Antiretroviral therapy as a cardiovascular disease risk factor: fact or fiction? A review of clinical and surrogate outcome studies.

abstract：PURPOSE OF REVIEW:This review provides information on the natural history of end-stage liver disease in HIV/hepatitis C virus-coinfected patients from diagnosis to liver transplantation or death and summarizes recent developments in the epidemiology, management, and prognosis of end-stage liver disease and orthotopic l...

journal_title：Current opinion in HIV and AIDS

authors： Agüero F,Laguno M,Moreno A,Rimola A,Miró JM,Hospital Clinic OLT in HIV Working Group.

更新日期：2007-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Increasing evidence suggests that purging the latent HIV reservoir in virally suppressed individuals will require both the induction of viral replication from its latent state and the elimination of these reactivated HIV-infected cells ('Shock and Kill' strategy). Boosting potent HIV-specific CD8 T ce...

journal_title：Current opinion in HIV and AIDS

authors： Trautmann L

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the changes in the presentation of HIV-associated neurocognitive disorders (HAND) comparing the current combination antiretroviral therapy (cART) treatment era to the pre-cART era. RECENT FINDINGS:The frequency of the most severe stage of HAND, HIV-associated dementia (HAD), has decreased...

journal_title：Current opinion in HIV and AIDS

authors： Sacktor N,Robertson K

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The review addresses the role of dolutegravir (DTG) in first-line therapy. In the era of test and treat, where United Nations AIDS Program and WHO have set the ambitious targets of 90/90/90, new efficacious, well tolerated, and simple therapeutic options are needed. RECENT FINDINGS:DTG has been teste...

journal_title：Current opinion in HIV and AIDS

authors： Cahn P

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This article explores new data from recent studies addressing the role of coinfections in immune activation in HIV-1-infected patients, with a focus on immune reconstitution inflammatory syndrome (IRIS), an aberrant inflammatory response occurring shortly after antiretroviral therapy (ART) initiation....

journal_title：Current opinion in HIV and AIDS

authors： Boulougoura A,Sereti I

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Differential rates of disease progression are obviously multifactorial, but the virulence of the actual infecting virus is most frequently ignored as potential source of slow or rapid disease progression. In this review, the argument will be made that nearly all elite suppressors are infected by weak ...

journal_title：Current opinion in HIV and AIDS

authors： Lobritz MA,Lassen KG,Arts EJ

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The recent findings pertaining to the public health impact of schistosomiasis on the epidemiology of HIV/AIDS are summarized. RECENT FINDINGS:Both empiric data and mathematical models support the hypothesis that schistosome infections lead to increased susceptibility to infection with HIV-1, a more r...

journal_title：Current opinion in HIV and AIDS

authors： Secor WE

更新日期：2012-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Early studies have cast doubt on the utility of animal models for predicting success or failure of HIV-prevention strategies, but results of multiple human phase 3 microbicide trials, and interrogations into the discrepancies between human and animal model trials, indicate that animal models were, and...

journal_title：Current opinion in HIV and AIDS

authors： Veazey RS

更新日期：2013-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight promising areas of research and preview future generations of microbicides, this review will focus on reports that described new cellular or viral targets, drug substances, or strategies that are specifically intended for topical microbicides. Those reports that dealt with the design, dis...

journal_title：Current opinion in HIV and AIDS

authors： Zydowsky TM

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To review current knowledge and the role of integrase inhibitors in the setting of HIV salvage therapy. We will discuss results from recent studies and literature and comment on the potential for integrase inhibitors in defined clinical settings. RECENT FINDINGS:Raltegravir has been studied most inte...

journal_title：Current opinion in HIV and AIDS

authors： Koelsch KK,Cooper DA

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Antiviral therapy for chronic hepatitis B infection is rarely curative, thus research in HBV cure strategies is a priority. Drug development and testing has been hampered by the lack of robust cell culture systems and small animal models. This review summarizes existing models for HBV cure research an...

journal_title：Current opinion in HIV and AIDS

authors： Allweiss L,Strick-Marchand H

更新日期：2020-05-01 00:00:00

abstract：PURPOSE OF REVIEW:We reviewed the global state of harm reduction for people who use and/or inject drugs. KEY FINDINGS:Although harm reduction is now the key response to HIV among people who use drugs globally, intervention coverage remains suboptimal, exacerbated by chronic under-funding, declining donor support and l...

journal_title：Current opinion in HIV and AIDS

authors： Southwell M,Shelly S,MacDonald V,Verster A,Maher L

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The epidemiology of HIV epidemics provides the roadmap for prioritization of programmes and serves over time to evaluate broadly the successes and challenges in prevention. The purpose of this review was to summarize recent information about the epidemiology of HIV in high-income countries with concen...

journal_title：Current opinion in HIV and AIDS

authors： Sullivan PS,Jones JS,Baral SD

更新日期：2014-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Although the goal of preventive HIV vaccine design is primarily the induction of broadly neutralizing antibodies (bNAbs), recent evidence suggests that a protective response will also benefit from Fc effector functions. Here, we provide an update on the antibody response to HIV infection, including bo...

journal_title：Current opinion in HIV and AIDS

authors： Richardson SI,Moore PL

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Significant gastrointestinal pathology occurs in progressive HIV and simian immunodeficiency virus (SIV) infections. This review will examine the relationship between the detrimental events to the gastrointestinal tract during the acute phase of infection and disease progression through the chronic ph...

journal_title：Current opinion in HIV and AIDS

authors： Brenchley JM,Douek DC

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The intricate balance between positive and negative signals delivered by accessory molecules is crucial to generate efficient immune responses while maintaining tolerance and preventing autoimmunity. Of these molecules, programmed death 1 has been described as a negative regulator of T-cell activation...

journal_title：Current opinion in HIV and AIDS

authors： Trautmann L,Said EA,Halwani R,Janbazian L,Chomont N,El-Far M,Breton G,Haddad EK,Sekaly RP

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review was to summarize recent studies on the effect of early antiretroviral therapy (ART) in HIV-infected patients on markers of immune activation/inflammation, viral persistence and serious non-AIDS events. RECENT FINDINGS:Early ART, initiated within days to months of HIV infect...

journal_title：Current opinion in HIV and AIDS

authors： Rajasuriar R,Wright E,Lewin SR

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Rare patients naturally control HIV replication without antiretroviral therapy. Understanding the mechanisms implicated in natural HIV control will inform the development of immunotherapies against HIV. Elite controllers are known for developing efficient antiviral T-cell responses, but recent finding...

journal_title：Current opinion in HIV and AIDS

authors： Moris A,Pereira M,Chakrabarti L

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The achievement of significant reductions in the price of antiretroviral drugs constitutes one of the main economic pillars of antiretroviral treatment scale-up in developing countries. Today this economic pillar is threatened. RECENT FINDINGS:The prohibitive prices of newer first-line and second-lin...

journal_title：Current opinion in HIV and AIDS

authors： Orsi F,d'almeida C

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The introduction of combination antiretroviral therapy (cART) led to substantial reductions in HIV-associated morbidity and mortality. However, the regimens in the early cART era were cumbersome and toxic. The introduction of new ART agents, fixed-dose combinations and novel strategies for cART delive...

journal_title：Current opinion in HIV and AIDS

authors： Boyd MA

更新日期：2009-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent trends in knowledge of HIV status, care and viral suppression, and the status of implementation of relevant contextual requirements for the United States to achieve the 90-90-90 goals. Recently, the US government announced a plan to decrease HIV incidence by over 90% by 2030. Reach...

journal_title：Current opinion in HIV and AIDS

authors： Hall HI,Brooks JT,Mermin J

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:People with HIV continue to live with the health consequences of an episodic illness that limits their ability to fully participate in society, particularly for the growing number of older people living with HIV. The present review describes the recent evidence exploring the psychosocial challenges fa...

journal_title：Current opinion in HIV and AIDS

authors： Rueda S,Law S,Rourke SB

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines evidence regarding the differential effects of high dead-space syringes (HDSS) and low dead-space syringes (LDSS) on HIV transmission among people who inject drugs (PWID). It also identifies areas for additional research and examines potential barriers to interventions that promot...

journal_title：Current opinion in HIV and AIDS

authors： Zule WA

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Although there has been a significant increase in mHealth interventions addressing the HIV prevention and care continuum, interventions using game mechanics have been less explored. Digital games are rapidly becoming an important tool for improving health behaviors and supporting the delivery of care ...

journal_title：Current opinion in HIV and AIDS

authors： Hightow-Weidman LB,Muessig KE,Bauermeister JA,LeGrand S,Fiellin LE

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The detrimental synergy of colliding HIV and tuberculosis (TB) epidemics is most devastating among children and adolescents living with HIV (CALWH) who shoulder a disproportionate burden of all child TB mortality. RECENT FINDINGS:CALWH benefit less from Bacille-Calmette Guerin vaccination than HIV-un...

journal_title：Current opinion in HIV and AIDS

authors： Kay A,Garcia-Prats AJ,Mandalakas AM

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the role of mathematical models of sexual transmission of HIV: the methods used and their impact. RECENT FINDINGS:We use mathematical modelling of 'universal test and treat' as a case study to illustrate wider issues relevant to all modelling of sexual HIV transmission. SUMMARY:Mathematic...

journal_title：Current opinion in HIV and AIDS

authors： Baggaley RF,Fraser C

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to summarize the current standards of care for both HIV treatment and HIV prevention in 2019. RECENT FINDINGS:Current HIV treatment is started as soon as feasible in a person with HIV infection and consists of a three-drug oral daily antiretroviral regimen, consisting of...

journal_title：Current opinion in HIV and AIDS

authors： Phanuphak N,Gulick RM

更新日期：2020-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Alcohol and noninjection drug use has been shown to be associated with increased risk of HIV infection in select populations. In this review, we discuss recent data on the prevalence of alcohol and noninjection drug use and the relationship to HIV acquisition and transmission risk. RECENT FINDINGS:A ...

journal_title：Current opinion in HIV and AIDS

authors： Van Tieu H,Koblin BA

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to summarize data in the last 18 months on the sexual and reproductive health of perinatally and horizontally infected adolescents and young people living with HIV (age 13-25 years) and to highlight some key issues faced by this group of adolescents as they reach puberty and sexual de...

journal_title：Current opinion in HIV and AIDS

authors： Hamzah L,Hamlyn E

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the risk of cardiovascular complications in HIV-infected patients receiving combination antiretroviral treatment. RECENT FINDINGS:Recent data suggest that patients with chronic HIV infection will require continuous lifelong combination antiretroviral treatment, which may increase the risk o...

journal_title：Current opinion in HIV and AIDS

authors： Law MG

更新日期：2006-11-01 00:00:00