset of diabetes up to 29 years of duration to investigate when such disturbances start. MATERIAL AND METHODS:Seventeen adult patients with type 1...

journal_title：Diabetes & vascular disease research

authors： Santesson P,Lins PE,Kalani M,Adamson U,Lelic I,von Wendt G,Fagrell B,Jörneskog G

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:To examine the relationship between leisure-time physical activity (LTPA) and the metabolic syndrome in the U.S. adult population. METHODS:The sample (N=5,620) in this cross-sectional study included adults aged 20 years and older. Physical activity was measured in two ways: a six-level measure based upon those...

journal_title：Diabetes & vascular disease research

authors： Churilla JR,Fitzhugh EC

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Musclin is a newly identified skeletal muscle-derived secretory factor, which has been recently characterized as a stimulator that induces insulin resistance in mice. However, the pathophysiological role of musclin in humans remains poorly understood. The aim of this study was to explore the potential correl...

journal_title：Diabetes & vascular disease research

authors： Chen WJ,Liu Y,Sui YB,Zhang B,Zhang XH,Yin XH

更新日期：2017-03-01 00:00:00

abstract：:Cardiovascular disease is the most common complication of type 2 diabetes mellitus (type 2 DM), accounting for approximately 80% of deaths. While atherosclerotic vascular disease accounts for much of the cardiovascular morbidity and mortality among diabetic patients, congestive heart failure (CHF) is another key compl...

journal_title：Diabetes & vascular disease research

authors： Patel C,Wyne KL,McGuire DK

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:To characterize copeptin levels and to explore its prognostic importance in patients with acute myocardial infarction with newly detected glucose abnormalities. METHODS:Copeptin was measured in 166 patients with acute myocardial infarction without known diabetes and in 168 age- and gender-matched controls. P...

journal_title：Diabetes & vascular disease research

authors： Smaradottir MI,Ritsinger V,Gyberg V,Norhammar A,Näsman P,Mellbin LG

更新日期：2017-03-01 00:00:00

abstract：:Vascular complications associated with type 2 diabetes confer significant morbidity and mortality. Atherosclerosis develops much earlier and progresses more rapidly than in subjects without diabetes. The clustering of cardiovascular risk factors associated with type 2 diabetes is mainly responsible for accelerated ath...

journal_title：Diabetes & vascular disease research

authors： Steiner G

更新日期：2007-12-01 00:00:00

abstract：:The objective of this study was to evaluate the safety and tolerability of atorvastatin 10 mg compared with placebo in 2,838 patients with type 2 diabetes and no history of coronary heart disease who were enrolled in the Collaborative Atorvastatin Diabetes Study (CARDS) and followed for 3.9 years. The percentages of p...

journal_title：Diabetes & vascular disease research

authors： Newman CB,Szarek M,Colhoun HM,Betteridge DJ,Durrington PN,Hitman GA,Neil HA,Demicco DA,Auster S,Fuller JH,Cards Investigators.

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To investigate the long-term prognostic value of insulin-like growth factor-binding protein 1 in patients with acute myocardial infarction. METHODS:Patients ( n = 180) with admission glucose < 11 mmol/L without previously known diabetes admitted for an acute myocardial infarction in 1998-2000 were followed f...

journal_title：Diabetes & vascular disease research

authors： Ritsinger V,Brismar K,Mellbin L,Näsman P,Rydén L,Söderberg S,Norhammar A

更新日期：2018-09-01 00:00:00

abstract：AIM:We examined eligibility and preventable cardiovascular disease events in US adults with diabetes mellitus from the Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME). METHODS:We identified adults with diabetes mellitus eligible for EMPA-REG OUTCOME based on tri...

journal_title：Diabetes & vascular disease research

authors： Wong ND,Fan W,Pak J

更新日期：2020-07-01 00:00:00

abstract：:In order to discuss and establish a joint position on the treatment of low serum levels of high-density lipoprotein cholesterol (HDL-C), a group of experts involved in the care of people with dyslipidaemia and at risk of cardiovascular disease met in Miami, Florida, U.S., on 5th and 6th March 2005. The experts came fr...

journal_title：Diabetes & vascular disease research

authors： Espinosa-Larrañaga F,Vejar-Jalaf M,Medina-Santillán R,Latin American Group.

更新日期：2005-10-01 00:00:00

abstract：:Glucose-lowering treatment options for type 2 diabetes mellitus patients with chronic kidney disease are limited. We evaluated the potential for linagliptin in combination with insulin in type 2 diabetes mellitus patients with mild-to-severe renal impairment. Data for participants in two phase 3 trials with linaglipti...

journal_title：Diabetes & vascular disease research

authors： McGill JB,Yki-Järvinen H,Crowe S,Woerle HJ,von Eynatten M

更新日期：2015-07-01 00:00:00

abstract：:Insulin resistance has a broad pathogenic impact affecting metabolic, cardio-renal and other disease areas. Extensive studies to dissect the mechanisms of insulin resistance have provided valuable insights to shape current clinical awareness and advance therapeutic practice. However, the development of direct interven...

journal_title：Diabetes & vascular disease research

authors： Bailey CJ

更新日期：2019-03-01 00:00:00

abstract：:This study assessed the effects of tesaglitazar (0.5 or 1 mg/day), a dual peroxisome proliferator-activated receptor alpha/gamma agonist, when added to maximally tolerated metformin (2-2.5 g/day) in patients with poorly controlled type 2 diabetes. The primary end point of this 24-week, randomised, placebo-controlled s...

journal_title：Diabetes & vascular disease research

authors： Göke B,Gause-Nilsson I,Persson A,GALLANT 8 Study Group.

更新日期：2007-09-01 00:00:00

abstract：:Telmisartan partially activates the peroxisome proliferator-activated receptor γ (PPARγ), which may ameliorate the accumulation of visceral adipose tissues and sensitise insulin action. Nineteen patients with essential hypertension and metabolic syndrome were randomly assigned to receive 40 mg of telmisartan (TELMI gr...

journal_title：Diabetes & vascular disease research

authors： Murakami K,Wada J,Ogawa D,Horiguchi CS,Miyoshi T,Sasaki M,Uchida HA,Nakamura Y,Makino H

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine whether high fitness attenuates the defects in left ventricular (LV) structure, function and triglyceride (TG) content in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS:Patients (n = 74) with T2DM and ≥1 additional cardiac risk factor were recruite...

journal_title：Diabetes & vascular disease research

authors： Sénéchal M,Ayers CR,Szczepaniak LS,Gore MO,See R,Abdullah SM,Berry JD,McGuire DK,McGavock JM

更新日期：2014-09-01 00:00:00

abstract：:Peripheral artery disease is a severe complication of diabetes. We have reported that the deletion of angiotensin type 2 receptor in diabetic mice promoted vascular angiogenesis in the ischaemic muscle 4 weeks following ischaemia. However, the angiotensin type 2 receptor deletion beneficial effects occurred 2 weeks po...

journal_title：Diabetes & vascular disease research

authors： Robillard S,Mercier C,Breton V,Paquin-Veillette J,Guay A,Lizotte F,Geraldes P

更新日期：2020-01-01 00:00:00

abstract：:Diabetes mellitus and angina pectoris are important conditions in older persons. The utility of pre-diabetes mellitus, diabetes mellitus and other risk factors as predictors of incident angina pectoris among older adults has not been characterized. We examined incident angina pectoris rates by sex and diabetes mellitu...

journal_title：Diabetes & vascular disease research

authors： Mathenge N,Fan W,Wong ND,Hirsch C,Delaney CJ,Amsterdam EA,Koch B,Calara R,Gardin JM

更新日期：2020-01-01 00:00:00

abstract：:To assess the prevalence of metabolic syndrome (MS) and estimates of global risk by Framingham Risk Score in young subjects with acute myocardial infarction (MI), we assessed metabolic parameters and global risk assessment in 165 consecutive subjects who presented with myocardial infarction prior to 45 years of age. N...

journal_title：Diabetes & vascular disease research

authors： Zarich S,Luciano C,Hulford J,Abdullah A

更新日期：2006-09-01 00:00:00

abstract：:A cross-sectional analysis of ethnic differences in dietary intake, insulin sensitivity and beta-cell function, using the intravenous glucose tolerance test (IVGTT), was conducted on 497 healthy adult participants of the 'Reading, Imperial, Surrey, Cambridge, and Kings' (RISCK) study. Insulin sensitivity (Si) was sign...

journal_title：Diabetes & vascular disease research

authors： Goff LM,Griffin BA,Lovegrove JA,Sanders TA,Jebb SA,Bluck LJ,Frost GS,RISCK Study Group.

更新日期：2013-07-01 00:00:00

abstract：:Inhibitors of the enzyme dipeptidyl peptidase IV (DPP IV) provide a strategy for the treatment of type 2 diabetes. DPP IV rapidly inactivates the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Inhibition of DPP IV prolongs and enhances the activity of endogeno...

journal_title：Diabetes & vascular disease research

authors： Green BD,Flatt PR,Bailey CJ

更新日期：2006-12-01 00:00:00

abstract：:Antidiabetic thiazolidinediones (TZDs) improve endothelial function in patients with or without type 2 diabetes. The present randomised, placebo-controlled, double-blind study examined the time course of a single dose of rosiglitazone on flow-mediated endothelium-dependent vasodilation (FMD), metabolic parameters, and...

journal_title：Diabetes & vascular disease research

authors： Walcher T,Walcher D,Hetzel J,Mielke C,Rau M,Rittig K,Balletshofer B,Schwedhelm E,Hombach V,Böger RH,Koenig W,Marx N

更新日期：2010-07-01 00:00:00

abstract：:The global prevalence of diabetes mellitus (DM) continues to climb, and is accompanied by an increase in DM associated complications, most often manifesting as coronary heart disease. Platelet dysfunction has been implicated as a central contributor to the increased risk of coronary artery disease in patients with DM,...

journal_title：Diabetes & vascular disease research

authors： Hall HM,Banerjee S,McGuire DK

更新日期：2011-10-01 00:00:00

abstract：:The aim of this study was to evaluate changes in lipid profiles in patients with type 2 diabetes after treatment conversion from rosiglitazone to pioglitazone while maintaining stable statin and other lipid-altering therapies. A total of 305 patients were enrolled in this open-label study. Patients had been taking sta...

journal_title：Diabetes & vascular disease research

authors： Berhanu P,Kipnes MS,Khan MA,Perez AT,Kupfer SF,Spanheimer RC,Demissie S,Fleck PR

更新日期：2006-05-01 00:00:00

abstract：:Physical activity decreases risk for diabetes and cardiovascular disease morbidity and mortality; however, the specific impact of exercise on the diabetic vasculature is unexamined. We hypothesized that an acute, moderate exercise intervention in diabetic and hypertensive rats would induce mitochondrial biogenesis and...

journal_title：Diabetes & vascular disease research

authors： Knaub LA,McCune S,Chicco AJ,Miller M,Moore RL,Birdsey N,Lloyd MI,Villarreal J,Keller AC,Watson PA,Reusch JE

更新日期：2013-05-01 00:00:00

abstract：:We conducted a meta-analysis of cohort and case-control studies to evaluate all-cause and cardiovascular (CV) mortality of patients with type 2 diabetes mellitus (T2DM) who received sulphonylurea (SU) treatment, when compared to any other diabetes treatment. Only studies reporting raw data on mortality during SU treat...

journal_title：Diabetes & vascular disease research

authors： Forst T,Hanefeld M,Jacob S,Moeser G,Schwenk G,Pfützner A,Haupt A

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:Statins are extensively used for lowering LDL-cholesterol and reducing cardiovascular events. Recent studies have shown that statins have beneficial anti-inflammatory effects. We aimed to determine whether and how adipokines are regulated during statin treatment in type 2 diabetic patients. METHOD:In this st...

journal_title：Diabetes & vascular disease research

authors： Hu Y,Tong G,Xu W,Pan J,Ryan K,Yang R,Shuldiner AR,Gong DW,Zhu D

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:We have previously reported insignificant changes in HbA1c after exercise in patients with both type 2 diabetes and coronary artery disease. In this study, we investigated the effect of exercise on endothelial function and possible associations between changes in endothelial function and HbA1c. METHODS:Patie...

journal_title：Diabetes & vascular disease research

authors： Byrkjeland R,Njerve IU,Arnesen H,Seljeflot I,Solheim S

更新日期：2017-03-01 00:00:00

abstract：:Guidelines recommend aggressive goals for lipid and blood pressure reduction for high risk patients with diabetes mellitus and atherosclerotic coronary disease. However, it remains unclear how many patients achieve treatment goals versus the number of people merely placed on treatment. We conducted an observational st...

journal_title：Diabetes & vascular disease research

authors： DeGuzman PB,Akosah KO,Simpson AG,Barbieri KE,Megginson GC,Goldberg RI,Beller GA

更新日期：2012-04-01 00:00:00

abstract：:Prehypertension is considered to be associated with increased cardiovascular disease (CVD), and some data suggest that insulin resistance is common in this group. The goal of this study was to quantify insulin action by determining the steady-state plasma glucose (SSPG) concentration during the insulin suppression tes...

journal_title：Diabetes & vascular disease research

authors： Knobler H,Abbasi F,Lamendola C,Reaven GM

更新日期：2011-01-01 00:00:00

abstract：:There are few data concerning the relationship between diabetes mellitus, the metabolic syndrome and inflammation following elective percutaneous coronary intervention (PCI). The purpose of this study was to assess basal and peak levels of candidate cytokines in 40 patients undergoing elective PCI. Patients were categ...

journal_title：Diabetes & vascular disease research

authors： Marso SP,Murphy JW,House JA,Safley DM,Harris WS

更新日期：2005-02-01 00:00:00