Low dead-space syringes for preventing HIV among people who inject drugs: promise and barriers.

abstract：PURPOSE OF REVIEW:To briefly describe some of the replication-competent vectors being investigated for development of candidate HIV vaccines focusing primarily on technologies that have advanced to testing in macaques or have entered clinical trials. RECENT FINDINGS:Replication-competent viral vectors have advanced to...

journal_title：Current opinion in HIV and AIDS

authors： Parks CL,Picker LJ,King CR

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review discusses the use of the inhibitory quotient in light of therapeutic drug monitoring of antiretroviral drugs. The inhibitory quotient is a parameter that combines viral resistance data with drug exposure data, and has its main role in therapeutic drug monitoring of protease inhibitors in e...

journal_title：Current opinion in HIV and AIDS

authors： la Porte C

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an update of recent data on the development of HIV-1 drug resistance during treatment and its transmission in sub-Saharan Africa after the scale-up of antiretroviral therapy (ART). RECENT FINDINGS:Evidence is accumulating of a rising prevalence of transmitted HIV drug resistance ...

journal_title：Current opinion in HIV and AIDS

authors： Hamers RL,Sigaloff KC,Kityo C,Mugyenyi P,de Wit TF

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine kinetic issues related to the stability of the latent reservoir and the observation of low levels of viremia (< 50 copies/ml) in patients treated with highly active antiretroviral therapy. RECENT FINDINGS:Once HIV-1 RNA becomes undetectable it is difficult to deduce the events occurring in...

journal_title：Current opinion in HIV and AIDS

authors： Kim H,Perelson AS

更新日期：2006-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Highly active antiretroviral therapy has markedly reduced HIV morbidity and mortality in industrialized countries. Expanded access to the 6.5 million individuals in immediate need of antiretroviral therapy using a public-health-systems approach is now promulgated as an international policy. An approxi...

journal_title：Current opinion in HIV and AIDS

authors： Bekker LG,Egger M,Wood R

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Globally, the number of deaths associated with tuberculosis (TB) and HIV coinfection remains unacceptably high. We review the evidence around the impact of strengthening the HIV treatment cascade in TB patients and explore recent findings about how best to deliver integrated TB/HIV services. RECENT F...

journal_title：Current opinion in HIV and AIDS

authors： Lessells RJ,Swaminathan S,Godfrey-Faussett P

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The epidemiology of HIV epidemics provides the roadmap for prioritization of programmes and serves over time to evaluate broadly the successes and challenges in prevention. The purpose of this review was to summarize recent information about the epidemiology of HIV in high-income countries with concen...

journal_title：Current opinion in HIV and AIDS

authors： Sullivan PS,Jones JS,Baral SD

更新日期：2014-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Deep sequencing of the V3 region of the HIV envelope gene can detect minority non-R5 variants in patients with high sensitivity and specificity. As next-generation sequencing approaches have matured, the clinical utility of deep sequencing for HIV tropism has entered the clinic. Accurate and sensitive...

journal_title：Current opinion in HIV and AIDS

authors： Swenson LC,Däumer M,Paredes R

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on the origin of the HIV epidemic and insights into how the immune response is shaping virus evolution. RECENT FINDINGS:Characterization of archival samples showed that by the 1960s, HIV had already diverged within humans. It is now estimated that HIV has been in humans since at ...

journal_title：Current opinion in HIV and AIDS

authors： Woodman Z,Williamson C

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The introduction of combination antiretroviral therapy (cART) led to substantial reductions in HIV-associated morbidity and mortality. However, the regimens in the early cART era were cumbersome and toxic. The introduction of new ART agents, fixed-dose combinations and novel strategies for cART delive...

journal_title：Current opinion in HIV and AIDS

authors： Boyd MA

更新日期：2009-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This article examines the dual HIV and sexually transmitted infection (STI) risk behaviors engaged in by women who use or inject drugs; the individual, social, and structural drivers of HIV and STI risk; prevention strategies; and the implications for multilevel, combined, sex-specific HIV prevention ...

journal_title：Current opinion in HIV and AIDS

authors： El-Bassel N,Wechsberg WM,Shaw SA

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to describe progress in research and development of vaccines to prevent HIV/AIDS, emphasizing clinical trials and human studies published during the past year. RECENT FINDINGS:Clinical trial design depends, in large part, on whether vaccines are expected to provide protecti...

journal_title：Current opinion in HIV and AIDS

authors： Fast PE

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Here we present recent studies examining the gastrointestinal tract during primary HIV and simian immunodeficiency virus infections and emphasizing the onset of severe pathologic processes that are not adequately reflected in peripheral blood. We discuss these findings and hypotheses relating to the r...

journal_title：Current opinion in HIV and AIDS

authors： Mehandru S,Dandekar S

更新日期：2008-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review current knowledge and the role of integrase inhibitors in the setting of HIV salvage therapy. We will discuss results from recent studies and literature and comment on the potential for integrase inhibitors in defined clinical settings. RECENT FINDINGS:Raltegravir has been studied most inte...

journal_title：Current opinion in HIV and AIDS

authors： Koelsch KK,Cooper DA

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Alcohol and noninjection drug use has been shown to be associated with increased risk of HIV infection in select populations. In this review, we discuss recent data on the prevalence of alcohol and noninjection drug use and the relationship to HIV acquisition and transmission risk. RECENT FINDINGS:A ...

journal_title：Current opinion in HIV and AIDS

authors： Van Tieu H,Koblin BA

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review recent advances in the clinical care of HIV-infected children. RECENT FINDINGS:Obstacles to diagnosing HIV in children and providing clinical care to those HIV infected relate to a number of technical and operational factors. Most countries now have antiretroviral...

journal_title：Current opinion in HIV and AIDS

authors： Crowley S,Kekitiinwa A,Vaz P

更新日期：2007-09-01 00:00:00

abstract：PURPOSE OF REVIEW:We reviewed the global state of harm reduction for people who use and/or inject drugs. KEY FINDINGS:Although harm reduction is now the key response to HIV among people who use drugs globally, intervention coverage remains suboptimal, exacerbated by chronic under-funding, declining donor support and l...

journal_title：Current opinion in HIV and AIDS

authors： Southwell M,Shelly S,MacDonald V,Verster A,Maher L

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the role of mathematical models of sexual transmission of HIV: the methods used and their impact. RECENT FINDINGS:We use mathematical modelling of 'universal test and treat' as a case study to illustrate wider issues relevant to all modelling of sexual HIV transmission. SUMMARY:Mathematic...

journal_title：Current opinion in HIV and AIDS

authors： Baggaley RF,Fraser C

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The detrimental synergy of colliding HIV and tuberculosis (TB) epidemics is most devastating among children and adolescents living with HIV (CALWH) who shoulder a disproportionate burden of all child TB mortality. RECENT FINDINGS:CALWH benefit less from Bacille-Calmette Guerin vaccination than HIV-un...

journal_title：Current opinion in HIV and AIDS

authors： Kay A,Garcia-Prats AJ,Mandalakas AM

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:With the introduction of combined antiretroviral therapy (cART) and consequent reduction in the incidence of AIDS-related mortality, there has been a relative increase in the importance of non-AIDS-related conditions such as liver disease. This article reviews the positive and potential negative impac...

journal_title：Current opinion in HIV and AIDS

authors： Allen J,Smith C,Bhagani S

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this paper is to assess the contribution of antiretroviral therapy to cardiovascular disease, by evaluating relevant clinical and surrogate outcome studies. RECENT FINDINGS:A large proportion of patients receiving antiretroviral therapy develop insulin resistance and dyslipidemia, particul...

journal_title：Current opinion in HIV and AIDS

authors： Friis-Møller N,Smieja M,Klein D

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review was to summarize recent studies on the effect of early antiretroviral therapy (ART) in HIV-infected patients on markers of immune activation/inflammation, viral persistence and serious non-AIDS events. RECENT FINDINGS:Early ART, initiated within days to months of HIV infect...

journal_title：Current opinion in HIV and AIDS

authors： Rajasuriar R,Wright E,Lewin SR

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The intricate balance between positive and negative signals delivered by accessory molecules is crucial to generate efficient immune responses while maintaining tolerance and preventing autoimmunity. Of these molecules, programmed death 1 has been described as a negative regulator of T-cell activation...

journal_title：Current opinion in HIV and AIDS

authors： Trautmann L,Said EA,Halwani R,Janbazian L,Chomont N,El-Far M,Breton G,Haddad EK,Sekaly RP

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Effective therapies have transformed HIV infection into a chronic disease, and new problems are arising related to aging. This article reviews the aging process, age-related deficit accumulation and frailty, and how these might be affected by chronic HIV infection. RECENT FINDINGS:Aging is characteri...

journal_title：Current opinion in HIV and AIDS

authors： Brothers TD,Rockwood K

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:It is generally accepted that a high degree of adherence to the dosing regimens of protease inhibitors is essential to avoid virological failure. It is also believed that once-daily dosing of protease inhibitors, by improving adherence, will lead to better outcomes. This review will discuss the patter...

journal_title：Current opinion in HIV and AIDS

authors： Blaschke TF

更新日期：2008-11-01 00:00:00

abstract：PURPOSE OF REVIEW:RNA interference is a type of nucleic-acid-based immunity used by cells to restrict transposons, transgenes and viruses. The RNA interference machinery targets long double-stranded RNAs to produce short RNAs that arm cellular ribonucleases to degrade foreign RNAs in a sequence-specific manner. Despite...

journal_title：Current opinion in HIV and AIDS

authors： Bennasser Y,Yeung ML,Benkirane M,Jeang KT

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:For the first time in decades, there are multiple new drugs in the pipeline for the treatment of tuberculosis (TB). In addition, existing drugs are being repurposed or optimized for TB with the goal of shortened treatment duration for drug-sensitive TB and safer, shorter treatments for multidrug-resis...

journal_title：Current opinion in HIV and AIDS

authors： Dooley KE,Nuermberger EL,Diacon AH

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:To explore the utility of home and community-based HIV testing and counseling (HTC) to increase detection of undiagnosed HIV among female spouses and children of HIV-positive PWID in Punjab province, Pakistan. DESIGN:Between March 2014 and March 2015, home-based HTC was provided by a local NGO to spouses of...

journal_title：Current opinion in HIV and AIDS

authors： Shahid S,Majeed MF,Awaan AB,Mirza H,Sarfraz N,Veronese V

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the status of HIV vaccine development RECENT FINDINGS:Since the discovery of HIV-1 in the early 1980s considerable effort has been exerted to develop a prophylactic vaccine, with relatively meagre results. The absence of natural immunity has proven to be a major stumbling block in identifyi...

journal_title：Current opinion in HIV and AIDS

authors： Girard MP,Plotkin SA

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The available vaccine and therapies against hepatitis B virus (HBV) rarely eliminate chronic infection with the virus. High mortality resulting from complicating cirrhosis and hepatocellular carcinoma makes improving anti-HBV therapy an important priority. Recent advances with using gene therapy to co...

journal_title：Current opinion in HIV and AIDS

authors： Maepa MB,Jacobs R,van den Berg F,Arbuthnot P

更新日期：2020-05-01 00:00:00