Raised natriuretic peptides, big-endothelin-1 and improved beta-cell function in type 2 diabetic males with hyperuricaemia.

abstract：BACKGROUND:Antiretroviral therapy in HIV-positive patients leads to insulin resistance which is central to the pathogenesis of various metabolic abnormalities and cardiovascular disease seen in this patient group. We have investigated the dose-response relationship of telmisartan, an antihypertensive, on adipocytes in ...

journal_title：Diabetes & vascular disease research

authors： Pushpakom SP,Adaikalakoteswari A,Owen A,Back DJ,Tripathi G,Kumar S,McTernan P,Pirmohamed M

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:We conducted a prospective pilot study in patients with diabetes to analyse the interobserver reliability of the ankle-brachial index, toe-brachial index and distal pulse palpation depending on the training of the professional involved. MATERIALS AND METHODS:The ankle-brachial index, toe-brachial index and d...

journal_title：Diabetes & vascular disease research

authors： Álvaro-Afonso FJ,García-Morales E,Molines-Barroso RJ,García-Álvarez Y,Sanz-Corbalán I,Lázaro-Martínez JL

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:Coronary atherosclerosis in patients with type 2 diabetes mellitus may be promoted by regional fat distribution. We investigated the association between anthropometric measures of obesity, truncal fat mass, epicardial adipose tissue and coronary atherosclerosis in asymptomatic patients and matched controls. ...

journal_title：Diabetes & vascular disease research

authors： Gullaksen S,Funck KL,Laugesen E,Hansen TK,Dey D,Poulsen PL

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:To investigate the long-term prognostic value of insulin-like growth factor-binding protein 1 in patients with acute myocardial infarction. METHODS:Patients ( n = 180) with admission glucose < 11 mmol/L without previously known diabetes admitted for an acute myocardial infarction in 1998-2000 were followed f...

journal_title：Diabetes & vascular disease research

authors： Ritsinger V,Brismar K,Mellbin L,Näsman P,Rydén L,Söderberg S,Norhammar A

更新日期：2018-09-01 00:00:00

abstract：:Cardiovascular disease is the most common complication of type 2 diabetes mellitus (type 2 DM), accounting for approximately 80% of deaths. While atherosclerotic vascular disease accounts for much of the cardiovascular morbidity and mortality among diabetic patients, congestive heart failure (CHF) is another key compl...

journal_title：Diabetes & vascular disease research

authors： Patel C,Wyne KL,McGuire DK

更新日期：2005-05-01 00:00:00

abstract：:Roux-en-Y bypass surgery is increasingly used for treatment of gross obesity due to the general inability of lifestyle change and existing drug treatments to counter the obesity epidemic. This common form of bariatric surgery involves bypass of the small intestine with significant reduction of body of weight that is i...

journal_title：Diabetes & vascular disease research

authors： Flatt PR

更新日期：2007-06-01 00:00:00

abstract：:The aim of this study was to characterise microvascular blood flow in the skin and to compare it with biomarkers of endothelial dysfunction and tissue inflammation in patients with type 2 diabetes with (n=20) or without (n=20) microvascular complications and 20 control subjects. Microvascular function was measured by ...

journal_title：Diabetes & vascular disease research

authors： Brooks BA,McLennan SV,Twigg SM,Yue DK

更新日期：2008-03-01 00:00:00

abstract：:Insulin resistance typically reflects multiple defects of insulin receptor and post-receptor signalling that impair a diverse range of metabolic and vascular actions. Many potential intervention targets and compounds with therapeutic activity have been described. Proof of principle for a non-peptide insulin mimetic ha...

journal_title：Diabetes & vascular disease research

authors： Bailey CJ

更新日期：2007-03-01 00:00:00

abstract：:Adiponectin circulates in plasma as various isoforms. However, the biological activity of each isoform has not been firmly established. High molecular weight (HMW) adiponectin may be the active form of adiponectin, while a proteolytic cleavage product of adiponectin, known as globular adiponectin (gAd), has recently b...

journal_title：Diabetes & vascular disease research

authors： Tomizawa A,Hattori Y,Kasai K,Nakano Y

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The risk of major adverse cardiac and cerebrovascular events following acute coronary syndrome is increased in people with diabetes. Predicting out-of-hospital outcomes upon follow-up remains difficult, and no simple, well-validated tools exist for this population at present. We aim to evaluat...

journal_title：Diabetes & vascular disease research

authors： Baluja A,Rodríguez-Mañero M,Cordero A,Kreidieh B,Iglesias-Alvarez D,García-Acuña JM,Martínez-Gómez A,Agra-Bermejo R,Alvarez-Rodríguez L,Abou-Jokh C,López-Ratón M,Gude-Sampedro F,Alvarez-Escudero J,González-Juanatey JR

更新日期：2020-01-01 00:00:00

abstract：:This study assessed the effects of tesaglitazar (0.5 or 1 mg/day), a dual peroxisome proliferator-activated receptor alpha/gamma agonist, when added to maximally tolerated metformin (2-2.5 g/day) in patients with poorly controlled type 2 diabetes. The primary end point of this 24-week, randomised, placebo-controlled s...

journal_title：Diabetes & vascular disease research

authors： Göke B,Gause-Nilsson I,Persson A,GALLANT 8 Study Group.

更新日期：2007-09-01 00:00:00

abstract：:Inhibitors of the enzyme dipeptidyl peptidase IV (DPP IV) provide a strategy for the treatment of type 2 diabetes. DPP IV rapidly inactivates the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Inhibition of DPP IV prolongs and enhances the activity of endogeno...

journal_title：Diabetes & vascular disease research

authors： Green BD,Flatt PR,Bailey CJ

更新日期：2006-12-01 00:00:00

abstract：:We investigated the effect of atorvastatin monotherapy and combined treatment with atorvastatin and pioglitazone on intima-media thickness, vascular function and the cardiovascular risk profile. In all, 148 patients (76 male, 72 female; aged 61.4+/-6.5 years; body mass index [BMI] 29.2+/-4.1 kg/m2; mean +/- SD) with i...

journal_title：Diabetes & vascular disease research

authors： Forst T,Wilhelm B,Pfützner A,Fuchs W,Lehmann U,Schaper F,Weber M,Müller J,Konrad T,Hanefeld M

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine whether high fitness attenuates the defects in left ventricular (LV) structure, function and triglyceride (TG) content in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS:Patients (n = 74) with T2DM and ≥1 additional cardiac risk factor were recruite...

journal_title：Diabetes & vascular disease research

authors： Sénéchal M,Ayers CR,Szczepaniak LS,Gore MO,See R,Abdullah SM,Berry JD,McGuire DK,McGavock JM

更新日期：2014-09-01 00:00:00

abstract：:Chronic diseases account for approximately 45% of all deaths in developed countries and are particularly prevalent in countries with the most sophisticated and robust public health systems. Chronic metabolic diseases, specifically lifestyle-related diseases pertaining to diet and exercise, continue to be difficult to ...

journal_title：Diabetes & vascular disease research

authors： Ackers I,Malgor R

更新日期：2018-01-01 00:00:00

abstract：:Antidiabetic thiazolidinediones (TZDs) improve endothelial function in patients with or without type 2 diabetes. The present randomised, placebo-controlled, double-blind study examined the time course of a single dose of rosiglitazone on flow-mediated endothelium-dependent vasodilation (FMD), metabolic parameters, and...

journal_title：Diabetes & vascular disease research

authors： Walcher T,Walcher D,Hetzel J,Mielke C,Rau M,Rittig K,Balletshofer B,Schwedhelm E,Hombach V,Böger RH,Koenig W,Marx N

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Continuous-wave Doppler is frequently used for detecting peripheral arterial disease in patients with diabetes; however, there is limited evidence investigating diagnostic accuracy. This study aimed to determine sensitivity and specificity of continuous-wave Doppler for detecting peripheral arterial disease ...

journal_title：Diabetes & vascular disease research

authors： Tehan PE,Sebastian M,Barwick AL,Chuter VH

更新日期：2018-09-01 00:00:00

abstract：:To assess the prevalence of metabolic syndrome (MS) and estimates of global risk by Framingham Risk Score in young subjects with acute myocardial infarction (MI), we assessed metabolic parameters and global risk assessment in 165 consecutive subjects who presented with myocardial infarction prior to 45 years of age. N...

journal_title：Diabetes & vascular disease research

authors： Zarich S,Luciano C,Hulford J,Abdullah A

更新日期：2006-09-01 00:00:00

abstract：:We respond to the letter of Nadery and Shahsavari regarding our paper entitled 'Interobserver reliability of the ankle brachial index, toe -brachial index and distal pulse palpation in patients with diabetes. In this letter, we concluded that despite some limitations, the kappa coefficient is an informative measure of...

journal_title：Diabetes & vascular disease research

authors： Álvaro Afonso FJ,García-Morales E,Molines-Barroso RJ,García-Álvarez Y,Sanz-Corbalán I,Lázaro-Martínez JL

更新日期：2018-11-01 00:00:00

abstract：:We investigated the usefulness of Holter monitoring to detect cardiac disease and predict future cardiovascular risk in asymptomatic diabetic patients. This is a multi-centre, prospective study in 406 asymptomatic diabetic patients. They were categorized into three groups based on findings of Holter monitoring. A tota...

journal_title：Diabetes & vascular disease research

authors： Nakao YM,Ueshima K,Nohara R,Mizunuma Y,Segawa I,Tanaka-Mizuno S,Yasuno S,Nakao K,Hiramori K,Kihara Y

更新日期：2015-11-01 00:00:00

abstract：:In order to discuss and establish a joint position on the treatment of low serum levels of high-density lipoprotein cholesterol (HDL-C), a group of experts involved in the care of people with dyslipidaemia and at risk of cardiovascular disease met in Miami, Florida, U.S., on 5th and 6th March 2005. The experts came fr...

journal_title：Diabetes & vascular disease research

authors： Espinosa-Larrañaga F,Vejar-Jalaf M,Medina-Santillán R,Latin American Group.

更新日期：2005-10-01 00:00:00

abstract：:Diabetes contributes directly to the development of cardiovascular aortic valve disease. There is currently no drug therapy available for a dysfunctional valve and this urges the need for additional research to identify distinctive mechanisms of cardiovascular aortic valve disease evolution. The aim of this study was ...

journal_title：Diabetes & vascular disease research

authors： Tucureanu MM,Filippi A,Alexandru N,Ana Constantinescu C,Ciortan L,Macarie R,Vadana M,Voicu G,Frunza S,Nistor D,Simionescu A,Simionescu DT,Georgescu A,Manduteanu I

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:Assess the effect of risk factors changes on risk for cardiovascular disease and mortality in patients with type 2 diabetes selected from the Swedish National Diabetes Register. METHODS:Observational study of 13,477 females and males aged 30-75 years, with baseline HbA1c 41-67 mmol/mol, systolic blood press...

journal_title：Diabetes & vascular disease research

authors： Eeg-Olofsson K,Zethelius B,Gudbjörnsdottir S,Eliasson B,Svensson AM,Cederholm J

更新日期：2016-07-01 00:00:00

abstract：:The objective of this study was to evaluate the safety and tolerability of atorvastatin 10 mg compared with placebo in 2,838 patients with type 2 diabetes and no history of coronary heart disease who were enrolled in the Collaborative Atorvastatin Diabetes Study (CARDS) and followed for 3.9 years. The percentages of p...

journal_title：Diabetes & vascular disease research

authors： Newman CB,Szarek M,Colhoun HM,Betteridge DJ,Durrington PN,Hitman GA,Neil HA,Demicco DA,Auster S,Fuller JH,Cards Investigators.

更新日期：2008-09-01 00:00:00

abstract：:Metabolic syndrome (MetS) is a clustering of atherosclerotic coronary heart disease risk factors. This post-hoc analysis compared the effects of switching to ezetimibe/simvastatin 10/20 mg or rosuvastatin 10 mg in a cohort of 618 high-risk hypercholesterolaemic patients with (n=368) and without (n=217) MetS who had pr...

journal_title：Diabetes & vascular disease research

authors： Averna M,Missault L,Vaverkova H,Farnier M,Viigimaa M,Dong Q,Shah A,Johnson-Levonas AO,Taggart W,Brudi P

更新日期：2011-10-01 00:00:00

abstract：:With the growing prevalence of childhood obesity and type 2 diabetes mellitus (T2DM) in youth, the challenge of cardiovascular disease risk management has entered the paediatric realm, affecting specialists, family physicians and allied healthcare professionals alike. Currently, there is little evidence to support opt...

journal_title：Diabetes & vascular disease research

authors： McGavock J,Sellers E,Dean H

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:The main manifestation of hyperglycaemia during pregnancy is gestational diabetes mellitus. It can herald diabetes mellitus type 2 and its deleterious long-term effects, such as hypertension and cardiovascular disease. The aim of this study was to assess diastolic function in women with gestational diabetes ...

journal_title：Diabetes & vascular disease research

authors： Oliveira AP,Calderon IM,Costa RA,Roscani MG,Magalhães CG,Borges VT

更新日期：2015-05-01 00:00:00

abstract：:Heart failure is now recognized as a progressive disease in which patients transition through the stages of being at risk of heart failure (stage A), to asymptomatic structural heart disease (stage B), to clinical manifestations of heart failure (stage C) and finally end-stage or refractory heart failure (stage D). Th...

journal_title：Diabetes & vascular disease research

authors： Lam CS

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:We have previously reported insignificant changes in HbA1c after exercise in patients with both type 2 diabetes and coronary artery disease. In this study, we investigated the effect of exercise on endothelial function and possible associations between changes in endothelial function and HbA1c. METHODS:Patie...

journal_title：Diabetes & vascular disease research

authors： Byrkjeland R,Njerve IU,Arnesen H,Seljeflot I,Solheim S

更新日期：2017-03-01 00:00:00

abstract：:We conducted a meta-analysis of cohort and case-control studies to evaluate all-cause and cardiovascular (CV) mortality of patients with type 2 diabetes mellitus (T2DM) who received sulphonylurea (SU) treatment, when compared to any other diabetes treatment. Only studies reporting raw data on mortality during SU treat...

journal_title：Diabetes & vascular disease research

authors： Forst T,Hanefeld M,Jacob S,Moeser G,Schwenk G,Pfützner A,Haupt A

更新日期：2013-07-01 00:00:00